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profileHans-Ulrich Klein, Ph.D.

TitleResearch Fellow in Neurology (EXT)
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressBrigham and Women's Hospital
Ctr for Neurologic Diseases -NRB 168
75 Francis St
Boston MA 02115
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Klein HU, Bennett DA, De Jager PL. The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism. Acta Neuropathol. 2016 Oct; 132(4):503-14. PMID: 27573688.
    View in: PubMed
  2. Klein HU, De Jager PL. Uncovering the Role of the Methylome in Dementia and Neurodegeneration. Trends Mol Med. 2016 Aug; 22(8):687-700. PMID: 27423266.
    View in: PubMed
  3. Klein HU, Schäfer M. Integrative Analysis of Histone ChIP-seq and RNA-seq Data. Curr Protoc Hum Genet. 2016 Jul 01; 90:20.3.1-20.3.16. PMID: 27367165.
    View in: PubMed
  4. Kanojia D, Nagata Y, Garg M, Lee DH, Sato A, Yoshida K, Sato Y, Sanada M, Mayakonda A, Bartenhagen C, Klein HU, Doan NB, Said JW, Mohith S, Gunasekar S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Myklebost O, Yang H, Dugas M, Meza-Zepeda LA, Silberman AW, Forscher C, Tyner JW, Ogawa S, Koeffler HP. Genomic landscape of liposarcoma. Oncotarget. 2015 Dec 15; 6(40):42429-44. PMID: 26643872; PMCID: PMC4767443.
  5. Orent W, Mchenry AR, Rao DA, White C, Klein HU, Bassil R, Srivastava G, Replogle JM, Raj T, Frangieh M, Cimpean M, Cuerdon N, Chibnik L, Khoury SJ, Karlson EW, Brenner MB, De Jager P, Bradshaw EM, Elyaman W. Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells. Hum Mol Genet. 2016 Jan 15; 25(2):404-17. PMID: 26604133; PMCID: PMC4881829 [Available on 01/15/17].
  6. Klein HU, Hebestreit K. An evaluation of methods to test predefined genomic regions for differential methylation in bisulfite sequencing data. Brief Bioinform. 2016 Sep; 17(5):796-807. PMID: 26515532.
    View in: PubMed
  7. Agelopoulos K, Richter GH, Schmidt E, Dirksen U, von Heyking K, Moser B, Klein HU, Kontny U, Dugas M, Poos K, Korsching E, Buch T, Weckesser M, Schulze I, Besoke R, Witten A, Stoll M, Köhler G, Hartmann W, Wardelmann E, Rossig C, Baumhoer D, Jürgens H, Burdach S, Berdel WE, Müller-Tidow C. Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma. Clin Cancer Res. 2015 Nov 01; 21(21):4935-46. PMID: 26179511.
    View in: PubMed
  8. Bulk E, Ay AS, Hammadi M, Ouadid-Ahidouch H, Schelhaas S, Hascher A, Rohde C, Thoennissen NH, Wiewrodt R, Schmidt E, Marra A, Hillejan L, Jacobs AH, Klein HU, Dugas M, Berdel WE, Müller-Tidow C, Schwab A. Epigenetic dysregulation of KCa 3.1 channels induces poor prognosis in lung cancer. Int J Cancer. 2015 Sep 15; 137(6):1306-17. PMID: 25704182.
    View in: PubMed
  9. Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Okuno Y, Nagae G, Hosono N, Schnittger S, Sanada M, Przychodzen B, Kon A, Polprasert C, Shen W, Clemente MJ, Phillips JG, Alpermann T, Yoshida K, Nadarajah N, Sekeres MA, Oakley K, Nguyen N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Miyano S, Haferlach C, Kern W, Haferlach T, Du Y, Ogawa S, Makishima H. BRCC3 mutations in myeloid neoplasms. Haematologica. 2015 Aug; 100(8):1051-7. PMID: 26001790; PMCID: PMC5004421.
  10. Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B, Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M, Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y, Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE, Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Müller-Tidow C, Maciejewski JP. Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms. Cancer Cell. 2015 May 11; 27(5):658-70. PMID: 25920683.
    View in: PubMed
  11. Binder V, Bartenhagen C, Okpanyi V, Gombert M, Moehlendick B, Behrens B, Klein HU, Rieder H, Ida Krell PF, Dugas M, Stoecklein NH, Borkhardt A. A new workflow for whole-genome sequencing of single human cells. Hum Mutat. 2014 Oct; 35(10):1260-70. PMID: 25066732.
    View in: PubMed
  12. Klein HU, Schäfer M, Porse BT, Hasemann MS, Ickstadt K, Dugas M. Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models. Bioinformatics. 2014 Apr 15; 30(8):1154-1162. PMID: 24403540.
    View in: PubMed
  13. Hascher A, Haase AK, Hebestreit K, Rohde C, Klein HU, Rius M, Jungen D, Witten A, Stoll M, Schulze I, Ogawa S, Wiewrodt R, Tickenbrock L, Berdel WE, Dugas M, Thoennissen NH, Müller-Tidow C. DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes. Clin Cancer Res. 2014 Feb 15; 20(4):814-26. PMID: 24334763.
    View in: PubMed
  14. Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Kohlmann A, Miyano S, Haferlach C, Kern W, Ogawa S. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia. 2014 Feb; 28(2):241-7. PMID: 24220272; PMCID: PMC3918868.
  15. Capalbo G, Mueller-Kuller T, Koschmieder S, Klein HU, Ottmann OG, Hoelzer D, Scheuring UJ. Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML. Oncol Rep. 2013 Nov; 30(5):2254-62. PMID: 24008279.
    View in: PubMed
  16. Grossmann V, Roller A, Klein HU, Weissmann S, Kern W, Haferlach C, Dugas M, Haferlach T, Schnittger S, Kohlmann A. Robustness of amplicon deep sequencing underlines its utility in clinical applications. J Mol Diagn. 2013 Jul; 15(4):473-84. PMID: 23680131.
    View in: PubMed
  17. Hebestreit K, Dugas M, Klein HU. Detection of significantly differentially methylated regions in targeted bisulfite sequencing data. Bioinformatics. 2013 Jul 01; 29(13):1647-53. PMID: 23658421.
    View in: PubMed
  18. Capalbo G, Mueller-Kuller T, Koschmieder S, Klein HU, Ottmann OG, Hoelzer D, Scheuring UJ. Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NF?B pathway and overexpressed in AML. Int J Oncol. 2013 Jul; 43(1):246-54. PMID: 23624947.
    View in: PubMed
  19. Bolton-Gillespie E, Schemionek M, Klein HU, Flis S, Hoser G, Lange T, Nieborowska-Skorska M, Maier J, Kerstiens L, Koptyra M, Müller MC, Modi H, Stoklosa T, Seferynska I, Bhatia R, Holyoake TL, Koschmieder S, Skorski T. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood. 2013 May 16; 121(20):4175-83. PMID: 23543457; PMCID: PMC3656452.
  20. Leich E, Weißbach S, Klein HU, Grieb T, Pischimarov J, Stühmer T, Chatterjee M, Steinbrunn T, Langer C, Eilers M, Knop S, Einsele H, Bargou R, Rosenwald A. Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules. Blood Cancer J. 2013 Feb 08; 3:e102. PMID: 23396385; PMCID: PMC3584721.
  21. Machherndl-Spandl S, Suessner S, Danzer M, Proell J, Gabriel C, Lauf J, Sylie R, Klein HU, Béné MC, Weltermann A, Bettelheim P. Molecular pathways of early CD105-positive erythroid cells as compared with CD34-positive common precursor cells by flow cytometric cell-sorting and gene expression profiling. Blood Cancer J. 2013 Jan 11; 3:e100. PMID: 23310930; PMCID: PMC3556575.
  22. Schoofs T, Rohde C, Hebestreit K, Klein HU, Göllner S, Schulze I, Lerdrup M, Dietrich N, Agrawal-Singh S, Witten A, Stoll M, Lengfelder E, Hofmann WK, Schlenke P, Büchner T, Hansen K, Berdel WE, Rosenbauer F, Dugas M, Müller-Tidow C. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. Blood. 2013 Jan 03; 121(1):178-87. PMID: 23152544.
    View in: PubMed
  23. Hebestreit K, Gröttrup S, Emden D, Veerkamp J, Ruckert C, Klein HU, Müller-Tidow C, Dugas M. Leukemia gene atlas--a public platform for integrative exploration of genome-wide molecular data. PLoS One. 2012; 7(6):e39148. PMID: 22720055; PMCID: PMC3375295.
  24. Lahti L, Schäfer M, Klein HU, Bicciato S, Dugas M. Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review. Brief Bioinform. 2013 Jan; 14(1):27-35. PMID: 22441573; PMCID: PMC3548603.
  25. Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA, Marton L, Woster P, Minden MD, Dugas M, Wang JC, Dick JE, Müller-Tidow C, Petrie K, Zelent A. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012 Mar 11; 18(4):605-11. PMID: 22406747; PMCID: PMC3539284.
  26. Fischer U, Ruckert C, Hubner B, Eckermann O, Binder V, Bakchoul T, Schuster FR, Merk S, Klein HU, Führer M, Dugas M, Borkhardt A. CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL. Haematologica. 2012 Sep; 97(9):1304-11. PMID: 22315490; PMCID: PMC3436230.
  27. Grossmann V, Bacher U, Kohlmann A, Artusi V, Klein HU, Dugas M, Schnittger S, Alpermann T, Kern W, Haferlach T, Haferlach C. EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia. Br J Haematol. 2012 May; 157(3):387-90. PMID: 22235851.
    View in: PubMed
  28. Schäfer M, Lkhagvasuren O, Klein HU, Elling C, Wüstefeld T, Müller-Tidow C, Zender L, Koschmieder S, Dugas M, Ickstadt K. Integrative analyses for omics data: a Bayesian mixture model to assess the concordance of ChIP-chip and ChIP-seq measurements. J Toxicol Environ Health A. 2012; 75(8-10):461-70. PMID: 22686305.
    View in: PubMed
  29. Agrawal-Singh S, Isken F, Agelopoulos K, Klein HU, Thoennissen NH, Koehler G, Hascher A, Bäumer N, Berdel WE, Thiede C, Ehninger G, Becker A, Schlenke P, Wang Y, McClelland M, Krug U, Koschmieder S, Büchner T, Yu DY, Singh SV, Hansen K, Serve H, Dugas M, Müller-Tidow C. Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene. Blood. 2012 Mar 08; 119(10):2346-57. PMID: 22207736.
    View in: PubMed
  30. Grossmann V, Tiacci E, Holmes AB, Kohlmann A, Martelli MP, Kern W, Spanhol-Rosseto A, Klein HU, Dugas M, Schindela S, Trifonov V, Schnittger S, Haferlach C, Bassan R, Wells VA, Spinelli O, Chan J, Rossi R, Baldoni S, De Carolis L, Goetze K, Serve H, Peceny R, Kreuzer KA, Oruzio D, Specchia G, Di Raimondo F, Fabbiano F, Sborgia M, Liso A, Farinelli L, Rambaldi A, Pasqualucci L, Rabadan R, Haferlach T, Falini B. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood. 2011 Dec 01; 118(23):6153-63. PMID: 22012066.
    View in: PubMed
  31. Kohlmann A, Klein HU, Weissmann S, Bresolin S, Chaplin T, Cuppens H, Haschke-Becher E, Garicochea B, Grossmann V, Hanczaruk B, Hebestreit K, Gabriel C, Iacobucci I, Jansen JH, te Kronnie G, van de Locht L, Martinelli G, McGowan K, Schweiger MR, Timmermann B, Vandenberghe P, Young BD, Dugas M, Haferlach T. The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories. Leukemia. 2011 Dec; 25(12):1840-8. PMID: 21681191.
    View in: PubMed
  32. Bacher U, Kern W, Alpermann T, Schnittger S, Kohlmann A, Klein HU, Dugas M, Haferlach C, Haferlach T. Prognosis in patients with MDS or AML and bone marrow blasts between 10% and 30% is not associated with blast counts but depends on cytogenetic and molecular genetic characteristics. Leukemia. 2011 Aug; 25(8):1361-4. PMID: 21494258.
    View in: PubMed
  33. Grossmann V, Schnittger S, Schindela S, Klein HU, Eder C, Dugas M, Kern W, Haferlach T, Haferlach C, Kohlmann A. Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology. J Mol Diagn. 2011 Mar; 13(2):129-36. PMID: 21354046; PMCID: PMC3128616.
  34. Klein HU, Bartenhagen C, Kohlmann A, Grossmann V, Ruckert C, Haferlach T, Dugas M. R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data. Bioinformatics. 2011 Apr 15; 27(8):1162-3. PMID: 21349869.
    View in: PubMed
  35. Grossmann V, Kohlmann A, Klein HU, Schindela S, Schnittger S, Dicker F, Dugas M, Kern W, Haferlach T, Haferlach C. Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure. Leukemia. 2011 Apr; 25(4):671-80. PMID: 21252984.
    View in: PubMed
  36. Tickenbrock L, Klein HU, Trento C, Hascher A, Göllner S, Bäumer N, Kuss R, Agrawal S, Bug G, Serve H, Thiede C, Ehninger G, Stadt UZ, McClelland M, Wang Y, Becker A, Koschmieder S, Berdel WE, Dugas M, Müller-Tidow C. Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival. Leuk Res. 2011 May; 35(5):620-5. PMID: 21176959.
    View in: PubMed
  37. Bartenhagen C, Klein HU, Ruckert C, Jiang X, Dugas M. Comparative study of unsupervised dimension reduction techniques for the visualization of microarray gene expression data. BMC Bioinformatics. 2010 Nov 18; 11:567. PMID: 21087509; PMCID: PMC2998530.
  38. Kohlmann A, Grossmann V, Klein HU, Schindela S, Weiss T, Kazak B, Dicker F, Schnittger S, Dugas M, Kern W, Haferlach C, Haferlach T. Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1. J Clin Oncol. 2010 Aug 20; 28(24):3858-65. PMID: 20644105.
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  39. Miesner M, Haferlach C, Bacher U, Weiss T, Macijewski K, Kohlmann A, Klein HU, Dugas M, Kern W, Schnittger S, Haferlach T. Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not otherwise specified" (AML-NOS) or "AML with myelodysplasia-related changes" (AML-MRC). Blood. 2010 Oct 14; 116(15):2742-51. PMID: 20581309.
    View in: PubMed
  40. Müller-Tidow C, Klein HU, Hascher A, Isken F, Tickenbrock L, Thoennissen N, Agrawal-Singh S, Tschanter P, Disselhoff C, Wang Y, Becker A, Thiede C, Ehninger G, zur Stadt U, Koschmieder S, Seidl M, Müller FU, Schmitz W, Schlenke P, McClelland M, Berdel WE, Dugas M, Serve H. Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood. 2010 Nov 04; 116(18):3564-71. PMID: 20498303; PMCID: PMC2981478.
  41. Kohlmann A, Bullinger L, Thiede C, Schaich M, Schnittger S, Döhner K, Dugas M, Klein HU, Döhner H, Ehninger G, Haferlach T. Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia. 2010 Jun; 24(6):1216-20. PMID: 20428199.
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  42. Falini B, Macijewski K, Weiss T, Bacher U, Schnittger S, Kern W, Kohlmann A, Klein HU, Vignetti M, Piciocchi A, Fazi P, Martelli MP, Vitale A, Pileri S, Miesner M, Santucci A, Haferlach C, Mandelli F, Haferlach T. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood. 2010 May 06; 115(18):3776-86. PMID: 20203266.
    View in: PubMed
  43. Klein HU, Ruckert C, Kohlmann A, Bullinger L, Thiede C, Haferlach T, Dugas M. Quantitative comparison of microarray experiments with published leukemia related gene expression signatures. BMC Bioinformatics. 2009 Dec 15; 10:422. PMID: 20003504; PMCID: PMC2803858.
  44. Haferlach T, Kohlmann A, Klein HU, Ruckert C, Dugas M, Williams PM, Kern W, Schnittger S, Bacher U, Löffler H, Haferlach C. AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features. Leukemia. 2009 May; 23(5):934-43. PMID: 19194466.
    View in: PubMed
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