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Andrew Kruse, Ph.D.

Title
Institution
Department
Address
Profile Picture

Biography
2016 - 2019
Smith Family Award for Excellence in Biomedical Research
2015 - 2020
NIH Early Independence Award
2010 - 2013
NSF Graduate Research Fellowship

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA260415 (LIU, CHANG C) Sep 10, 2020 - Aug 31, 2025
    NIH
    Making antibody generation rapid, scalable, and democratic through machine learning and continuous evolution
    Role: Co-Principal Investigator
  2. R01AI153358 (KAHNE, DANIEL) May 21, 2020 - Apr 30, 2025
    NIH
    Targeting Membrane Transport Steps in Cell Envelope Assembly
    Role: Co-Principal Investigator
  3. R21HD101596 (KRUSE, ANDREW) Mar 16, 2020 - Feb 28, 2022
    NIH
    Angiotensin receptor blocking antibody fragments as next-generation therapeutics for preeclampsia
    Role: Principal Investigator
  4. R01GM119185 (KRUSE, ANDREW) Aug 15, 2017 - Apr 30, 2021
    NIH
    Molecular mechanisms of sigma receptor signaling
    Role: Principal Investigator
  5. DP5OD021345 (KRUSE, ANDREW) Sep 15, 2015 - Aug 31, 2020
    NIH
    Molecular mechanisms of adiponectin signaling and PAQR function
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Page JE, Skiba MA, Do T, Kruse AC, Walker S. Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation. Proc Natl Acad Sci U S A. 2022 06 28; 119(26):e2201141119. PMID: 35733252; PMCID: PMC9245657.
    Citations:    Fields:    Translation:Cells
  2. Gao Y, Barajas-Ornelas RDC, Amon JD, Ramírez-Guadiana FH, Alon A, Brock KP, Marks DS, Kruse AC, Rudner DZ. The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination. Genes Dev. 2022 05 01; 36(9-10):634-646. PMID: 35654455; PMCID: PMC9186386.
    Citations:    Fields:    Translation:Cells
  3. Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC. Structures of the s2 receptor enable docking for bioactive ligand discovery. Nature. 2021 Dec; 600(7890):759-764. PMID: 34880501; PMCID: PMC8867396.
    Citations: 8     Fields:    Translation:Animals
  4. Artzi L, Alon A, Brock KP, Green AG, Tam A, Ramírez-Guadiana FH, Marks D, Kruse A, Rudner DZ. Dormant spores sense amino acids through the B subunits of their germination receptors. Nat Commun. 2021 11 25; 12(1):6842. PMID: 34824238.
    Citations: 4     Fields:    Translation:Cells
  5. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 10; 17(10):1057-1064. PMID: 34168368.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science. 2021 07 30; 373(6554):541-547. PMID: 34326236; PMCID: PMC8501941.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  7. Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS. Protein design and variant prediction using autoregressive generative models. Nat Commun. 2021 04 23; 12(1):2403. PMID: 33893299.
    Citations: 27     Fields:    Translation:HumansCells
  8. Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, Zhang Z, Alon A, O'Donnell HR, Lyu J, Schadt H, White KM, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. bioRxiv. 2021 Mar 24. PMID: 33791693; PMCID: PMC8010720.
    Citations:    
  9. Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Blair RV, Roy CJ, Smith N, Hall JM, Tomera KM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Front Pharmacol. 2021; 12:633680. PMID: 33833683.
    Citations: 26     
  10. Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y. Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design. Sci Rep. 2021 02 02; 11(1):2751. PMID: 33531570.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Susa KJ, Rawson S, Kruse AC, Blacklow SC. Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Science. 2021 01 15; 371(6526):300-305. PMID: 33446559.
    Citations: 8     Fields:    Translation:HumansCells
  12. Skiba MA, Kruse AC. Autoantibodies as Endogenous Modulators of GPCR Signaling. Trends Pharmacol Sci. 2021 03; 42(3):135-150. PMID: 33358695.
    Citations: 3     Fields:    Translation:HumansCells
  13. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. bioRxiv. 2020 Nov 11. PMID: 33200136.
    Citations: 1     
  14. McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20284-20291. PMID: 32753386.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  15. Greenfield DA, Schmidt HR, Skiba MA, Mandler MD, Anderson JR, Sliz P, Kruse AC. Virtual Screening for Ligand Discovery at the s1 Receptor. ACS Med Chem Lett. 2020 Aug 13; 11(8):1555-1561. PMID: 32832023.
    Citations: 3