Harvard Catalyst Profiles

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Maria Kristiina Lehtinen, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1DA048790 (LEHTINEN, MARIA) Aug 1, 2019 - Jul 31, 2022
    NIH
    A Functional and Selective Toolkit for Choroid Plexus Networks
    Role: Principal Investigator
  2. R01NS088566 (LEHTINEN, MARIA) May 15, 2014 - Apr 30, 2025
    NIH
    Activity-dependent regulation of the choroid plexus-cerebrospinal fluid stem cell niche
    Role: Principal Investigator
  3. R00NS072192 (LEHTINEN, MARIA) Sep 30, 2010 - Dec 31, 2014
    NIH
    Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Role: Principal Investigator
  4. K99NS072192 (LEHTINEN, MARIA) Sep 30, 2010 - Aug 31, 2012
    NIH
    Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li Q, Han Z, Singh N, Terré B, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K, Wu L, Virga JQ, Zhao YT, Schüller U, Wechsler-Reya RJ, Lehtinen MK, Roy S, Liu Z, Stracker TH, Zhao H. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death Differ. 2022 Mar 23. PMID: 35322202.
    Citations:    Fields:    
  2. Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V. Correction: MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2022 02 01; 149(3). PMID: 35119069.
    Citations:    Fields:    
  3. Fame RM, Lehtinen MK. Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis. Front Cell Dev Biol. 2021; 9:780207. PMID: 34888312.
    Citations:    
  4. Cui J, Xu H, Lehtinen MK. Macrophages on the margin: choroid plexus immune responses. Trends Neurosci. 2021 11; 44(11):864-875. PMID: 34312005.
    Citations: 4     Fields:    
  5. Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V. MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2021 05 15; 148(10). PMID: 34032267.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, Nguyen L, Rodman C, Riesenfeld SJ, Prochazka J, Prochazkova M, Sedlacek R, Zhang F, Bryja V, Rozenblatt-Rosen O, Habib N, Regev A, Lehtinen MK. A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021 05 27; 184(11):3056-3074.e21. PMID: 33932339.
    Citations: 22     Fields:    Translation:AnimalsCells
  7. Xu H, Fame RM, Sadegh C, Sutin J, Naranjo C, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin PY, Lehtinen MK. Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development. Nat Commun. 2021 01 19; 12(1):447. PMID: 33469018.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Cui J, Shipley FB, Shannon ML, Alturkistani O, Dani N, Webb MD, Sugden AU, Andermann ML, Lehtinen MK. Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation. Dev Cell. 2020 12 07; 55(5):617-628.e6. PMID: 33038331.
    Citations: 11     Fields:    Translation:AnimalsCells
  9. Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron. 2020 11 25; 108(4):623-639.e10. PMID: 32961128.
    Citations: 12     Fields:    Translation:Animals
  10. Xu H, Lehtinen MK. Choroid Plexus Organoids: Harnessing CSF Gatekeepers for Brain Therapeutics. Cell Stem Cell. 2020 08 06; 27(2):191-192. PMID: 32763178.
    Citations:    Fields:    Translation:Humans
  11. Xu H, Lehtinen MK. Cerebrospinal Fluid Magnetic Resonance Imaging: Improving Early Diagnosis of Autism and Other Neurodevelopmental Conditions. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 07; 5(7):635-637. PMID: 32646616.
    Citations: 1     Fields:    Translation:Humans
  12. Fame RM, Lehtinen MK. Emergence and Developmental Roles of the Cerebrospinal Fluid System. Dev Cell. 2020 02 10; 52(3):261-275. PMID: 32049038.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  13. Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK. A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Development. 2019 10 24; 146(20). PMID: 31575649.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK. Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome. Am J Pathol. 2019 12; 189(12):2440-2449. PMID: 31541646.
    Citations:    Fields:    Translation:AnimalsCells
  15. Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 2019 08 08; 178(4):867-886.e24. PMID: 31398341.
    Citations: 40     Fields:    Translation:AnimalsCells
  16. Fame RM, Lehtinen MK. Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members. Neuron. 2019 04 17; 102(2):278-279. PMID: 30998898.
    Citations: 2     Fields:    Translation:HumansCells
  17. Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, Salonen O, Barkovich AJ, Poduri A, Wilke M, de Wit MCY, Mancini GMS, Sztriha L, Im K, Amrom D, Andermann E, Paetau R, Lehesjoki AE, Walsh CA, Lehtinen MK. Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development. Neuron. 2018 09 05; 99(5):905-913.e7. PMID: 30146301.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  18. Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 07 24; 24(4):973-986.e8. PMID: 30044992.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  19. Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK. Downregulation of ribosome biogenesis during early forebrain development. Elife. 2018 05 10; 7. PMID: 29745900.
    Citations: 19     Fields:    Translation:AnimalsCells
  20. Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018 06; 188(6):1334-1344. PMID: 29545198.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  21. Lehtinen MK. Shining new light on migraine. Sci Transl Med. 2017 07 12; 9(398). PMID: 28701480.
    Citations:    Fields:    Translation:Humans
  22. Lehtinen MK. Say good night to your pain. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566427.
    Citations:    Fields:    Translation:Animals
  23. Anttonen AK, Laari A, Kousi M, Yang YJ, Jääskeläinen T, Somer M, Siintola E, Jakkula E, Muona M, Tegelberg S, Lönnqvist T, Pihko H, Valanne L, Paetau A, Lun MP, Hästbacka J, Kopra O, Joensuu T, Katsanis N, Lehtinen MK, Palvimo JJ, Lehesjoki AE. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. Brain. 2017 05 01; 140(5):1267-1279. PMID: 28335020.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  24. Lehtinen MK. Filtering more than light in the developing retina. Sci Transl Med. 2017 04 19; 9(386). PMID: 28424331.
    Citations:    Fields:    Translation:Animals
  25. Lehtinen MK. The brain's matchmakers. Sci Transl Med. 2017 03 08; 9(380). PMID: 28275158.
    Citations:    Fields:    Translation:HumansCells
  26. Dani N, Lehtinen MK. CSF Makes Waves in the Neural Stem Cell Niche. Cell Stem Cell. 2016 11 03; 19(5):565-566. PMID: 27814476.
    Citations: 1     Fields:    Translation:HumansCells
  27. Crespel A, Ferlazzo E, Franceschetti S, Genton P, Gouider R, Kälviäinen R, Korja M, Lehtinen MK, Mervaala E, Simonato M, Vaarmann A. Unverricht-Lundborg disease. Epileptic Disord. 2016 Sep 01; 18(S2):28-37. PMID: 27582036.
    Citations: 13     Fields:    Translation:HumansAnimals
  28. Mathew RS, Mullan H, Blusztajn JK, Lehtinen MK. Comment on "Multiple repressive mechanisms in the hippocampus during memory formation". Science. 2016 Jul 29; 353(6298):453. PMID: 27482552.
    Citations: 8     Fields:    
  29. Terauchi A, Johnson-Venkatesh EM, Bullock B, Lehtinen MK, Umemori H. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. Elife. 2016 04 15; 5. PMID: 27083047.
    Citations: 14     Fields:    Translation:AnimalsCells
  30. Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016 Apr; 18(4):418-30. PMID: 26999738.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  31. Chau KF, Springel MW, Broadbelt KG, Park HY, Topal S, Lun MP, Mullan H, Maynard T, Steen H, LaMantia AS, Lehtinen MK. Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure. Dev Cell. 2015 Dec 21; 35(6):789-802. PMID: 26702835.
    Citations: 31     Fields:    Translation:AnimalsCells
  32. Zhou G, Hotta J, Lehtinen MK, Forss N, Hari R. Enlargement of choroid plexus in complex regional pain syndrome. Sci Rep. 2015 Sep 21; 5:14329. PMID: 26388497.
    Citations: 9     Fields:    Translation:Humans
  33. Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci. 2015 Aug; 16(8):445-57. PMID: 26174708.
    Citations: 148     Fields:    Translation:HumansAnimals
  34. Chang JT, Lehtinen MK, Sive H. Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Dev Neurobiol. 2016 Jan; 76(1):75-92. PMID: 25980532.
    Citations: 15     Fields:    Translation:AnimalsCells
  35. Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, Sestan N, Steen H, Monuki ES, Lehtinen MK. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25; 35(12):4903-16. PMID: 25810521.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  36. Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J Neurosci. 2013 Nov 06; 33(45):17553-9. PMID: 24198345.
    Citations: 68     Fields:    Translation:Humans
  37. Zappaterra MW, LaMantia AS, Walsh CA, Lehtinen MK. Isolation of cerebrospinal fluid from rodent embryos for use with dissected cerebral cortical explants. J Vis Exp. 2013 Mar 11; (73):e50333. PMID: 23524481.
    Citations: 9     Fields:    Translation:Animals
  38. Lehtinen MK. Adult neurogenesis: VCAM stems the tide. Cell Stem Cell. 2012 Aug 03; 11(2):137-8. PMID: 22862936.
    Citations: 1     Fields:    
  39. Poduri A, Evrony GD, Cai X, Elhosary PC, Beroukhim R, Lehtinen MK, Hills LB, Heinzen EL, Hill A, Hill RS, Barry BJ, Bourgeois BF, Riviello JJ, Barkovich AJ, Black PM, Ligon KL, Walsh CA. Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron. 2012 Apr 12; 74(1):41-8. PMID: 22500628.
    Citations: 192     Fields:    Translation:HumansCells
  40. Zappaterra MW, Lehtinen MK. The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond. Cell Mol Life Sci. 2012 Sep; 69(17):2863-78. PMID: 22415326.
    Citations: 59     Fields:    Translation:Humans
  41. Lehtinen MK, Walsh CA. Neurogenesis at the brain-cerebrospinal fluid interface. Annu Rev Cell Dev Biol. 2011; 27:653-79. PMID: 21801012.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  42. Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 2011 Mar 10; 69(5):893-905. PMID: 21382550.
    Citations: 273     Fields:    Translation:HumansAnimalsCells
  43. Tucker ES, Lehtinen MK, Maynard T, Zirlinger M, Dulac C, Rawson N, Pevny L, Lamantia AS. Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development. 2010 Aug 01; 137(15):2471-81. PMID: 20573694.
    Citations: 57     Fields:    Translation:AnimalsCells
  44. Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010 Apr 15; 66(1):69-84. PMID: 20399730.
    Citations: 58     Fields:    Translation:AnimalsCells
  45. Lehtinen MK, Tegelberg S, Schipper H, Su H, Zukor H, Manninen O, Kopra O, Joensuu T, Hakala P, Bonni A, Lehesjoki AE. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J Neurosci. 2009 May 06; 29(18):5910-5. PMID: 19420257.
    Citations: 47     Fields:    Translation:AnimalsCells
  46. Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A. Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem. 2009 Apr 24; 284(17):11285-92. PMID: 19221179.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  47. Lehtinen MK, Bonni A. Demystifying MST family kinases in cell death. Curr Mol Med. 2008 Jun; 8(4):313-8. PMID: 18537638.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Lehtinen MK, Bonni A. Modeling oxidative stress in the central nervous system. Curr Mol Med. 2006 Dec; 6(8):871-81. PMID: 17168738.
    Citations: 11     Fields:    Translation:HumansCells
  49. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 2006 Jun 02; 125(5):987-1001. PMID: 16751106.
    Citations: 384     Fields:    Translation:AnimalsCells
  50. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005 Jan 28; 280(4):2818-25. PMID: 15537643.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  51. Shalizi A, Lehtinen M, Gaudilliere B, Donovan N, Han J, Konishi Y, Bonni A. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci. 2003 Aug 13; 23(19):7326-36. PMID: 12917366.
    Citations: 43     Fields:    Translation:AnimalsCells
  52. Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell. 2002 May; 9(5):1005-16. PMID: 12049737.
    Citations: 104     Fields:    Translation:AnimalsCells
  53. Wiemelt AP, Lehtinen M, McMorris FA. Agonists calcitonin, corticotropin-releasing hormone, and vasoactive intestinal peptide, but not prostaglandins or beta-adrenergic agonists, elevate cyclic adenosine monophosphate levels in oligodendroglial cells. J Neurosci Res. 2001 Jul 15; 65(2):165-72. PMID: 11438985.
    Citations: 2     Fields:    Translation:AnimalsCells
  54. Anttila T, Saikku P, Koskela P, Bloigu A, Dillner J, Ikäheimo I, Jellum E, Lehtinen M, Lenner P, Hakulinen T, Närvänen A, Pukkala E, Thoresen S, Youngman L, Paavonen J. Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. JAMA. 2001 Jan 03; 285(1):47-51. PMID: 11150108.
    Citations: 83     Fields:    Translation:HumansCells
  55. Paavonen J, Halttunen M, Hansson BG, Nieminen P, Rostila T, Lehtinen M. Prerequisites for human papillomavirus vaccine trial: results of feasibility studies. J Clin Virol. 2000 Oct; 19(1-2):25-30. PMID: 11091145.
    Citations: 4     Fields:    Translation:HumansCells
  56. Johnsen HE, Björkstrand B, Carlson K, Gruber A, Blystad A, Fast A, Boesen AM, Björkholm M, Sallerfors B, Ruutu T, Carneskog J, Malm A, Geisler C, Lehtinen M, Schrøder H, Brinch L, Remes K, Tidefelt U, Heilmann C, Hörnsten P, Thorling K, Daugaard G. Outcome for patients with leukemia, multiple myeloma and lymphoma who relapse after high dose therapy and autologous stem cell support. Leuk Lymphoma. 1996 Dec; 24(1-2):81-91. PMID: 9049964.
    Citations: 2     Fields:    Translation:Humans
  57. Lehtinen T, Lehtinen M, Aine R, Dammert K, Kulomaa P, Alavaikko M, Leinikki P. Quantity of nuclear DNA in malignancies and benign lymphadenopathies associated with Epstein-Barr virus. J Clin Pathol. 1989 Jul; 42(7):699-704. PMID: 2547845.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.