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Robert V. Farese Jr., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01GM124348 (FARESE, ROBERT V) Sep 1, 2017 - May 31, 2021
    NIH/NIGMS
    Mechanisms of Lipid Droplet Formation
    Role: Principal Investigator
  2. R13HL123268 (FARESE, ROBERT V) Jun 10, 2014 - May 31, 2015
    NIH/NHLBI
    2014 Lipoprotein Metabolism Gordon Research Conference and Gordon Research Semina
    Role: Principal Investigator
  3. R01DK101579 (FARESE, ROBERT V) May 1, 2014 - Apr 30, 2019
    NIH/NIDDK
    Physiology of Lipid Droplets and Triglyceride Storage
    Role: Principal Investigator
  4. R01GM099844 (FARESE, ROBERT V) Mar 1, 2012 - Nov 30, 2015
    NIH/NIGMS
    The Mechanisms of Lipid Droplet Formation and Regulation
    Role: Principal Investigator
  5. R56DK056084 (FARESE, ROBERT V) Sep 30, 2010 - Aug 31, 2011
    NIH/NIDDK
    Role of DGAT in Triacyglycerol Metabolism
    Role: Principal Investigator

Featured Content

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J Cell Biol. 2018 Oct 16. PMID: 30327422.
    View in: PubMed
  2. Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 Oct; 277:145-154. PMID: 30212683.
    View in: PubMed
  3. Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 Aug 15; 29(17):2045-2054. PMID: 29949452.
    View in: PubMed
  4. Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2849-E2858. PMID: 29511098.
    View in: PubMed
  5. Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV. Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 May; 17(5):836-849. PMID: 29414761.
    View in: PubMed
  6. Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Dev Cell. 2018 Jan 08; 44(1):73-86.e4. PMID: 29316443.
    View in: PubMed
  7. Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 06; 57(5):827-838. PMID: 29278326.
    View in: PubMed
  8. Sajan MP, Lee MC, Foufelle F, Sajan J, Cleland C, Farese RV. Coordinated regulation of hepatic FoxO1, PGC-1a and SREBP-1c facilitates insulin action and resistance. Cell Signal. 2018 Mar; 43:62-70. PMID: 29269047.
    View in: PubMed
  9. Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. Atypical PKC, PKC?/?, activates ß-secretase and increases Aß1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease. Neurobiol Aging. 2018 01; 61:225-237. PMID: 29032894.
    View in: PubMed
  10. Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL. An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimers Dement (N Y). 2017 Nov; 3(4):507-512. PMID: 29124108.
    View in: PubMed
  11. Walther TC, Chung J, Farese RV. Lipid Droplet Biogenesis. Annu Rev Cell Dev Biol. 2017 10 06; 33:491-510. PMID: 28793795.
    View in: PubMed
  12. Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab. 2017 Aug 01; 26(2):407-418.e3. PMID: 28768178.
    View in: PubMed
  13. Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV, Gan L. Microglial NF?B-TNFa hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):5029-5034. PMID: 28438992.
    View in: PubMed
  14. Gluchowski NL, Becuwe M, Walther TC, Farese RV. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol. 2017 Jun; 14(6):343-355. PMID: 28428634.
    View in: PubMed
  15. Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res. 2017 Jun; 58(6):1230-1237. PMID: 28373485.
    View in: PubMed
  16. Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP. Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 04; 66(4):920-934. PMID: 28073831.
    View in: PubMed
  17. Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 2017 01; 58(1):226-235. PMID: 27836991.
    View in: PubMed
  18. Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 2016 11; 16(21):2759-2763. PMID: 27717283.
    View in: PubMed
  19. Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5. PMID: 27564575.
    View in: PubMed
  20. Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hernández AI, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC. Compensation for PKM? in long-term potentiation and spatial long-term memory in mutant mice. Elife. 2016 05 17; 5. PMID: 27187150.
    View in: PubMed
  21. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. PMID: 27114033.
    View in: PubMed
  22. Kory N, Farese RV, Walther TC. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends Cell Biol. 2016 07; 26(7):535-546. PMID: 26995697; PMCID: PMC4976449 [Available on 07/01/17].
    View in: PubMed, PubMed Central
  23. Sajan M, Hansen B, Ivey R, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV. Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1a and Increases in Aß1-40/42 and Phospho-Tau May Abet Alzheimer Development. Diabetes. 2016 07; 65(7):1892-903. PMID: 26895791; PMCID: PMC4915579 [Available on 07/01/17].
    View in: PubMed, PubMed Central
  24. Agarwal AK, Tunison K, Dalal JS, Yen CL, Farese RV, Horton JD, Garg A. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr; 57(4):616-30. PMID: 26880786; PMCID: PMC4808770 [Available on 04/01/17].
    View in: PubMed, PubMed Central
  25. Farese RV, Walther TC. Lipid droplets go nuclear. J Cell Biol. 2016 Jan 04; 212(1):7-8. PMID: 26728852; PMCID: PMC4700486.
    View in: PubMed, PubMed Central
  26. Olson DK, Fröhlich F, Farese RV, Walther TC. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta. 2016 Aug; 1861(8 Pt B):784-792. PMID: 26747648; PMCID: PMC4907851 [Available on 08/01/17].
    View in: PubMed, PubMed Central
  27. Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ. Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiol Rep. 2015 Nov; 3(11). PMID: 26564060; PMCID: PMC4673624.
    View in: PubMed, PubMed Central
  28. Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 2015 Sep 10; 4. PMID: 26357016; PMCID: PMC4600884.
    View in: PubMed, PubMed Central
  29. Sajan MP, Ivey RA, Farese RV. BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1a in livers of obese and type 2 diabetic humans. Metabolism. 2015 Nov; 64(11):1454-65. PMID: 26386696; PMCID: PMC4576742 [Available on 11/01/16].
    View in: PubMed, PubMed Central
  30. Kory N, Thiam AR, Farese RV, Walther TC. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015 Aug 10; 34(3):351-63. PMID: 26212136; PMCID: PMC4536137.
    View in: PubMed, PubMed Central
  31. Zhang N, Liang H, Farese RV, Li J, Musi N, Hussey SE. Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats. PLoS One. 2015; 10(7):e0132575. PMID: 26196892; PMCID: PMC4510579.
    View in: PubMed, PubMed Central
  32. Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014 Dec 26; 289(52):35770-80. PMID: 25381252; PMCID: PMC4276846.
    View in: PubMed, PubMed Central
  33. Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 01; 307(11):E1065-72. PMID: 25315695; PMCID: PMC4254982.
    View in: PubMed, PubMed Central
  34. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. Progranulin protects against amyloid ß deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. PMID: 25261995; PMCID: PMC4196723.
    View in: PubMed, PubMed Central
  35. Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. J Biol Chem. 2014 Oct 24; 289(43):29881-91. PMID: 25157099; PMCID: PMC4207999.
    View in: PubMed, PubMed Central
  36. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45. PMID: 25155018; PMCID: PMC4172214.
    View in: PubMed, PubMed Central
  37. Farese RV, Lee MC, Sajan MP. Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus. J Clin Med. 2014 Jul 07; 3(3):724-40. PMID: 26237474; PMCID: PMC4449650.
    View in: PubMed, PubMed Central
  38. Fu D, Yu Y, Folick A, Currie E, Farese RV, Tsai TH, Xie XS, Wang MC. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc. 2014 Jun 18; 136(24):8820-8. PMID: 24869754; PMCID: PMC4073829.
    View in: PubMed, PubMed Central
  39. Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014 07; 55(7):1465-77. PMID: 24868093.
    View in: PubMed
  40. Wilfling F, Haas JT, Walther TC, Farese RV. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014 Aug; 29:39-45. PMID: 24736091; PMCID: PMC4526149.
    View in: PubMed, PubMed Central
  41. Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014; 3:e01607. PMID: 24497546; PMCID: PMC3913038.
    View in: PubMed, PubMed Central
  42. Thiam AR, Farese RV, Walther TC. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013 Dec; 14(12):775-86. PMID: 24220094; PMCID: PMC4526153.
    View in: PubMed, PubMed Central
  43. Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013; 8(10):e76055. PMID: 24143176.
    View in: PubMed
  44. Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol Metab. 2013 Dec; 24(12):597-606. PMID: 24035620; PMCID: PMC3842380.
    View in: PubMed, PubMed Central
  45. Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R, Simons K, Krogan NJ, Ernst R. A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell. 2013 Aug 22; 51(4):519-30. PMID: 23891562; PMCID: PMC3791312.
    View in: PubMed, PubMed Central
  46. Currie E, Schulze A, Zechner R, Walther TC, Farese RV. Cellular fatty acid metabolism and cancer. Cell Metab. 2013 Aug 06; 18(2):153-61. PMID: 23791484; PMCID: PMC3742569.
    View in: PubMed, PubMed Central
  47. Krahmer N, Farese RV, Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013 Jul; 5(7):973-83. PMID: 23740690; PMCID: PMC3721468.
    View in: PubMed, PubMed Central
  48. Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Kukar T, Tansey MG. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013 May 22; 33(21):9202-13. PMID: 23699531; PMCID: PMC3707136.
    View in: PubMed, PubMed Central
  49. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. PMID: 23684613; PMCID: PMC3742324.
    View in: PubMed, PubMed Central
  50. Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Roberson ED. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. J Neurosci. 2013 Mar 20; 33(12):5352-61. PMID: 23516300; PMCID: PMC3740510.
    View in: PubMed, PubMed Central
  51. Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013 Apr 05; 288(14):9915-23. PMID: 23420847; PMCID: PMC3617291.
    View in: PubMed, PubMed Central
  52. Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Walther TC. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013 Feb 25; 24(4):384-99. PMID: 23415954.
    View in: PubMed
  53. Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013 Mar 22; 288(12):8627-35. PMID: 23364791; PMCID: PMC3605681.
    View in: PubMed, PubMed Central
  54. Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013 May; 12(5):1115-26. PMID: 23319140; PMCID: PMC3650325.
    View in: PubMed, PubMed Central
  55. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. PMID: 23223453; PMCID: PMC3735349.
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  56. Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest. 2012 Dec; 122(12):4680-4. PMID: 23114594; PMCID: PMC3533555.
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  57. Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec; 44(12):1302-9. PMID: 23104007; PMCID: PMC3510335.
    View in: PubMed, PubMed Central
  58. Eichmann TO, Kumari M, Haas JT, Farese RV, Zimmermann R, Lass A, Zechner R. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30; 287(49):41446-57. PMID: 23066022; PMCID: PMC3510842.
    View in: PubMed, PubMed Central
  59. Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Rep. 2012 Oct 25; 2(4):789-98. PMID: 23063362; PMCID: PMC3532907.
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  60. Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. PMID: 23062850.
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  61. Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov; 122(11):3955-9. PMID: 23041626; PMCID: PMC3484443.
    View in: PubMed, PubMed Central
  62. Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88. PMID: 23043900; PMCID: PMC3542408.
    View in: PubMed, PubMed Central
  63. Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S, Farese RV, Mak HY. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. J Cell Biol. 2012 Sep 03; 198(5):895-911. PMID: 22927462; PMCID: PMC3432760.
    View in: PubMed, PubMed Central
  64. Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84. PMID: 22682225; PMCID: PMC3383842.
    View in: PubMed, PubMed Central
  65. Farese RV, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012 May 02; 15(5):570-3. PMID: 22560209; PMCID: PMC3767424.
    View in: PubMed, PubMed Central
  66. Walther TC, Farese RV. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012; 81:687-714. PMID: 22524315; PMCID: PMC3767414.
    View in: PubMed, PubMed Central
  67. Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV, Brown JM, Rudel LL. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res. 2012 Jun; 53(6):1144-52. PMID: 22460046; PMCID: PMC3351821.
    View in: PubMed, PubMed Central
  68. Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging (Albany NY). 2012 Jan; 4(1):13-27. PMID: 22291164; PMCID: PMC3292902.
    View in: PubMed, PubMed Central
  69. Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. PMID: 22205519.
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  71. Harris C, Herker E, Farese RV, Ott M. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem. 2011 Dec 09; 286(49):42615-25. PMID: 21984835; PMCID: PMC3234948.
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  72. Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab. 2011 Oct 05; 14(4):504-15. PMID: 21982710; PMCID: PMC3735358.
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  73. Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. 2011 Sep 22; 71(6):1030-42. PMID: 21943601; PMCID: PMC3633414.
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  74. Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):E523; author reply E524. PMID: 21807991; PMCID: PMC3161537.
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  75. Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem. 2011 May 06; 286(18):16101-8. PMID: 21454553; PMCID: PMC3091219.
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  76. Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4441-6. PMID: 21368173; PMCID: PMC3060230.
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  77. Harris CA, Haas JT, Streeper RS, Stone SJ, Kumari M, Yang K, Han X, Brownell N, Gross RW, Zechner R, Farese RV. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res. 2011 Apr; 52(4):657-67. PMID: 21317108; PMCID: PMC3284159.
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  78. Bewersdorf J, Farese RV, Walther TC. A new way to look at fat. Nat Methods. 2011 Feb; 8(2):132-3. PMID: 21278725.
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  79. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med. 2010 Nov; 16(11):1295-8. PMID: 20935628; PMCID: PMC3431199.
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  80. Jiao J, Herl LD, Farese RV, Gao FB. MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. PLoS One. 2010 May 10; 5(5):e10551. PMID: 20479936.
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  81. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. PMID: 20203611; PMCID: PMC2841477.
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  82. Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest. 2010 Mar; 120(3):756-67. PMID: 20124729; PMCID: PMC2827941.
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  83. Farese RV, Walther TC. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009 Nov 25; 139(5):855-60. PMID: 19945371; PMCID: PMC3097139.
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  84. Krahmer N, Guo Y, Farese RV, Walther TC. SnapShot: Lipid Droplets. Cell. 2009 Nov 25; 139(5):1024-1024.e1. PMID: 19945384.
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  85. Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology. 2009 Aug; 50(2):434-42. PMID: 19472314; PMCID: PMC3097135.
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  86. Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV, Wang JC. Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J Biol Chem. 2009 Sep 18; 284(38):25593-601. PMID: 19628874; PMCID: PMC2757961.
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  87. Guo Y, Cordes KR, Farese RV, Walther TC. Lipid droplets at a glance. J Cell Sci. 2009 Mar 15; 122(Pt 6):749-52. PMID: 19261844; PMCID: PMC2714424.
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  88. Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki J, Wong JS, Hubbard B, Marmor S, Farese RV. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat Med. 2009 Apr; 15(4):442-6. PMID: 19287392; PMCID: PMC2786494.
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  89. Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem. 2009 Feb 20; 284(8):5352-61. PMID: 19049983; PMCID: PMC2643492.
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  90. Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem. 2009 Feb 13; 284(7):4292-9. PMID: 19028692; PMCID: PMC2640966.
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  91. Walther TC, Farese RV. The life of lipid droplets. Biochim Biophys Acta. 2009 Jun; 1791(6):459-66. PMID: 19041421; PMCID: PMC2782899.
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  92. Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008 Nov; 49(11):2283-301. PMID: 18757836; PMCID: PMC3837458.
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  93. Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep; 49(9):2038-44. PMID: 18515909; PMCID: PMC3837456.
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  94. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. PMID: 18408709; PMCID: PMC2734507.
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  95. Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV. Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1772-81. PMID: 17940217.
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  96. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. PMID: 17923681; PMCID: PMC2169418.
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  97. Chan LC, Peters W, Xu Y, Chun J, Farese RV, Cases S. LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J Leukoc Biol. 2007 Nov; 82(5):1193-200. PMID: 17709403.
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  98. Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul; 6(1):69-78. PMID: 17618857.
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  99. Stone SJ, Levin MC, Farese RV. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J Biol Chem. 2006 Dec 29; 281(52):40273-82. PMID: 17035227.
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  100. Feldman BJ, Streeper RS, Farese RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15675-80. PMID: 17030820; PMCID: PMC1592529.
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  101. Farese RV. The nine lives of ACAT inhibitors. Arterioscler Thromb Vasc Biol. 2006 Aug; 26(8):1684-6. PMID: 16857957.
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  102. Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV, Rader DJ. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. J Lipid Res. 2006 Oct; 47(10):2297-305. PMID: 16877777.
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  103. Rudel LL, Farese RV. ACAT inhibition and the progression of coronary atherosclerosis. N Engl J Med. 2006 Jun 15; 354(24):2616-7; author reply 2616-7. PMID: 16775245.
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  104. Yen CL, Farese RV. Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle. Cell Metab. 2006 May; 3(5):305-7. PMID: 16679288.
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  105. Streeper RS, Koliwad SK, Villanueva CJ, Farese RV. Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E388-94. PMID: 16595853; PMCID: PMC1552042.
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  106. Yen CL, Brown CH, Monetti M, Farese RV. A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Nov; 46(11):2388-97. PMID: 16106050; PMCID: PMC1540095.
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  107. Yen CL, Monetti M, Burri BJ, Farese RV. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J Lipid Res. 2005 Jul; 46(7):1502-11. PMID: 15834126.
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  108. Chen HC, Farese RV. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):482-6. PMID: 15569818.
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  109. Repa JJ, Buhman KK, Farese RV, Dietschy JM, Turley SD. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004 Nov; 40(5):1088-97. PMID: 15486928.
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  110. Lee RG, Kelley KL, Sawyer JK, Farese RV, Parks JS, Rudel LL. Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential. Circ Res. 2004 Nov 12; 95(10):998-1004. PMID: 15486318.
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  111. Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV, Farese RV. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Diabetes. 2004 Jun; 53(6):1445-51. PMID: 15161747.
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  112. Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development. 2004 Jul; 131(13):3047-55. PMID: 15163627; PMCID: PMC2775443.
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  113. Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV, Farese RV. Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states. J Biol Chem. 2004 Jun 11; 279(24):24929-34. PMID: 15069067.
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  114. Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004 Mar 19; 279(12):11767-76. PMID: 14668353.
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  115. Gohil K, Schock BC, Chakraborty AA, Terasawa Y, Raber J, Farese RV, Packer L, Cross CE, Traber MG. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Free Radic Biol Med. 2003 Dec 01; 35(11):1343-54. PMID: 14642382.
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  116. Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2003 Jun; 111(11):1715-22. PMID: 12782674; PMCID: PMC156099.
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  117. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3077-82. PMID: 12629214; PMCID: PMC152249.
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  118. Yen CL, Farese RV. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem. 2003 May 16; 278(20):18532-7. PMID: 12621063.
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  119. Willner EL, Tow B, Buhman KK, Wilson M, Sanan DA, Rudel LL, Farese RV. Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1262-7. PMID: 12538880; PMCID: PMC298761.
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  120. Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 2002 Nov; 51(11):3189-95. PMID: 12401709.
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  121. Chen HC, Ladha Z, Smith SJ, Farese RV. Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E213-8. PMID: 12388146.
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  122. Chen HC, Ladha Z, Farese RV. Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. Endocrinology. 2002 Aug; 143(8):2893-8. PMID: 12130553.
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  123. Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV. DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. Clin Genet. 2002 Jul; 62(1):68-73. PMID: 12123490.
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  124. Chen HC, Farese RV. Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice. Curr Opin Clin Nutr Metab Care. 2002 Jul; 5(4):359-63. PMID: 12107369.
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  125. Yen CL, Stone SJ, Cases S, Zhou P, Farese RV. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8512-7. PMID: 12077311; PMCID: PMC124292.
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  126. Chen HC, Farese RV. Determination of adipocyte size by computer image analysis. J Lipid Res. 2002 Jun; 43(6):986-9. PMID: 12032175.
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  127. Standaert ML, Kanoh Y, Sajan MP, Bandyopadhyay G, Farese RV. Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-?, and Glucose Transport in 3T3/L1 Adipocytes. Endocrinology. 2002 May 01; 143(5):1705-1716. PMID: 28201608.
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  128. Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV, Farese RV. Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport. J Biol Chem. 2002 Jun 28; 277(26):23554-62. PMID: 11978788.
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  129. Buhman KK, Smith SJ, Stone SJ, Repa JJ, Wong JS, Knapp FF, Burri BJ, Hamilton RL, Abumrad NA, Farese RV. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem. 2002 Jul 12; 277(28):25474-9. PMID: 11959864.
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  130. Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2002 Apr; 109(8):1049-55. PMID: 11956242; PMCID: PMC150948.
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  131. Leonard SW, Terasawa Y, Farese RV, Traber MG. Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. Am J Clin Nutr. 2002 Mar; 75(3):555-60. PMID: 11864863.
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  132. Chen HC, Smith SJ, Tow B, Elias PM, Farese RV. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J Clin Invest. 2002 Jan; 109(2):175-81. PMID: 11805129; PMCID: PMC150839.
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  133. Chen HC, Farese RV. Turning WAT into BAT gets rid of fat. Nat Med. 2001 Oct; 7(10):1102-3. PMID: 11590426.
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  134. Raffai RL, Dong LM, Farese RV, Weisgraber KH. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11587-91. PMID: 11553788; PMCID: PMC58773.
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  135. Buhman KK, Chen HC, Farese RV. The enzymes of neutral lipid synthesis. J Biol Chem. 2001 Nov 02; 276(44):40369-72. PMID: 11544264.
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  136. Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001 Oct 19; 276(42):38870-6. PMID: 11481335.
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  137. Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem. 2001 Sep 14; 276(37):34434-40. PMID: 11457847.
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  138. Kanoh Y, Bandyopadhyay G, Sajan MP, Standaert ML, Farese RV. Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-?/? by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats. Endocrinology. 2001 Apr 01; 142(4):1595-1605. PMID: 28201396.
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  139. Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV. Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. J Clin Invest. 2001 Jan; 107(2):163-71. PMID: 11160132; PMCID: PMC198874.
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  140. Buhman KF, Accad M, Farese RV. Mammalian acyl-CoA:cholesterol acyltransferases. Biochim Biophys Acta. 2000 Dec 15; 1529(1-3):142-54. PMID: 11111084.
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  141. Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG, Farese RV. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13830-4. PMID: 11095717; PMCID: PMC17661.
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  142. Buhman KK, Accad M, Novak S, Choi RS, Wong JS, Hamilton RL, Turley S, Farese RV. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat Med. 2000 Dec; 6(12):1341-7. PMID: 11100118.
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  143. Bandyopadhyay G, Kanoh Y, Sajan MP, Standaert ML, Farese RV. Effects of Adenoviral Gene Transfer of Wild-Type, Constitutively Active, and Kinase-Defective Protein Kinase C-? on Insulin-Stimulated Glucose Transport in L6 Myotubes* * This work was supported by funds from the Department of Veterans Affairs Merit Review Program and NIH Research Grant 2R01-DK- 38079-09A1. Endocrinology. 2000 Nov 01; 141(11):4120-4127. PMID: 28201044.
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  144. Yamanaka S, Zhang XY, Maeda M, Miura K, Wang S, Farese RV, Iwao H, Innerarity TL. Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J. 2000 Oct 16; 19(20):5533-41. PMID: 11032820; PMCID: PMC314019.
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  145. Chang CC, Sakashita N, Ornvold K, Lee O, Chang ET, Dong R, Lin S, Lee CY, Strom SC, Kashyap R, Fung JJ, Farese RV, Patoiseau JF, Delhon A, Chang TY. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J Biol Chem. 2000 Sep 08; 275(36):28083-92. PMID: 10846185.
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  146. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol. 2000 Jul; 20(14):5208-15. PMID: 10866676; PMCID: PMC85969.
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  147. Chen HC, Farese RV. DGAT and triglyceride synthesis: a new target for obesity treatment? Trends Cardiovasc Med. 2000 Jul; 10(5):188-92. PMID: 11282293.
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  148. Farese RV, Cases S, Smith SJ. Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. Curr Opin Lipidol. 2000 Jun; 11(3):229-34. PMID: 10882337.
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  149. Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May; 25(1):87-90. PMID: 10802663.
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  150. Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RV. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. J Clin Invest. 2000 Mar; 105(6):711-9. PMID: 10727439; PMCID: PMC377465.
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  151. Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol. 2000 Feb; 20(3):755-9. PMID: 10629031; PMCID: PMC85191.
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  152. Terasawa Y, Cases SJ, Wong JS, Jamil H, Jothi S, Traber MG, Packer L, Gordon DA, Hamilton RL, Farese RV. Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. J Lipid Res. 1999 Nov; 40(11):1967-77. PMID: 10553000.
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  153. Standaert ML, Bandyopadhyay G, Galloway L, Soto J, Ono Y, Kikkawa U, Farese RV, Leitges M. Effects of Knockout of the Protein Kinase C ß Gene on Glucose Transport and Glucose Homeostasis1. Endocrinology. 1999 Oct 01; 140(10):4470-4477. PMID: 28204259.
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  154. Chen HC, Farese RV. Steroid hormones: Interactions with membrane-bound receptors. Curr Biol. 1999 Jul 01; 9(13):R478-81. PMID: 10395533.
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  155. Herz J, Farese RV. The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. J Nutr. 1999 02; 129(2S Suppl):473S-475S. PMID: 10064312.
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  156. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13018-23. PMID: 9789033; PMCID: PMC23692.
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  157. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998 Oct 09; 273(41):26755-64. PMID: 9756919.
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  158. Accad M, Farese RV. Cholesterol homeostasis: a role for oxysterols. Curr Biol. 1998 Aug 27; 8(17):R601-4. PMID: 9742388.
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  159. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13; 394(6694):690-4. PMID: 9716134.
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  160. Khelef N, Buton X, Beatini N, Wang H, Meiner V, Chang TY, Farese RV, Maxfield FR, Tabas I. Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. J Biol Chem. 1998 May 01; 273(18):11218-24. PMID: 9556612.
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  161. Farese RV. Acyl CoA:cholesterol acyltransferase genes and knockout mice. Curr Opin Lipidol. 1998 Apr; 9(2):119-23. PMID: 9559268.
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  162. Farese RV, Herz J. Cholesterol metabolism and embryogenesis. Trends Genet. 1998 Mar; 14(3):115-20. PMID: 9540409.
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  163. Meiner VL, Welch CL, Cases S, Myers HM, Sande E, Lusis AJ, Farese RV. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. J Biol Chem. 1998 Jan 09; 273(2):1064-9. PMID: 9422770.
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  164. Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RV, Broxmeyer HE, Charo IF. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest. 1997 Nov 15; 100(10):2552-61. PMID: 9366570; PMCID: PMC508456.
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  165. Khovidhunkit W, Farese RV. Resolution of propylthiouracil-induced hepatic failure after treatment of thyrotoxicosis. West J Med. 1997 Nov; 167(5):353-6. PMID: 9392993; PMCID: PMC1304632.
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  166. Bandyopadhyay G, Standaert ML, Galloway L, Moscat J, Farese RV. Evidence for Involvement of Protein Kinase C (PKC)-? and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes. Endocrinology. 1997 Nov 01; 138(11):4721-4731. PMID: 28204211.
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  167. Meiner V, Tam C, Gunn MD, Dong LM, Weisgraber KH, Novak S, Myers HM, Erickson SK, Farese RV. Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res. 1997 Sep; 38(9):1928-33. PMID: 9323603.
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  168. Herz J, Willnow TE, Farese RV. Cholesterol, hedgehog and embryogenesis. Nat Genet. 1997 Feb; 15(2):123-4. PMID: 9020834.
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  169. Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, Pitas RE, McGuire J, Herz J, Farese RV. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14041-6. PMID: 8943057; PMCID: PMC19491.
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  170. Welch CL, Xia YR, Shechter I, Farese R, Mehrabian M, Mehdizadeh S, Warden CH, Lusis AJ. Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul; 37(7):1406-21. PMID: 8827514.
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  171. Farese RV, Véniant MM, Cham CM, Flynn LM, Pierotti V, Loring JF, Traber M, Ruland S, Stokowski RS, Huszar D, Young SG. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6393-8. PMID: 8692825; PMCID: PMC39033.
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  172. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 06; 381(6582):516-9. PMID: 8632823.
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  173. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May; 133(4):921-8. PMID: 8666675; PMCID: PMC2120829.
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  174. Hirano K, Young SG, Farese RV, Ng J, Sande E, Warburton C, Powell-Braxton LM, Davidson NO. Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26; 271(17):9887-90. PMID: 8626621.
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  175. Farese RV, Cases S, Ruland SL, Kayden HJ, Wong JS, Young SG, Hamilton RL. A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice. J Lipid Res. 1996 Feb; 37(2):347-60. PMID: 9026532.
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  176. Young SG, Krul ES, McCormick S, Farese RV, Linton MF. Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia. Methods Enzymol. 1996; 263:120-45. PMID: 8749004.
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  177. Young SG, Cham CM, Pitas RE, Burri BJ, Connolly A, Flynn L, Pappu AS, Wong JS, Hamilton RL, Farese RV. A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. J Clin Invest. 1995 Dec; 96(6):2932-46. PMID: 8675665; PMCID: PMC186005.
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  178. Purcell-Huynh DA, Farese RV, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG. Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J Clin Invest. 1995 May; 95(5):2246-57. PMID: 7738190; PMCID: PMC295837.
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  179. Farese RV, Ruland SL, Flynn LM, Stokowski RP, Young SG. Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1774-8. PMID: 7878058; PMCID: PMC42602.
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  180. Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP. The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred. Clin Genet. 1994 Jun; 45(6):292-7. PMID: 7923858.
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  181. Young SG, Farese RV, Pierotti VR, Taylor S, Grass DS, Linton MF. Transgenic mice expressing human apoB100 and apoB48. Curr Opin Lipidol. 1994 Apr; 5(2):94-101. PMID: 8044422.
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  182. Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG. Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). J Clin Invest. 1993 Dec; 92(6):3029-37. PMID: 8254057; PMCID: PMC288508.
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  183. Linton MF, Farese RV, Young SG. Familial hypobetalipoproteinemia. J Lipid Res. 1993 Apr; 34(4):521-41. PMID: 8496659.
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  184. Young SG, Pullinger CR, Zysow BR, Hofmann-Radvani H, Linton MF, Farese RV, Terdiman JF, Snyder SM, Grundy SM, Vega GL, et al. Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length. J Lipid Res. 1993 Mar; 34(3):501-7. PMID: 8468533.
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  185. Farese RV, Flynn LM, Young SG. Modification of the apolipoprotein B gene in HepG2 cells by gene targeting. J Clin Invest. 1992 Jul; 90(1):256-61. PMID: 1321843; PMCID: PMC443089.
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  186. Farese RV, Linton MF, Young SG. Apolipoprotein B gene mutations affecting cholesterol levels. J Intern Med. 1992 Jun; 231(6):643-52. PMID: 1619387.
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  187. Farese RV, Garg A, Pierotti VR, Vega GL, Young SG. A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia. J Lipid Res. 1992 Apr; 33(4):569-77. PMID: 1527480.
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  188. Farese RV, Biglieri EG, Shackleton CH, Irony I, Gomez-Fontes R. Licorice-induced hypermineralocorticoidism. N Engl J Med. 1991 Oct 24; 325(17):1223-7. PMID: 1922210.
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  189. Farese RV, Yost TJ, Eckel RH. Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans. Metabolism. 1991 Feb; 40(2):214-6. PMID: 1988780.
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  190. Farese RV, Schambelan M, Hollander H, Stringari S, Jacobson MA. Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis. Ann Intern Med. 1990 Jun 15; 112(12):955-6. PMID: 2160217.
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  191. Hainsworth JD, Johnson DH, Farese RV, Macey JW, Vaughn WK, Greco FA. Limited stage small cell lung cancer: analysis of clinical prognostic factors. South Med J. 1987 Dec; 80(12):1518-22. PMID: 2827319.
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  192. Davis JS, Weakland LL, Farese RV, West LA. Luteinizing hormone increases inositol trisphosphate and cytosolic free Ca2+ in isolated bovine luteal cells. J Biol Chem. 1987 Jun 25; 262(18):8515-21. PMID: 3496333.
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  193. Davis JS, West LA, Weakland LL, Farese RV. Human chorionic gonadotropin activates the inositol 1,4,5-trisphosphate-Ca2+ intracellular signalling system in bovine luteal cells. FEBS Lett. 1986 Nov 24; 208(2):287-91. PMID: 3023139.
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  194. Trimble ER, Bruzzone R, Biden TJ, Farese RV. Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini. Biochem J. 1986 Oct 15; 239(2):257-61. PMID: 3028367; PMCID: PMC1147275.
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  195. Davis JS, Weakland LL, West LA, Farese RV. Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone. Biochem J. 1986 Sep 01; 238(2):597-604. PMID: 3026357; PMCID: PMC1147174.
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  196. Davis JS, West LA, Farese RV. Gonadotropin-releasing hormone rapidly alters polyphosphoinositide metabolism in rat granulosa cells. Biochem Biophys Res Commun. 1984 Aug 16; 122(3):1289-95. PMID: 6089778.
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  197. Farese RV, Farese RV, Sabir MA, Larson RE, Trudeau WL, Barnes D. The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase. Diabetes. 1984 Jul; 33(7):648-55. PMID: 6329860.
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  198. Farese RV. How to make sense out of the new thyroid tests. Med Times. 1980 Apr; 108(4):95-111. PMID: 6767171.
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  199. Farese RV. Hypothyroidism: primary or secondary? Hosp Pract. 1979 Feb; 14(2):153, 159. PMID: 428982.
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  200. Farese RV, Rodriguez ME, O'Malley BC, Jamieson E, Pollet RJ. Combined hypothalamic hypothyroidism and secondary adrenal insufficiency. Misdiagnosed as primary hypothyroidism. Arch Intern Med. 1979 Jan; 139(1):99-100. PMID: 104680.
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  201. Farese RV. Inhibition of cholesterol side chain cleavage by cyanoketone. Steroids. 1970 Feb; 15(2):245-50. PMID: 5459077.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.