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Franziska Wachter, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, Rees MG, Tiv HL, Hwang JH, Walsh KH, Cook A, Krill-Burger JM, Tsherniak A, Gokhale PC, Park PJ, Stegmaier K, Walensky LD, Hahn WC, Roberts CWM. MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Res. 2019 05 01; 79(9):2404-2414. PMID: 30755442.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  2. Pease-Raissi SE, Pazyra-Murphy MF, Li Y, Wachter F, Fukuda Y, Fenstermacher SJ, Barclay LA, Bird GH, Walensky LD, Segal RA. Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration. Neuron. 2017 Oct 11; 96(2):373-386.e6. PMID: 29024661.
    Citations: 8     Fields:    Translation:AnimalsCells
  3. Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic BAX. Nat Chem Biol. 2017 Sep; 13(9):961-967. PMID: 28692068.
    Citations: 7     Fields:    Translation:HumansCells
  4. Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene. 2017 04; 36(15):2184-2190. PMID: 27721413.
    Citations: 11     Fields:    Translation:HumansCells
  5. Edwards AL, Wachter F, Lammert M, Huhn AJ, Luccarelli J, Bird GH, Walensky LD. Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. ACS Chem Biol. 2015 Sep 18; 10(9):2149-57. PMID: 26151238.
    Citations: 10     Fields:    Translation:AnimalsCells
  6. Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Mol Cell. 2015 Mar 05; 57(5):873-886. PMID: 25684204.
    Citations: 43     Fields:    Translation:HumansCells
  7. Ehrhardt H, Pfeiffer S, Schrembs D, Wachter F, Grunert M, Jeremias I. Activation of DNA damage response by antitumor therapy counteracts the activity of vinca alkaloids. Anticancer Res. 2013 Dec; 33(12):5273-87. PMID: 24324060.
    Citations:    Fields:    Translation:HumansCells
  8. Ehrhardt H, Wachter F, Grunert M, Jeremias I. Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis. Cell Death Dis. 2013 Jun 06; 4:e661. PMID: 23744361.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  9. Wachter F, Grunert M, Blaj C, Weinstock DM, Jeremias I, Ehrhardt H. Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling. Cell Commun Signal. 2013 Apr 17; 11(1):27. PMID: 23594441.
    Citations: 1     Fields:    
  10. Ehrhardt H, Pannert L, Pfeiffer S, Wachter F, Amtmann E, Jeremias I. Enhanced anti-tumour effects of Vinca alkaloids given separately from cytostatic therapies. Br J Pharmacol. 2013 Apr; 168(7):1558-69. PMID: 23186127.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Ehrhardt H, Höfig I, Wachter F, Obexer P, Fulda S, Terziyska N, Jeremias I. NOXA as critical mediator for drug combinations in polychemotherapy. Cell Death Dis. 2012 Jun 21; 3:e327. PMID: 22717582.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  12. Ehrhardt H, Wachter F, Maurer M, Stahnke K, Jeremias I. Important role of caspase-8 for chemosensitivity of ALL cells. Clin Cancer Res. 2011 Dec 15; 17(24):7605-13. PMID: 22010212.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Ehrhardt H, Schrembs D, Moritz C, Wachter F, Haldar S, Graubner U, Nathrath M, Jeremias I. Optimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule. Blood. 2011 Dec 01; 118(23):6123-31. PMID: 21926351.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.