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Jessica Lehoczky, Ph.D.

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Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R13HD104440 (WHITED, JESSICA L.) May 1, 2021 - Apr 30, 2022
    NIH
    16th International Conference on Limb Development and Regeneration
    Role: Co-Principal Investigator
  2. R21HD097405 (LEHOCZKY, JESSICA A) Feb 1, 2019 - Jan 31, 2021
    NIH
    TRANSLATING NEW INSIGHTS FROM AXOLOTL LIMB REGENERATION INTO MICE
    Role: Principal Investigator
  3. R03HD093922 (LEHOCZKY, JESSICA A) Aug 1, 2018 - Jul 31, 2021
    NIH
    Investigation into establishing morphology during mouse digit tip regeneration, in the context of vertebrate limb development
    Role: Principal Investigator
  4. F32AR056149 (LEHOCZKY, JESSICA A) Apr 1, 2008 - Mar 31, 2011
    NIH
    Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Krishnamoorthy N, Walker KH, Brüggemann TR, Tavares LP, Smith EW, Nijmeh J, Bai Y, Ai X, Cagnina RE, Duvall MG, Lehoczky JA, Levy BD. The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2206480120. PMID: 36595677; PMCID: PMC9926266.
    Citations:    Fields:    Translation:AnimalsCells
  2. Johnson GL, Glasser MB, Charles JF, Duryea J, Lehoczky JA. En1 and Lmx1b do not recapitulate embryonic dorsal-ventral limb patterning functions during mouse digit tip regeneration. Cell Rep. 2022 11 22; 41(8):111701. PMID: 36417876; PMCID: PMC9727699.
    Citations:    Fields:    Translation:Animals
  3. Johnson GL, Lehoczky JA. Mammalian Digit Tip Regeneration: Moving from Phenomenon to Molecular Mechanism. Cold Spring Harb Perspect Biol. 2022 01 04; 14(1). PMID: 34312249; PMCID: PMC8725625.
    Citations: 1     Fields:    Translation:Animals
  4. Khedgikar V, Charles JF, Lehoczky JA. Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use. Bone. 2022 02; 155:116267. PMID: 34856421.
    Citations:    Fields:    Translation:AnimalsCells
  5. Johnson GL, Masias EJ, Lehoczky JA. Cellular Heterogeneity and Lineage Restriction during Mouse Digit Tip Regeneration at Single-Cell Resolution. Dev Cell. 2020 02 24; 52(4):525-540.e5. PMID: 32097654.
    Citations: 19     Fields:    Translation:AnimalsCells
  6. Kaji DA, Tan Z, Johnson GL, Huang W, Vasquez K, Lehoczky JA, Levi B, Cheah KSE, Huang AH. Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease. J Orthop Res. 2020 04; 38(4):708-718. PMID: 31721278.
    Citations: 2     Fields:    Translation:HumansAnimals
  7. Khedgikar V, Lehoczky JA. Evidence for Lgr6 as a Novel Marker of Osteoblastic Progenitors in Mice. JBMR Plus. 2019 Feb; 3(2):e10075. PMID: 30828690; PMCID: PMC6383705.
    Citations: 4     
  8. Lehoczky JA, Tabin CJ. Rethinking WNT signalling. Nature. 2018 05; 557(7706):495-496. PMID: 29777190.
    Citations: 6     Fields:    Translation:Cells
  9. Lehoczky JA. Are fingernails a key to unlocking the puzzle of mammalian limb regeneration? Exp Dermatol. 2017 06; 26(6):478-482. PMID: 27761955.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Lehoczky JA. Digit Tip Regeneration and Beyond: Schwann Cell Progenitors to the Rescue. Cell Stem Cell. 2016 10 06; 19(4):417-418. PMID: 27716518.
    Citations:    Fields:    Translation:AnimalsCells
  11. Lehoczky JA, Tabin CJ. Lgr6 marks nail stem cells and is required for digit tip regeneration. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13249-54. PMID: 26460010; PMCID: PMC4629333.
    Citations: 44     Fields:    Translation:AnimalsCells
  12. Lehoczky JA, Thomas PE, Patrie KM, Owens KM, Villarreal LM, Galbraith K, Washburn J, Johnson CN, Gavino B, Borowsky AD, Millen KJ, Wakenight P, Law W, Van Keuren ML, Gavrilina G, Hughes ED, Saunders TL, Brihn L, Nadeau JH, Innis JW. A novel intergenic ETnII-ß insertion mutation causes multiple malformations in polypodia mice. PLoS Genet. 2013; 9(12):e1003967. PMID: 24339789.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Whited JL, Lehoczky JA, Tabin CJ. Inducible genetic system for the axolotl. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13662-7. PMID: 22869739.
    Citations: 18     Fields:    Translation:AnimalsCells
  14. Lehoczky JA, Robert B, Tabin CJ. Mouse digit tip regeneration is mediated by fate-restricted progenitor cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20609-14. PMID: 22143790.
    Citations: 89     Fields:    Translation:AnimalsCells
  15. Whited JL, Lehoczky JA, Austin CA, Tabin CJ. Dynamic expression of two thrombospondins during axolotl limb regeneration. Dev Dyn. 2011 May; 240(5):1249-58. PMID: 21360624.
    Citations: 12     Fields:    Translation:Animals
  16. Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH. cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation. Bioinformatics. 2008 Oct 15; 24(20):2418-9. PMID: 18718943.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  17. Lehoczky JA, Innis JW. Expanded HOXA13 polyalanine tracts in a monotreme. Evol Dev. 2008 Jul-Aug; 10(4):433-8. PMID: 18638320; PMCID: PMC3152211.
    Citations: 2     Fields:    Translation:AnimalsCells
  18. Lehoczky JA, Innis JW. BAC transgenic analysis reveals enhancers sufficient for Hoxa13 and neighborhood gene expression in mouse embryonic distal limbs and genital bud. Evol Dev. 2008 Jul-Aug; 10(4):421-32. PMID: 18638319.
    Citations: 13     Fields:    Translation:AnimalsCells
  19. Lehoczky JA, Innis JW. A mouse transgene drives embryonic dorsal posterior commissure expression. Transgenic Res. 2007 Dec; 16(6):823-8. PMID: 17549599.
    Citations:    Fields:    Translation:HumansAnimalsCells
  20. Lehoczky JA, Cai WW, Douglas JA, Moran JL, Beier DR, Innis JW. Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mamm Genome. 2006 Sep; 17(9):903-13. PMID: 16964440.
    Citations: 7     Fields:    Translation:Animals
  21. Williams ME, Lehoczky JA, Innis JW. A group 13 homeodomain is neither necessary nor sufficient for posterior prevalence in the mouse limb. Dev Biol. 2006 Sep 15; 297(2):493-507. PMID: 16806154.
    Citations: 6     Fields:    Translation:AnimalsCells
  22. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20; 440(7087):1045-9. PMID: 16625196; PMCID: PMC2610434.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  23. Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES. DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22; 437(7058):551-5. PMID: 16177791.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  24. Lehoczky JA, Williams ME, Innis JW. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Evol Dev. 2004 Nov-Dec; 6(6):423-30. PMID: 15509224.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  25. Askew DJ, Askew YS, Kato Y, Turner RF, Dewar K, Lehoczky J, Silverman GA. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Genomics. 2004 Jul; 84(1):176-84. PMID: 15203215.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  26. Wechsler SB, Lehoczky JA, Hall JG, Innis JW. Tibial aplasia, lower extremity mirror image polydactyly, brachyphalangy, craniofacial dysmorphism and genital hypoplasia: further delineation and mutational analysis. Clin Dysmorphol. 2004 Apr; 13(2):63-69. PMID: 15057119.
    Citations: 3     Fields:    Translation:Humans
  27. Keegan CE, Vilain E, Mohammed M, Lehoczky J, Dobyns WB, Archer SM, Innis JW. Microcephaly, jejunal atresia, aberrant right bronchus, ocular anomalies, and XY sex reversal. Am J Med Genet A. 2004 Mar 15; 125A(3):293-8. PMID: 14994240.
    Citations: 2     Fields:    Translation:HumansCells
  28. Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. 2002 Dec; 129(24):5839-46. PMID: 12421721.
    Citations: 89     Fields:    Translation:AnimalsCells
  29. Stojanovic N, Chang JL, Lehoczky J, Zody MC, Dewar K. Identification of mixups among DNA sequencing plates. Bioinformatics. 2002 Nov; 18(11):1418-26. PMID: 12424111.
    Citations: 1     Fields:    Translation:Humans
  30. Park SS, Stankiewicz P, Bi W, Shaw C, Lehoczky J, Dewar K, Birren B, Lupski JR. Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs. Genome Res. 2002 May; 12(5):729-38. PMID: 11997339; PMCID: PMC186597.
    Citations: 39     Fields:    Translation:HumansCells
  31. Askew YS, Pak SC, Luke CJ, Askew DJ, Cataltepe S, Mills DR, Kato H, Lehoczky J, Dewar K, Birren B, Silverman GA. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. J Biol Chem. 2001 Dec 28; 276(52):49320-30. PMID: 11604408.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  32. Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol. 2001 Oct 02; 11(19):1503-11. PMID: 11591317.
    Citations: 23     Fields:    Translation:AnimalsCells
  33. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann Y, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15; 409(6822):860-921. PMID: 11237011.
    Citations: 7220     Fields:    Translation:HumansAnimalsCells
  34. Miyoshi K, Cui Y, Riedlinger G, Robinson P, Lehoczky J, Zon L, Oka T, Dewar K, Hennighausen L. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Genomics. 2001 Jan 15; 71(2):150-5. PMID: 11161808.
    Citations: 19     Fields:    Translation:AnimalsCells
  35. Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP. Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain. Genome Res. 2000 Nov; 10(11):1697-710. PMID: 11076855.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  36. Wiltshire T, Pletcher M, Cole SE, Villanueva M, Birren B, Lehoczky J, Dewar K, Reeves RH. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Genome Res. 1999 Dec; 9(12):1214-22. PMID: 10613844; PMCID: PMC311004.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.