Harvard Catalyst Profiles

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Maofu Liao, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM122797 (LIAO, MAOFU) Aug 1, 2017 - Apr 30, 2022
    Molecular Mechanisms of Lipopolysaccharide Transport Driven by ABC Transporters
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Plummer AM, Culbertson AT, Liao M. The ABCs of Sterol Transport. Annu Rev Physiol. 2021 02 10; 83:153-181. PMID: 33141631.
    Citations:    Fields:    
  2. Luo M, Zhou W, Patel H, Srivastava AP, Symersky J, Bonar MM, Faraldo-Gómez JD, Liao M, Mueller DM. Bedaquiline inhibits the yeast and human mitochondrial ATP synthases. Commun Biol. 2020 08 19; 3(1):452. PMID: 32814813.
    Citations: 2     
  3. Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L. Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex. Nature. 2020 06; 582(7810):129-133. PMID: 32494073.
    Citations: 25     Fields:    Translation:HumansCells
  4. Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 05; 581(7808):323-328. PMID: 32433611.
    Citations: 3     Fields:    Translation:HumansCells
  5. Orlando BJ, Liao M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun. 2020 05 08; 11(1):2264. PMID: 32385283.
    Citations: 17     Fields:    Translation:HumansCells
  6. Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA. Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex. Science. 2020 04 24; 368(6489). PMID: 32327568.
    Citations: 15     Fields:    Translation:Cells
  7. Thélot F, Orlando BJ, Li Y, Liao M. High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC. Curr Opin Struct Biol. 2020 08; 63:26-33. PMID: 32335504.
    Citations: 1     Fields:    
  8. Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L. Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature. 2019 08; 572(7770):488-492. PMID: 31367042.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA. Large protein organelles form a new iron sequestration system with high storage capacity. Elife. 2019 07 08; 8. PMID: 31282860.
    Citations: 9     Fields:    Translation:Cells
  10. Li Y, Orlando BJ, Liao M. Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature. 2019 03; 567(7749):486-490. PMID: 30894744.
    Citations: 37     Fields:    Translation:Cells
  11. Shaik MM, Peng H, Lu J, Rits-Volloch S, Xu C, Liao M, Chen B. Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature. 2019 01; 565(7739):318-323. PMID: 30542158.
    Citations: 42     Fields:    Translation:HumansCells
  12. Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J Cell Biol. 2018 12 03; 217(12):4080-4091. PMID: 30327422.
    Citations: 30     Fields:    Translation:AnimalsCells
  13. Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H. DNA melting initiates the RAG catalytic pathway. Nat Struct Mol Biol. 2018 08; 25(8):732-742. PMID: 30061602.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  14. Fan C, Fan M, Orlando BJ, Fastman NM, Zhang J, Xu Y, Chambers MG, Xu X, Perry K, Liao M, Feng L. X-ray and cryo-EM structures of the mitochondrial calcium uniporter. Nature. 2018 07; 559(7715):575-579. PMID: 29995856.
    Citations: 34     Fields:    Translation:AnimalsCells
  15. Xiao Y, Luo M, Dolan AE, Liao M, Ke A. Structure basis for RNA-guided DNA degradation by Cascade and Cas3. Science. 2018 07 06; 361(6397). PMID: 29880725.
    Citations: 16     Fields:    Translation:Cells
  16. Srivastava AP, Luo M, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M, Mueller DM. High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane. Science. 2018 05 11; 360(6389). PMID: 29650704.
    Citations: 31     Fields:    Translation:Cells
  17. Vigolo M, Chambers MG, Willen L, Chevalley D, Maskos K, Lammens A, Tardivel A, Das D, Kowalczyk-Quintas C, Schuepbach-Mallepell S, Smulski CR, Eslami M, Rolink A, Hummler E, Samy E, Fomekong Nanfack Y, Mackay F, Liao M, Hess H, Jiang X, Schneider P. A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors. Nat Commun. 2018 03 23; 9(1):1199. PMID: 29572442.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  18. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem. 2018 04 06; 293(14):5360-5373. PMID: 29462788.
    Citations: 6     Fields:    Translation:Cells
  19. Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M. Structural basis of MsbA-mediated lipopolysaccharide transport. Nature. 2017 09 14; 549(7671):233-237. PMID: 28869968.
    Citations: 50     Fields:    Translation:Cells
  20. Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017 08 17; 548(7667):352-355. PMID: 28682307.
    Citations: 55     Fields:    Translation:AnimalsCells
  21. Xiao Y, Luo M, Hayes RP, Kim J, Ng S, Ding F, Liao M, Ke A. Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System. Cell. 2017 Jun 29; 170(1):48-60.e11. PMID: 28666122.
    Citations: 36     Fields:    Translation:Cells
  22. Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H. Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. 2015 Nov 19; 163(5):1138-1152. PMID: 26548953.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  23. De Zorzi R, Mi W, Liao M, Walz T. Single-particle electron microscopy in the study of membrane protein structure. Microscopy (Oxf). 2016 Feb; 65(1):81-96. PMID: 26470917.
    Citations: 7     Fields:    Translation:Cells
  24. Bhabha G, Cheng HC, Zhang N, Moeller A, Liao M, Speir JA, Cheng Y, Vale RD. Allosteric communication in the dynein motor domain. Cell. 2014 Nov 06; 159(4):857-68. PMID: 25417161.
    Citations: 35     Fields:    Translation:AnimalsCells
  25. Liao M, Cao E, Julius D, Cheng Y. Single particle electron cryo-microscopy of a mammalian ion channel. Curr Opin Struct Biol. 2014 Aug; 27:1-7. PMID: 24681231.
    Citations: 35     Fields:    Translation:Animals
  26. Liao M, Cao E, Julius D, Cheng Y. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 05; 504(7478):107-12. PMID: 24305160.
    Citations: 578     Fields:    Translation:HumansAnimalsCells
  27. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. PMID: 23485968.
    Citations: 55     Fields:    Translation:AnimalsCells
  28. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 04; 20(4):582-92. PMID: 22483106.
    Citations: 64     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.