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Ritchie Edward Brown, PH.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS093000 (BROWN, RITCHIE EDWARD) Jul 15, 2015 - Jun 30, 2017
    vGLUT2-Tomato mice: a novel tool to study Basal Forebrain Glutamate Neurons
    Role: Principal Investigator
  2. I01BX001356 (BROWN, RITCHIE EDWARD) Oct 1, 2011 - Sep 30, 2019
    Sleep Spindles: Role of Thalamic Reticular Nucleus and Parvalbumin GABA Neurons
    Role: Principal Investigator
  3. R21MH094803 (BROWN, RITCHIE EDWARD) Jul 25, 2011 - Apr 30, 2014
    Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    Role: Principal Investigator
  4. R01MH039683 (BROWN, RITCHIE EDWARD) Sep 30, 1984 - Jun 30, 2018
    Synaptic Basis of Sleep Cycle Control
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Thankachan S, Katsuki F, McKenna JT, Yang C, Shukla C, Deisseroth K, Uygun DS, Strecker RE, Brown RE, McNally JM, Basheer R. Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice. Sci Rep. 2019 Mar 05; 9(1):3607. PMID: 30837664.
  2. Hwang E, Brown RE, Kocsis B, Kim T, McKenna JT, McNally JM, Han HB, Choi JH. Optogenetic stimulation of basal forebrain parvalbumin neurons modulates the cortical topography of auditory steady-state responses. Brain Struct Funct. 2019 May; 224(4):1505-1518. PMID: 30826928.
  3. Uygun DS, Katsuki F, Bolortuya Y, Aguilar DD, McKenna JT, Thankachan S, McCarley RW, Basheer R, Brown RE, Strecker RE, McNally JM. Validation of an automated sleep spindle detection method for mouse electroencephalography. Sleep. 2019 Feb 01; 42(2). PMID: 30476300.
    Citations:    Fields:    
  4. Yang C, Larin A, McKenna JT, Jacobson KA, Winston S, Strecker RE, Kalinchuk A, Basheer R, Brown RE. Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice. Sci Rep. 2018 Jul 16; 8(1):10730. PMID: 30013200.
    Citations:    Fields:    
  5. Yang C, Thankachan S, McCarley RW, Brown RE. Corrigendum to 'The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?' [Curr Opin Neurobiol 2017, 44:159-166]. Curr Opin Neurobiol. 2017 08; 45:221. PMID: 28802540.
    Citations:    Fields:    
  6. Yang C, Thankachan S, McCarley RW, Brown RE. The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom? Curr Opin Neurobiol. 2017 06; 44:159-166. PMID: 28538168.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Yang C, McKenna JT, Brown RE. Intrinsic membrane properties and cholinergic modulation of mouse basal forebrain glutamatergic neurons in vitro. Neuroscience. 2017 06 03; 352:249-261. PMID: 28411158.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Prerau MJ, Brown RE, Bianchi MT, Ellenbogen JM, Purdon PL. Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis. Physiology (Bethesda). 2017 01; 32(1):60-92. PMID: 27927806.
    Citations: 5     Fields:    Translation:HumansAnimals
  9. Zant JC, Kim T, Prokai L, Szarka S, McNally J, McKenna JT, Shukla C, Yang C, Kalinchuk AV, McCarley RW, Brown RE, Basheer R. Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study. J Neurosci. 2016 Feb 10; 36(6):2057-67. PMID: 26865627.
    Citations: 19     Fields:    Translation:AnimalsCells
  10. Lin SC, Brown RE, Hussain Shuler MG, Petersen CC, Kepecs A. Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition. J Neurosci. 2015 Oct 14; 35(41):13896-903. PMID: 26468190.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  11. Brown RE, McKenna JT. Turning a Negative into a Positive: Ascending GABAergic Control of Cortical Activation and Arousal. Front Neurol. 2015; 6:135. PMID: 26124745.
    Citations: 14     
  12. Kim T, Thankachan S, McKenna JT, McNally JM, Yang C, Choi JH, Chen L, Kocsis B, Deisseroth K, Strecker RE, Basheer R, Brown RE, McCarley RW. Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3535-40. PMID: 25733878.
    Citations: 44     Fields:    Translation:AnimalsCells
  13. Yang C, McKenna JT, Zant JC, Winston S, Basheer R, Brown RE. Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons. J Neurosci. 2014 Feb 19; 34(8):2832-44. PMID: 24553925.
    Citations: 24     Fields:    Translation:AnimalsCells
  14. McNally JM, McCarley RW, Brown RE. Chronic Ketamine Reduces the Peak Frequency of Gamma Oscillations in Mouse Prefrontal Cortex Ex vivo. Front Psychiatry. 2013; 4:106. PMID: 24062700.
    Citations: 11     
  15. Yang C, Franciosi S, Brown RE. Adenosine inhibits the excitatory synaptic inputs to Basal forebrain cholinergic, GABAergic, and parvalbumin neurons in mice. Front Neurol. 2013; 4:77. PMID: 23801984.
    Citations: 9     
  16. Kocsis B, Brown RE, McCarley RW, Hajos M. Impact of ketamine on neuronal network dynamics: translational modeling of schizophrenia-relevant deficits. CNS Neurosci Ther. 2013 Jun; 19(6):437-47. PMID: 23611295.
    Citations: 28     Fields:    Translation:HumansAnimals
  17. McKenna JT, Yang C, Franciosi S, Winston S, Abarr KK, Rigby MS, Yanagawa Y, McCarley RW, Brown RE. Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse. J Comp Neurol. 2013 Apr 15; 521(6):1225-50. PMID: 23254904.
    Citations: 23     Fields:    Translation:AnimalsCells
  18. McNally JM, McCarley RW, Brown RE. Impaired GABAergic neurotransmission in schizophrenia underlies impairments in cortical gamma band oscillations. Curr Psychiatry Rep. 2013 Mar; 15(3):346. PMID: 23400808.
    Citations: 15     Fields:    Translation:HumansCells
  19. Chen L, McKenna JT, Bolortuya Y, Brown RE, McCarley RW. Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep. Eur J Neurosci. 2013 Mar; 37(6):957-63. PMID: 23282008.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Control of sleep and wakefulness. Physiol Rev. 2012 Jul; 92(3):1087-187. PMID: 22811426.
    Citations: 210     Fields:    Translation:HumansAnimalsCells
  21. Chen L, McKenna JT, Bolortuya Y, Winston S, Thakkar MM, Basheer R, Brown RE, McCarley RW. Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period. Eur J Neurosci. 2010 Nov; 32(9):1528-36. PMID: 21089218.
    Citations: 14     Fields:    Translation:Animals
  22. Chen L, McKenna JT, Leonard MZ, Yanagawa Y, McCarley RW, Brown RE. GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis. Neuroreport. 2010 Feb 17; 21(3):216-20. PMID: 20051926.
    Citations: 8     Fields:    Translation:AnimalsCells
  23. Tartar JL, McKenna JT, Ward CP, McCarley RW, Strecker RE, Brown RE. Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine. Neurosci Lett. 2010 Jan 18; 469(1):1-5. PMID: 19914331.
    Citations: 14     Fields:    Translation:AnimalsCells
  24. Chen L, Brown RE, McKenna JT, McCarley RW. Animal models of narcolepsy. CNS Neurol Disord Drug Targets. 2009 Aug; 8(4):296-308. PMID: 19689311.
    Citations: 9     Fields:    Translation:HumansAnimals
  25. Brown RE, McKenna JT, Winston S, Basheer R, Yanagawa Y, Thakkar MM, McCarley RW. Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice. Eur J Neurosci. 2008 Jan; 27(2):352-63. PMID: 18215233.
    Citations: 33     Fields:    Translation:AnimalsCells
  26. Brown RE, Winston S, Basheer R, Thakkar MM, McCarley RW. Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins. Neuroscience. 2006 Dec; 143(3):739-55. PMID: 17008019.
    Citations: 29     Fields:    Translation:AnimalsCells
  27. Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Brown RE, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci. 2006 May; 23(10):2739-48. PMID: 16817877.
    Citations: 66     Fields:    Translation:Animals
  28. Basheer R, Brown R, Ramesh V, Begum S, McCarley RW. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity. J Neurosci Res. 2005 Dec 01; 82(5):650-8. PMID: 16273548.
    Citations: 23     Fields:    Translation:AnimalsCells
  29. Korotkova TM, Ponomarenko AA, Brown RE, Haas HL. Functional diversity of ventral midbrain dopamine and GABAergic neurons. Mol Neurobiol. 2004 Jun; 29(3):243-59. PMID: 15181237.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  30. Selbach O, Doreulee N, Bohla C, Eriksson KS, Sergeeva OA, Poelchen W, Brown RE, Haas HL. Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling. Neuroscience. 2004; 127(2):519-28. PMID: 15262340.
    Citations: 21     Fields:    Translation:AnimalsCells
  31. Sergeeva OA, Korotkova TM, Scherer A, Brown RE, Haas HL. Co-expression of non-selective cation channels of the transient receptor potential canonical family in central aminergic neurones. J Neurochem. 2003 Jun; 85(6):1547-52. PMID: 12787073.
    Citations: 11     Fields:    Translation:AnimalsCells
  32. Brown RE. Involvement of hypocretins/orexins in sleep disorders and narcolepsy. Drug News Perspect. 2003 Mar; 16(2):75-9. PMID: 12792667.
    Citations: 2     Fields:    Translation:HumansAnimals
  33. Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE. Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci. 2003 Jan 01; 23(1):7-11. PMID: 12514194.
    Citations: 146     Fields:    Translation:AnimalsCells
  34. Brown RE, Sergeeva OA, Eriksson KS, Haas HL. Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). J Neurosci. 2002 Oct 15; 22(20):8850-9. PMID: 12388591.
    Citations: 75     Fields:    Translation:AnimalsCells
  35. Korotkova TM, Eriksson KS, Haas HL, Brown RE. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regul Pept. 2002 Mar 15; 104(1-3):83-9. PMID: 11830281.
    Citations: 21     Fields:    Translation:AnimalsCells
  36. Korotkova TM, Haas HL, Brown RE. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro. Neurosci Lett. 2002 Mar 08; 320(3):133-6. PMID: 11852180.
    Citations: 15     Fields:    Translation:AnimalsCells
  37. Eriksson KS, Sergeeva O, Brown RE, Haas HL. Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci. 2001 Dec 01; 21(23):9273-9. PMID: 11717361.
    Citations: 103     Fields:    Translation:AnimalsCells
  38. Stevens DR, Eriksson KS, Brown RE, Haas HL. The mechanism of spontaneous firing in histamine neurons. Behav Brain Res. 2001 Oct 15; 124(2):105-12. PMID: 11640962.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  39. Doreulee N, Brown RE, Yanovsky Y, Gödecke A, Schrader J, Haas HL. Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice. Synapse. 2001 Sep 01; 41(3):191-4. PMID: 11391779.
    Citations: 1     Fields:    Translation:AnimalsCells
  40. Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001 Apr; 63(6):637-72. PMID: 11164999.
    Citations: 151     Fields:    Translation:HumansAnimalsCells
  41. Brown RE, Sergeeva O, Eriksson KS, Haas HL. Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology. 2001 Mar; 40(3):457-9. PMID: 11166339.
    Citations: 59     Fields:    Translation:AnimalsCells
  42. Doreulee N, Yanovsky Y, Flagmeyer I, Stevens DR, Haas HL, Brown RE. Histamine H(3) receptors depress synaptic transmission in the corticostriatal pathway. Neuropharmacology. 2001; 40(1):106-13. PMID: 11077076.
    Citations: 13     Fields:    Translation:AnimalsCells
  43. Brown RE, Haas HL. On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus. J Physiol. 1999 Mar 15; 515 ( Pt 3):777-86. PMID: 10066904.
    Citations: 22     Fields:    Translation:AnimalsCells
  44. Wilson RI, Gödecke A, Brown RE, Schrader J, Haas HL. Mice deficient in endothelial nitric oxide synthase exhibit a selective deficit in hippocampal long-term potentiation. Neuroscience. 1999; 90(4):1157-65. PMID: 10338286.
    Citations: 6     Fields:    Translation:AnimalsCells
  45. Manahan-Vaughan D, Reymann KG, Brown RE. In vivo electrophysiological investigations into the role of histamine in the dentate gyrus of the rat. Neuroscience. 1998 Jun; 84(3):783-90. PMID: 9579783.
    Citations: 4     Fields:    Translation:Animals
  46. Selbach O, Brown RE, Haas HL. Long-term increase of hippocampal excitability by histamine and cyclic AMP. Neuropharmacology. 1997 Nov-Dec; 36(11-12):1539-48. PMID: 9517424.
    Citations: 12     Fields:    Translation:AnimalsCells
  47. Fedorov NB, Brown RE, Reymann KG. Fast increases of AMPA receptor sensitivity following tetanus-induced potentiation in the CA1 region of the rat hippocampus. Neuroreport. 1997 Jan 20; 8(2):411-4. PMID: 9080418.
    Citations:    Fields:    Translation:Animals
  48. Brown RE, Reymann KG. Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro. J Physiol. 1996 Oct 01; 496 ( Pt 1):175-84. PMID: 8910206.
    Citations: 14     Fields:    Translation:AnimalsCells
  49. Brown RE, Reymann KG. Class I metabotropic glutamate receptor agonists do not facilitate the induction of long-term potentiation in the dentate gyrus of the rat in vitro. Neurosci Lett. 1995 Dec 29; 202(1-2):73-6. PMID: 8787834.
    Citations: 2     Fields:    Translation:Animals
  50. Brown RE, Reymann KG. Metabotropic glutamate receptor agonists reduce paired-pulse depression in the dentate gyrus of the rat in vitro. Neurosci Lett. 1995 Aug 18; 196(1-2):17-20. PMID: 7501246.
    Citations: 6     Fields:    Translation:AnimalsCells
  51. Brown RE, Fedorov NB, Haas HL, Reymann KG. Histaminergic modulation of synaptic plasticity in area CA1 of rat hippocampal slices. Neuropharmacology. 1995 Feb; 34(2):181-90. PMID: 7617144.
    Citations: 10     Fields:    Translation:AnimalsCells
  52. Brown RE, Rabe H, Reymann KG. (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) does not block theta burst-induced long-term potentiation in area CA1 of rat hippocampal slices. Neurosci Lett. 1994 Mar 28; 170(1):17-21. PMID: 8041499.
    Citations: 5     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.