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Ercument Dirice, PH.D.

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Biography
2001
BAYG-Grant
2003
Poster Award 3rd place
2004
Young Investigator Award
2007
Poster Award 2nd Place
2009
Diabetes Research Fellowship
2009
Novartis Science Award
2009
Young Investigator Award
2009
Poster Award 1st Place
2009
Poster Award 1st Place
2009
Appreciation Letter
2009
Journal Cover Award
2009
Altan Gunalp Medical Research Award
2010
Best Scientific Publication
2010
JDRF Research Grant (#3-2010-474)
2011
Altan Gunalp Medical Research Award
2013
Young Investigator Award
2014
JDRF Advanced Research Grant (#3-APF-2014-220-A-N)

Overview
Please find more details on my webpage: www.ercumentdirice.com

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Human duct cells contribute to ß cell compensation in insulin resistance. JCI Insight. 2019 Apr 18; 4(8). PMID: 30996131.
    Citations:    
  2. Yi L, Tsai CF, Dirice E, Swensen AC, Chen J, Shi T, Gritsenko MA, Chu RK, Piehowski PD, Smith RD, Rodland KD, Atkinson MA, Mathews CE, Kulkarni RN, Liu T, Qian WJ. Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells. Anal Chem. 2019 May 07; 91(9):5794-5801. PMID: 30843680.
    Citations:    
  3. Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, Homan EP, Dirice E, Kahn CR, El Ouaamari A. TRPV1 neurons regulate ß-cell function in a sex-dependent manner. Mol Metab. 2018 Dec; 18:60-67. PMID: 30473098.
    Citations:    Fields:    
  4. Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. J Biol Chem. 2017 10 27; 292(43):17598-17608. PMID: 28860191.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN. Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep. 2016 Apr 19; 15(3):460-470. PMID: 27068459.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016 Apr 01; 126(4):1401-12. PMID: 26974159.
    Citations: 13     Fields:    Translation:Animals
  7. Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dancík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human ß-Cell Proliferation. Diabetes. 2016 06; 65(6):1660-71. PMID: 26953159.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  8. Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-ß Signaling Promotes Human Pancreatic ß-Cell Replication. Diabetes. 2016 05; 65(5):1208-18. PMID: 26936960.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN. Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. Stem Cell Reports. 2016 Mar 08; 6(3):357-67. PMID: 26876668.
    Citations: 6     Fields:    Translation:HumansCells
  10. Dirice E, Kulkarni RN. Harnessing immune cells to enhance ß-cell mass in type 1 diabetes. J Investig Med. 2016 Jan; 64(1):14-20. PMID: 26755809.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic ß Cell Proliferation. Cell Metab. 2016 Jan 12; 23(1):194-205. PMID: 26701651.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  12. Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 04; 22(2):239-52. PMID: 26244933.
    Citations: 9     Fields:    Translation:HumansCells
  13. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG, Smith RD, Qian WJ, Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015 Aug 07; 14(8):3111-3122. PMID: 26151086.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Kahraman S, Aydin C, Elpek GO, Dirice E, Sanlioglu AD. Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions. J Diabetes Res. 2015; 2015:450128. PMID: 25699277.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Kahraman S, Dirice E, Altunbas HA, Sanlioglu AD. Proliferative Effect of sTRAIL on Mouse Pancreatic Beta Cells. JOP. 2014; 15(5):2790. PMID: 25262744.
    Citations:    
  16. Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15; 307(10):E906-18. PMID: 25249504.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Teo AK, Valdez IA, Dirice E, Kulkarni RN. Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum. Stem Cell Reports. 2014 Jul 08; 3(1):5-14. PMID: 25068117.
    Citations: 5     Fields:    Translation:HumansCells
  18. Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85a deficiency protects ß-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1192-7. PMID: 24395790.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Soluble factors secreted by T cells promote ß-cell proliferation. Diabetes. 2014 Jan; 63(1):188-202. PMID: 24089508.
    Citations: 22     Fields:    Translation:AnimalsCells
  20. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. Liver-derived systemic factors drive ß cell hyperplasia in insulin-resistant states. Cell Rep. 2013 Feb 21; 3(2):401-10. PMID: 23375376.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  21. Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN. Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 2013 Feb 22; 288(8):5353-6. PMID: 23306198.
    Citations: 24     Fields:    Translation:HumansCells
  22. Dirice E, Kahraman S, Elpek GO, Aydin C, Balci MK, Omer A, Sanlioglu S, Sanlioglu AD. TRAIL and DcR1 expressions are differentially regulated in the pancreatic islets of STZ- versus CY-applied NOD mice. Exp Diabetes Res. 2011; 2011:625813. PMID: 22144989.
    Citations: 4     Fields:    Translation:Animals
  23. Kahraman S, Dirice E, Hapil FZ, Ertosun MG, Ozturk S, Griffith TS, Sanlioglu S, Sanlioglu AD. Tracing of islet graft survival by way of in vivo fluorescence imaging. Diabetes Metab Res Rev. 2011 Sep; 27(6):575-83. PMID: 21584921.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Dirice E, Sanlioglu AD, Kahraman S, Ozturk S, Balci MK, Omer A, Griffith TS, Sanlioglu S. Adenovirus-mediated TRAIL gene (Ad5hTRAIL) delivery into pancreatic islets prolongs normoglycemia in streptozotocin-induced diabetic rats. Hum Gene Ther. 2009 Oct; 20(10):1177-89. PMID: 19572802.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Kahraman S, Dirice E, Sanlioglu AD, Yoldas B, Bagci H, Erkilic M, Griffith TS, Sanlioglu S. In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms. Mol Imaging Biol. 2010 Jun; 12(3):278-85. PMID: 19789926.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Ozdogan M, Suleymanlar I, Balci MK, Griffith TS, Sanlioglu S. High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. Pancreas. 2009 Mar; 38(2):154-60. PMID: 18981952.
    Citations: 11     Fields:    Translation:Humans
  27. Sanlioglu AD, Griffith TS, Omer A, Dirice E, Sari R, Altunbas HA, Balci MK, Sanlioglu S. Molecular mechanisms of death ligand-mediated immune modulation: a gene therapy model to prolong islet survival in type 1 diabetes. J Cell Biochem. 2008 Jun 01; 104(3):710-20. PMID: 18247339.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  28. Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Balci MK, Omer A, Griffith TS, Sanlioglu S. Differential alteration of TRAIL and its receptor expression profiles in patients with pancreatic ductal adenocarcinoma. J Clin Oncol. 2008 May 20; 26(15_suppl):15607. PMID: 27947441.
    Citations:    
  29. Sanlioglu AD, Dirice E, Elpek O, Korcum AF, Balci MK, Omer A, Griffith TS, Sanlioglu S. High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas. Pancreas. 2008 May; 36(4):385-93. PMID: 18437085.
    Citations: 10     Fields:    Translation:Humans
  30. Karauzum SB, Yasar D, Dirice E, Imir N, Luleci G, Ozes ON. Lack of BCL-2 confers interferon-alpha sensitivity to B-cell lymphomas. Growth Factors. 2007 Apr; 25(2):94-100. PMID: 17852408.
    Citations: 1     Fields:    Translation:HumansCells
  31. Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25; 5:54. PMID: 15916713.
    Citations: 34     Fields:    Translation:HumansCells
  32. Koksal IT, Yasar D, Dirice E, Usta MF, Karauzum S, Luleci G, Baykara M, Sanlioglu S. Differential PTEN protein expression profiles in superficial versus invasive bladder cancers. Urol Int. 2005; 75(2):102-6. PMID: 16123561.
    Citations: 5     Fields:    Translation:Humans
  33. Koksal IT, Dirice E, Yasar D, Sanlioglu AD, Ciftcioglu A, Gulkesen KH, Ozes NO, Baykara M, Luleci G, Sanlioglu S. The assessment of PTEN tumor suppressor gene in combination with Gleason scoring and serum PSA to evaluate progression of prostate carcinoma. Urol Oncol. 2004 Jul-Aug; 22(4):307-12. PMID: 15283888.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.