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Ryohichi Sugimura, Ph.D., M.D.

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Biography
2007
Kishimoto Memorial Scholarship
2009
March of Dimes General Scholarship
2011
The International Society for Stem Cell Research (ISSCR) Travel Award
2012
The International Society for Stem Cell Research (ISSCR) Travel Award
2012
American Society of Hematology (ASH) Abstract Achievement Award
2013
The International Society for Stem Cell Research (ISSCR) Travel Award
2013
Winner of Oral Presentation in Stowers Young Investigators’ Research Day
2013
Kirin-Ji prize
2015
Research Scholar Fellowship (Uehara Memorial Foundation)

Overview
My envision is that blood system as an experimental model to study molecular genetic programs defining cell fate, and as a therapeutic model to apply genetic correction for congenital diseases.
I am using human pluripitent stem cell as a practical venue to engineer blood cells.

I have obtained broad knowledge of basic biology, physiology, pathology and clinical training as a medical student for MD degree in Osaka University, Japan. I have experienced laboratory techniques and scientific discussion, particularity for stem ell research under supervision of Dr. Jun-ichi Miyazaki, Dr. Shin-ichi Nishikawa and Dr. Toru Nakano. As a PhD student of Dr. Linheng Li laboratory at Stowers Institute for Medical Research, I studied the mechanism to maintain hematopoietic stem cells. Currently, I am working with Dr. George Daley as a postdoctoral researcher. My particular research topics include hematopoietic stem cell specification in vitro. I have been serving as Associate Faculty Member of Faculty1000 Medicine since 2010. I have been an Associate Member of ISSCR. I have obtained PhD in 2012.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sugimura R. The significance and application of vascular niche in the development and maintenance of hematopoietic stem cells. Int J Hematol. 2018 Jun; 107(6):642-645. PMID: 29603068.
    View in: PubMed
  2. Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 05 25; 545(7655):432-438. PMID: 28514439.
    View in: PubMed
  3. Sugimura R. Bioengineering Hematopoietic Stem Cell Niche toward Regenerative Medicine. Adv Drug Deliv Rev. 2016 Apr 01; 99(Pt B):212-220. PMID: 26527127.
    View in: PubMed
  4. He XC, Li Z, Sugimura R, Ross J, Zhao M, Li L. Homing and migration assays of hematopoietic stem/progenitor cells. Methods Mol Biol. 2014; 1185:279-84. PMID: 25062636.
    View in: PubMed
  5. Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature. 2013 Aug 15; 500(7462):345-9. PMID: 23863936; PMCID: PMC3896866.
  6. Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012 Jul 20; 150(2):351-65. PMID: 22817897; PMCID: PMC4492542.
  7. Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev. 2011 Sep 15; 25(18):1928-42. PMID: 21890648; PMCID: PMC3185965.
  8. Sugimura R, Li L. Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases. Birth Defects Res C Embryo Today. 2010 Dec; 90(4):243-56. PMID: 21181886.
    View in: PubMed
  9. Sugimura R, Li L. Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis. J Mol Cell Biol. 2010 Apr; 2(2):61-2. PMID: 19833634.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.