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Farese, Robert
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Robert V. Farese Jr., M.D.
Title
Adjunct Professor of Molecular Metabolism
Institution
Harvard T.H. Chan School of Public Health
Department
Molecular Metabolism
Address
Harvard School of Public Health
Building 1, room 208
665 Huntington Ave
Boston MA 02115
overview
|
webpage
|
research activities and funding
|
selected publications
|
Overview
overview
Robert Farese, Jr., is Chair and Professor of the Department of Molecular Metabolism at the Harvard School of Public Health and Professor of Cell Biology at Harvard Medical School, where he has run a laboratory jointly with Dr. Tobias Walther since 2014. Dr. Farese earned a B.S. in chemistry at the University of Florida and an M.D. at Vanderbilt University School of Medicine. He trained in medicine at the University of Colorado School of Medicine, and completed a research fellowship in Endocrinology and Metabolism at the University of California, San Francisco and the Gladstone Institutes.
Dr. Farese serves on the board of the Bluefield Project to Cure Frontotemporal Dementia (FTD). He has received numerous honors, including election to the American Society for Clinical Investigation and the Association of American Physicians, the Bristol-Myers Squibb “Freedom to Discover Award”, and the Avanti Award in Lipids.
Research
The Farese-Walther laboratory studies cellular lipid and energy metabolism, in particular the mechanisms and physiology of neutral lipid synthesis and storage in lipid droplets. More broadly, the lab investigates the mechanisms by which cells regulate the abundance of lipids, how they store lipids to buffer fluctuations in their availability, and how these processes function in membrane biology and cell physiology.
Dr. Farese has made important contributions to our understanding of lipid metabolism. His laboratory discovered genes that encode enzymes critical for neutral lipid metabolism, including the DGAT enzymes which mediate triglyceride (TG) synthesis. Excessive accumulation of TGs underlies obesity, diabetes, fatty liver, and other metabolic diseases. Since 2007, Dr. Farese’s laboratory has studied the role of lipid metabolism in the central nervous system, particularly in neurodegenerative disorders such as Frontotemporal Dementia (FTD).
webpage
Farese & Walther Laboratory
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01GM141050
(FARESE, ROBERT V)
Apr 1, 2021 - Jan 31, 2025
NIH
Lipotoxic Protective Response of the Endoplasmic Reticulum
Role: Principal Investigator
R13DK126215
(FARESE, ROBERT V)
Jul 1, 2020 - Jun 30, 2021
NIH
FASEB's The Lipid Droplets Conference
Role: Principal Investigator
R01DK124913
(WALTHER, TOBIAS)
Apr 1, 2020 - Feb 28, 2025
NIH
Lipid Droplets and Transcriptional Regulation of Metabolism
Role: Co-Principal Investigator
R01GM124348
(FARESE, ROBERT V)
Sep 1, 2017 - Jul 31, 2025
NIH
Mechanisms of Lipid Droplet Formation
Role: Principal Investigator
R13HL123268
(FARESE, ROBERT V)
Jun 10, 2014 - May 31, 2015
NIH
2014 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Semina
Role: Principal Investigator
R01DK101579
(FARESE, ROBERT V)
May 1, 2014 - Apr 30, 2019
NIH
Physiology of Lipid Droplets and Triglyceride Storage
Role: Principal Investigator
I01BX001415
(FARESE, ROBERT V)
Oct 1, 2012 - Sep 30, 2016
NIH
Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
Role: Principal Investigator
R01GM099844
(FARESE, ROBERT V)
Mar 1, 2012 - Nov 30, 2017
NIH
The Mechanisms of Lipid Droplet Formation and Regulation
Role: Principal Investigator
R56DK056084
(FARESE, ROBERT V)
Sep 30, 2010 - Aug 31, 2011
NIH
Role of DGAT in Triacyglycerol Metabolism
Role: Principal Investigator
RC1NS068697
(HERZ, JOACHIM J)
Sep 30, 2009 - Aug 31, 2011
NIH
Enhancing Progranulin Expression - a Therapy for Frontotemporal Dementia
Role: Principal Investigator
R01DK077233
(FARESE, ROBERT V)
Aug 1, 2007 - Oct 31, 2011
NIH
Functional Analysis of MGAT Enzymes
Role: Principal Investigator
R21DK078254
(FARESE, ROBERT V)
Apr 20, 2007 - Mar 31, 2009
NIH
Identification of Genes that Regulate Cellular Lipid Storage
Role: Principal Investigator
P50AG023501
(MILLER, BRUCE L)
Apr 1, 2004 - Mar 31, 2019
NIH/NIA
New Approaches to Dementia Heterogeneity
Role: Co-Principal Investigator
R01DK065969
(FARESE, ROBERT V)
Jul 1, 2003 - Sep 30, 2016
NIH
Activation of Atypical PKC by Insulin and Other Agonists
Role: Principal Investigator
R01DK065599
(FARESE, ROBERT V)
Apr 15, 2003 - Mar 31, 2007
NIH
Triglyceride Synthesis and Lipotoxicity
Role: Principal Investigator
R01DK056084
(FARESE, ROBERT V)
May 1, 2000 - Jul 31, 2017
NIH
Role of DGAT in Triacyglycerol Metabolism
Role: Principal Investigator
R01HL057170
(FARESE, ROBERT V)
Feb 1, 1997 - Jan 31, 2008
NIH
Investigation of ACAT Functions Using Knockout
Role: Principal Investigator
P01HL041633
(YOUNG, STEPHEN G)
Feb 1, 1989 - Jan 31, 2005
NIH/NHLBI
LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM
Role: Co-Principal Investigator
R01DK038079
(FARESE, ROBERT V)
Aug 1, 1987 - Dec 31, 2002
NIH
LIPID REGULATED KINASES IN INSULIN ACTION
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C,
Paulo JA
, Nguyen AD, Harper JW,
Walther TC
,
Farese RV
. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022 10 07; 13(1):5924.
PMID:
36207292
; PMCID:
PMC9546883
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Farese RV
,
Walther TC
. Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2022 Sep 12.
PMID:
36096640
.
Citations:
Fields:
Bio
Biology
Song J,
Mizrak A
, Lee CW, Cicconet M, Lai ZW, Tang WC, Lu CH,
Mohr SE
,
Farese RV
,
Walther TC
. Identification of two pathways mediating protein targeting from ER to lipid droplets. Nat Cell Biol. 2022 09; 24(9):1364-1377.
PMID:
36050470
; PMCID:
PMC9481466
.
Citations:
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Arlt H
,
Sui X
, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM,
Farese RV
,
Walther TC
. Seipin forms a flexible cage at lipid droplet formation sites. Nat Struct Mol Biol. 2022 03; 29(3):194-202.
PMID:
35210614
; PMCID:
PMC8930772
.
Citations:
4
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA,
Flannick J
, Burtt NP,
Farese RV
,
Walther TC
. The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology. Dev Cell. 2022 02 07; 57(3):387-397.e4.
PMID:
35134345
; PMCID:
PMC9129885
.
Citations:
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Kim S, Li C,
Farese RV
,
Walther TC
, Voth GA. Key Factors Governing Initial Stages of Lipid Droplet Formation. J Phys Chem B. 2022 01 20; 126(2):453-462.
PMID:
34990551
; PMCID:
PMC8922452
.
Citations:
2
Fields:
Che
Chemistry
Translation:
Cells
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N,
Chung J
, Bennett D, Weigel AV, Freeman M, van Engelenburg SB,
Walther TC
,
Farese RV
, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021 Nov; 599(7885):E5.
PMID:
34732896
.
Citations:
Fields:
Sci
Science
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N,
Chung J
, Bennett D, Weigel AV, Freeman M, van Engelenburg SB,
Walther TC
,
Farese RV
, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021 11; 599(7883):147-151.
PMID:
34616045
; PMCID:
PMC9004664
.
Citations:
5
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Olarte MJ, Swanson JMJ,
Walther TC
,
Farese RV
. The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting. Trends Biochem Sci. 2022 01; 47(1):39-51.
PMID:
34583871
; PMCID:
PMC8688270
.
Citations:
6
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Kumar S, Chitraju C,
Farese RV
,
Walther TC
, Burd CG. Conditional targeting of phosphatidylserine decarboxylase to lipid droplets. Biol Open. 2021 03 03; 10(3).
PMID:
33593792
; PMCID:
PMC7938800
.
Citations:
2
Fields:
Bio
Biology
Translation:
Humans
Cells
Sajan MP, Hansen BC, Acevedo-Duncan M, Kindy MS, Cooper DR,
Farese RV
. Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus. MedComm (2020). 2021 Mar; 2(1):3-16.
PMID:
34766133
.
Citations:
4
Farese RV
,
Walther TC
. The power of two: lessons from a scientific partnership. J Clin Invest. 2021 01 19; 131(2).
PMID:
33463550
; PMCID:
PMC7810469
.
Citations:
Fields:
Med
Medicine (General)
Translation:
Humans
Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M,
Farese RV
. Control of ß-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-?/? and Nuclear Factor ?-B. Curr Alzheimer Res. 2021; 18(12):941-955.
PMID:
34951366
.
Citations:
Fields:
Neu
Neurology
Translation:
Animals
Christiano R,
Arlt H
, Kabatnik S, Mejhert N, Lai ZW,
Farese RV
,
Walther TC
. A Systematic Protein Turnover Map for Decoding Protein Degradation. Cell Rep. 2020 11 10; 33(6):108378.
PMID:
33176155
; PMCID:
PMC7745259
.
Citations:
8
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Chitraju C, Fischer AW,
Farese RV
,
Walther TC
. Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis. Cell Rep. 2020 11 03; 33(5):108348.
PMID:
33147469
.
Citations:
17
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A,
Walther TC
,
Farese RV
. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. J Cell Biol. 2020 10 05; 219(10).
PMID:
32915949
.
Citations:
8
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL,
Walther TC
,
Farese RV
, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 12; 588(7838):459-465.
PMID:
32866962
; PMCID:
PMC7746606
.
Citations:
31
Fields:
Sci
Science
Translation:
Animals
Cells
Olarte MJ, Kim S, Sharp ME, Swanson JMJ,
Farese RV
,
Walther TC
. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Dev Cell. 2020 08 24; 54(4):471-487.e7.
PMID:
32730754
.
Citations:
11
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Animals
Cells
Sui X
, Wang K, Gluchowski NL, Elliott SD, Liao M,
Walther TC
,
Farese RV
. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 05; 581(7808):323-328.
PMID:
32433611
.
Citations:
12
Fields:
Sci
Science
Translation:
Humans
Cells
Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ,
Bronson RT
,
Harper JW
,
Farese RV
,
Walther TC
. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10565-10574.
PMID:
32345721
.
Citations:
9
Fields:
Sci
Science
Translation:
Animals
Cells
Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW,
Lane EA
, Christiano R,
Danial NN
,
Farese RV
,
Walther TC
. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Mol Cell. 2020 03 19; 77(6):1251-1264.e9.
PMID:
32023484
.
Citations:
25
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Chung J
, Wu X,
Lambert TJ
, Lai ZW,
Walther TC
,
Farese RV
. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Dev Cell. 2019 12 02; 51(5):551-563.e7.
PMID:
31708432
; PMCID:
PMC7235935
.
Citations:
52
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Cells
Walther TC
,
Farese RV
. Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. Dev Cell. 2019 09 09; 50(5):530-532.
PMID:
31505174
.
Citations:
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Cells
Gluchowski NL, Gabriel KR, Chitraju C,
Bronson RT
, Mejhert N, Boland S, Wang K, Lai ZW,
Farese RV
,
Walther TC
. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. Hepatology. 2019 12; 70(6):1972-1985.
PMID:
31081165
; PMCID:
PMC6893913
.
Citations:
19
Fields:
Gas
Gastroenterology
Translation:
Animals
Cells
Chitraju C,
Walther TC
,
Farese RV
. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 2019 06; 60(6):1112-1120.
PMID:
30936184
.
Citations:
32
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD,
Paulo JA
,
Harper JW
, Weissman JS,
Walther TC
,
Farese RV
. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8.
PMID:
30846318
.
Citations:
49
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Farese RV
, Sajan MP. Atypical PKC: therapeutic target for Alzheimer's? Aging (Albany NY). 2018 12 20; 11(1):13-14.
PMID:
30573704
; PMCID:
PMC6339803
.
Citations:
3
Fields:
Ger
Geriatrics
Translation:
Humans
Cells
Fanning S
, Haque A, Imberdis T, Baru V, Barrasa MI,
Nuber S
, Termine D,
Ramalingam N
,
Ho GPH
, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB,
Walther TC
,
Farese RV
, Srinivasan S, Welte MA, Kohlwein SD,
Dettmer U
, Lindquist S,
Selkoe D
. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8.
PMID:
30527540
; PMCID:
PMC6408259
.
Citations:
81
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Sui X
,
Arlt H
, Brock KP, Lai ZW, DiMaio F,
Marks DS
, Liao M,
Farese RV
,
Walther TC
. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J Cell Biol. 2018 12 03; 217(12):4080-4091.
PMID:
30327422
; PMCID:
PMC6279392
.
Citations:
53
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR,
Walther TC
,
Farese RV
. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 10; 277:145-154.
PMID:
30212683
; PMCID:
PMC6432779
.
Citations:
7
Fields:
Vas
Vascular Diseases
Translation:
Animals
Cells
Jayson CBK,
Arlt H
, Fischer AW, Lai ZW,
Farese RV
,
Walther TC
. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 08 15; 29(17):2045-2054.
PMID:
29949452
; PMCID:
PMC6232964
.
Citations:
12
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ,
Walther TC
,
Farese RV
. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2849-E2858.
PMID:
29511098
; PMCID:
PMC5866607
.
Citations:
24
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Li Z, Lai ZW, Christiano R, Gazos-Lopes F,
Walther TC
,
Farese RV
. Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 05; 17(5):836-849.
PMID:
29414761
.
Citations:
7
Fields:
Bio
Biochemistry
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Prévost C, Sharp ME,
Kory N
, Lin Q, Voth GA,
Farese RV
,
Walther TC
. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Dev Cell. 2018 Jan 08; 44(1):73-86.e4.
PMID:
29316443
; PMCID:
PMC5764114
.
Citations:
67
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Animals
Cells
Inloes JM, Kiosses WB, Wang H,
Walther TC
,
Farese RV
, Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 06; 57(5):827-838.
PMID:
29278326
.
Citations:
21
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Sajan MP, Lee MC, Foufelle F, Sajan J, Cleland C,
Farese RV
. Coordinated regulation of hepatic FoxO1, PGC-1a and SREBP-1c facilitates insulin action and resistance. Cell Signal. 2018 03; 43:62-70.
PMID:
29269047
.
Citations:
5
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM,
Farese RV
. Atypical PKC, PKC?/?, activates ß-secretase and increases Aß1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease. Neurobiol Aging. 2018 01; 61:225-237.
PMID:
29032894
; PMCID:
PMC5705272
.
Citations:
11
Fields:
Ger
Geriatrics
Neu
Neurology
Phy
Physiology
Translation:
Animals
Cells
Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM,
Farese RV
, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL. An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimers Dement (N Y). 2017 Nov; 3(4):507-512.
PMID:
29124108
; PMCID:
PMC5671622
.
Citations:
13
Walther TC
,
Chung J
,
Farese RV
. Lipid Droplet Biogenesis. Annu Rev Cell Dev Biol. 2017 10 06; 33:491-510.
PMID:
28793795
; PMCID:
PMC6986389
.
Citations:
197
Fields:
Bio
Biology
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK,
Walther TC
,
Farese RV
. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab. 2017 Aug 01; 26(2):407-418.e3.
PMID:
28768178
.
Citations:
89
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Humans
Animals
Cells
Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL,
Farese RV
, Gan L. Microglial NF?B-TNFa hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):5029-5034.
PMID:
28438992
; PMCID:
PMC5441749
.
Citations:
39
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Gluchowski NL, Becuwe M,
Walther TC
,
Farese RV
. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol. 2017 Jun; 14(6):343-355.
PMID:
28428634
; PMCID:
PMC6319657
.
Citations:
140
Fields:
Gas
Gastroenterology
Translation:
Humans
Cells
Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W,
Kamin DS
,
Winter HS
, Chung WK,
Walther TC
,
Farese RV
. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res. 2017 06; 58(6):1230-1237.
PMID:
28373485
.
Citations:
18
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ,
Farese RV
, Schwartz MW, Thaler JP. Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 04; 66(4):920-934.
PMID:
28073831
; PMCID:
PMC5360303
.
Citations:
6
Fields:
End
Endocrinology
Translation:
Animals
Cells
Kory N
, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F,
Semova I
, Ejsing C, Zechner R, Cravatt BF,
Farese RV
,
Walther TC
. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 2017 01; 58(1):226-235.
PMID:
27836991
.
Citations:
9
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Fröhlich F, Olson DK, Christiano R,
Farese RV
,
Walther TC
. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 2016 11; 16(21):2759-2763.
PMID:
27717283
; PMCID:
PMC5688516
.
Citations:
9
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK,
Upadhyayula S
,
Perrimon N
,
Kirchhausen T
, Ejsing CS,
Walther TC
,
Farese RV
. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5.
PMID:
27564575
; PMCID:
PMC5035145
.
Citations:
132
Fields:
Bio
Biology
Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B,
Farese RV
, Sajan MP, Bergold PJ, Hernández AI, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC. Compensation for PKM? in long-term potentiation and spatial long-term memory in mutant mice. Elife. 2016 05 17; 5.
PMID:
27187150
; PMCID:
PMC4869915
.
Citations:
72
Fields:
Bio
Biology
Translation:
Animals
Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R,
Farese RV
, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35.
PMID:
27114033
; PMCID:
PMC4860138
.
Citations:
265
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Kory N
,
Farese RV
,
Walther TC
. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends Cell Biol. 2016 07; 26(7):535-546.
PMID:
26995697
; PMCID:
PMC4976449
.
Citations:
118
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Sajan M, Hansen B, Ivey R, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M,
Farese RV
. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1a and Increases in Aß1-40/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. 2016 07; 65(7):1892-903.
PMID:
26895791
; PMCID:
PMC4915579
.
Citations:
27
Fields:
End
Endocrinology
Translation:
Animals
Cells
Agarwal AK, Tunison K, Dalal JS, Yen CL,
Farese RV
, Horton JD, Garg A. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr; 57(4):616-30.
PMID:
26880786
.
Citations:
10
Fields:
Bio
Biochemistry
Translation:
Animals
Farese RV
,
Walther TC
. Lipid droplets go nuclear. J Cell Biol. 2016 Jan 04; 212(1):7-8.
PMID:
26728852
; PMCID:
PMC4700486
.
Citations:
11
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Olson DK, Fröhlich F,
Farese RV
,
Walther TC
. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta. 2016 Aug; 1861(8 Pt B):784-792.
PMID:
26747648
; PMCID:
PMC4907851
.
Citations:
22
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Cells
Yu H, Fujii NL, Toyoda T, An D,
Farese RV
, Leitges M, Hirshman MF, Mul JD,
Goodyear LJ
. Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiol Rep. 2015 Nov; 3(11).
PMID:
26564060
.
Citations:
2
Fields:
Phy
Physiology
Fröhlich F, Petit C,
Kory N
, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS,
Farese RV
,
Walther TC
. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 2015 Sep 10; 4.
PMID:
26357016
.
Citations:
37
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Sajan MP, Ivey RA,
Farese RV
. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1a in livers of obese and type 2 diabetic humans. Metabolism. 2015 Nov; 64(11):1454-65.
PMID:
26386696
; PMCID:
PMC4576742
.
Citations:
9
Fields:
Met
Metabolism
Translation:
Humans
Cells
Kory N
, Thiam AR,
Farese RV
,
Walther TC
. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015 Aug 10; 34(3):351-63.
PMID:
26212136
; PMCID:
PMC4536137
.
Citations:
64
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Animals
Cells
Zhang N, Liang H,
Farese RV
, Li J, Musi N, Hussey SE. Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats. PLoS One. 2015; 10(7):e0132575.
PMID:
26196892
.
Citations:
12
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL,
Farese RV
, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80.
PMID:
25381252
.
Citations:
16
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC,
Farese RV
, Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 01; 307(11):E1065-72.
PMID:
25315695
.
Citations:
9
Fields:
End
Endocrinology
Met
Metabolism
Phy
Physiology
Translation:
Animals
Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L,
Farese RV
, Gan L. Progranulin protects against amyloid ß deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64.
PMID:
25261995
.
Citations:
103
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX,
Farese RV
, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. J Biol Chem. 2014 Oct 24; 289(43):29881-91.
PMID:
25157099
.
Citations:
30
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW,
Farese RV
, Green A, Gan L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45.
PMID:
25155018
.
Citations:
49
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Humans
Animals
Farese RV
, Lee MC, Sajan MP. Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. J Clin Med. 2014 Jul 07; 3(3):724-40.
PMID:
26237474
; PMCID:
PMC4449650
.
Citations:
2
Fu D, Yu Y, Folick A, Currie E,
Farese RV
, Tsai TH, Xie XS, Wang MC. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc. 2014 Jun 18; 136(24):8820-8.
PMID:
24869754
.
Citations:
50
Fields:
Che
Chemistry
Translation:
Animals
Cells
Currie E, Guo X, Christiano R, Chitraju C,
Kory N
, Harrison K, Haas J,
Walther TC
,
Farese RV
. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014 07; 55(7):1465-77.
PMID:
24868093
.
Citations:
51
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Wilfling F, Haas JT,
Walther TC
,
Farese RV
. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014 Aug; 29:39-45.
PMID:
24736091
.
Citations:
152
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J,
Farese RV
,
Walther TC
. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014; 3:e01607.
PMID:
24497546
.
Citations:
110
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Thiam AR,
Farese RV
,
Walther TC
. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013 Dec; 14(12):775-86.
PMID:
24220094
.
Citations:
260
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL,
Farese RV
, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055.
PMID:
24143176
; PMCID:
PMC3797144
.
Citations:
66
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Nguyen AD, Nguyen TA, Martens LH, Mitic LL,
Farese RV
. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol Metab. 2013 Dec; 24(12):597-606.
PMID:
24035620
.
Citations:
30
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Animals
Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS,
Farese R
, Simons K, Krogan NJ, Ernst R. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell. 2013 Aug 22; 51(4):519-30.
PMID:
23891562
.
Citations:
60
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Currie E, Schulze A, Zechner R,
Walther TC
,
Farese RV
. Cellular fatty acid metabolism and cancer. Cell Metab. 2013 Aug 06; 18(2):153-61.
PMID:
23791484
.
Citations:
675
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Humans
Krahmer N,
Farese RV
,
Walther TC
. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013 Jul; 5(7):973-83.
PMID:
23740690
.
Citations:
165
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J,
Farese RV
, Kukar T, Tansey MG. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013 May 22; 33(21):9202-13.
PMID:
23699531
.
Citations:
43
Fields:
Neu
Neurology
Translation:
Humans
Animals
Cells
Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H,
Rapoport TA
,
Farese RV
,
Blackstone C
, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75.
PMID:
23684613
.
Citations:
63
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB,
Farese RV
, Roberson ED. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. J Neurosci. 2013 Mar 20; 33(12):5352-61.
PMID:
23516300
.
Citations:
68
Fields:
Neu
Neurology
Translation:
Animals
Cells
Camus G, Herker E, Modi AA, Haas JT, Ramage HR,
Farese RV
, Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-9923.
PMID:
23420847
.
Citations:
55
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J,
Farese RV
,
Walther TC
. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013 Feb 25; 24(4):384-99.
PMID:
23415954
.
Citations:
290
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Animals
Cells
Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J,
Walther TC
, Davidson WS,
Farese RV
. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013 Mar 22; 288(12):8627-8635.
PMID:
23364791
.
Citations:
12
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Krahmer N, Hilger M,
Kory N
, Wilfling F, Stoehr G, Mann M,
Farese RV
,
Walther TC
. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013 May; 12(5):1115-26.
PMID:
23319140
.
Citations:
77
Fields:
Bio
Biochemistry
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB,
Farese RV
, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4.
PMID:
23223453
.
Citations:
588
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Haas JT,
Winter HS
, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS,
Walther TC
,
Daly MJ
,
Farese RV
. DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest. 2012 Dec; 122(12):4680-4.
PMID:
23114594
; PMCID:
PMC3533555
.
Citations:
58
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S,
Farese RV
, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec; 44(12):1302-9.
PMID:
23104007
.
Citations:
122
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Eichmann TO, Kumari M, Haas JT,
Farese RV
, Zimmermann R, Lass A, Zechner R. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30; 287(49):41446-57.
PMID:
23066022
; PMCID:
PMC3510842
.
Citations:
80
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL,
Farese RV
, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012 Oct 25; 2(4):789-98.
PMID:
23063362
.
Citations:
73
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J,
Farese R
, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98.
PMID:
23062850
.
Citations:
28
Fields:
Neu
Neurology
Psy
Psychiatry
Translation:
Humans
Animals
Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ,
Farese RV
. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 11; 122(11):3955-9.
PMID:
23041626
; PMCID:
PMC3484443
.
Citations:
136
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M,
Farese R
, Miller BL, Cummings J. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88.
PMID:
23043900
.
Citations:
30
Fields:
Neu
Neurology
Psy
Psychiatry
Translation:
Humans
Animals
Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S,
Farese RV
, Mak HY. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol. 2012 Sep 03; 198(5):895-911.
PMID:
22927462
.
Citations:
112
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Haas JT,
Miao J
, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B,
Farese RV
, Kurland IJ, Graham M, Crooke R, Foufelle F,
Biddinger SB
. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84.
PMID:
22682225
.
Citations:
95
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Animals
Cells
Farese RV
, Zechner R, Newgard CB,
Walther TC
. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012 May 02; 15(5):570-3.
PMID:
22560209
.
Citations:
111
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Humans
Animals
Walther TC
,
Farese RV
. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012; 81:687-714.
PMID:
22524315
.
Citations:
497
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK,
Farese RV
, Brown JM, Rudel LL. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res. 2012 Jun; 53(6):1144-52.
PMID:
22460046
.
Citations:
21
Fields:
Bio
Biochemistry
Translation:
Animals
Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E,
Farese RV
. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan; 4(1):13-27.
PMID:
22291164
.
Citations:
21
Fields:
Ger
Geriatrics
Translation:
Animals
Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH,
Farese RV
, Galgani JE, Hambly C, Herman MA, Horvath TL,
Kahn BB
, Kozma SC,
Maratos-Flier E
, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G,
Kahn CR
, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63.
PMID:
22205519
.
Citations:
366
Fields:
Cli
Clinical Laboratory Techniques
Translation:
Animals
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M,
Alt FW
, Newgard CB,
Farese RV
,
Kahn CR
, Verdin E. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90.
PMID:
21856199
.
Citations:
340
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Harris C, Herker E,
Farese RV
, Ott M. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-42625.
PMID:
21984835
.
Citations:
41
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells