Harvard Catalyst Profiles

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Christian Peter Larsen, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI138909 (LARSEN, CHRISTIAN P) Aug 1, 2018 - Jul 31, 2023
    NIH/NIAID
    Selective CD28 Blockade in Renal Transplant Recipients
    Role: Principal Investigator
  2. U01AI084150 (NEWELL, KENNETH A) Sep 25, 2009 - Aug 31, 2014
    NIH/NIAID
    Preserving Renal Function &Protective Immunity Via Anti-LFA1-Based CNI Avoidance
    Role: Co-Principal Investigator
  3. R01AI073707 (FORD, MANDY L) Jun 25, 2008 - Oct 31, 2021
    NIH/NIAID
    Determinants of T Cell Fate in Transplantation Tolerance
    Role: Co-Principal Investigator
  4. R21AI060609 (LARSEN, CHRISTIAN P) Apr 1, 2004 - Mar 31, 2006
    NIH/NIAID
    Pathogenesis/murine polyomavirus allograft nephropathy
    Role: Principal Investigator
  5. U19AI051731 (LARSEN, CHRISTIAN P) Aug 15, 2002 - May 31, 2012
    NIH/NIAID
    Transplant Tolerance in Non-Human Primates
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mannon RB, Armstrong B, Stock PG, Mehta AK, Farris AB, Watson N, Morrison Y, Sarwal M, Sigdel T, Bridges N, Robien M, Newell KA, Larsen CP. Avoidance of CNI and Steroids Using Belatacept - Results of the Clinical Trials in Organ Transplantation 16 Trial. Am J Transplant. 2020 Jun 18. PMID: 32558199.
    Citations:    
  2. Karadkhele G, Hogan J, Magua W, Zhang W, Badell IR, Mehta A, Lyon M, Pastan S, Pearson TC, Larsen CP. CMV high-risk status and post-transplant outcomes in kidney transplant recipients treated with Belatacept. Am J Transplant. 2020 Jun 09. PMID: 32519434.
    Citations:    
  3. Krummey SM, Morris AB, Jacobs JR, McGuire DJ, Ando S, Tong KP, Zhang W, Robertson J, Guasch SA, Araki K, Larsen CP, Evavold BD, Kissick HT, Ford ML. CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell Rep. 2020 Feb 04; 30(5):1282-1291.e5. PMID: 32023448.
    Citations:    
  4. Parsons RF, Larsen CP, Pearson TC, Badell IR. Belatacept and CD28 Costimulation Blockade: Preventing and Reducing Alloantibodies over the Long Term. Curr Transplant Rep. 2019 12; 6(4):277-284. PMID: 32158639.
    Citations:    
  5. Parsons RF, Zahid A, Bumb S, Decker H, Sullivan HC, Eun-Hyung Lee F, Badell IR, Ford ML, Larsen CP, Pearson TC, Jackson AM, Chen DF, Levine M, Kamoun M, Bray RA, Gebel HM. The impact of belatacept on third-party HLA alloantibodies in highly sensitized kidney transplant recipients. Am J Transplant. 2020 02; 20(2):573-581. PMID: 31452332.
    Citations:    
  6. Ju A, Josephson MA, Butt Z, Jowsey-Gregoire S, Tan J, Taylor Q, Fowler K, Dobbels F, Caskey F, Jha V, Locke J, Knoll G, Ahn C, Hanson CS, Sautenet B, Manera K, Craig JC, Howell M, Rutherford C, Tong A, Harden P, Hawley C, Holdaas H, Israni A, Jesse M, Kane B, Kanellis J, Kiberd B, Kim J, Larsen C, Leichtman A, Lentine K, Malone A, Mannon R, Oberbauer R, Patzer R, Peipert JD, Phan HA, Poggio E, Reed R, Scandling J, Tang I, Watson C, Contrares D, Contreras P, Cross D, Juodvalkis E, Koide D, Koide J, Kozarewicz A, Kozarewicz L, Kozarewicz R, Koritala A, Lisiecki E, Lipuma C, Lyman M, Mueller R, Mueller G, Noble L, Nolan N, Nolan S, Thomas J, Urbancyzk L, Zerante J, Zerante S. Establishing a Core Outcome Measure for Life Participation: A Standardized Outcomes in Nephrology-kidney Transplantation Consensus Workshop Report. Transplantation. 2019 06; 103(6):1199-1205. PMID: 30300284.
    Citations:    
  7. Patzer RE, Larsen CP. Patient Navigators in Transplantation-Where Do We Go From Here? Transplantation. 2019 06; 103(6):1076-1077. PMID: 31246931.
    Citations:    
  8. Anderson DJ, Lo DJ, Leopardi F, Song M, Strobert EA, Jenkins JB, Larsen CP, Kirk AD. Corticosteroids and methotrexate as adjuvants to costimulation blockade in non-human primate renal transplantation. Clin Transplant. 2019 06; 33(6):e13568. PMID: 31006146.
    Citations:    
  9. Kim SC, Mathews DV, Breeden CP, Higginbotham LB, Ladowski J, Martens G, Stephenson A, Farris AB, Strobert EA, Jenkins J, Walters EM, Larsen CP, Tector M, Tector AJ, Adams AB. Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion. Am J Transplant. 2019 08; 19(8):2174-2185. PMID: 30821922.
    Citations:    
  10. Badell IR, Karadkhele GM, Vasanth P, Farris AB, Robertson JM, Larsen CP. Abatacept as rescue immunosuppression after calcineurin inhibitor treatment failure in renal transplantation. Am J Transplant. 2019 08; 19(8):2342-2349. PMID: 30768841.
    Citations:    
  11. Gangappa S, Wrammert J, Wang D, Li ZN, Liepkalns JS, Cao W, Chen J, Levine MZ, Stevens J, Sambhara S, Begley B, Mehta A, Pearson TC, Ahmed R, Larsen CP. Kinetics of antibody response to influenza vaccination in renal transplant recipients. Transpl Immunol. 2019 04; 53:51-60. PMID: 30664927.
    Citations:    Fields:    
  12. Kwon Y, Larsen CPS, Lee M. Tree species richness predicted using a spatial environmental model including forest area and frost frequency, eastern USA. PLoS One. 2018; 13(9):e0203881. PMID: 30226902.
    Citations:    Fields:    
  13. Mathews DV, Dong Y, Higginbotham LB, Kim SC, Breeden CP, Stobert EA, Jenkins J, Tso JY, Larsen CP, Adams AB. CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection. J Clin Invest. 2018 10 01; 128(10):4557-4572. PMID: 30222140.
    Citations:    Fields:    
  14. Patzer RE, Larsen CP. Patient Navigators in Transplantation - where do we go from here? Transplantation. 2018 Sep 11. PMID: 30211829.
    Citations:    Fields:    
  15. Gopalsamy SN, Woodworth MH, Wang T, Carpentieri CT, Mehta N, Friedman-Moraco RJ, Mehta AK, Larsen CP, Kraft CS. The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms. Am J Med Sci. 2018 11; 356(5):433-440. PMID: 30384952.
    Citations:    Fields:    
  16. Ravindran A, Cortese C, Larsen CP, Wadei HM, Gandhi MJ, Cosio FG, Sethi S. Karyomegalic interstitial nephritis in a renal allograft. Am J Transplant. 2019 01; 19(1):285-290. PMID: 30040181.
    Citations:    Fields:    
  17. Patzer RE, McPherson L, Basu M, Mohan S, Wolf M, Chiles M, Russell A, Gander JC, Friedewald JJ, Ladner D, Larsen CP, Pearson T, Pastan S. Effect of the iChoose Kidney decision aid in improving knowledge about treatment options among transplant candidates: A randomized controlled trial. Am J Transplant. 2018 08; 18(8):1954-1965. PMID: 29446209.
    Citations: 2     Fields:    
  18. Basu M, Petgrave-Nelson L, Smith KD, Perryman JP, Clark K, Pastan SO, Pearson TC, Larsen CP, Paul S, Patzer RE. Transplant Center Patient Navigator and Access to Transplantation among High-Risk Population: A Randomized, Controlled Trial. Clin J Am Soc Nephrol. 2018 04 06; 13(4):620-627. PMID: 29581107.
    Citations: 2     Fields:    
  19. Florman S, Vincenti F, Durrbach A, Abouljoud M, Bresnahan B, Garcia VD, Mulloy L, Rice K, Rostaing L, Zayas C, Calderon K, Meier-Kriesche U, Polinsky M, Yang L, Medina Pestana J, Larsen CP. Outcomes at 7 years post-transplant in black vs nonblack kidney transplant recipients administered belatacept or cyclosporine in BENEFIT and BENEFIT-EXT. Clin Transplant. 2018 04; 32(4):e13225. PMID: 29461660.
    Citations:    Fields:    
  20. Lovasik BP, Zhang R, Hockenberry JM, Schrager JD, Pastan SO, Adams AB, Mohan S, Larsen CP, Patzer RE. Emergency department use among kidney transplant recipients in the United States. Am J Transplant. 2018 04; 18(4):868-880. PMID: 29116680.
    Citations:    Fields:    
  21. Newell KA, Mehta AK, Larsen CP, Stock PG, Farris AB, Mehta SG, Ikle D, Armstrong B, Morrison Y, Bridges N, Robien M, Mannon RB. Lessons Learned: Early Termination of a Randomized Trial of Calcineurin Inhibitor and Corticosteroid Avoidance Using Belatacept. Am J Transplant. 2017 Oct; 17(10):2712-2719. PMID: 28556519.
    Citations: 1     Fields:    Translation:Humans
  22. Cortes-Cerisuelo M, Laurie SJ, Mathews DV, Winterberg PD, Larsen CP, Adams AB, Ford ML. Increased Pretransplant Frequency of CD28+ CD4+ TEM Predicts Belatacept-Resistant Rejection in Human Renal Transplant Recipients. Am J Transplant. 2017 Sep; 17(9):2350-2362. PMID: 28502091.
    Citations: 4     Fields:    Translation:HumansCells
  23. Kitchens WH, Dong Y, Mathews DV, Breeden CP, Strobert E, Fuentes ME, Larsen CP, Ford ML, Adams AB. Interruption of OX40L signaling prevents costimulation blockade-resistant allograft rejection. JCI Insight. 2017 03 09; 2(5):e90317. PMID: 28289708.
    Citations: 1     Fields:    
  24. Kim SC, Wakwe W, Higginbotham LB, Mathews DV, Breeden CP, Stephenson AC, Jenkins J, Strobert E, Price K, Price L, Kuhn R, Wang H, Yamniuk A, Suchard S, Farris AB, Pearson TC, Larsen CP, Ford ML, Suri A, Nadler S, Adams AB. Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection. Am J Transplant. 2017 May; 17(5):1182-1192. PMID: 28097811.
    Citations: 7     Fields:    Translation:AnimalsCells
  25. Lynch RJ, Zhang R, Patzer RE, Larsen CP, Adams AB. Waitlist Hospital Admissions Predict Resource Utilization and Survival After Renal Transplantation. Ann Surg. 2016 Dec; 264(6):1168-1173. PMID: 26720436.
    Citations: 2     Fields:    Translation:Humans
  26. Adams AB, Ford ML, Larsen CP. Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway. J Immunol. 2016 09 15; 197(6):2045-50. PMID: 27591335.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  27. Krummey SM, Chen CW, Guasch SA, Liu D, Wagener M, Larsen CP, Ford ML. Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+ T Cells during Heterologous Immunity. J Immunol. 2016 09 01; 197(5):2009-15. PMID: 27481849.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Hering BJ, Clarke WR, Bridges ND, Eggerman TL, Alejandro R, Bellin MD, Chaloner K, Czarniecki CW, Goldstein JS, Hunsicker LG, Kaufman DB, Korsgren O, Larsen CP, Luo X, Markmann JF, Naji A, Oberholzer J, Posselt AM, Rickels MR, Ricordi C, Robien MA, Senior PA, Shapiro AM, Stock PG, Turgeon NA. Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia. Diabetes Care. 2016 Jul; 39(7):1230-40. PMID: 27208344.
    Citations: 50     Fields:    Translation:HumansCTClinical Trials
  29. Patzer RE, Basu M, Larsen CP, Pastan SO, Mohan S, Patzer M, Konomos M, McClellan WM, Lea J, Howard D, Gander J, Arriola KJ. iChoose Kidney: A Clinical Decision Aid for Kidney Transplantation Versus Dialysis Treatment. Transplantation. 2016 Mar; 100(3):630-9. PMID: 26714121.
    Citations: 9     Fields:    Translation:Humans
  30. Krummey SM, Martinez RJ, Andargachew R, Liu D, Wagener M, Kohlmeier JE, Evavold BD, Larsen CP, Ford ML. Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity. J Immunol. 2016 Mar 15; 196(6):2838-46. PMID: 26864034.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Vincenti F, Rostaing L, Grinyo J, Rice K, Steinberg S, Gaite L, Moal MC, Mondragon-Ramirez GA, Kothari J, Polinsky MS, Meier-Kriesche HU, Munier S, Larsen CP. Belatacept and Long-Term Outcomes in Kidney Transplantation. N Engl J Med. 2016 Jan 28; 374(4):333-43. PMID: 26816011.
    Citations: 74     Fields:    Translation:HumansCTClinical Trials
  32. Rune I, Rolin B, Larsen C, Nielsen DS, Kanter JE, Bornfeldt KE, Lykkesfeldt J, Buschard K, Kirk RK, Christoffersen B, Fels JJ, Josefsen K, Kihl P, Hansen AK. Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice. PLoS One. 2016; 11(1):e0146439. PMID: 26799618.
    Citations: 8     Fields:    Translation:Animals
  33. Larsen CP, Whitehead SS, Durbin AP. WITHDRAWN: Dengue Human Infection Models to Advance Dengue Vaccine Development. Vaccine. 2015 Oct 27. PMID: 26501186.
    Citations: 1     Fields:    
  34. Larsen CP, Whitehead SS, Durbin AP. Dengue human infection models to advance dengue vaccine development. Vaccine. 2015 Dec 10; 33(50):7075-82. PMID: 26424605.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  35. Stephens DS, Ribner BS, Gartland BD, Feistritzer NR, Farley MM, Larsen CP, Fox JT. Ebola Virus Disease: Experience and Decision Making for the First Patients outside of Africa. PLoS Med. 2015 Jul; 12(7):e1001857. PMID: 26218574.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  36. Higginbotham L, Mathews D, Breeden CA, Song M, Farris AB, Larsen CP, Ford ML, Lutz AJ, Tector M, Newell KA, Tector AJ, Adams AB. Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model. Xenotransplantation. 2015 May-Jun; 22(3):221-30. PMID: 25847130.
    Citations: 34     Fields:    Translation:Animals
  37. Bonomo JA, Ng MC, Palmer ND, Keaton JM, Larsen CP, Hicks PJ, Langefeld CD, Freedman BI, Bowden DW. Coding variants in nephrin (NPHS1) and susceptibility to nephropathy in African Americans. Clin J Am Soc Nephrol. 2014 Aug 07; 9(8):1434-40. PMID: 24948143.
    Citations: 5     Fields:    Translation:Humans
  38. Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS. In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial. Biol Blood Marrow Transplant. 2013 Nov; 19(11):1638-49. PMID: 24047754.
    Citations: 18     Fields:    Translation:HumansCells
  39. Tang H, Sha H, Sun H, Wu X, Xie L, Wang P, Xu C, Larsen C, Zhang HL, Gong Y, Mao Y, Chen X, Zhou L, Feng X, Zhu J. Tracking induced pluripotent stem cells-derived neural stem cells in the central nervous system of rats and monkeys. Cell Reprogram. 2013 Oct; 15(5):435-42. PMID: 24020696.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  40. Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS. Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. PLoS One. 2013; 8(8):e71221. PMID: 23940724.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. Cossey LN, Walker PD, Larsen CP. Phospholipase A2 receptor staining in pediatric idiopathic membranous glomerulopathy. Pediatr Nephrol. 2013 Dec; 28(12):2307-11. PMID: 23903693.
    Citations:    
  42. Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, Pattou F, Berney T, Secchi A, Messinger S, Senior PA, Maffi P, Posselt A, Stock PG, Kaufman DB, Luo X, Kandeel F, Cagliero E, Turgeon NA, Witkowski P, Naji A, O'Connell PJ, Greenbaum C, Kudva YC, Brayman KL, Aull MJ, Larsen C, Kay TW, Fernandez LA, Vantyghem MC, Bellin M, Shapiro AM. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care. 2012 Jul; 35(7):1436-45. PMID: 22723582.
    Citations: 146     Fields:    Translation:HumansCTClinical Trials
  43. Turgeon NA, Perez S, Mondestin M, Davis SS, Lin E, Tata S, Kirk AD, Larsen CP, Pearson TC, Sweeney JF. The impact of renal function on outcomes of bariatric surgery. J Am Soc Nephrol. 2012 May; 23(5):885-94. PMID: 22383694.
    Citations: 21     Fields:    Translation:Humans
  44. Ferrer IR, Wagener ME, Song M, Kirk AD, Larsen CP, Ford ML. Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20701-6. PMID: 22143783.
    Citations: 27     Fields:    Translation:AnimalsCells
  45. Mwangi SM, Usta Y, Shahnavaz N, Joseph I, Avila J, Cano J, Chetty VK, Larsen CP, Sitaraman SV, Srinivasan S. Glial cell line-derived neurotrophic factor enhances human islet posttransplantation survival. Transplantation. 2011 Oct 15; 92(7):745-51. PMID: 21869742.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  46. Reisman NM, Floyd TL, Wagener ME, Kirk AD, Larsen CP, Ford ML. LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function. Blood. 2011 Nov 24; 118(22):5851-61. PMID: 21972294.
    Citations: 18     Fields:    Translation:AnimalsCells
  47. Ford ML, Larsen CP. Transplantation tolerance: memories that haunt us. Sci Transl Med. 2011 Jun 08; 3(86):86ps22. PMID: 21653828.
    Citations: 6     Fields:    Translation:AnimalsCells
  48. Vanrenterghem Y, Bresnahan B, Campistol J, Durrbach A, Grinyó J, Neumayer HH, Lang P, Larsen CP, Mancilla-Urrea E, Pestana JM, Block A, Duan T, Glicklich A, Gujrathi S, Vincenti F. Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies). Transplantation. 2011 May 15; 91(9):976-83. PMID: 21372756.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  49. López MN, Pesce B, Kurte M, Pérez C, Segal G, Roa J, Aguillón JC, Mendoza-Naranjo A, Gesser B, Larsen C, Villablanca A, Choudhury A, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-ß+ tolerogenic dendritic cells. Immunobiology. 2011 Oct; 216(10):1117-26. PMID: 21601308.
    Citations: 4     Fields:    Translation:HumansCells
  50. Neujahr DC, Larsen CP. Regulatory T cells in lung transplantation--an emerging concept. Semin Immunopathol. 2011 Mar; 33(2):117-27. PMID: 21424593.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  51. Kitchens WH, Larsen CP, Ford ML. Integrin antagonists for transplant immunosuppression: panacea or peril? Immunotherapy. 2011 Mar; 3(3):305-7. PMID: 21395371.
    Citations: 8     Fields:    Translation:HumansAnimals
  52. Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn KJ, Pearson TC. Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996. J Immunol. 2011 Mar 01; 186(5):2693-7. PMID: 21325218.
    Citations:    Fields:    Translation:HumansAnimalsCells
  53. Floyd TL, Koehn BH, Kitchens WH, Robertson JM, Cheeseman JA, Stempora L, Larsen CP, Ford ML. Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall. J Immunol. 2011 Feb 15; 186(4):2033-41. PMID: 21257960.
    Citations: 21     Fields:    Translation:AnimalsCells
  54. Larsen CP, Grinyó J, Medina-Pestana J, Vanrenterghem Y, Vincenti F, Breshahan B, Campistol JM, Florman S, Rial Mdel C, Kamar N, Block A, Di Russo G, Lin CS, Garg P, Charpentier B. Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies. Transplantation. 2010 Dec 27; 90(12):1528-35. PMID: 21076381.
    Citations: 31     Fields:    Translation:Humans
  55. Grinyó J, Charpentier B, Pestana JM, Vanrenterghem Y, Vincenti F, Reyes-Acevedo R, Apanovitch AM, Gujrathi S, Agarwal M, Thomas D, Larsen CP. An integrated safety profile analysis of belatacept in kidney transplant recipients. Transplantation. 2010 Dec 27; 90(12):1521-7. PMID: 21088650.
    Citations: 22     Fields:    Translation:Humans
  56. Badell IR, Russell MC, Thompson PW, Turner AP, Weaver TA, Robertson JM, Avila JG, Cano JA, Johnson BE, Song M, Leopardi FV, Swygert S, Strobert EA, Ford ML, Kirk AD, Larsen CP. LFA-1-specific therapy prolongs allograft survival in rhesus macaques. J Clin Invest. 2010 Dec; 120(12):4520-31. PMID: 21099108.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  57. Ford ML, Stempora LL, Larsen CP. CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha. Transpl Immunol. 2011 Jan 15; 24(2):94-9. PMID: 21073953.
    Citations: 1     Fields:    Translation:AnimalsCells
  58. Araki K, Gangappa S, Dillehay DL, Rouse BT, Larsen CP, Ahmed R. Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation. J Exp Med. 2010 Oct 25; 207(11):2355-67. PMID: 20921283.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  59. Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, Wheeler C, Anderson DC, Sharma P, Garcia A, Strobert E, Elder E, Crocker I, Crenshaw T, Penedo MC, Ward T, Song M, Horan J, Larsen CP, Blazar BR, Kean LS. GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood. 2010 Dec 09; 116(24):5403-18. PMID: 20833977.
    Citations: 20     Fields:    Translation:AnimalsCells
  60. Ford ML, Larsen CP. Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations. Curr Opin Organ Transplant. 2010 Aug; 15(4):405-10. PMID: 20616729.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  61. Vincenti F, Blancho G, Durrbach A, Friend P, Grinyo J, Halloran PF, Klempnauer J, Lang P, Larsen CP, Mühlbacher F, Nashan B, Soulillou JP, Vanrenterghem Y, Wekerle T, Agarwal M, Gujrathi S, Shen J, Shi R, Townsend R, Charpentier B. Five-year safety and efficacy of belatacept in renal transplantation. J Am Soc Nephrol. 2010 Sep; 21(9):1587-96. PMID: 20634298.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  62. Ferrer IR, Wagener ME, Robertson JM, Turner AP, Araki K, Ahmed R, Kirk AD, Larsen CP, Ford ML. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J Immunol. 2010 Aug 15; 185(4):2004-8. PMID: 20631309.
    Citations: 43     Fields:    Translation:AnimalsCells
  63. Ma D, Zhang M, Mori Y, Yao C, Larsen CP, Yamashima T, Zhou L. Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia. Hippocampus. 2010 Jul; 20(7):811-9. PMID: 19623607.
    Citations: 6     Fields:    Translation:AnimalsCells
  64. Neujahr DC, Mohammed A, Ulukpo O, Force SD, Ramirez AM, Pelaez A, Lawrence EC, Larsen CP, Kirk AD. Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series. Chest. 2010 Oct; 138(4):937-43. PMID: 20522573.
    Citations: 5     Fields:    Translation:HumansCells
  65. Floyd TL, Orr SB, Coley SM, Hanna SS, Wagener ME, Kirk AD, Larsen CP, Ford ML. High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade. Transplantation. 2010 May 27; 89(10):1208-17. PMID: 20407401.
    Citations: 4     Fields:    Translation:AnimalsCells
  66. Ma D, Zhang M, Larsen CP, Xu F, Hua W, Yamashima T, Mao Y, Zhou L. DHA promotes the neuronal differentiation of rat neural stem cells transfected with GPR40 gene. Brain Res. 2010 May 12; 1330:1-8. PMID: 20211608.
    Citations: 7     Fields:    Translation:AnimalsCells
  67. Martin DR, Krishnamoorthy SK, Kalb B, Salman KN, Sharma P, Carew JD, Martin PA, Chapman AB, Ray GL, Larsen CP, Pearson TC. Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols. J Magn Reson Imaging. 2010 Feb; 31(2):440-6. PMID: 20099361.
    Citations: 19     Fields:    Translation:HumansCells
  68. Radziewicz H, Ibegbu CC, Hon H, Bédard N, Bruneau J, Workowski KA, Knechtle SJ, Kirk AD, Larsen CP, Shoukry NH, Grakoui A. Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. J Immunol. 2010 Mar 01; 184(5):2410-22. PMID: 20100932.
    Citations: 6     Fields:    Translation:HumansCells
  69. Neujahr DC, Cardona AC, Ulukpo O, Rigby M, Pelaez A, Ramirez A, Gal AA, Force SD, Lawrence EC, Kirk AD, Larsen CP. Dynamics of human regulatory T cells in lung lavages of lung transplant recipients. Transplantation. 2009 Aug 27; 88(4):521-7. PMID: 19696635.
    Citations: 10     Fields:    Translation:HumansCells
  70. Gilson CR, Milas Z, Gangappa S, Hollenbaugh D, Pearson TC, Ford ML, Larsen CP. Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. J Immunol. 2009 Aug 01; 183(3):1625-35. PMID: 19592649.
    Citations: 32     Fields:    Translation:Animals
  71. Weaver TA, Charafeddine AH, Agarwal A, Turner AP, Russell M, Leopardi FV, Kampen RL, Stempora L, Song M, Larsen CP, Kirk AD. Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates. Nat Med. 2009 Jul; 15(7):746-9. PMID: 19584865.
    Citations: 85     Fields:    Translation:AnimalsCells
  72. Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, Larsen CP, Ahmed R. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009 Jul 02; 460(7251):108-12. PMID: 19543266.
    Citations: 503     Fields:    Translation:AnimalsCells
  73. Heffron TG, Rodriguez J, Fasola CG, Casper K, Pillen T, Smallwood G, Warshaw B, Romero R, Larsen C. Successful outcome after early combined liver and en bloc-kidney transplant in an infant with primary hyperoxaluria type 1: a case report. Pediatr Transplant. 2009 Nov; 13(7):940-2. PMID: 19496983.
    Citations: 1     Fields:    Translation:Humans
  74. Ford ML, Kirk AD, Larsen CP. Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. Transplantation. 2009 May 15; 87(9 Suppl):S69-74. PMID: 19424013.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  75. Ford ML, Larsen CP. Translating costimulation blockade to the clinic: lessons learned from three pathways. Immunol Rev. 2009 May; 229(1):294-306. PMID: 19426229.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  76. Coley SM, Ford ML, Hanna SC, Wagener ME, Kirk AD, Larsen CP. IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses. J Immunol. 2009 Jan 01; 182(1):225-33. PMID: 19109153.
    Citations: 12     Fields:    Translation:AnimalsCells
  77. Koehn BH, Ford ML, Ferrer IR, Borom K, Gangappa S, Kirk AD, Larsen CP. PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. J Immunol. 2008 Oct 15; 181(8):5313-22. PMID: 18832687.
    Citations: 21     Fields:    Translation:AnimalsCells
  78. Kalb B, Martin DR, Salman K, Sharma P, Votaw J, Larsen C. Kidney transplantation: structural and functional evaluation using MR Nephro-Urography. J Magn Reson Imaging. 2008 Oct; 28(4):805-22. PMID: 18821623.
    Citations: 8     Fields:    Translation:Humans
  79. Ford ML, Wagener ME, Hanna SS, Pearson TC, Kirk AD, Larsen CP. A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. J Immunol. 2008 Jun 01; 180(11):7203-11. PMID: 18490719.
    Citations: 18     Fields:    Translation:AnimalsCells
  80. Dobbels F, Moons P, Abraham I, Larsen CP, Dupont L, De Geest S. Measuring symptom experience of side-effects of immunosuppressive drugs: the Modified Transplant Symptom Occurrence and Distress Scale. Transpl Int. 2008 Aug; 21(8):764-73. PMID: 18435683.
    Citations: 9     Fields:    Translation:Humans
  81. Rigby MR, Trexler AM, Pearson TC, Larsen CP. CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion. Diabetes. 2008 Oct; 57(10):2672-83. PMID: 18492787.
    Citations: 15     Fields:    Translation:AnimalsCells
  82. Wrammert J, Smith K, Miller J, Langley WA, Kokko K, Larsen C, Zheng NY, Mays I, Garman L, Helms C, James J, Air GM, Capra JD, Ahmed R, Wilson PC. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature. 2008 May 29; 453(7195):667-71. PMID: 18449194.
    Citations: 370     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  83. Gangappa S, Larsen CP. Immunosuppressive protocols for pig-to-human islet transplantation: lessons from pre-clinical non-human primate models. Xenotransplantation. 2008 Mar-Apr; 15(2):107-11. PMID: 18447881.
    Citations: 2     Fields:    Translation:HumansAnimals
  84. Stapler D, Lee ED, Selvaraj SA, Evans AG, Kean LS, Speck SH, Larsen CP, Gangappa S. Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance. J Immunol. 2008 Mar 01; 180(5):3190-200. PMID: 18292543.
    Citations: 19     Fields:    Translation:AnimalsCells
  85. Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S. Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance. Gastroenterology. 2008 Mar; 134(3):727-37. PMID: 18241861.
    Citations: 16     Fields:    Translation:AnimalsCells
  86. Gangappa S, Kokko KE, Carlson LM, Gourley T, Newell KA, Pearson TC, Ahmed R, Larsen CP. Immune responsiveness and protective immunity after transplantation. Transpl Int. 2008 Apr; 21(4):293-303. PMID: 18225995.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  87. Emamaullee JA, Merani S, Larsen CP, Shapiro AM. Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity. Transplantation. 2008 Jan 15; 85(1):118-24. PMID: 18192921.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  88. Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15430-5. PMID: 17878315.
    Citations: 87     Fields:    Translation:AnimalsCells
  89. Koehn BH, Williams MA, Borom K, Gangappa S, Pearson TC, Ahmed R, Larsen CP. Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. J Immunol. 2007 Aug 15; 179(4):2616-26. PMID: 17675525.
    Citations: 8     Fields:    Translation:AnimalsCells
  90. Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation. 2007 Jul 27; 84(2):196-206. PMID: 17667811.
    Citations: 24     Fields:    Translation:AnimalsCells
  91. Newell KA, Larsen CP. Transplantation tolerance. Semin Nephrol. 2007 Jul; 27(4):487-97. PMID: 17616279.
    Citations: 3     Fields:    Translation:HumansAnimals
  92. Singh N, Chandler PR, Seki Y, Baban B, Takezaki M, Kahler DJ, Munn DH, Larsen CP, Mellor AL, Iwashima M. Role of CD28 in fatal autoimmune disorder in scurfy mice. Blood. 2007 Aug 15; 110(4):1199-206. PMID: 17463170.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  93. Ford ML, Koehn BH, Wagener ME, Jiang W, Gangappa S, Pearson TC, Larsen CP. Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. J Exp Med. 2007 Feb 19; 204(2):299-309. PMID: 17261633.
    Citations: 60     Fields:    Translation:AnimalsCells
  94. Li JM, Gorechlad J, Larsen CP, Waller EK. Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2006 Dec; 12(12):1239-49. PMID: 17162205.
    Citations: 4     Fields:    Translation:AnimalsCells
  95. Vezys V, Masopust D, Kemball CC, Barber DL, O'Mara LA, Larsen CP, Pearson TC, Ahmed R, Lukacher AE. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J Exp Med. 2006 Oct 02; 203(10):2263-9. PMID: 16966427.
    Citations: 96     Fields:    Translation:AnimalsCells
  96. Newell KA, Larsen CP. Tolerance assays: measuring the unknown. Transplantation. 2006 Jun 15; 81(11):1503-9. PMID: 16770237.
    Citations: 7     Fields:    Translation:HumansCells
  97. Koehn B, Gangappa S, Miller JD, Ahmed R, Larsen CP. Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation. J Immunol. 2006 Mar 01; 176(5):2691-6. PMID: 16493023.
    Citations: 7     Fields:    Translation:HumansCells
  98. Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangappa S, Weber CJ, Pearson TC, Rajotte RV, Larsen CP. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med. 2006 Mar; 12(3):304-6. PMID: 16501570.
    Citations: 99     Fields:    Translation:Animals
  99. Emmanouilidis N, Guo Z, Dong Y, Newton-West M, Adams AB, Lee ED, Wang J, Pearson TC, Larsen CP, Newell KA. Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells. Transplantation. 2006 Feb 15; 81(3):455-62. PMID: 16477234.
    Citations: 5     Fields:    Translation:AnimalsCells
  100. Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE. Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection. J Immunol. 2006 Feb 01; 176(3):1814-24. PMID: 16424212.
    Citations: 20     Fields:    Translation:AnimalsCells
  101. Newell KA, Larsen CP, Kirk AD. Transplant tolerance: converging on a moving target. Transplantation. 2006 Jan 15; 81(1):1-6. PMID: 16421467.
    Citations: 6     Fields:    Translation:HumansAnimals
  102. Vincenti F, Larsen C, Durrbach A, Wekerle T, Nashan B, Blancho G, Lang P, Grinyo J, Halloran PF, Solez K, Hagerty D, Levy E, Zhou W, Natarajan K, Charpentier B. Costimulation blockade with belatacept in renal transplantation. N Engl J Med. 2005 Aug 25; 353(8):770-81. PMID: 16120857.
    Citations: 184     Fields:    Translation:HumansCellsCTClinical Trials
  103. Kemball CC, Lee ED, Vezys V, Pearson TC, Larsen CP, Lukacher AE. Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection. J Immunol. 2005 Jun 15; 174(12):7950-60. PMID: 15944301.
    Citations: 42     Fields:    Translation:AnimalsCells
  104. Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobert E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Turk LA, Bajorath J, Townsend R, Hagerty D, Linsley PS, Peach RJ. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant. 2005 Mar; 5(3):443-53. PMID: 15707398.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  105. Dai Z, Nasr IW, Reel M, Deng S, Diggs L, Larsen CP, Rothstein DM, Lakkis FG. Impaired recall of CD8 memory T cells in immunologically privileged tissue. J Immunol. 2005 Feb 01; 174(3):1165-70. PMID: 15661869.
    Citations: 13     Fields:    Translation:AnimalsCells
  106. Adams AB, Shirasugi N, Jones TR, Durham MM, Strobert EA, Cowan S, Rees P, Hendrix R, Price K, Kenyon NS, Hagerty D, Townsend R, Hollenbaugh D, Pearson TC, Larsen CP. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol. 2005 Jan 01; 174(1):542-50. PMID: 15611281.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  107. Emmanouilidis N, Larsen CP. Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice. Methods Mol Med. 2005; 109:459-68. PMID: 15585938.
    Citations: 2     Fields:    Translation:AnimalsCells
  108. Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wang L, Coyle AJ, Larsen CP, Shapiro AM. Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. Am J Transplant. 2004 Apr; 4(4):526-36. PMID: 15023144.
    Citations: 19     Fields:    Translation:AnimalsCells
  109. Garber DA, Silvestri G, Barry AP, Fedanov A, Kozyr N, McClure H, Montefiori DC, Larsen CP, Altman JD, Staprans SI, Feinberg MB. Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication. J Clin Invest. 2004 Mar; 113(6):836-45. PMID: 15067316.
    Citations: 31     Fields:    Translation:AnimalsCells
  110. Adams AB, Pearson TC, Larsen CP. Heterologous immunity: an overlooked barrier to tolerance. Immunol Rev. 2003 Dec; 196:147-60. PMID: 14617203.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  111. Jones TR, Adams AB, Shirasugi NJ, Bingaman AW, Durham MM, Pearson TC, Larsen CP. Allogeneic parenchymal and hematopoietic tissues differ in their ability to induce deletion of donor-reactive T cells. Am J Transplant. 2003 Dec; 3(12):1520-30. PMID: 14629282.
    Citations:    Fields:    Translation:HumansAnimalsCells
  112. Jones TR, Shirasugi N, Adams AB, Pearson TC, Larsen CP. Intravital microscopy identifies selectins that regulate T cell traffic into allografts. J Clin Invest. 2003 Dec; 112(11):1714-23. PMID: 14660747.
    Citations: 6     Fields:    Translation:AnimalsCells
  113. Tso PL, Cash MP, Pearson TC, Larsen CP, Newell KA. Simultaneous pancreas-kidney transplantation utilizing a common arterial conduit: early experience and potential applications. Am J Transplant. 2003 Nov; 3(11):1440-3. PMID: 14525607.
    Citations: 2     Fields:    Translation:Humans
  114. Guo Z, Wang J, Dong Y, Adams AB, Shirasugi N, Kim O, Hart J, Newton-West M, Pearson TC, Larsen CP, Newell KA. Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion. Am J Transplant. 2003 Sep; 3(9):1091-8. PMID: 12919088.
    Citations: 11     Fields:    Translation:AnimalsCells
  115. Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15; 102(13):4582-93. PMID: 12933586.
    Citations: 18     Fields:    Translation:HumansAnimals
  116. Adams AB, Shirasugi N, Jones TR, Williams MA, Durham MM, Ha J, Dong Y, Guo Z, Newell KA, Pearson TC, Larsen CP. Conventional immunosuppression is compatible with costimulation blockade-based, mixed chimerism tolerance induction. Am J Transplant. 2003 Jul; 3(7):895-901. PMID: 12814483.
    Citations: 3     Fields:    Translation:HumansAnimals
  117. Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R, Larsen CP. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest. 2003 Jun; 111(12):1887-95. PMID: 12813024.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  118. Larsson LC, Corbascio M, Pearson TC, Larsen CP, Ekberg H, Widner H. Induction of operational tolerance to discordant dopaminergic porcine xenografts. Transplantation. 2003 May 15; 75(9):1448-54. PMID: 12792495.
    Citations: 2     Fields:    Translation:Animals
  119. Wang J, Guo Z, Dong Y, Kim O, Hart J, Adams A, Larsen CP, Mittler RS, Newell KA. Role of 4-1BB in allograft rejection mediated by CD8+ T cells. Am J Transplant. 2003 May; 3(5):543-51. PMID: 12752310.
    Citations: 20     Fields:    Translation:AnimalsCells
  120. Lögdberg L, Sgan SL, Larsen CP, Hillyer CD. Islet transplantation, stem cells, and transfusion medicine. Transfus Med Rev. 2003 Apr; 17(2):95-109. PMID: 12733103.
    Citations: 2     Fields:    Translation:HumansCells
  121. Williams MA, Adams AB, Walsh MB, Shirasugi N, Onami TM, Pearson TC, Ahmed R, Larsen CP. Primary and secondary immunocompetence in mixed allogeneic chimeras. J Immunol. 2003 Mar 01; 170(5):2382-9. PMID: 12594261.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  122. Williams MA, Onami TM, Adams AB, Durham MM, Pearson TC, Ahmed R, Larsen CP. Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol. 2002 Nov 15; 169(10):5387-91. PMID: 12421910.
    Citations: 40     Fields:    Translation:AnimalsCells
  123. Pearson TC, Trambley J, Odom K, Anderson DC, Cowan S, Bray R, Lin A, Hollenbaugh D, Aruffo A, Siadak AW, Strobert E, Hennigar R, Larsen CP. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation. 2002 Oct 15; 74(7):933-40. PMID: 12394833.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  124. Shirasugi N, Adams AB, Durham MM, Lukacher AE, Xu H, Rees P, Cowan SR, Williams MA, Pearson TC, Larsen CP. Prevention of chronic rejection in murine cardiac allografts: a comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens. J Immunol. 2002 Sep 01; 169(5):2677-84. PMID: 12193741.
    Citations: 18     Fields:    Translation:AnimalsCells
  125. Arbiser JL, Bingaman A, Durham M, Cowan S, Cohen C, Zarnegar E, Varma V, Larsen CP. SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways. Mol Med. 2002 Sep; 8(9):551-8. PMID: 12456994.
    Citations: 5     Fields:    Translation:AnimalsCells
  126. Corbascio M, Mahanty H, Osterholm C, Qi Z, Pearson TC, Larsen CP, Freise CE, Ekberg H. Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice. Transplantation. 2002 Jul 15; 74(1):35-41. PMID: 12134096.
    Citations: 2     Fields:    Translation:AnimalsCells
  127. Onami TM, Harrington LE, Williams MA, Galvan M, Larsen CP, Pearson TC, Manjunath N, Baum LG, Pearce BD, Ahmed R. Dynamic regulation of T cell immunity by CD43. J Immunol. 2002 Jun 15; 168(12):6022-31. PMID: 12055210.
    Citations: 44     Fields:    Translation:AnimalsCells
  128. Corbascio M, Ekstrand H, Osterholm C, Qi Z, Simanaitis M, Larsen CP, Pearson TC, Riesbeck K, Ekberg H. CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely. Transpl Immunol. 2002 Jun; 10(1):55-61. PMID: 12182466.
    Citations: 12     Fields:    Translation:Animals
  129. Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood. 2002 Mar 01; 99(5):1840-9. PMID: 11861303.
    Citations: 11     Fields:    Translation:Animals
  130. Jones TR, Ha J, Williams MA, Adams AB, Durham MM, Rees PA, Cowan SR, Pearson TC, Larsen CP. The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts. J Immunol. 2002 Feb 01; 168(3):1123-30. PMID: 11801646.
    Citations: 11     Fields:    Translation:AnimalsCells
  131. Adams AB, Shirasugi N, Durham MM, Strobert E, Anderson D, Rees P, Cowan S, Xu H, Blinder Y, Cheung M, Hollenbaugh D, Kenyon NS, Pearson TC, Larsen CP. Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes. 2002 Feb; 51(2):265-70. PMID: 11812731.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  132. Malm H, Corbascio M, Osterholm C, Cowan S, Larsen CP, Pearson TC, Ekberg H. CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice. Transplantation. 2002 Jan 27; 73(2):293-7. PMID: 11821746.
    Citations: 3     Fields:    Translation:AnimalsCells
  133. Larsson LC, Corbascio M, Widner H, Pearson TC, Larsen CP, Ekberg H. Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L. Xenotransplantation. 2002 Jan; 9(1):68-76. PMID: 12005106.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  134. Adams AB, Larsen CP, Pearson TC, Newell KA. The role of TNF receptor and TNF superfamily molecules in organ transplantation. Am J Transplant. 2002 Jan; 2(1):12-8. PMID: 12095050.
    Citations: 11     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.