Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Ritchie Edward Brown, Ph.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture

Biography
Cambridge University, EnglandB.A.06/1992Natural Sciences
Cambridge University, EnglandM.A.01/1996Natural Sciences
Otto-von-Guericke University, Magdeburg, GermanyDr. Rer. Nat.11/1996Neurophysiology

Overview
I am a Research Health Scientist at VA Boston Healthcare System (VA BHS) and an Associate Professor of Psychiatry at Harvard Medical School. I am an affiliated faculty member and associate preceptor of the Division of Sleep Medicine. My laboratory at the West Roxbury campus of VA BHS studies the sleep-wake cycle and brain electrical rhythms in mice. I am the PI of a VA Merit award and an NIMH R01 grant. I am also an investigator on 4 other NIH/VA grants. My scholarship includes 46 original peer-reviewed articles & 9 peer-reviewed review articles, many of which are highly cited (average 74 citations per publication; 20 articles with >50 citations). I have given local, national and international presentations of my work. I served as the chair of the Scientific Review Committee of the Sleep Research Society for two years and I am currently Associate Editor at Frontiers in Neuroscience, Sleep and circadian rhythms section. I have reviewed grant proposals for NIH, DoD and other scientific organizations around the world. I currently act as a mentor for three postdoctoral fellows and three Assistant Professors at VA BHS. Many of my previous mentees have gone on to senior faculty positions in the US, Europe and Asia. I am course director/neuroscience expert for the South Shore Residency Program for HMS psychiatry residents at VA BHS, a member of the program evaluation committee and the local HMS promotions committee.
SOCIETY MEMBERSHIPS: Sleep Research Society (SRS)
CURRENT TRAINEES: Fumi Katsuki, Felipe Schiffino (co-mentored with Robert Strecker), David Uygun co-mentored with Radhika Basheer).
RESEARCH HIGHLIGHTS: In 1999, the sleep disorder narcolepsy was shown to be caused by degeneration of orexin neurons. While a postdoctoral researcher in Germany I reported the excitatory effects of the orexins on wake-promoting aminergic neurons (4 articles with >150 citations). My scientific findings have been translated into practice in several important ways. The loss of the orexin/hypocretin effects I demonstrated is thought to explain several symptoms of narcolepsy, such as excessive daytime sleepiness and sleep-associated hallucinations. As such, a new drug, Belsomra, which antagonizes brain orexin/hypocretin receptors was recently approved by the FDA as a novel treatment for insomnia. In addition, the orexin excitation of ventral tegmental area dopamine neurons, which we demonstrated for the first time (Korotkova et al., 2003, > 300 citations, Brown senior author) has been implicated in reinstatement of drug addiction.
Synthesis of knowledge and formation of theory concerning cellular mechanisms which control sleep-wake behavior. I have authored 9 comprehensive review articles and 4 book chapters which summarize our current knowledge of the cellular mechanisms controlling sleep-wakefulness and EEG. This includes a review of the physiology of the brain histamine system, the most recently discovered of the brain aminergic systems (Brown et al., 2001; >700 citations). Based on this review I proposed the brain histamine system is a “danger response system” which acts to increase wakefulness and alertness and suppress unnecessary systems (e.g. feeding) in the short-term in response to threats. More recently, I was the first author and major writer of an unusually comprehensive (100 page, 1479 references) review of sleep-wake mechanisms published in Physiological reviews, the most highly cited physiology journal. This review (Brown et al., 2012) was selected as a highly cited article in field of biology and biochemistry by essential science indicators (Thomson Reuters) and has ~500 citations.
Identification of the cellular properties and functional role of GABAergic neurons regulating arousal and REM sleep (reviewed in Brown and McKenna, 2015). Pharmacological agents which enhance GABAergic neurotransmission represent a major class of anxiolytic, hypnotic and anesthetic drugs. However, surprisingly little is known about the location, subtypes and properties of GABAergic neurons controlling the sleep-wake cycle due to technical difficulties in identification. My group validated a novel genetic tool expressing green fluorescent protein in GABAergic neurons (GAD67-GFP knock-in mice) to investigate the properties of GABAergic neurons involved in sleep-wake control and cortical rhythms. We showed that GFP selectively labels GABAergic neurons (Brown et al., 2008; McNally et al., 2011; McKenna et al., 2013) and confirmed that sleep-wake behavior (Chen et al., 2010) and cortical rhythms are normal (McNally et al., 2011). Using these mice, I performed the first electrophysiological recordings from identified GABAergic neurons in the brainstem involved in control of REM sleep (Brown et al., 2008) and basal forebrain (BF) GABAergic neurons projecting to the neocortex (McKenna et al., 2013). My mentee and I found that these BF GABA neurons are excited by neighboring cholinergic neurons (Yang et al., 2014) and together with other investigators in the department we found that these neurons regulate cortical gamma oscillations (Kim et al., 2015). These findings represent a paradigm shift away from a cholinergic-centric view of BF control of arousal towards a model whereby cholinergic neurons work together with neighboring GABAergic neurons to ‘wake up the cortex’. The BF is severely affected in Alzheimer’s disease and other types of dementia. Thus, our results may have important implications for the treatment of the cognitive impairments associated with these conditions.
Control of neocortical gamma band oscillations (GBO; 30-80 Hz). Cortical GBO are involved in cognitive functions such as attention and working memory and are abnormal in several neuropsychiatric disorders, in particular, schizophrenia. Designing treatments to correct GBO abnormalities requires better methods to elicit them in reduced preparations and a better understanding of their state-dependent control. My postdoc and I developed a novel method to elicit GBO in neocortical slices in vitro (McNally et al., 2011). We found using this method that the psychomimetic and rapidly acting anti-depressant, ketamine, causes GBO abnormalities which mimic those observed in schizophrenia (McNally et al., 2011, 2013). Recently our group found that GBO are regulated by inputs from a particular subcortical system, basal forebrain parvalbumin neurons (Kim et al., PNAS 2015). These results identify two potential avenues to develop novel therapeutic agents to correct GBO abnormalities: a) study of effects on cortical circuitry using our novel in vitro method and; b) modulation of the activity level of basal forebrain parvalbumin neurons. In recent work, we are manipulating this system to study the understand the symptoms of schizophrenia (McNally et al., under review) and improve the pathophysiology in Alzheimer’s disease model mice (Schiffino et al., unpublished). Furthermore, our preliminary work suggests a role of the basal forebrain system in control of attention and rescuing the effects of sleep deprivation (Felipe Schiffino F32 application selected for funding).
Control of sleep spindles by the thalamic reticular nucleus. Abnormalities in sleep spindles, a 10-15 Hz, waxing and waning oscillation observed in light non-REM sleep have been linked to deficits in memory consolidation in schizophrenia. Our major findings/advances are as follows: (i) We published two complementary methods to investigate sleep spindles and their dysfunction in neurophysiological disorders (Prerau et a., 2017; Uygun et al., 2019); (ii) Using a novel paradigm of optogenetic stimulation of thalamic reticular nucleus (TRN) parvalbumin (PV) neurons we can elicit ‘naturalistic’ sleep spindles (Thankachan, Katsuki et al., 2019) without altering behavioral state, a major methodological advance which facilitates our ongoing work to test the role of spindles in sleep-dependent memory consolidation; (iii) The type of T-type calcium channels most highly expressed in TRN, Cav3.3, is a Sz risk gene. We found that pharmacological blockade of T-type calcium channels in TRN inhibited sleep spindles without affecting NREM sleep time or cortical delta band activity (Thankachan et al., 2019); (iv) Optogenetic stimulation studies revealed that the Basal forebrain GABA/PV input to TRN regulates sleep spindles and wakefulness (Thankachan, Katsuki et al., 2019). (v) Manipulations of TRN activity also modulate other electrophysiological features of schizophrenia, cortical gamma (30-80 Hz) and delta oscillations (1-4 Hz) during wakefulness (Thankachan, Katsuki et al., 2019). These results suggest that manipulations of the activity of TRN PV neurons or their major input arising from basal forebrain PV neurons may be beneficial in correcting electrophysiological abnormalities observed in schizophrenia and promote sleep-dependent memory consolidation.

TEACHING. I serve as a course director and basic neuroscience expert in teaching 3 separate courses to psychiatry residents at the Brockton campus of VA BHS. I have developed innovative curricula for these courses. The teaching focus is on having residents learn how to talk about neuroscience and apply it in their clinical work. For example, in my course ‘Eat. Sleep, Exercise’, after teaching physiology and neuroscience, I have students role-play how to teach their patients about the science underlying patients’ challenges with eating, sleep and exercising. In “From Synapses to Systems” I work one-on-one with residents to help them prepare to teach their peers about various neuroscience topics. In the ‘Neuroscience Seminar” for third year residents I cover a wide range of cutting-edge neuroscience topics and test the residents on the knowledge needed to pass the Psychiatry Resident In Training Exam (PRITE). These courses are well-received by residents as they appreciate the translation from bench to bedside.

SUMMARY. My research aims to reveal the brain circuits and cellular mechanisms which wake us up and put us to sleep. I apply this knowledge to animal models of neuropsychiatric disease in order to design rational treatments and disseminate this knowledge through the writing of comprehensive review articles and book chapters, training junior researchers and teaching medical residents.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I01BX004673 (BROWN, RITCHIE EDWARD) Apr 1, 2020 - Mar 31, 2024
    VA
    Specification of sleep-wake control neurons in the basal forebrain
    Role: Principal Investigator
  2. R21NS093000 (BROWN, RITCHIE EDWARD) Jul 15, 2015 - Jun 30, 2017
    NIH/NINDS
    vGLUT2-Tomato mice: a novel tool to study Basal Forebrain Glutamate Neurons
    Role: Principal Investigator
  3. I01BX001356 (BROWN, RITCHIE EDWARD) Oct 1, 2011 - Sep 30, 2020
    VA
    Sleep Spindles: Role of Thalamic Reticular Nucleus and Parvalbumin GABA Neurons
    Role: Principal Investigator
  4. R21MH094803 (BROWN, RITCHIE EDWARD) Jul 25, 2011 - Apr 30, 2014
    NIH/NIMH
    Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    Role: Principal Investigator
  5. R01MH039683 (BROWN, RITCHIE EDWARD) Sep 30, 1984 - Jun 30, 2018
    NIH/NIMH
    Synaptic Basis of Sleep Cycle Control
    Role Description: Former PI, Robert W. McCarley. Ritchie Brown Replacement PI 2017-2020
    Role: PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McNally JM, Aguilar DD, Katsuki F, Radzik LK, Schiffino FL, Uygun DS, McKenna JT, Strecker RE, Deisseroth K, Spencer KM, Brown RE. Optogenetic manipulation of an ascending arousal system tunes cortical broadband gamma power and reveals functional deficits relevant to schizophrenia. Mol Psychiatry. 2020 Jul 20. PMID: 32690865.
    Citations:    
  2. McKenna JT, Thankachan S, Uygun DS, Shukla C, McNally JM, Schiffino FL, Cordeira J, Katsuki F, Zant JC, Gamble MC, Deisseroth K, McCarley RW, Brown RE, Strecker RE, Basheer R. Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli. Curr Biol. 2020 Jun 22; 30(12):2379-2385.e4. PMID: 32413301.
    Citations:    
  3. Ghoshal A, Uygun DS, Yang L, McNally JM, Lopez-Huerta VG, Arias-Garcia MA, Baez-Nieto D, Allen A, Fitzgerald M, Choi S, Zhang Q, Hope JM, Yan K, Mao X, Nicholson TB, Imaizumi K, Fu Z, Feng G, Brown RE, Strecker RE, Purcell SM, Pan JQ. Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits. Transl Psychiatry. 2020 Jan 23; 10(1):29. PMID: 32066662.
    Citations:    
  4. Thankachan S, Katsuki F, McKenna JT, Yang C, Shukla C, Deisseroth K, Uygun DS, Strecker RE, Brown RE, McNally JM, Basheer R. Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice. Sci Rep. 2019 03 05; 9(1):3607. PMID: 30837664.
    Citations:    
  5. Hwang E, Brown RE, Kocsis B, Kim T, McKenna JT, McNally JM, Han HB, Choi JH. Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses. Brain Struct Funct. 2019 May; 224(4):1505-1518. PMID: 30826928.
    Citations:    
  6. Uygun DS, Katsuki F, Bolortuya Y, Aguilar DD, McKenna JT, Thankachan S, McCarley RW, Basheer R, Brown RE, Strecker RE, McNally JM. Validation of an automated sleep spindle detection method for mouse electroencephalography. Sleep. 2019 02 01; 42(2). PMID: 30476300.
    Citations:    Fields:    
  7. Yang C, Larin A, McKenna JT, Jacobson KA, Winston S, Strecker RE, Kalinchuk A, Basheer R, Brown RE. Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice. Sci Rep. 2018 Jul 16; 8(1):10730. PMID: 30013200.
    Citations:    Fields:    
  8. Yang C, Thankachan S, McCarley RW, Brown RE. Corrigendum to 'The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?' [Curr Opin Neurobiol 2017, 44:159-166]. Curr Opin Neurobiol. 2017 08; 45:221. PMID: 28802540.
    Citations:    Fields:    
  9. Yang C, Thankachan S, McCarley RW, Brown RE. The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom? Curr Opin Neurobiol. 2017 06; 44:159-166. PMID: 28538168.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Yang C, McKenna JT, Brown RE. Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro. Neuroscience. 2017 06 03; 352:249-261. PMID: 28411158.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Prerau MJ, Brown RE, Bianchi MT, Ellenbogen JM, Purdon PL. Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis. Physiology (Bethesda). 2017 01; 32(1):60-92. PMID: 27927806.
    Citations: 5     Fields:    Translation:HumansAnimals
  12. Zant JC, Kim T, Prokai L, Szarka S, McNally J, McKenna JT, Shukla C, Yang C, Kalinchuk AV, McCarley RW, Brown RE, Basheer R. Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study. J Neurosci. 2016 Feb 10; 36(6):2057-67. PMID: 26865627.
    Citations: 19     Fields:    Translation:AnimalsCells
  13. Lin SC, Brown RE, Hussain Shuler MG, Petersen CC, Kepecs A. Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition. J Neurosci. 2015 Oct 14; 35(41):13896-903. PMID: 26468190.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  14. Brown RE, McKenna JT. Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal. Front Neurol. 2015; 6:135. PMID: 26124745.
    Citations: 14     
  15. Kim T, Thankachan S, McKenna JT, McNally JM, Yang C, Choi JH, Chen L, Kocsis B, Deisseroth K, Strecker RE, Basheer R, Brown RE, McCarley RW. Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3535-40. PMID: 25733878.
    Citations: 44     Fields:    Translation:AnimalsCells
  16. Yang C, McKenna JT, Zant JC, Winston S, Basheer R, Brown RE. Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons. J Neurosci. 2014 Feb 19; 34(8):2832-44. PMID: 24553925.
    Citations: 24     Fields:    Translation:AnimalsCells
  17. McNally JM, McCarley RW, Brown RE. Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo. Front Psychiatry. 2013; 4:106. PMID: 24062700.
    Citations: 11     
  18. Yang C, Franciosi S, Brown RE. Adenosine inhibits the excitatory synaptic inputs to Basal forebrain cholinergic, GABAergic, and parvalbumin neurons in mice. Front Neurol. 2013; 4:77. PMID: 23801984.
    Citations: 9     
  19. Kocsis B, Brown RE, McCarley RW, Hajos M. Impact of ketamine on neuronal network dynamics: translational modeling of schizophrenia-relevant deficits. CNS Neurosci Ther. 2013 Jun; 19(6):437-47. PMID: 23611295.
    Citations: 28     Fields:    Translation:HumansAnimals
  20. McKenna JT, Yang C, Franciosi S, Winston S, Abarr KK, Rigby MS, Yanagawa Y, McCarley RW, Brown RE. Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse. J Comp Neurol. 2013 Apr 15; 521(6):1225-50. PMID: 23254904.
    Citations: 23     Fields:    Translation:AnimalsCells
  21. McNally JM, McCarley RW, Brown RE. Impaired GABAergic neurotransmission in schizophrenia underlies impairments in cortical gamma band oscillations. Curr Psychiatry Rep. 2013 Mar; 15(3):346. PMID: 23400808.
    Citations: 15     Fields:    Translation:HumansCells
  22. Chen L, McKenna JT, Bolortuya Y, Brown RE, McCarley RW. Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep. Eur J Neurosci. 2013 Mar; 37(6):957-63. PMID: 23282008.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Control of sleep and wakefulness. Physiol Rev. 2012 Jul; 92(3):1087-187. PMID: 22811426.
    Citations: 210     Fields:    Translation:HumansAnimalsCells
  24. McNally JM, McCarley RW, McKenna JT, Yanagawa Y, Brown RE. Complex receptor mediation of acute ketamine application on in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation abnormalities in schizophrenia. Neuroscience. 2011 Dec 29; 199:51-63. PMID: 22027237.
    Citations: 28     Fields:    Translation:AnimalsCells
  25. Chen L, McKenna JT, Bolortuya Y, Winston S, Thakkar MM, Basheer R, Brown RE, McCarley RW. Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period. Eur J Neurosci. 2010 Nov; 32(9):1528-36. PMID: 21089218.
    Citations: 14     Fields:    Translation:Animals
  26. Chen L, McKenna JT, Leonard MZ, Yanagawa Y, McCarley RW, Brown RE. GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis. Neuroreport. 2010 Feb 17; 21(3):216-20. PMID: 20051926.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Tartar JL, McKenna JT, Ward CP, McCarley RW, Strecker RE, Brown RE. Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine. Neurosci Lett. 2010 Jan 18; 469(1):1-5. PMID: 19914331.
    Citations: 14     Fields:    Translation:AnimalsCells
  28. Chen L, Brown RE, McKenna JT, McCarley RW. Animal models of narcolepsy. CNS Neurol Disord Drug Targets. 2009 Aug; 8(4):296-308. PMID: 19689311.
    Citations: 9     Fields:    Translation:HumansAnimals
  29. Brown RE, McKenna JT, Winston S, Basheer R, Yanagawa Y, Thakkar MM, McCarley RW. Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice. Eur J Neurosci. 2008 Jan; 27(2):352-63. PMID: 18215233.
    Citations: 33     Fields:    Translation:AnimalsCells
  30. Brown RE, Winston S, Basheer R, Thakkar MM, McCarley RW. Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins. Neuroscience. 2006 Dec; 143(3):739-55. PMID: 17008019.
    Citations: 29     Fields:    Translation:AnimalsCells
  31. Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Brown RE, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci. 2006 May; 23(10):2739-48. PMID: 16817877.
    Citations: 66     Fields:    Translation:Animals
  32. Basheer R, Brown R, Ramesh V, Begum S, McCarley RW. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity. J Neurosci Res. 2005 Dec 01; 82(5):650-8. PMID: 16273548.
    Citations: 23     Fields:    Translation:AnimalsCells
  33. Korotkova TM, Ponomarenko AA, Brown RE, Haas HL. Functional diversity of ventral midbrain dopamine and GABAergic neurons. Mol Neurobiol. 2004 Jun; 29(3):243-59. PMID: 15181237.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  34. Selbach O, Doreulee N, Bohla C, Eriksson KS, Sergeeva OA, Poelchen W, Brown RE, Haas HL. Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling. Neuroscience. 2004; 127(2):519-28. PMID: 15262340.
    Citations: 21     Fields:    Translation:AnimalsCells
  35. Sergeeva OA, Korotkova TM, Scherer A, Brown RE, Haas HL. Co-expression of non-selective cation channels of the transient receptor potential canonical family in central aminergic neurones. J Neurochem. 2003 Jun; 85(6):1547-52. PMID: 12787073.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Brown RE. Involvement of hypocretins/orexins in sleep disorders and narcolepsy. Drug News Perspect. 2003 Mar; 16(2):75-9. PMID: 12792667.
    Citations: 2     Fields:    Translation:HumansAnimals
  37. Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE. Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci. 2003 Jan 01; 23(1):7-11. PMID: 12514194.
    Citations: 146     Fields:    Translation:AnimalsCells
  38. Brown RE, Sergeeva OA, Eriksson KS, Haas HL. Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). J Neurosci. 2002 Oct 15; 22(20):8850-9. PMID: 12388591.
    Citations: 75     Fields:    Translation:AnimalsCells
  39. Korotkova TM, Eriksson KS, Haas HL, Brown RE. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regul Pept. 2002 Mar 15; 104(1-3):83-9. PMID: 11830281.
    Citations: 21     Fields:    Translation:AnimalsCells
  40. Korotkova TM, Haas HL, Brown RE. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro. Neurosci Lett. 2002 Mar 08; 320(3):133-6. PMID: 11852180.
    Citations: 15     Fields:    Translation:AnimalsCells
  41. Eriksson KS, Sergeeva O, Brown RE, Haas HL. Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci. 2001 Dec 01; 21(23):9273-9. PMID: 11717361.
    Citations: 103     Fields:    Translation:AnimalsCells
  42. Stevens DR, Eriksson KS, Brown RE, Haas HL. The mechanism of spontaneous firing in histamine neurons. Behav Brain Res. 2001 Oct 15; 124(2):105-12. PMID: 11640962.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Doreulee N, Brown RE, Yanovsky Y, Gödecke A, Schrader J, Haas HL. Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice. Synapse. 2001 Sep 01; 41(3):191-4. PMID: 11391779.
    Citations: 1     Fields:    Translation:AnimalsCells
  44. Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001 Apr; 63(6):637-72. PMID: 11164999.
    Citations: 151     Fields:    Translation:HumansAnimalsCells
  45. Brown RE, Sergeeva O, Eriksson KS, Haas HL. Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology. 2001 Mar; 40(3):457-9. PMID: 11166339.
    Citations: 59     Fields:    Translation:AnimalsCells
  46. Doreulee N, Yanovsky Y, Flagmeyer I, Stevens DR, Haas HL, Brown RE. Histamine H(3) receptors depress synaptic transmission in the corticostriatal pathway. Neuropharmacology. 2001; 40(1):106-13. PMID: 11077076.
    Citations: 13     Fields:    Translation:AnimalsCells
  47. Brown RE, Haas HL. On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus. J Physiol. 1999 Mar 15; 515 ( Pt 3):777-86. PMID: 10066904.
    Citations: 22     Fields:    Translation:AnimalsCells
  48. Wilson RI, Gödecke A, Brown RE, Schrader J, Haas HL. Mice deficient in endothelial nitric oxide synthase exhibit a selective deficit in hippocampal long-term potentiation. Neuroscience. 1999; 90(4):1157-65. PMID: 10338286.
    Citations: 6     Fields:    Translation:AnimalsCells
  49. Manahan-Vaughan D, Reymann KG, Brown RE. In vivo electrophysiological investigations into the role of histamine in the dentate gyrus of the rat. Neuroscience. 1998 Jun; 84(3):783-90. PMID: 9579783.
    Citations: 4     Fields:    Translation:Animals
  50. Selbach O, Brown RE, Haas HL. Long-term increase of hippocampal excitability by histamine and cyclic AMP. Neuropharmacology. 1997 Nov-Dec; 36(11-12):1539-48. PMID: 9517424.
    Citations: 12     Fields:    Translation:AnimalsCells
  51. Fedorov NB, Brown RE, Reymann KG. Fast increases of AMPA receptor sensitivity following tetanus-induced potentiation in the CA1 region of the rat hippocampus. Neuroreport. 1997 Jan 20; 8(2):411-4. PMID: 9080418.
    Citations:    Fields:    Translation:Animals
  52. Brown RE, Reymann KG. Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro. J Physiol. 1996 Oct 01; 496 ( Pt 1):175-84. PMID: 8910206.
    Citations: 14     Fields:    Translation:AnimalsCells
  53. Brown RE, Reymann KG. Class I metabotropic glutamate receptor agonists do not facilitate the induction of long-term potentiation in the dentate gyrus of the rat in vitro. Neurosci Lett. 1995 Dec 29; 202(1-2):73-6. PMID: 8787834.
    Citations: 2     Fields:    Translation:Animals
  54. Brown RE, Reymann KG. Metabotropic glutamate receptor agonists reduce paired-pulse depression in the dentate gyrus of the rat in vitro. Neurosci Lett. 1995 Aug 18; 196(1-2):17-20. PMID: 7501246.
    Citations: 6     Fields:    Translation:AnimalsCells
  55. Brown RE, Fedorov NB, Haas HL, Reymann KG. Histaminergic modulation of synaptic plasticity in area CA1 of rat hippocampal slices. Neuropharmacology. 1995 Feb; 34(2):181-90. PMID: 7617144.
    Citations: 10     Fields:    Translation:AnimalsCells
  56. Brown RE, Rabe H, Reymann KG. (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) does not block theta burst-induced long-term potentiation in area CA1 of rat hippocampal slices. Neurosci Lett. 1994 Mar 28; 170(1):17-21. PMID: 8041499.
    Citations: 5     Fields:    Translation:Animals
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Brown's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (239)
Explore
_
Co-Authors (18)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.