Harvard Catalyst Profiles

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Tobias Walther, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13DK103464 (WALTHER, TOBIAS) Jul 1, 2014 - Jun 30, 2015
    NIH/NIDDK
    FASEB SRC on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lip
    Role: Principal Investigator
  2. R01DK101579 (FARESE, ROBERT V) May 1, 2014 - Apr 30, 2019
    NIH/NIDDK
    Physiology of Lipid Droplets and Triglyceride Storage
    Role: Co-Principal Investigator
  3. R01GM095982 (WALTHER, TOBIAS) Feb 15, 2012 - Dec 31, 2015
    NIH/NIGMS
    Cellular Functions of Plasma Membrane Organization by Eisosomes
    Role: Principal Investigator
  4. R01GM097194 (WALTHER, TOBIAS) Sep 30, 2011 - Nov 30, 2020
    NIH/NIGMS
    Mechanisms of Lipid Droplet Protein Targeting
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vejnar CE, Abdel Messih M, Takacs CM, Yartseva V, Oikonomou P, Christiano R, Stoeckius M, Lau S, Lee MT, Beaudoin JD, Musaev D, Darwich-Codore H, Walther TC, Tavazoie S, Cifuentes D, Giraldez AJ. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Genome Res. 2019 Jul; 29(7):1100-1114. PMID: 31227602.
    Citations:    
  2. Luscher A, Fröhlich F, Barisch C, Littlewood C, Metcalfe J, Leuba F, Palma A, Pirruccello M, Cesareni G, Stagi M, Walther TC, Soldati T, De Camilli P, Swan LE. Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum. Mol Biol Cell. 2019 Jun 19; mbcE18080510. PMID: 31216233.
    Citations:    
  3. Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. Hepatology. 2019 May 13. PMID: 31081165.
    Citations:    
  4. Chitraju C, Walther TC, Farese RV. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 2019 Jun; 60(6):1112-1120. PMID: 30936184.
    Citations:    
  5. Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Mol Cell. 2019 04 04; 74(1):32-44.e8. PMID: 30846318.
    Citations:    
  6. Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 2018 12 24; 7. PMID: 30582518.
    Citations:    Fields:    
  7. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8. PMID: 30527540.
    Citations:    Fields:    
  8. Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH, Mann M. Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis. Dev Cell. 2018 10 22; 47(2):205-221.e7. PMID: 30352176.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J Cell Biol. 2018 Dec 03; 217(12):4080-4091. PMID: 30327422.
    Citations:    Fields:    
  10. Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 Oct; 277:145-154. PMID: 30212683.
    Citations:    Fields:    
  11. Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J. Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop. Circulation. 2018 Jul 17; 138(3):305-315. PMID: 30012703.
    Citations:    Fields:    
  12. Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 08 15; 29(17):2045-2054. PMID: 29949452.
    Citations:    Fields:    
  13. Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):E2849-E2858. PMID: 29511098.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV. Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity. Mol Cell Proteomics. 2018 05; 17(5):836-849. PMID: 29414761.
    Citations: 2     Fields:    
  15. Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Dev Cell. 2018 Jan 08; 44(1):73-86.e4. PMID: 29316443.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 06; 57(5):827-838. PMID: 29278326.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Walther TC, Chung J, Farese RV. Lipid Droplet Biogenesis. Annu Rev Cell Dev Biol. 2017 10 06; 33:491-510. PMID: 28793795.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  18. Christiano R, Kolev NG, Shi H, Ullu E, Walther TC, Tschudi C. The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. Mol Microbiol. 2017 Oct; 106(1):74-92. PMID: 28742275.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab. 2017 Aug 01; 26(2):407-418.e3. PMID: 28768178.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Gluchowski NL, Becuwe M, Walther TC, Farese RV. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol. 2017 Jun; 14(6):343-355. PMID: 28428634.
    Citations: 16     Fields:    Translation:HumansCells
  21. Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res. 2017 06; 58(6):1230-1237. PMID: 28373485.
    Citations: 5     Fields:    Translation:HumansCells
  22. Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 2017 01; 58(1):226-235. PMID: 27836991.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 2016 11; 16(21):2759-2763. PMID: 27717283.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5. PMID: 27564575.
    Citations: 20     Fields:    
  25. Kory N, Farese RV, Walther TC. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends Cell Biol. 2016 07; 26(7):535-546. PMID: 26995697.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  26. Farese RV, Walther TC. Lipid droplets go nuclear. J Cell Biol. 2016 Jan 04; 212(1):7-8. PMID: 26728852.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  27. Olson DK, Fröhlich F, Farese RV, Walther TC. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta. 2016 Aug; 1861(8 Pt B):784-792. PMID: 26747648.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  28. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol. 2016 Jan; 18(1):132-8. PMID: 26571211.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  29. Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 2015 Sep 10; 4. PMID: 26357016.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  30. Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC. Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Sci Signal. 2015 Aug 18; 8(390):ra81. PMID: 26286023.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Kory N, Thiam AR, Farese RV, Walther TC. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015 Aug 10; 34(3):351-63. PMID: 26212136.
    Citations: 23     Fields:    Translation:AnimalsCells
  32. Shibuya A, Margulis N, Christiano R, Walther TC, Barlowe C. The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins. J Cell Biol. 2015 Jan 19; 208(2):197-209. PMID: 25583996.
    Citations: 9     Fields:    Translation:AnimalsCells
  33. Olson DK, Fröhlich F, Christiano R, Hannibal-Bach HK, Ejsing CS, Walther TC. Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids. J Biol Chem. 2015 Feb 13; 290(7):4238-47. PMID: 25519905.
    Citations: 5     Fields:    Translation:AnimalsCells
  34. Christiano R, Nagaraj N, Fröhlich F, Walther TC. Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe. Cell Rep. 2014 Dec 11; 9(5):1959-1965. PMID: 25466257.
    Citations: 31     Fields:    Translation:AnimalsCells
  35. Fröhlich F, Christiano R, Olson DK, Alcazar-Roman A, DeCamilli P, Walther TC. A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Mol Biol Cell. 2014 Sep 15; 25(18):2797-806. PMID: 25057013.
    Citations: 14     Fields:    Translation:AnimalsCells
  36. Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8901-6. PMID: 24889630.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  37. Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014 07; 55(7):1465-77. PMID: 24868093.
    Citations: 21     Fields:    Translation:AnimalsCells
  38. Wilfling F, Haas JT, Walther TC, Farese RV. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014 Aug; 29:39-45. PMID: 24736091.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  39. Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ. Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. EMBO J. 2014 May 02; 33(9):981-93. PMID: 24705786.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  40. Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014; 3:e01607. PMID: 24497546.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  41. Harrison MS, Hung CS, Liu TT, Christiano R, Walther TC, Burd CG. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):267-72. PMID: 24344282.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  42. Antonny B, Audhya J, l Bagnat M, von Blume J, Briggs JA, Giraudo C, Kaeser PS, Miller E, Reinisch K, Sbalzarini IF, Schuldiner M, Shen J, Takamori S, Verstreken P, Walther T. Directing traffic into the future. Dev Cell. 2013 Dec 09; 27(5):480-4. PMID: 24482802.
    Citations:    Fields:    Translation:HumansAnimalsCells
  43. Thiam AR, Farese RV, Walther TC. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013 Dec; 14(12):775-86. PMID: 24220094.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  44. Thiam AR, Antonny B, Wang J, Delacotte J, Wilfling F, Walther TC, Beck R, Rothman JE, Pincet F. COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13244-9. PMID: 23901109.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  45. Currie E, Schulze A, Zechner R, Walther TC, Farese RV. Cellular fatty acid metabolism and cancer. Cell Metab. 2013 Aug 06; 18(2):153-61. PMID: 23791484.
    Citations: 244     Fields:    Translation:Humans
  46. Krahmer N, Farese RV, Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013 Jul; 5(7):973-83. PMID: 23740690.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  47. Fröhlich F, Christiano R, Walther TC. Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation. Mol Cell Proteomics. 2013 Jul; 12(7):1995-2005. PMID: 23592334.
    Citations: 13     Fields:    Translation:AnimalsCells
  48. Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Walther TC. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013 Feb 25; 24(4):384-99. PMID: 23415954.
    Citations: 150     Fields:    Translation:AnimalsCells
  49. Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013 Mar 22; 288(12):8627-35. PMID: 23364791.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  50. Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013 May; 12(5):1115-26. PMID: 23319140.
    Citations: 40     Fields:    Translation:AnimalsCells
  51. Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. DGAT1 mutation is linked to a congenital diarrheal disorder. J Clin Invest. 2012 Dec; 122(12):4680-4. PMID: 23114594.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  52. Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P. Seg1 controls eisosome assembly and shape. J Cell Biol. 2012 Aug 06; 198(3):405-20. PMID: 22869600.
    Citations: 15     Fields:    Translation:AnimalsCells
  53. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Mol Cell Proteomics. 2012 Nov; 11(11):1510-22. PMID: 22865919.
    Citations: 74     Fields:    Translation:AnimalsCells
  54. Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Sci Signal. 2012 Jun 12; 5(228):ra42. PMID: 22692423.
    Citations: 249     Fields:    Translation:HumansCells
  55. Farese RV, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012 May 02; 15(5):570-3. PMID: 22560209.
    Citations: 68     Fields:    Translation:HumansAnimals
  56. Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R. Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol. 2012 Apr 15; 14(5):542-7. PMID: 22504275.
    Citations: 86     Fields:    Translation:HumansCells
  57. Walther TC, Farese RV. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 2012; 81:687-714. PMID: 22524315.
    Citations: 242     Fields:    Translation:HumansAnimalsCells
  58. Walther T. Tobias Walther: floating ideas on lipids. Interview by Caitlin Sedwick. J Cell Biol. 2012 Jan 23; 196(2):182-3. PMID: 22270913.
    Citations:    Fields:    Translation:AnimalsCells
  59. Ziólkowska NE, Christiano R, Walther TC. Organized living: formation mechanisms and functions of plasma membrane domains in yeast. Trends Cell Biol. 2012 Mar; 22(3):151-8. PMID: 22245053.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  60. Karotki L, Huiskonen JT, Stefan CJ, Ziólkowska NE, Roth R, Surma MA, Krogan NJ, Emr SD, Heuser J, Grünewald K, Walther TC. Eisosome proteins assemble into a membrane scaffold. J Cell Biol. 2011 Nov 28; 195(5):889-902. PMID: 22123866.
    Citations: 36     Fields:    Translation:AnimalsCells
  61. Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab. 2011 Oct 05; 14(4):504-15. PMID: 21982710.
    Citations: 103     Fields:    Translation:AnimalsCells
  62. Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC, Yang H. A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genet. 2011 Jul; 7(7):e1002201. PMID: 21829381.
    Citations: 85     Fields:    Translation:AnimalsCells
  63. Ziólkowska NE, Karotki L, Rehman M, Huiskonen JT, Walther TC. Eisosome-driven plasma membrane organization is mediated by BAR domains. Nat Struct Mol Biol. 2011 Jun 19; 18(7):854-6. PMID: 21685922.
    Citations: 30     Fields:    Translation:AnimalsCells
  64. Bewersdorf J, Farese RV, Walther TC. A new way to look at fat. Nat Methods. 2011 Feb; 8(2):132-3. PMID: 21278725.
    Citations: 2     Fields:    Translation:Animals
  65. Walther TC, Mann M. Mass spectrometry-based proteomics in cell biology. J Cell Biol. 2010 Aug 23; 190(4):491-500. PMID: 20733050.
    Citations: 96     Fields:    Translation:Cells
  66. Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor. Diabetologia. 2010 Nov; 53(11):2442-51. PMID: 20631980.
    Citations: 14     Fields:    Translation:HumansAnimals
  67. Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol. 2010 Jul; 17(7):901-8. PMID: 20526336.
    Citations: 50     Fields:    Translation:AnimalsCells
  68. Walther TC. Keeping sphingolipid levels nORMal. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5701-2. PMID: 20304791.
    Citations: 7     Fields:    Translation:Animals
  69. Walther TC, Olsen JV, Mann M. Yeast expression proteomics by high-resolution mass spectrometry. Methods Enzymol. 2010; 470:259-80. PMID: 20946814.
    Citations: 6     Fields:    Translation:Animals
  70. Aguilar PS, Heiman MG, Walther TC, Engel A, Schwudke D, Gushwa N, Kurzchalia T, Walter P. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4170-5. PMID: 20150508.
    Citations: 19     Fields:    Translation:AnimalsCells
  71. Koïtka A, Cao Z, Koh P, Watson AM, Sourris KC, Loufrani L, Soro-Paavonen A, Walther T, Woollard KJ, Jandeleit-Dahm KA, Cooper ME, Allen TJ. Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes. Diabetologia. 2010 Mar; 53(3):584-92. PMID: 19957160.
    Citations: 10     Fields:    Translation:Animals
  72. Krahmer N, Guo Y, Farese RV, Walther TC. SnapShot: Lipid Droplets. Cell. 2009 Nov 25; 139(5):1024-1024.e1. PMID: 19945384.
    Citations: 22     Fields:    Translation:AnimalsCells
  73. Farese RV, Walther TC. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009 Nov 25; 139(5):855-60. PMID: 19945371.
    Citations: 248     Fields:    Translation:AnimalsCells
  74. Fröhlich F, Walther TC. Comparing cellular proteomes by mass spectrometry. Genome Biol. 2009; 10(10):240. PMID: 19886975.
    Citations:    Fields:    Translation:HumansAnimalsCells
  75. Soufi B, Kelstrup CD, Stoehr G, Fröhlich F, Walther TC, Olsen JV. Global analysis of the yeast osmotic stress response by quantitative proteomics. Mol Biosyst. 2009 Nov; 5(11):1337-46. PMID: 19823750.
    Citations: 55     Fields:    Translation:AnimalsCells
  76. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14; 325(5942):834-40. PMID: 19608861.
    Citations: 1227     Fields:    Translation:HumansAnimalsCells
  77. Fröhlich F, Moreira K, Aguilar PS, Hubner NC, Mann M, Walter P, Walther TC. A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol. 2009 Jun 29; 185(7):1227-42. PMID: 19564405.
    Citations: 50     Fields:    Translation:AnimalsCells
  78. Guo Y, Cordes KR, Farese RV, Walther TC. Lipid droplets at a glance. J Cell Sci. 2009 Mar 15; 122(Pt 6):749-52. PMID: 19261844.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  79. Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics. 2009 Jun; 8(6):1361-81. PMID: 19176519.
    Citations: 35     Fields:    Translation:AnimalsCells
  80. Berchtold D, Walther TC. TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell. 2009 Mar; 20(5):1565-75. PMID: 19144819.
    Citations: 74     Fields:    Translation:AnimalsCells
  81. Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem. 2009 Feb 20; 284(8):5352-61. PMID: 19049983.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  82. Moreira KE, Walther TC, Aguilar PS, Walter P. Pil1 controls eisosome biogenesis. Mol Biol Cell. 2009 Feb; 20(3):809-18. PMID: 19037108.
    Citations: 26     Fields:    Translation:AnimalsCells
  83. Walther TC, Farese RV. The life of lipid droplets. Biochim Biophys Acta. 2009 Jun; 1791(6):459-66. PMID: 19041421.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  84. de Godoy LM, Olsen JV, Cox J, Nielsen ML, Hubner NC, Fröhlich F, Walther TC, Mann M. Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature. 2008 Oct 30; 455(7217):1251-4. PMID: 18820680.
    Citations: 353     Fields:    Translation:AnimalsCells
  85. Matic I, Macek B, Hilger M, Walther TC, Mann M. Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution. J Proteome Res. 2008 Sep; 7(9):4050-7. PMID: 18707152.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  86. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 2008 May 29; 453(7195):657-61. PMID: 18408709.
    Citations: 231     Fields:    Translation:AnimalsCells
  87. Walther TC, Aguilar PS, Fröhlich F, Chu F, Moreira K, Burlingame AL, Walter P. Pkh-kinases control eisosome assembly and organization. EMBO J. 2007 Dec 12; 26(24):4946-55. PMID: 18034155.
    Citations: 46     Fields:    Translation:AnimalsCells
  88. Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature. 2006 Feb 23; 439(7079):998-1003. PMID: 16496001.
    Citations: 130     Fields:    Translation:AnimalsCells
  89. Hetzer MW, Walther TC, Mattaj IW. Pushing the envelope: structure, function, and dynamics of the nuclear periphery. Annu Rev Cell Dev Biol. 2005; 21:347-80. PMID: 16212499.
    Citations: 122     Fields:    Translation:AnimalsCells
  90. Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M. RanGTP mediates nuclear pore complex assembly. Nature. 2003 Aug 07; 424(6949):689-94. PMID: 12894213.
    Citations: 80     Fields:    Translation:AnimalsCells
  91. Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 2003 Apr 18; 113(2):195-206. PMID: 12705868.
    Citations: 150     Fields:    Translation:HumansAnimalsCells
  92. Hinkle B, Slepchenko B, Rolls MM, Walther TC, Stein PA, Mehlmann LM, Ellenberg J, Terasaki M. Chromosomal association of Ran during meiotic and mitotic divisions. J Cell Sci. 2002 Dec 01; 115(Pt 23):4685-93. PMID: 12415012.
    Citations: 4     Fields:    Translation:AnimalsCells
  93. Kuersten S, Arts GJ, Walther TC, Englmeier L, Mattaj IW. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol Cell Biol. 2002 Aug; 22(16):5708-20. PMID: 12138183.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  94. Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M. The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J Cell Biol. 2002 Jul 08; 158(1):63-77. PMID: 12105182.
    Citations: 76     Fields:    Translation:AnimalsCells
  95. Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol. 2001 Dec; 3(12):1086-91. PMID: 11781570.
    Citations: 101     Fields:    Translation:AnimalsCells
  96. Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen TD, Mattaj IW. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J. 2001 Oct 15; 20(20):5703-14. PMID: 11598013.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  97. Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell. 2000 Jun; 5(6):1013-24. PMID: 10911995.
    Citations: 70     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.