Harvard Catalyst Profiles

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Charles H Cook, M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. 5R01CA263324-02 (Lawler, Sean - Cook, Charles H) Apr 11, 2022 - Mar 31, 2027
    NIH/NCI
    Defining the role of cytomegalovirus in glioblastoma therapies
    Role Description: Glioblastoma (GBM) is an incurable brain tumor for which improved therapies are badly needed. There are roughly 10,000 cases diagnosed in the US each year, and median survival is ~14 months. Evidence has been accumulating over recent years linking cytomegalovirus (CMV) to GBM and other cancers. However, the role of CMV in GBM remains poorly defined. CMV is a prevalent virus in humans, where it resides lifelong in a latent state but can be reactivated under certain conditions. Several clinical trials targeting CMV using diverse approaches including immunotherapies and the anti-viral drug CMV have shown very promising responses in GBM patients, but the underlying mechanisms are not clear.
    Role: P.I.
  2. R01CA263324 (LAWLER, SEAN EDWARD) Apr 11, 2022 - Mar 31, 2027
    NIH
    Defining the role of cytomegalovirus in glioblastoma therapies
    Role: Co-Principal Investigator
  3. 5R01CA195532-05 (Chiocca, E.A.) Mar 1, 2015 - Feb 28, 2021
    NIH
    Investigating the cytomegalovirus link to glioblastoma using a novel mouse model
    Role: Co-Investigator
  4. R01GM066115 (COOK, CHARLES H) May 8, 2003 - May 31, 2016
    NIH
    Bacterial Sepsis and Reactivation of Latent Cytomegalovirus
    Role: Principal Investigator
  5. R01AI053094 (COOK, CHARLES H) Dec 1, 2002 - Nov 30, 2008
    NIH
    THE IMMUNOBIOLOGY OF MURINE ALLOGRAFT ACCEPTANCE
    Role: Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.