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Last Name

profileErcument Dirice, PH.D.

TitleInstructor in Medicine
InstitutionJoslin Diabetes Center
AddressJoslin Diabetes Center
Research - 6th Floor
One Joslin Place
Boston MA 02215
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Collapse Biography 
Collapse awards and honors
2003Poster Award 3rd place
2004Young Investigator Award
2007Poster Award 2nd Place
2009Diabetes Research Fellowship
2009Novartis Science Award
2009Young Investigator Award
2009Poster Award 1st Place
2009Poster Award 1st Place
2009Appreciation Letter
2009Journal Cover Award
2009Altan Gunalp Medical Research Award
2010Best Scientific Publication
2010JDRF Research Grant (#3-2010-474)
2011Altan Gunalp Medical Research Award
2013Young Investigator Award
2014JDRF Advanced Research Grant (#3-APF-2014-220-A-N)

Collapse Overview 
Collapse overview
Please find more details on my webpage:

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. J Biol Chem. 2017 10 27; 292(43):17598-17608. PMID: 28860191.
    View in: PubMed
  2. Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN. Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep. 2016 Apr 19; 15(3):460-470. PMID: 27068459; PMCID: PMC4838491.
  3. Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016 Apr 01; 126(4):1401-12. PMID: 26974159; PMCID: PMC4811129.
  4. Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dancík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human ß-Cell Proliferation. Diabetes. 2016 06; 65(6):1660-71. PMID: 26953159; PMCID: PMC4878416 [Available on 06/01/17].
  5. Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-ß Signaling Promotes Human Pancreatic ß-Cell Replication. Diabetes. 2016 05; 65(5):1208-18. PMID: 26936960; PMCID: PMC4839200 [Available on 05/01/17].
  6. Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN. Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. Stem Cell Reports. 2016 Mar 08; 6(3):357-67. PMID: 26876668; PMCID: PMC4788763.
  7. Dirice E, Kulkarni RN. Harnessing immune cells to enhance ß-cell mass in type 1 diabetes. J Investig Med. 2016 Jan; 64(1):14-20. PMID: 26755809.
    View in: PubMed
  8. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic ß Cell Proliferation. Cell Metab. 2016 Jan 12; 23(1):194-205. PMID: 26701651; PMCID: PMC4715773 [Available on 01/12/17].
  9. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 04; 22(2):239-52. PMID: 26244933; PMCID: PMC4589213.
  10. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG, Smith RD, Qian WJ, Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015 Aug 07; 14(8):3111-3122. PMID: 26151086; PMCID: PMC4615688.
  11. Kahraman S, Aydin C, Elpek GO, Dirice E, Sanlioglu AD. Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions. J Diabetes Res. 2015; 2015:450128. PMID: 25699277; PMCID: PMC4324984.
  12. Kahraman S, Dirice E, Altunbas HA, Sanlioglu AD. Proliferative Effect of sTRAIL on Mouse Pancreatic Beta Cells. JOP. 2014; 15(5):2790. PMID: 25262744.
    View in: PubMed
  13. Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15; 307(10):E906-18. PMID: 25249504; PMCID: PMC4233258.
  14. Teo AK, Valdez IA, Dirice E, Kulkarni RN. Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum. Stem Cell Reports. 2014 Jul 08; 3(1):5-14. PMID: 25068117; PMCID: PMC4110751.
  15. Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85a deficiency protects ß-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1192-7. PMID: 24395790; PMCID: PMC3903202.
  16. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Soluble factors secreted by T cells promote ß-cell proliferation. Diabetes. 2014 Jan; 63(1):188-202. PMID: 24089508; PMCID: PMC3868047.
  17. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-derived systemic factors drive ß cell hyperplasia in insulin-resistant states. Cell Rep. 2013 Feb 21; 3(2):401-10. PMID: 23375376; PMCID: PMC3655439.
  18. Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN. Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 2013 Feb 22; 288(8):5353-6. PMID: 23306198; PMCID: PMC3581399.
  19. Dirice E, Kahraman S, Elpek GO, Aydin C, Balci MK, Omer A, Sanlioglu S, Sanlioglu AD. TRAIL and DcR1 expressions are differentially regulated in the pancreatic islets of STZ- versus CY-applied NOD mice. Exp Diabetes Res. 2011; 2011:625813. PMID: 22144989; PMCID: PMC3226359.
  20. Kahraman S, Dirice E, Hapil FZ, Ertosun MG, Ozturk S, Griffith TS, Sanlioglu S, Sanlioglu AD. Tracing of islet graft survival by way of in vivo fluorescence imaging. Diabetes Metab Res Rev. 2011 Sep; 27(6):575-83. PMID: 21584921.
    View in: PubMed
  21. Dirice E, Sanlioglu AD, Kahraman S, Ozturk S, Balci MK, Omer A, Griffith TS, Sanlioglu S. Adenovirus-mediated TRAIL gene (Ad5hTRAIL) delivery into pancreatic islets prolongs normoglycemia in streptozotocin-induced diabetic rats. Hum Gene Ther. 2009 Oct; 20(10):1177-89. PMID: 19572802.
    View in: PubMed
  22. Kahraman S, Dirice E, Sanlioglu AD, Yoldas B, Bagci H, Erkilic M, Griffith TS, Sanlioglu S. In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms. Mol Imaging Biol. 2010 Jun; 12(3):278-85. PMID: 19789926.
    View in: PubMed
  23. Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Ozdogan M, Suleymanlar I, Balci MK, Griffith TS, Sanlioglu S. High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. Pancreas. 2009 Mar; 38(2):154-60. PMID: 18981952.
    View in: PubMed
  24. Sanlioglu AD, Griffith TS, Omer A, Dirice E, Sari R, Altunbas HA, Balci MK, Sanlioglu S. Molecular mechanisms of death ligand-mediated immune modulation: a gene therapy model to prolong islet survival in type 1 diabetes. J Cell Biochem. 2008 Jun 01; 104(3):710-20. PMID: 18247339.
    View in: PubMed
  25. Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Balci MK, Omer A, Griffith TS, Sanlioglu S. Differential alteration of TRAIL and its receptor expression profiles in patients with pancreatic ductal adenocarcinoma. J Clin Oncol. 2008 May 20; 26(15_suppl):15607. PMID: 27947441.
    View in: PubMed
  26. Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Balci MK, Omer A, Griffith TS, Sanlioglu S. High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas. Pancreas. 2008 May; 36(4):385-93. PMID: 18437085.
    View in: PubMed
  27. Karauzum SB, Yasar D, Dirice E, Imir N, Luleci G, Ozes ON. Lack of BCL-2 confers interferon-alpha sensitivity to B-cell lymphomas. Growth Factors. 2007 Apr; 25(2):94-100. PMID: 17852408.
    View in: PubMed
  28. Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25; 5:54. PMID: 15916713; PMCID: PMC1156874.
  29. Koksal IT, Yasar D, Dirice E, Usta MF, Karauzum S, Luleci G, Baykara M, Sanlioglu S. Differential PTEN protein expression profiles in superficial versus invasive bladder cancers. Urol Int. 2005; 75(2):102-6. PMID: 16123561.
    View in: PubMed
  30. Koksal IT, Dirice E, Yasar D, Sanlioglu AD, Ciftcioglu A, Gulkesen KH, Ozes NO, Baykara M, Luleci G, Sanlioglu S. The assessment of PTEN tumor suppressor gene in combination with Gleason scoring and serum PSA to evaluate progression of prostate carcinoma. Urol Oncol. 2004 Jul-Aug; 22(4):307-12. PMID: 15283888.
    View in: PubMed
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