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William Nicholas Haining, B.M., B.Ch.

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Overview
Our laboratory studies the mechanisms that regulate T cell function in humans. We use a range of approaches including cellular immunology, functional genomics and chemical biology to understand why protective T cell memory fails to occur in cancer and chronic viral infection.

Our work focuses on understanding the molecular differences between functional CD8 T cells and dysfunctional, exhausted CD8 T cells that are characteristic of chronic infection and cancer. For example, we have used transcriptional profiling of rare populations of virus-specific CD8 T cells from human blood to identify the molecular differences between effective and ineffective T cell responses in HIV.

These studies have uncovered a mechanism by which the inhibitory receptor PD-1 upregulates a novel transcription factor, BATF, that impairs T cell function.

We are also interested in developing novel therapeutic approaches to rescue function in exhausted T cells. We are using chemical screens to identify small molecules that reverse the inhibition caused by the receptor PD-1, and are developing novel genetic and computational approaches to match active compounds to their target molecules.

For more information:
http://haining.dfci.harvard.edu

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U2CCA233195 (JOHNSON, BRUCE E.) Sep 24, 2018 - Aug 31, 2023
    NIH/NCI
    The Cellular Geography of Therapeutic Resistance in Cancer
    Role: Co-Principal Investigator
  2. R01AI115712 (KADOCH, CIGALL) Apr 1, 2015 - Mar 31, 2020
    NIH/NIAID
    Testing the role of BATF as a pioneer transcription factor in effector T cells
    Role: Principal Investigator
  3. R01AI091493 (HAINING, WILLIAM NICHOLAS) Sep 30, 2010 - Aug 31, 2016
    NIH/NIAID
    Functional genomic analysis of the CD8 T cell response to HIV vaccines in
    Role: Co-Principal Investigator
  4. U19AI090023 (PULENDRAN, BALI) Jul 12, 2010 - Jun 30, 2020
    NIH/NIAID
    System Biological Analyses of Innate and Adaptive Responses to Vaccination
    Role: Co-Principal Investigator
  5. U19AI082630 (CHUNG, RAYMOND T) Jun 8, 2009 - May 31, 2024
    NIH/NIAID
    Impact of Immunotherapy on Viral Immunity in Humans
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. LaFleur MW, Nguyen TH, Coxe MA, Yates KB, Trombley JD, Weiss SA, Brown FD, Gillis JE, Coxe DJ, Doench JG, Haining WN, Sharpe AH. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nat Commun. 2019 04 10; 10(1):1668. PMID: 30971695.
    Citations:    
  2. Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN. Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. Nat Immunol. 2019 03; 20(3):326-336. PMID: 30778252.
    Citations:    
  3. Ishizuka JJ, Manguso RT, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019 01; 565(7737):43-48. PMID: 30559380.
    Citations:    Fields:    
  4. Haining WN, Weiss SA. Publisher Correction: Gene regulation: c-Maf in CD4+ T cells: it's all about context. Nat Immunol. 2018 Oct; 19(10):1146. PMID: 30143753.
    Citations:    Fields:    
  5. Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nat Immunol. 2018 08; 19(8):838-848. PMID: 29988091.
    Citations:    
  6. Haining WN, Weiss SA. c-Maf in CD4+ T cells: it's all about context. Nat Immunol. 2018 05; 19(5):429-431. PMID: 29670237.
    Citations:    Fields:    
  7. Lane-Reticker SK, Manguso RT, Haining WN. Pooled in vivo screens for cancer immunotherapy target discovery. Immunotherapy. 2018 03; 10(3):167-170. PMID: 29370725.
    Citations:    Fields:    
  8. Yates K, Bi K, Haining WN, Cantor H, Kim HJ. Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2162-2167. PMID: 29440380.
    Citations:    Fields:    Translation:AnimalsCells
  9. Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R. Origin and differentiation of human memory CD8 T cells after vaccination. Nature. 2017 12 21; 552(7685):362-367. PMID: 29236685.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  10. Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018 02; 8(2):216-233. PMID: 29101163.
    Citations: 4     Fields:    
  11. Wolski D, Foote PK, Chen DY, Lewis-Ximenez LL, Fauvelle C, Aneja J, Walker A, Tonnerre P, Torres-Cornejo A, Kvistad D, Imam S, Waring MT, Tully DC, Allen TM, Chung RT, Timm J, Haining WN, Kim AY, Baumert TF, Lauer GM. Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection. Immunity. 2017 10 17; 47(4):648-663.e8. PMID: 29045899.
    Citations:    Fields:    Translation:HumansCells
  12. Afik S, Yates KB, Bi K, Darko S, Godec J, Gerdemann U, Swadling L, Douek DC, Klenerman P, Barnes EJ, Sharpe AH, Haining WN, Yosef N. Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state. Nucleic Acids Res. 2017 Sep 19; 45(16):e148. PMID: 28934479.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  13. Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature. 2017 07 27; 547(7664):413-418. PMID: 28723893.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  14. Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017 06 15; 546(7658):426-430. PMID: 28607489.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  15. Juneja VR, McGuire KA, Manguso RT, LaFleur MW, Collins N, Haining WN, Freeman GJ, Sharpe AH. PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. J Exp Med. 2017 04 03; 214(4):895-904. PMID: 28302645.
    Citations: 30     Fields:    Translation:AnimalsCells
  16. Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2017 02; 18(2):184-195. PMID: 27992400.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 2016 12 02; 354(6316):1160-1165. PMID: 27789795.
    Citations: 65     Fields:    Translation:AnimalsCells
  18. Sen DR, Kaminski J, Barnitz RA, Kurachi M, Gerdemann U, Yates KB, Tsao HW, Godec J, LaFleur MW, Brown FD, Tonnerre P, Chung RT, Tully DC, Allen TM, Frahm N, Lauer GM, Wherry EJ, Yosef N, Haining WN. The epigenetic landscape of T cell exhaustion. Science. 2016 12 02; 354(6316):1165-1169. PMID: 27789799.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  19. Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446. PMID: 27695002.
    Citations: 31     Fields:    Translation:AnimalsCells
  20. Provine NM, Larocca RA, Aid M, Penaloza-MacMaster P, Badamchi-Zadeh A, Borducchi EN, Yates KB, Abbink P, Kirilova M, Ng'ang'a D, Bramson J, Haining WN, Barouch DH. Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells. J Immunol. 2016 09 01; 197(5):1809-22. PMID: 27448585.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  21. Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature. 2016 Apr 28; 532(7600):512-6. PMID: 27096360.
    Citations: 132     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  22. Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW. Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response. Cell Host Microbe. 2016 May 11; 19(5):713-9. PMID: 27107939.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  23. Pesenacker AM, Wang AY, Singh A, Gillies J, Kim Y, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK. A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes. Diabetes. 2016 04; 65(4):1031-9. PMID: 26786322.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  24. Godec J, Tan Y, Liberzon A, Tamayo P, Bhattacharya S, Butte AJ, Mesirov JP, Haining WN. Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation. Immunity. 2016 Jan 19; 44(1):194-206. PMID: 26795250.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  25. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. PMID: 26485519.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  26. Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015 Oct 16; 350(6258):334-9. PMID: 26472910.
    Citations: 57     Fields:    Translation:AnimalsCells
  27. Plumlee CR, Obar JJ, Colpitts SL, Jellison ER, Haining WN, Lefrancois L, Khanna KM. Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection. Sci Rep. 2015 Jul 20; 5:12264. PMID: 26191658.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Tan Y, Wu F, Tamayo P, Haining WN, Mesirov JP. Constellation Map: Downstream visualization and interpretation of gene set enrichment results. F1000Res. 2015; 4:167. PMID: 26594333.
    Citations: 2     
  29. Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, Barouch DH. Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection. Science. 2015 Jan 16; 347(6219):278-82. PMID: 25593185.
    Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
  30. Godec J, Cowley GS, Barnitz RA, Alkan O, Root DE, Sharpe AH, Haining WN. Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):512-7. PMID: 25548173.
    Citations: 8     Fields:    Translation:AnimalsCells
  31. Stelekati E, Shin H, Doering TA, Dolfi DV, Ziegler CG, Beiting DP, Dawson L, Liboon J, Wolski D, Ali MA, Katsikis PD, Shen H, Roos DS, Haining WN, Lauer GM, Wherry EJ. Bystander chronic infection negatively impacts development of CD8(+) T cell memory. Immunity. 2014 May 15; 40(5):801-13. PMID: 24837104.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  32. Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, Yates K, Godec J, Klatt MG, Regev A, Wherry EJ, Haining WN. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol. 2014 Apr; 15(4):373-83. PMID: 24584090.
    Citations: 54     Fields:    Translation:AnimalsCells
  33. Haining WN. Strength in numbers: comparing vaccine signatures the modular way. Nat Immunol. 2014 Feb; 15(2):139-41. PMID: 24448573.
    Citations:    Fields:    Translation:HumansCells
  34. Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Zhang W, Liao X, Hodi FS, O'Connell K, Haining WN, Goldstein NR, Canning CM, Soiffer RJ, Ritz J, Hacohen N, Alyea EP, Kim HT, Wu CJ. Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion. Blood. 2014 Feb 27; 123(9):1412-21. PMID: 24357730.
    Citations: 20     Fields:    Translation:HumansCells
  35. Tan Y, Tamayo P, Nakaya H, Pulendran B, Mesirov JP, Haining WN. Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response. Eur J Immunol. 2014 Jan; 44(1):285-95. PMID: 24136404.
    Citations: 22     Fields:    Translation:HumansCellsPHPublic Health
  36. Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen availability determines CD8? T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity. 2013 Sep 19; 39(3):496-507. PMID: 24054328.
    Citations: 36     Fields:    Translation:AnimalsCells
  37. Barnitz RA, Imam S, Yates K, Haining WN. Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis. Methods Mol Biol. 2013; 979:161-73. PMID: 23397395.
    Citations: 4     Fields:    Translation:Cells
  38. Huang AY, Haining WN, Barkauskas DS, Myers JT, Petrosiute A, Garrett AP, Singh K, Cooke KR, Kean LS. Viewing transplantation immunology through today's lens: new models, new imaging, and new insights. Biol Blood Marrow Transplant. 2013 Jan; 19(1 Suppl):S44-51. PMID: 23092813.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  39. Haining WN. Thinking inside the box: how T cell inhibitory receptors signal. Nat Med. 2012 Sep; 18(9):1338-9. PMID: 22961161.
    Citations:    Fields:    Translation:HumansAnimalsCells
  40. Butte MJ, Lee SJ, Jesneck J, Keir ME, Haining WN, Sharpe AH. CD28 costimulation regulates genome-wide effects on alternative splicing. PLoS One. 2012; 7(6):e40032. PMID: 22768209.
    Citations: 10     Fields:    Translation:AnimalsCells
  41. Haining WN, Pulendran B. Identifying gnostic predictors of the vaccine response. Curr Opin Immunol. 2012 Jun; 24(3):332-6. PMID: 22633886.
    Citations: 7     Fields:    Translation:HumansAnimals
  42. Haining WN. The numerology of T cell functional diversity. Immunity. 2012 Jan 27; 36(1):10-2. PMID: 22284416.
    Citations: 1     Fields:    
  43. Haining WN. Travels in time: assessing the functional complexity of T cells. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1359-60. PMID: 22307586.
    Citations: 2     Fields:    Translation:HumansCells
  44. Haining WN, Barnitz RA. Deconvolving heterogeneity in the CD8+ T-cell response to HIV. Curr Opin HIV AIDS. 2012 Jan; 7(1):38-43. PMID: 22156844.
    Citations:    Fields:    Translation:HumansCells
  45. West EE, Youngblood B, Tan WG, Jin HT, Araki K, Alexe G, Konieczny BT, Calpe S, Freeman GJ, Terhorst C, Haining WN, Ahmed R. Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity. 2011 Aug 26; 35(2):285-98. PMID: 21856186.
    Citations: 72     Fields:    Translation:AnimalsCells
  46. Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li GM, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B. Systems biology of vaccination for seasonal influenza in humans. Nat Immunol. 2011 Jul 10; 12(8):786-95. PMID: 21743478.
    Citations: 282     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  47. Duraiswamy J, Ibegbu CC, Masopust D, Miller JD, Araki K, Doho GH, Tata P, Gupta S, Zilliox MJ, Nakaya HI, Pulendran B, Haining WN, Freeman GJ, Ahmed R. Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. J Immunol. 2011 Apr 01; 186(7):4200-12. PMID: 21383243.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  48. Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011 Jan 21; 144(2):296-309. PMID: 21241896.
    Citations: 285     Fields:    Translation:Humans
  49. Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med. 2010 Oct; 16(10):1147-51. PMID: 20890291.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  50. Haining WN, Wherry EJ. Integrating genomic signatures for immunologic discovery. Immunity. 2010 Feb 26; 32(2):152-61. PMID: 20189480.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  51. Kalia V, Sarkar S, Subramaniam S, Haining WN, Smith KA, Ahmed R. Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity. 2010 Jan 29; 32(1):91-103. PMID: 20096608.
    Citations: 207     Fields:    Translation:AnimalsCells
  52. Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009 Jan; 10(1):29-37. PMID: 19043418.
    Citations: 575     Fields:    Translation:AnimalsCells
  53. Haining WN, Davies J, Kanzler H, Drury L, Brenn T, Evans J, Angelosanto J, Rivoli S, Russell K, George S, Sims P, Neuberg D, Li X, Kutok J, Morgan J, Wen P, Demetri G, Coffman RL, Nadler LM. CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res. 2008 Sep 01; 14(17):5626-34. PMID: 18765557.
    Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
  54. Haining WN, Angelosanto J, Brosnahan K, Ross K, Hahn C, Russell K, Drury L, Norton S, Nadler L, Stegmaier K. High-throughput gene expression profiling of memory differentiation in primary human T cells. BMC Immunol. 2008 Aug 01; 9:44. PMID: 18673556.
    Citations: 8     Fields:    Translation:HumansCells
  55. Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 01; 181(3):1859-68. PMID: 18641323.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  56. Sarkar S, Kalia V, Haining WN, Konieczny BT, Subramaniam S, Ahmed R. Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med. 2008 Mar 17; 205(3):625-40. PMID: 18316415.
    Citations: 244     Fields:    Translation:AnimalsCells
  57. Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007 Oct; 27(4):670-84. PMID: 17950003.
    Citations: 593     Fields:    Translation:AnimalsCells
  58. Maia S, Haining WN, Ansén S, Xia Z, Armstrong SA, Seth NP, Ghia P, den Boer ML, Pieters R, Sallan SE, Nadler LM, Cardoso AA. Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. Cancer Res. 2005 Nov 01; 65(21):10050-8. PMID: 16267031.
    Citations: 11     Fields:    Translation:HumansCells
  59. Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S, Gelman R, Rosenblatt HM, Shearer WT, Guenaga J, Douek DC, Silverman LB, Sallan SE, Guinan EC, Nadler LM. Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood. 2005 Sep 01; 106(5):1749-54. PMID: 15920008.
    Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
  60. Haining WN, Cardoso AA, Keczkemethy HL, Fleming M, Neuberg D, DeAngelo DJ, Stone RM, Galinsky I, Silverman LB, Sallan SE, Nadler LM, Guinan EC. Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. Exp Hematol. 2005 Mar; 33(3):286-94. PMID: 15730852.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  61. Haining WN, Evans JW, Seth NP, Callaway GD, Wucherpfennig KW, Nadler LM, Guinan EC. Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol. 2004 Nov; 127(3):322-5. PMID: 15491293.
    Citations: 8     Fields:    Translation:HumansCells
  62. Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS, von Berwelt-Baildon MS. pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85. PMID: 15294974.
    Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  63. Cardoso AA, Veiga JP, Ghia P, Afonso HM, Haining WN, Sallan SE, Nadler LM. Adoptive T-cell therapy for B-cell acute lymphoblastic leukemia: preclinical studies. Blood. 1999 Nov 15; 94(10):3531-40. PMID: 10552964.
    Citations: 5     Fields:    Translation:HumansCells
  64. Haining WN, Carboy-Newcomb C, Wei CL, Steller H. The proapoptotic function of Drosophila Hid is conserved in mammalian cells. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):4936-41. PMID: 10220397.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  65. Noel GJ, Barenkamp SJ, St Geme JW, Haining WN, Mosser DM. High-molecular-weight surface-exposed proteins of Haemophilus influenzae mediate binding to macrophages. J Infect Dis. 1994 Feb; 169(2):425-9. PMID: 8106776.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  66. Bridges AB, Faed M, Boxer M, Haining WM, Pringle TH, McNeill GP. Marfan syndrome affecting four generations of a family without ocular involvement. Postgrad Med J. 1991 Jun; 67(788):538-42. PMID: 1924022.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.