Harvard Catalyst Profiles

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Yu-Ru Lee, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lin YT, Lin MH, Wu KY, Lee YL. Secondhand smoke effects on rhinoconjunctivitis and sleep quality in an adolescent asthma study. Ann Allergy Asthma Immunol. 2020 Aug 12. PMID: 32795606.
  2. Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. N Engl J Med. 2020 05 28; 382(22):2103-2116. PMID: 32459922.
  3. Lee YR, Pandolfi PP. PTEN Mouse Models of Cancer Initiation and Progression. Cold Spring Harb Perspect Med. 2020 02 03; 10(2). PMID: 31570383.
  4. Zhang J, Lee YR, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019 09; 9(9):1306-1323. PMID: 31217297.
  5. Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 05 17; 364(6441). PMID: 31097636.
  6. Lee YR, Chen M, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor: new modes and prospects. Nat Rev Mol Cell Biol. 2018 09; 19(9):547-562. PMID: 29858604.
    Citations:    Fields:    
  7. Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell. 2018 04 19; 173(3):649-664.e20. PMID: 29677511.
    Citations: 4     Fields:    
  8. Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP. An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nat Genet. 2018 02; 50(2):206-218. PMID: 29335545.
    Citations: 8     Fields:    
  9. Zhou Y, Bao WW, Qian ZM, Dee Geiger S, Parrish KL, Yang BY, Lee YL, Dong GH. Perfluoroalkyl substance exposure and urine CC16 levels among asthmatics: A case-control study of children. Environ Res. 2017 11; 159:158-163. PMID: 28802206.
  10. Zhou Y, Hu LW, Qian ZM, Geiger SD, Parrish KL, Dharmage SC, Campbell B, Roponen M, Jalava P, Hirvonen MR, Heinrich J, Zeng XW, Yang BY, Qin XD, Lee YL, Dong GH. Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. Sci Rep. 2017 04 18; 7(1):899. PMID: 28420867.
  11. Qin XD, Qian ZM, Dharmage SC, Perret J, Geiger SD, Rigdon SE, Howard S, Zeng XW, Hu LW, Yang BY, Zhou Y, Li M, Xu SL, Bao WW, Zhang YZ, Yuan P, Wang J, Zhang C, Tian YP, Nian M, Xiao X, Chen W, Lee YL, Dong GH. Association of perfluoroalkyl substances exposure with impaired lung function in children. Environ Res. 2017 05; 155:15-21. PMID: 28171771.
  12. Zhou Y, Hu LW, Qian ZM, Chang JJ, King C, Paul G, Lin S, Chen PC, Lee YL, Dong GH. Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status. Environ Int. 2016 Sep; 94:189-195. PMID: 27258660.
  13. Zhu Y, Qin XD, Zeng XW, Paul G, Morawska L, Su MW, Tsai CH, Wang SQ, Lee YL, Dong GH. Associations of serum perfluoroalkyl acid levels with T-helper cell-specific cytokines in children: By gender and asthma status. Sci Total Environ. 2016 07 15; 559:166-173. PMID: 27060656.
  14. Qin XD, Qian Z, Vaughn MG, Huang J, Ward P, Zeng XW, Zhou Y, Zhu Y, Yuan P, Li M, Bai Z, Paul G, Hao YT, Chen W, Chen PC, Dong GH, Lee YL. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environ Pollut. 2016 May; 212:519-524. PMID: 26970855.
  15. Yuan WC, Lee YR, Lin SY, Chang LY, Tan YP, Hung CC, Kuo JC, Liu CH, Lin MY, Xu M, Chen ZJ, Chen RH. K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol Cell. 2014 May 22; 54(4):586-600. PMID: 24768539.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  16. Chen HY, Lee YR, Chen RH. The functions and regulations of DAPK in cancer metastasis. Apoptosis. 2014 Feb; 19(2):364-70. PMID: 24166138.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Chen RH, Lee YR, Yuan WC. The role of PML ubiquitination in human malignancies. J Biomed Sci. 2012 Aug 30; 19:81. PMID: 22935031.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  18. Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH. A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):214-28. PMID: 21840486.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  19. Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM, Chen RH. The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J. 2010 May 19; 29(10):1748-61. PMID: 20389280.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  20. Wang WJ, Kuo JC, Ku W, Lee YR, Lin FC, Chang YL, Lin YM, Chen CH, Huang YP, Chiang MJ, Yeh SW, Wu PR, Shen CH, Wu CT, Chen RH. The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR. Mol Cell. 2007 Sep 07; 27(5):701-16. PMID: 17803936.
    Citations: 21     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.