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profileDavid Thomas Riglar, Ph.D.

TitleResearch Fellow in Systems Biology (INT)
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Warren Alpert Bldg- 536
200 Longwood Ave
Boston MA 02115
Phone617/432-1486
Fax617/432-5012
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA. Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation. Nat Biotechnol. 2017 May 29. PMID: 28553941.
    View in: PubMed
  2. Baum J, Richard D, Riglar DT. Malaria Parasite Invasion: Achieving Superb Resolution. Cell Host Microbe. 2017 Mar 08; 21(3):294-296. PMID: 28279334.
    View in: PubMed
  3. Riglar DT, Whitehead L, Cowman AF, Rogers KL, Baum J. Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion. J Cell Sci. 2016 Jan 01; 129(1):228-42. PMID: 26604223; PMCID: PMC4732298.
  4. Olshina MA, Angrisano F, Marapana DS, Riglar DT, Bane K, Wong W, Catimel B, Yin MX, Holmes AB, Frischknecht F, Kovar DR, Baum J. Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites. Malar J. 2015 Jul 18; 14:280. PMID: 26187846; PMCID: PMC4506582.
  5. Dasgupta S, Auth T, Gov NS, Satchwell TJ, Hanssen E, Zuccala ES, Riglar DT, Toye AM, Betz T, Baum J, Gompper G. Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte. Biophys J. 2014 Jul 01; 107(1):43-54. PMID: 24988340; PMCID: PMC4184798.
  6. Healer J, Thompson JK, Riglar DT, Wilson DW, Chiu YH, Miura K, Chen L, Hodder AN, Long CA, Hansen DS, Baum J, Cowman AF. Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum. PLoS One. 2013; 8(9):e72504. PMID: 24039774; PMCID: PMC3769340.
  7. Hanssen E, Dekiwadia C, Riglar DT, Rug M, Lemgruber L, Cowman AF, Cyrklaff M, Kudryashev M, Frischknecht F, Baum J, Ralph SA. Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion. Cell Microbiol. 2013 Sep; 15(9):1457-72. PMID: 23461734.
    View in: PubMed
  8. Lemgruber L, Kudryashev M, Dekiwadia C, Riglar DT, Baum J, Stahlberg H, Ralph SA, Frischknecht F. Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast. Malar J. 2013 Jan 19; 12:25. PMID: 23331966; PMCID: PMC3662607.
  9. Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF. Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes. Nat Commun. 2013; 4:1415. PMID: 23361006; PMCID: PMC3562467.
  10. Riglar DT, Baum J. Static and dynamic imaging of erythrocyte invasion and early intra-erythrocytic development in Plasmodium falciparum. Methods Mol Biol. 2013; 923:269-80. PMID: 22990784.
    View in: PubMed
  11. Zuccala ES, Gout AM, Dekiwadia C, Marapana DS, Angrisano F, Turnbull L, Riglar DT, Rogers KL, Whitchurch CB, Ralph SA, Speed TP, Baum J. Subcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite. PLoS One. 2012; 7(9):e46160. PMID: 23049965; PMCID: PMC3458004.
  12. Angrisano F, Riglar DT, Sturm A, Volz JC, Delves MJ, Zuccala ES, Turnbull L, Dekiwadia C, Olshina MA, Marapana DS, Wong W, Mollard V, Bradin CH, Tonkin CJ, Gunning PW, Ralph SA, Whitchurch CB, Sinden RE, Cowman AF, McFadden GI, Baum J. Spatial localisation of actin filaments across developmental stages of the malaria parasite. PLoS One. 2012; 7(2):e32188. PMID: 22389687; PMCID: PMC3289632.
  13. Bullen HE, Charnaud SC, Kalanon M, Riglar DT, Dekiwadia C, Kangwanrangsan N, Torii M, Tsuboi T, Baum J, Ralph SA, Cowman AF, de Koning-Ward TF, Crabb BS, Gilson PR. Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). J Biol Chem. 2012 Mar 09; 287(11):7871-84. PMID: 22253438; PMCID: PMC3318755.
  14. Chen L, Lopaticki S, Riglar DT, Dekiwadia C, Uboldi AD, Tham WH, O'Neill MT, Richard D, Baum J, Ralph SA, Cowman AF. An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum. PLoS Pathog. 2011 Sep; 7(9):e1002199. PMID: 21909261; PMCID: PMC3164636.
  15. Triglia T, Chen L, Lopaticki S, Dekiwadia C, Riglar DT, Hodder AN, Ralph SA, Baum J, Cowman AF. Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains. PLoS Pathog. 2011 Jun; 7(6):e1002075. PMID: 21698217; PMCID: PMC3116812.
  16. Wong W, Skau CT, Marapana DS, Hanssen E, Taylor NL, Riglar DT, Zuccala ES, Angrisano F, Lewis H, Catimel B, Clarke OB, Kershaw NJ, Perugini MA, Kovar DR, Gulbis JM, Baum J. Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9869-74. PMID: 21628589; PMCID: PMC3116436.
  17. Riglar DT, Richard D, Wilson DW, Boyle MJ, Dekiwadia C, Turnbull L, Angrisano F, Marapana DS, Rogers KL, Whitchurch CB, Beeson JG, Cowman AF, Ralph SA, Baum J. Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte. Cell Host Microbe. 2011 Jan 20; 9(1):9-20. PMID: 21238943.
    View in: PubMed
  18. Ehlgen F, Riglar D. Meeting report: Practical course in imaging and microscopy. Biotechnol J. 2010 Dec; 5(12):1253-6. PMID: 21154728.
    View in: PubMed
  19. Boyle MJ, Wilson DW, Richards JS, Riglar DT, Tetteh KK, Conway DJ, Ralph SA, Baum J, Beeson JG. Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14378-83. PMID: 20660744; PMCID: PMC2922570.
  20. Richard D, MacRaild CA, Riglar DT, Chan JA, Foley M, Baum J, Ralph SA, Norton RS, Cowman AF. Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites. J Biol Chem. 2010 May 07; 285(19):14815-22. PMID: 20228060; PMCID: PMC2863225.
  21. Fletcher JI, Meusburger S, Hawkins CJ, Riglar DT, Lee EF, Fairlie WD, Huang DC, Adams JM. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18081-7. PMID: 18981409.
    View in: PubMed
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