Harvard Catalyst Profiles

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Maria Kristiina Lehtinen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1DA048790 (LEHTINEN, MARIA) Aug 1, 2019 - Jul 31, 2022
    A Functional and Selective Toolkit for Choroid Plexus Networks
    Role: Principal Investigator
  2. R01NS088566 (LEHTINEN, MARIA) May 15, 2014 - Apr 30, 2025
    Activity-dependent regulation of the choroid plexus-cerebrospinal fluid stem cell niche
    Role: Principal Investigator
  3. R00NS072192 (LEHTINEN, MARIA) Sep 30, 2010 - Dec 31, 2014
    Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Role: Principal Investigator
  4. K99NS072192 (LEHTINEN, MARIA) Sep 30, 2010 - Aug 31, 2012
    Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xu H, Fame RM, Sadegh C, Sutin J, Naranjo C, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin PY, Lehtinen MK. Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development. Nat Commun. 2021 01 19; 12(1):447. PMID: 33469018.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Cui J, Shipley FB, Shannon ML, Alturkistani O, Dani N, Webb MD, Sugden AU, Andermann ML, Lehtinen MK. Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation. Dev Cell. 2020 12 07; 55(5):617-628.e6. PMID: 33038331.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK. Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron. 2020 11 25; 108(4):623-639.e10. PMID: 32961128.
    Citations: 2     Fields:    Translation:Animals
  4. Xu H, Lehtinen MK. Choroid Plexus Organoids: Harnessing CSF Gatekeepers for Brain Therapeutics. Cell Stem Cell. 2020 08 06; 27(2):191-192. PMID: 32763178.
    Citations:    Fields:    Translation:Humans
  5. Xu H, Lehtinen MK. Cerebrospinal Fluid Magnetic Resonance Imaging: Improving Early Diagnosis of Autism and Other Neurodevelopmental Conditions. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 07; 5(7):635-637. PMID: 32646616.
    Citations:    Fields:    Translation:Humans
  6. Fame RM, Lehtinen MK. Emergence and Developmental Roles of the Cerebrospinal Fluid System. Dev Cell. 2020 02 10; 52(3):261-275. PMID: 32049038.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  7. Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK. A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Development. 2019 10 24; 146(20). PMID: 31575649.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK. Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome. Am J Pathol. 2019 12; 189(12):2440-2449. PMID: 31541646.
    Citations:    Fields:    Translation:AnimalsCells
  9. Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 2019 08 08; 178(4):867-886.e24. PMID: 31398341.
    Citations: 20     Fields:    Translation:AnimalsCells
  10. Fame RM, Lehtinen MK. Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members. Neuron. 2019 04 17; 102(2):278-279. PMID: 30998898.
    Citations:    Fields:    Translation:HumansCells
  11. Smith RS, Kenny CJ, Ganesh V, Jang A, Borges-Monroy R, Partlow JN, Hill RS, Shin T, Chen AY, Doan RN, Anttonen AK, Ignatius J, Medne L, Bönnemann CG, Hecht JL, Salonen O, Barkovich AJ, Poduri A, Wilke M, de Wit MCY, Mancini GMS, Sztriha L, Im K, Amrom D, Andermann E, Paetau R, Lehesjoki AE, Walsh CA, Lehtinen MK. Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development. Neuron. 2018 09 05; 99(5):905-913.e7. PMID: 30146301.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  12. Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 07 24; 24(4):973-986.e8. PMID: 30044992.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  13. Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK. Downregulation of ribosome biogenesis during early forebrain development. Elife. 2018 05 10; 7. PMID: 29745900.
    Citations: 10     Fields:    Translation:AnimalsCells
  14. Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK. Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018 06; 188(6):1334-1344. PMID: 29545198.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Lehtinen MK. Shining new light on migraine. Sci Transl Med. 2017 07 12; 9(398). PMID: 28701480.
    Citations:    Fields:    Translation:Humans
  16. Lehtinen MK. Say good night to your pain. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566427.
    Citations:    Fields:    Translation:Animals
  17. Anttonen AK, Laari A, Kousi M, Yang YJ, Jääskeläinen T, Somer M, Siintola E, Jakkula E, Muona M, Tegelberg S, Lönnqvist T, Pihko H, Valanne L, Paetau A, Lun MP, Hästbacka J, Kopra O, Joensuu T, Katsanis N, Lehtinen MK, Palvimo JJ, Lehesjoki AE. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. Brain. 2017 05 01; 140(5):1267-1279. PMID: 28335020.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Lehtinen MK. Filtering more than light in the developing retina. Sci Transl Med. 2017 04 19; 9(386). PMID: 28424331.
    Citations:    Fields:    Translation:Animals
  19. Lehtinen MK. The brain's matchmakers. Sci Transl Med. 2017 03 08; 9(380). PMID: 28275158.
    Citations:    Fields:    Translation:HumansCells
  20. Dani N, Lehtinen MK. CSF Makes Waves in the Neural Stem Cell Niche. Cell Stem Cell. 2016 11 03; 19(5):565-566. PMID: 27814476.
    Citations: 1     Fields:    Translation:HumansCells
  21. Crespel A, Ferlazzo E, Franceschetti S, Genton P, Gouider R, Kälviäinen R, Korja M, Lehtinen MK, Mervaala E, Simonato M, Vaarmann A. Unverricht-Lundborg disease. Epileptic Disord. 2016 Sep 01; 18(S2):28-37. PMID: 27582036.
    Citations: 14     Fields:    Translation:HumansAnimals
  22. Mathew RS, Mullan H, Blusztajn JK, Lehtinen MK. Comment on "Multiple repressive mechanisms in the hippocampus during memory formation". Science. 2016 Jul 29; 353(6298):453. PMID: 27482552.
    Citations: 5     Fields:    
  23. Terauchi A, Johnson-Venkatesh EM, Bullock B, Lehtinen MK, Umemori H. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. Elife. 2016 04 15; 5. PMID: 27083047.
    Citations: 12     Fields:    Translation:AnimalsCells
  24. Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016 Apr; 18(4):418-30. PMID: 26999738.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  25. Chau KF, Springel MW, Broadbelt KG, Park HY, Topal S, Lun MP, Mullan H, Maynard T, Steen H, LaMantia AS, Lehtinen MK. Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure. Dev Cell. 2015 Dec 21; 35(6):789-802. PMID: 26702835.
    Citations: 23     Fields:    Translation:AnimalsCells
  26. Zhou G, Hotta J, Lehtinen MK, Forss N, Hari R. Enlargement of choroid plexus in complex regional pain syndrome. Sci Rep. 2015 Sep 21; 5:14329. PMID: 26388497.
    Citations: 5     Fields:    Translation:Humans
  27. Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci. 2015 Aug; 16(8):445-57. PMID: 26174708.
    Citations: 91     Fields:    Translation:HumansAnimals
  28. Chang JT, Lehtinen MK, Sive H. Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Dev Neurobiol. 2016 Jan; 76(1):75-92. PMID: 25980532.
    Citations: 12     Fields:    Translation:AnimalsCells
  29. Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, Sestan N, Steen H, Monuki ES, Lehtinen MK. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25; 35(12):4903-16. PMID: 25810521.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  30. Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J Neurosci. 2013 Nov 06; 33(45):17553-9. PMID: 24198345.
    Citations: 50     Fields:    Translation:Humans
  31. Zappaterra MW, LaMantia AS, Walsh CA, Lehtinen MK. Isolation of cerebrospinal fluid from rodent embryos for use with dissected cerebral cortical explants. J Vis Exp. 2013 Mar 11; (73):e50333. PMID: 23524481.
    Citations: 7     Fields:    Translation:Animals
  32. Lehtinen MK. Adult neurogenesis: VCAM stems the tide. Cell Stem Cell. 2012 Aug 03; 11(2):137-8. PMID: 22862936.
    Citations: 1     Fields:    
  33. Poduri A, Evrony GD, Cai X, Elhosary PC, Beroukhim R, Lehtinen MK, Hills LB, Heinzen EL, Hill A, Hill RS, Barry BJ, Bourgeois BF, Riviello JJ, Barkovich AJ, Black PM, Ligon KL, Walsh CA. Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron. 2012 Apr 12; 74(1):41-8. PMID: 22500628.
    Citations: 153     Fields:    Translation:HumansCells
  34. Zappaterra MW, Lehtinen MK. The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond. Cell Mol Life Sci. 2012 Sep; 69(17):2863-78. PMID: 22415326.
    Citations: 51     Fields:    Translation:Humans
  35. Lehtinen MK, Walsh CA. Neurogenesis at the brain-cerebrospinal fluid interface. Annu Rev Cell Dev Biol. 2011; 27:653-79. PMID: 21801012.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  36. Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 2011 Mar 10; 69(5):893-905. PMID: 21382550.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  37. Tucker ES, Lehtinen MK, Maynard T, Zirlinger M, Dulac C, Rawson N, Pevny L, Lamantia AS. Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development. 2010 Aug 01; 137(15):2471-81. PMID: 20573694.
    Citations: 49     Fields:    Translation:AnimalsCells
  38. Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010 Apr 15; 66(1):69-84. PMID: 20399730.
    Citations: 48     Fields:    Translation:AnimalsCells
  39. Lehtinen MK, Tegelberg S, Schipper H, Su H, Zukor H, Manninen O, Kopra O, Joensuu T, Hakala P, Bonni A, Lehesjoki AE. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J Neurosci. 2009 May 06; 29(18):5910-5. PMID: 19420257.
    Citations: 41     Fields:    Translation:AnimalsCells
  40. Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A. Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem. 2009 Apr 24; 284(17):11285-92. PMID: 19221179.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  41. Lehtinen MK, Bonni A. Demystifying MST family kinases in cell death. Curr Mol Med. 2008 Jun; 8(4):313-8. PMID: 18537638.
    Citations: 3     Fields:    Translation:AnimalsCells
  42. Lehtinen MK, Bonni A. Modeling oxidative stress in the central nervous system. Curr Mol Med. 2006 Dec; 6(8):871-81. PMID: 17168738.
    Citations: 10     Fields:    Translation:HumansCells
  43. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 2006 Jun 02; 125(5):987-1001. PMID: 16751106.
    Citations: 345     Fields:    Translation:AnimalsCells
  44. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A. The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005 Jan 28; 280(4):2818-25. PMID: 15537643.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  45. Shalizi A, Lehtinen M, Gaudilliere B, Donovan N, Han J, Konishi Y, Bonni A. Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci. 2003 Aug 13; 23(19):7326-36. PMID: 12917366.
    Citations: 37     Fields:    Translation:AnimalsCells
  46. Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell. 2002 May; 9(5):1005-16. PMID: 12049737.
    Citations: 88     Fields:    Translation:AnimalsCells
  47. Wiemelt AP, Lehtinen M, McMorris FA. Agonists calcitonin, corticotropin-releasing hormone, and vasoactive intestinal peptide, but not prostaglandins or beta-adrenergic agonists, elevate cyclic adenosine monophosphate levels in oligodendroglial cells. J Neurosci Res. 2001 Jul 15; 65(2):165-72. PMID: 11438985.
    Citations: 2     Fields:    Translation:AnimalsCells
  48. Anttila T, Saikku P, Koskela P, Bloigu A, Dillner J, Ikäheimo I, Jellum E, Lehtinen M, Lenner P, Hakulinen T, Närvänen A, Pukkala E, Thoresen S, Youngman L, Paavonen J. Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. JAMA. 2001 Jan 03; 285(1):47-51. PMID: 11150108.
    Citations: 75     Fields:    Translation:HumansCells
  49. Paavonen J, Halttunen M, Hansson BG, Nieminen P, Rostila T, Lehtinen M. Prerequisites for human papillomavirus vaccine trial: results of feasibility studies. J Clin Virol. 2000 Oct; 19(1-2):25-30. PMID: 11091145.
    Citations: 4     Fields:    Translation:HumansCells
  50. Johnsen HE, Björkstrand B, Carlson K, Gruber A, Blystad A, Fast A, Boesen AM, Björkholm M, Sallerfors B, Ruutu T, Carneskog J, Malm A, Geisler C, Lehtinen M, Schrøder H, Brinch L, Remes K, Tidefelt U, Heilmann C, Hörnsten P, Thorling K, Daugaard G. Outcome for patients with leukemia, multiple myeloma and lymphoma who relapse after high dose therapy and autologous stem cell support. Leuk Lymphoma. 1996 Dec; 24(1-2):81-91. PMID: 9049964.
    Citations: 2     Fields:    Translation:Humans
  51. Lehtinen T, Lehtinen M, Aine R, Dammert K, Kulomaa P, Alavaikko M, Leinikki P. Quantity of nuclear DNA in malignancies and benign lymphadenopathies associated with Epstein-Barr virus. J Clin Pathol. 1989 Jul; 42(7):699-704. PMID: 2547845.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.