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Paul B. Yu, Ph.D., M.D.

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Biography
2005 - 2007
GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease Young Investigator
2006 - 2011
Pulmonary Hypertension Association Mentored Clinical Scientist Award
2008 - 2013
Howard Hughes Medical Institute Physician Scientist Early Career Award
2008 - 2009
Massachusetts Technology Transfer Center Investigation Award
2009 - 2011
Harvard Stem Cell Institute Seed Grant
2010 - 2015
Fondation Leducq Transatlantic Network Award
2017 - 2019
Boston Biomedical Innovator Center - DRIVE grant
2018
American Society of Clinical Investigation

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR057374 (YU, PAUL B) Jul 1, 2019 - Jun 30, 2023
    NIH/NIAMS
    Molecular and cellular mechanisms of heterotopic ossification
    Role: Principal Investigator
  2. UG3TR002617 (YU, PAUL B) Sep 15, 2018 - Aug 31, 2020
    NIH/NCATS
    Repositioning AZD0530 for surgical treatment of fibrodysplasia ossificans progressiva
    Role: Principal Investigator
  3. R42HL132742 (YU, PAUL B) Aug 15, 2017 - Jan 31, 2018
    NIH/NHLBI
    HLS- Cyclic CAR peptide: a targeted therapy for pulmonary hypertension
    Role: Principal Investigator
  4. R01HL131910 (YU, PAUL B) Jul 15, 2016 - Apr 30, 2019
    NIH/NHLBI
    Molecular imaging of angiogenic activity in pulmonary arterial hypertension
    Role: Principal Investigator
  5. K08HL079943 (YU, PAUL B) Apr 1, 2006 - Mar 31, 2012
    NIH/NHLBI
    The role of the BMP type II receptor in vascular function
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang P, Yu PB. Periostin: A Novel Integrator of Hypoxic Signaling in Pulmonary Hypertension. Circ Res. 2020 Oct 09; 127(9):1153-1155. PMID: 33031025.
    Citations:    
  2. Szulcek R, Sanchez-Duffhues G, Rol N, Pan X, Tsonaka R, Dickhoff C, Yung LM, Manz XD, Kurakula K, Kielbasa SM, Mei H, Timens W, Yu PB, Bogaard HJ, Goumans MJ. Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells. Angiogenesis. 2020 Nov; 23(4):699-714. PMID: 32813135.
    Citations:    
  3. Yang P, Troncone L, Augur ZM, Kim SSJ, McNeil ME, Yu PB. The role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 Jul 28; 115542. PMID: 32736145.
    Citations:    
  4. Maron BA, Gladwin MT, Bonnet S, De Jesus Perez V, Perman SM, Yu PB, Ichinose F. Perspectives on Cardiopulmonary Critical Care for Patients With COVID-19: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. J Am Heart Assoc. 2020 07 21; 9(14):e017111. PMID: 32552164.
    Citations:    
  5. Rochon ER, Krowka MJ, Bartolome S, Heresi GA, Bull T, Roberts K, Hemnes A, Forde KA, Krok KL, Patel M, Lin G, McNeil M, Al-Naamani N, Roman BL, Yu PB, Fallon MB, Gladwin MT, Kawut SM. BMP9/10 in Pulmonary Vascular Complications of Liver Disease. Am J Respir Crit Care Med. 2020 06 15; 201(12):1575-1578. PMID: 32083953.
    Citations:    
  6. Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020 May 13; 12(543). PMID: 32404506.
    Citations:    
  7. Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08; 11(1):2289. PMID: 32385263.
    Citations:    
  8. Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW. Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 03 01; 201(5):575-585. PMID: 31661308.
    Citations:    
  9. Yin H, Kalra L, Lai Z, Guimaro MC, Aber L, Warner BM, Michael D, Zhang N, Cabrera-Perez J, Karim A, Swaim WD, Afione S, Voigt A, Nguyen CQ, Yu PB, Bloch DB, Chiorini JA. Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice. Sci Rep. 2020 02 19; 10(1):2967. PMID: 32076051.
    Citations:    
  10. Samokhin AO, Hsu S, Yu PB, Waxman AB, Alba GA, Wertheim BM, Hopkins CD, Bowman F, Channick RN, Nikolic I, Faria-Urbina M, Hassoun PM, Leopold JA, Tedford RJ, Ventetuolo CE, Leary PJ, Maron BA. Circulating NEDD9 is increased in pulmonary arterial hypertension: A multicenter, retrospective analysis. J Heart Lung Transplant. 2020 Apr; 39(4):289-299. PMID: 31952977.
    Citations:    
  11. Hwang C, Marini S, Huber AK, Stepien DM, Sorkin M, Loder S, Pagani CA, Li J, Visser ND, Vasquez K, Garada MA, Li S, Xu J, Hsu CY, Yu PB, James AW, Mishina Y, Agarwal S, Li J, Levi B. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019; 7:36. PMID: 31840004.
    Citations:    
  12. Atri DS, Tsao AL, Yu PB, Berry NC. ST-Segment Elevation Myocardial Infarction Due to Right Coronary Artery Compression by Cardiac Synovial Sarcoma. JACC Cardiovasc Interv. 2019 09 09; 12(17):e145-e147. PMID: 31422086.
    Citations:    
  13. Morrell NW, Upton PD, Li W, Yu PB. Letter by Morrell et al Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension". Circ Res. 2019 04 26; 124(9):e81. PMID: 31021722.
    Citations:    
  14. Padilha EC, Wang J, Kerns E, Lee A, Huang W, Jiang JK, McKew J, Mutlib A, Peccinini RG, Yu PB, Sanderson P, Xu X. Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). Front Pharmacol. 2019; 10:234. PMID: 31068801.
    Citations:    
  15. Nikolic I, Yung LM, Yang P, Malhotra R, Paskin-Flerlage SD, Dinter T, Bocobo GA, Tumelty KE, Faugno AJ, Troncone L, McNeil ME, Huang X, Coser KR, Lai CSC, Upton PD, Goumans MJ, Zamanian RT, Elliott CG, Lee A, Zheng W, Berasi SP, Huard C, Morrell NW, Chung RT, Channick RW, Roberts KE, Yu PB. Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension. Am J Respir Crit Care Med. 2019 04 01; 199(7):891-902. PMID: 30312106.
    Citations:    Fields:    
  16. Wertheim BM, Lin YD, Zhang YY, Samokhin AO, Alba GA, Arons E, Yu PB, Maron BA. Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials. PLoS One. 2019; 14(2):e0211909. PMID: 30811450.
    Citations:    
  17. Yang P, Yu PB. In Search of the Second Hit in Pulmonary Arterial Hypertension. Circ Res. 2019 01 04; 124(1):6-8. PMID: 30605416.
    Citations:    Fields:    
  18. Dinter T, Bocobo GA, Yu PB. Pharmacologic Strategies for Assaying BMP Signaling Function. Methods Mol Biol. 2019; 1891:221-233. PMID: 30414136.
    Citations:    Fields:    
  19. Graham BB, Yu PB. Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019 01 01; 199(1):9-11. PMID: 30130137.
    Citations:    Fields:    
  20. Jiang JK, Huang X, Shamim K, Patel PR, Lee A, Wang AQ, Nguyen K, Tawa G, Cuny GD, Yu PB, Zheng W, Xu X, Sanderson P, Huang W. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 11 01; 28(20):3356-3362. PMID: 30227946.
    Citations:    Fields:    
  21. Yung LM, Yu PB. Room With a View. Circ Cardiovasc Imaging. 2018 08; 11(8):e008148. PMID: 30354505.
    Citations:    Fields:    
  22. Brittain EL, Thennapan T, Maron BA, Chan SY, Austin ED, Spiekerkoetter E, Bogaard HJ, Guignabert C, Paulin R, Machado RF, Yu PB. Update in Pulmonary Vascular Disease 2016 and 2017. Am J Respir Crit Care Med. 2018 07 01; 198(1):13-23. PMID: 29533671.
    Citations:    Fields:    
  23. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899023.
    Citations:    
  24. Agarwal S, Spiekerkoetter E, Austin ED, de Jesus Perez V, Dezfulian C, Maron BA, Ryan JJ, Starks MA, Yu PB, Bonnet S, Perman SM. Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association. Circ Res. 2018 05 11; 122(10):1330-1333. PMID: 29748361.
    Citations:    Fields:    
  25. Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CSC, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation". Mol Cell Biol. 2017 10 01; 37(19). PMID: 28899999.
    Citations:    Fields:    
  26. Agarwal S, Loder SJ, Breuler C, Li J, Cholok D, Brownley C, Peterson J, Hsieh HH, Drake J, Ranganathan K, Niknafs YS, Xiao W, Li S, Kumar R, Tompkins R, Longaker MT, Davis TA, Yu PB, Mishina Y, Levi B. Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification. Mol Ther. 2017 08 02; 25(8):1974-1987. PMID: 28716575.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  27. Alessi Wolken DM, Idone V, Hatsell SJ, Yu PB, Economides AN. The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva. Bone. 2018 04; 109:210-217. PMID: 28629737.
    Citations: 1     Fields:    Translation:HumansCells
  28. Dey D, Wheatley BM, Cholok D, Agarwal S, Yu PB, Levi B, Davis TA. The traumatic bone: trauma-induced heterotopic ossification. Transl Res. 2017 08; 186:95-111. PMID: 28668522.
    Citations: 2     Fields:    Translation:Humans
  29. DuBrock HM, Rodriguez-Lopez JM, LeVarge BL, Curry MP, VanderLaan PA, Zsengeller ZK, Pernicone E, Preston IR, Yu PB, Nikolic I, Xu D, Thadhani RI, Channick RN, Ananth Karumanchi S. Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension. Pulm Circ. 2016 Dec; 6(4):498-507. PMID: 28090291.
    Citations: 1     
  30. Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016 11 23; 8(366):366ra163. PMID: 27881824.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  31. Yung LM, Nikolic I, Paskin-Flerlage SD, Pearsall RS, Kumar R, Yu PB. A Selective Transforming Growth Factor-ß Ligand Trap Attenuates Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 01; 194(9):1140-1151. PMID: 27115515.
    Citations: 11     Fields:    Translation:AnimalsCells
  32. Szulcek R, Happé CM, Rol N, Fontijn RD, Dickhoff C, Hartemink KJ, Grünberg K, Tu L, Timens W, Nossent GD, Paul MA, Leyen TA, Horrevoets AJ, de Man FS, Guignabert C, Yu PB, Vonk-Noordegraaf A, van Nieuw Amerongen GP, Bogaard HJ. Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage. Am J Respir Crit Care Med. 2016 06 15; 193(12):1410-20. PMID: 26760925.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  33. O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016 05 31; (111). PMID: 27284788.
    Citations: 1     Fields:    Translation:HumansAnimals
  34. Nikolic I, Yu PB. The Role of Bone Marrow-derived Cells in Pulmonary Arterial Hypertension. What Lies Beneath? Am J Respir Crit Care Med. 2016 Apr 15; 193(8):822-4. PMID: 27082534.
    Citations: 1     Fields:    Translation:HumansCells
  35. Aghamohammadzadeh R, Zhang YY, Stephens TE, Arons E, Zaman P, Polach KJ, Matar M, Yung LM, Yu PB, Bowman FP, Opotowsky AR, Waxman AB, Loscalzo J, Leopold JA, Maron BA. Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. FASEB J. 2016 07; 30(7):2511-27. PMID: 27006450.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Parikh VN, Park J, Nikolic I, Channick R, Yu PB, De Marco T, Hsue PY, Chan SY. Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection. . 2015 Nov 01; 70(3):236-41. PMID: 26473639.
    Citations: 2     Fields:    Translation:Humans
  37. Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD. Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol. 2016 Feb; 13(2):106-20. PMID: 26461965.
    Citations: 17     Fields:    Translation:HumansCells
  38. Dey D, Goldhamer DJ, Yu PB. Contributions of muscle-resident progenitor cells to homeostasis and disease. Curr Mol Biol Rep. 2015 Dec; 1(4):175-188. PMID: 29075589.
    Citations: 1     
  39. Wang A, Zsengellér ZK, Hecht JL, Buccafusca R, Burke SD, Rajakumar A, Weingart E, Yu PB, Salahuddin S, Karumanchi SA. Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. J Clin Invest. 2015 Nov 02; 125(11):4021-5. PMID: 26413870.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  40. Yung LM, Sánchez-Duffhues G, Ten Dijke P, Yu PB. Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells. Cardiovasc Res. 2015 Nov 01; 108(2):278-87. PMID: 26410368.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  41. Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, Schoenherr CJ, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides AN. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015 Sep 02; 7(303):303ra137. PMID: 26333933.
    Citations: 45     Fields:    Translation:AnimalsCells
  42. Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015 Jul; 21(7):777-85. PMID: 26076038.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  43. Chun HJ, Yu PB. Elafin in pulmonary arterial hypertension. Beyond targeting elastases. Am J Respir Crit Care Med. 2015 Jun 01; 191(11):1217-9. PMID: 26029832.
    Citations:    Fields:    Translation:HumansAnimalsCells
  44. Malhotra R, Burke MF, Martyn T, Shakartzi HR, Thayer TE, O'Rourke C, Li P, Derwall M, Spagnolli E, Kolodziej SA, Hoeft K, Mayeur C, Jiramongkolchai P, Kumar R, Buys ES, Yu PB, Bloch KD, Bloch DB. Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS One. 2015; 10(1):e0117098. PMID: 25603410.
    Citations: 14     Fields:    Translation:AnimalsCells
  45. Mayeur C, Kolodziej SA, Wang A, Xu X, Lee A, Yu PB, Shen J, Bloch KD, Bloch DB. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica. 2015 Feb; 100(2):e68-71. PMID: 25326432.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJ. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J Pharmacol Exp Ther. 2014 Dec; 351(3):549-58. PMID: 25271257.
    Citations: 9     Fields:    Translation:HumansAnimals
  47. Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 09; 57(19):7900-15. PMID: 25101911.
    Citations: 14     Fields:    Translation:Humans
  48. Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu PB, Feng XH, Lin X. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19; 289(38):26441-50. PMID: 25100727.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  49. Wu XG, Wang Y, Wu Q, Cheng WH, Liu W, Zhao Y, Mayeur C, Schmidt PJ, Yu PB, Wang F, Xia Y. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood. 2014 Aug 21; 124(8):1335-43. PMID: 24904118.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  50. Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AU. The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood. 2014 Apr 03; 123(14):2261-8. PMID: 24501215.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  51. Komatsu Y, Yu PB, Kamiya N, Pan H, Fukuda T, Scott GJ, Ray MK, Yamamura K, Mishina Y. Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice. J Bone Miner Res. 2013 Jun; 28(6):1422-33. PMID: 23281127.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  52. Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013; 8(4):e62721. PMID: 23646137.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  53. Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013; 8(6):1291-302. PMID: 23547776.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  54. Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Constitutively active ALK2 receptor mutants require type II receptor cooperation. Mol Cell Biol. 2013 Jun; 33(12):2413-24. PMID: 23572558.
    Citations: 21     Fields:    Translation:AnimalsCells
  55. Malhotra R, Paskin-Flerlage S, Zamanian RT, Zimmerman P, Schmidt JW, Deng DY, Southwood M, Spencer R, Lai CS, Parker W, Channick RN, Morrell NW, Elliott CG, Yu PB. Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension. Pulm Circ. 2013 Apr; 3(2):369-80. PMID: 24015338.
    Citations: 8     
  56. Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J. ?Np63a-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res. 2013 Jan 15; 73(2):1020-30. PMID: 23243027.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  57. Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y. Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. PLoS One. 2012; 7(9):e44622. PMID: 23028567.
    Citations: 10     Fields:    Translation:AnimalsCells
  58. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22. PMID: 22223731.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  59. Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011 Oct 13; 118(15):4224-30. PMID: 21841161.
    Citations: 61     Fields:    Translation:AnimalsCells
  60. Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 05; 117(18):4915-23. PMID: 21393479.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  61. Yeh RW, Yu PB, Drachman DE. Takotsubo cardiomyopathy complicated by cardiac tamponade: classic hemodynamic findings with a new disease. Circulation. 2010 Sep 21; 122(12):1239-41. PMID: 20855670.
    Citations: 7     Fields:    Translation:Humans
  62. Boergermann JH, Kopf J, Yu PB, Knaus P. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Int J Biochem Cell Biol. 2010 Nov; 42(11):1802-7. PMID: 20691279.
    Citations: 39     Fields:    Translation:AnimalsCells
  63. Kamiya N, Kobayashi T, Mochida Y, Yu PB, Yamauchi M, Kronenberg HM, Mishina Y. Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res. 2010 Feb; 25(2):200-10. PMID: 19874086.
    Citations: 64     Fields:    Translation:AnimalsCells
  64. Hong CC, Yu PB. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):409-18. PMID: 19914855.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  65. De Rosa L, Antonini D, Ferone G, Russo MT, Yu PB, Han R, Missero C. p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem. 2009 Oct 30; 284(44):30574-82. PMID: 19717565.
    Citations: 20     Fields:    Translation:AnimalsCells
  66. Wrighton KH, Lin X, Yu PB, Feng XH. Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem. 2009 Apr 10; 284(15):9755-63. PMID: 19224917.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  67. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9. PMID: 19029982.
    Citations: 223     Fields:    Translation:AnimalsCells
  68. Fukuda T, Kohda M, Kanomata K, Nojima J, Nakamura A, Kamizono J, Noguchi Y, Iwakiri K, Kondo T, Kurose J, Endo K, Awakura T, Fukushi J, Nakashima Y, Chiyonobu T, Kawara A, Nishida Y, Wada I, Akita M, Komori T, Nakayama K, Nanba A, Maruki Y, Yoda T, Tomoda H, Yu PB, Shore EM, Kaplan FS, Miyazono K, Matsuoka M, Ikebuchi K, Ohtake A, Oda H, Jimi E, Owan I, Okazaki Y, Katagiri T. Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem. 2009 Mar 13; 284(11):7149-56. PMID: 18684712.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  69. Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CC. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One. 2008 Aug 06; 3(8):e2904. PMID: 18682835.
    Citations: 79     Fields:    Translation:HumansCells
  70. Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug 01; 18(15):4388-92. PMID: 18621530.
    Citations: 115     Fields:    Translation:AnimalsCells
  71. Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD. Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J Biol Chem. 2008 Feb 15; 283(7):3877-88. PMID: 18042551.
    Citations: 34     Fields:    Translation:AnimalsCells
  72. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan; 4(1):33-41. PMID: 18026094.
    Citations: 358     Fields:    Translation:AnimalsCells
  73. D'Avila A, Ptaszek LM, Yu PB, Walker JD, Wright C, Noseworthy PA, Myers A, Refaat M, Ruskin JN. Images in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale. Circulation. 2007 May 01; 115(17):e432-3. PMID: 17470703.
    Citations: 6     Fields:    Translation:Humans
  74. Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22; 282(25):18129-40. PMID: 17472960.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  75. Yu PB, Parker W, Nayak JV, Platt JL. Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies. Transplantation. 2005 Jul 15; 80(1):102-9. PMID: 16003240.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  76. Yu PB, Beppu H, Kawai N, Li E, Bloch KD. Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem. 2005 Jul 01; 280(26):24443-50. PMID: 15883158.
    Citations: 67     Fields:    Translation:AnimalsCells
  77. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. . 2004 Dec; 287(6):L1241-7. PMID: 15286002.
    Citations: 59     Fields:    Translation:Animals
  78. Parker W, Stitzenberg KB, Yu PB, Pratt VS, Nakamura YC, Farel LS, Ward CM, Lin SS, Everett ML, Platt JL. Biophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation. Transplantation. 2001 Feb 15; 71(3):440-6. PMID: 11233908.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  79. Gonzalez-Stawinski GV, Yu PB, Love SD, Parker W, Davis RD. Hapten-induced primary and memory humoral responses are inhibited by the infusion of anti-CD20 monoclonal antibody (IDEC-C2B8, Rituximab). Clin Immunol. 2001 Feb; 98(2):175-9. PMID: 11161973.
    Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  80. Parker W, Lin SS, Yu PB, Sood A, Nakamura YC, Song A, Everett ML, Platt JL. Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies. Glycobiology. 1999 Sep; 9(9):865-73. PMID: 10460828.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  81. Yu PB, Parker W, Everett ML, Fox IJ, Platt JL. Immunochemical properties of anti-Gal alpha 1-3Gal antibodies after sensitization with xenogeneic tissues. J Clin Immunol. 1999 Mar; 19(2):116-26. PMID: 10226886.
    Citations: 2     Fields:    Translation:HumansAnimals
  82. Parker W, Yu PB, Holzknecht ZE, Lundberg K, Buckley RH, Platt JL. Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development. J Clin Immunol. 1997 Jul; 17(4):311-21. PMID: 9258770.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  83. Yu PB, Holzknecht ZE, Bruno D, Parker W, Platt JL. Modulation of natural IgM binding and complement activation by natural IgG antibodies: a role for IgG anti-Gal alpha1-3Gal antibodies. J Immunol. 1996 Dec 01; 157(11):5163-8. PMID: 8943428.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.