Harvard Catalyst Profiles

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Andrew Kruse, Ph.D.

Title
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Department
Address
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Biography
2016 - 2019
Smith Family Award for Excellence in Biomedical Research
2015 - 2020
NIH Early Independence Award
2010 - 2013
NSF Graduate Research Fellowship

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA260415 (LIU, CHANG C) Sep 10, 2020 - Aug 31, 2025
    NIH
    Making antibody generation rapid, scalable, and democratic through machine learning and continuous evolution
    Role: Co-Principal Investigator
  2. R01AI153358 (KAHNE, DANIEL) May 21, 2020 - Apr 30, 2025
    NIH
    Targeting Membrane Transport Steps in Cell Envelope Assembly
    Role: Co-Principal Investigator
  3. R21HD101596 (KRUSE, ANDREW) Mar 16, 2020 - Feb 28, 2022
    NIH
    Angiotensin receptor blocking antibody fragments as next-generation therapeutics for preeclampsia
    Role: Principal Investigator
  4. R01GM119185 (KRUSE, ANDREW) Aug 15, 2017 - Apr 30, 2021
    NIH
    Molecular mechanisms of sigma receptor signaling
    Role: Principal Investigator
  5. DP5OD021345 (KRUSE, ANDREW) Sep 15, 2015 - Aug 31, 2020
    NIH
    Molecular mechanisms of adiponectin signaling and PAQR function
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 10; 17(10):1057-1064. PMID: 34168368.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  2. Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science. 2021 07 30; 373(6554):541-547. PMID: 34326236.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS. Protein design and variant prediction using autoregressive generative models. Nat Commun. 2021 04 23; 12(1):2403. PMID: 33893299.
    Citations: 5     Fields:    Translation:HumansCells
  4. Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, Zhang Z, Alon A, O'Donnell HR, Lyu J, Schadt H, White KM, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2. bioRxiv. 2021 Mar 24. PMID: 33791693.
    Citations:    
  5. Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Blair RV, Roy CJ, Smith N, Hall JM, Tomera KM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Front Pharmacol. 2021; 12:633680. PMID: 33833683.
    Citations: 7     
  6. Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y. Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design. Sci Rep. 2021 02 02; 11(1):2751. PMID: 33531570.
    Citations:    Fields:    
  7. Susa KJ, Rawson S, Kruse AC, Blacklow SC. Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Science. 2021 01 15; 371(6526):300-305. PMID: 33446559.
    Citations: 3     Fields:    Translation:HumansCells
  8. Skiba MA, Kruse AC. Autoantibodies as Endogenous Modulators of GPCR Signaling. Trends Pharmacol Sci. 2021 03; 42(3):135-150. PMID: 33358695.
    Citations: 1     Fields:    Translation:HumansCells
  9. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. bioRxiv. 2020 Nov 11. PMID: 33200136.
    Citations:    
  10. McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20284-20291. PMID: 32753386.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Greenfield DA, Schmidt HR, Skiba MA, Mandler MD, Anderson JR, Sliz P, Kruse AC. Virtual Screening for Ligand Discovery at the s1 Receptor. ACS Med Chem Lett. 2020 Aug 13; 11(8):1555-1561. PMID: 32832023.
    Citations: 2     
  12. Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Olmo EMD, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Smith N, Hall JM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Res Sq. 2020 Jun 22. PMID: 32702719.
    Citations:    
  13. Susa KJ, Seegar TC, Blacklow SC, Kruse AC. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife. 2020 04 27; 9. PMID: 32338599.
    Citations: 4     Fields:    Translation:HumansCells
  14. Sjodt M, Rohs PDA, Gilman MSA, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks DS, Rudner DZ, Bernhardt TG, Kruse AC. Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol. 2020 06; 5(6):813-820. PMID: 32152588.
    Citations: 17     Fields:    Translation:Cells
  15. Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science. 2020 02 21; 367(6480):888-892. PMID: 32079768.
    Citations: 33     Fields:    Translation:HumansCells
  16. Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science. 2020 02 21; 367(6480):881-887. PMID: 32079767.
    Citations: 33     Fields:    Translation:HumansCells
  17. Yu C, Wang L, Rowe RG, Han A, Ji W, McMahon C, Baier AS, Huang YC, Marion W, Pearson DS, Kruse AC, Daley GQ, Wu H, Sliz P. A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4653-4663. PMID: 32060122.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Pascolutti R, Erlandson SC, Burri DJ, Zheng S, Kruse AC. Mapping and engineering the interaction between adiponectin and T-cadherin. J Biol Chem. 2020 02 28; 295(9):2749-2759. PMID: 31915248.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Schmidt HR, Kruse AC. The Molecular Function of s Receptors: Past, Present, and Future. Trends Pharmacol Sci. 2019 09; 40(9):636-654. PMID: 31387763.
    Citations: 31     Fields:    Translation:HumansAnimals
  20. Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology. Cell. 2019 05 16; 177(5):1217-1231.e18. PMID: 31006530.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  21. Owens TW, Taylor RJ, Pahil KS, Bertani BR, Ruiz N, Kruse AC, Kahne D. Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature. 2019 03; 567(7749):550-553. PMID: 30894747.
    Citations: 37     Fields:    Translation:Cells
  22. Zheng S, Abreu N, Levitz J, Kruse AC. Structural basis for KCTD-mediated rapid desensitization of GABAB signalling. Nature. 2019 03; 567(7746):127-131. PMID: 30814734.
    Citations: 15     Fields:    Translation:HumansCells
  23. Taguchi A, Welsh MA, Marmont LS, Lee W, Sjodt M, Kruse AC, Kahne D, Bernhardt TG, Walker S. FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein. Nat Microbiol. 2019 04; 4(4):587-594. PMID: 30692671.
    Citations: 66     Fields:    Translation:Cells
  24. Zheng S, Kruse AC. Solving a specificity mystery. Elife. 2019 01 16; 8. PMID: 30648532.
    Citations:    Fields:    Translation:HumansAnimalsCells
  25. Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. 2019 01 24; 176(3):479-490.e12. PMID: 30639100.
    Citations: 39     Fields:    Translation:HumansCells
  26. Ramírez-Guadiana FH, Rodrigues CDA, Marquis KA, Campo N, Barajas-Ornelas RDC, Brock K, Marks DS, Kruse AC, Rudner DZ. Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis. PLoS Genet. 2018 11; 14(11):e1007753. PMID: 30403663.
    Citations: 3     Fields:    Translation:Cells
  27. Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. PLoS Genet. 2018 10; 14(10):e1007726. PMID: 30335755.
    Citations: 33     Fields:    Translation:Cells
  28. Schmidt HR, Betz RM, Dror RO, Kruse AC. Structural basis for s1 receptor ligand recognition. Nat Struct Mol Biol. 2018 10; 25(10):981-987. PMID: 30291362.
    Citations: 31     Fields:    Translation:HumansCells
  29. Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell. 2018 09 20; 175(1):295-297. PMID: 30241610.
    Citations: 11     Fields:    
  30. Sham LT, Zheng S, Yakhnina AA, Kruse AC, Bernhardt TG. Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP-family flippases. Mol Microbiol. 2018 09; 109(5):633-641. PMID: 29907971.
    Citations: 5     Fields:    Translation: