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Jun Li

Title
Institution
Department
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Other Positions
Title
Institution
Department

Biography
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaMD06/2011Preventive Medicine
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaPhD06/2016Cardiovascular Epidemiology and Environmental Health
2020
Scott Grundy Fellowship Award for Excellence in Metabolism Research
2019
The Jeremiah and Rose Stamler Research Award winner
2019
The Barry R. and Irene Tilenius Bloom Fellowship Award
2018
The Postdoc Association Travel Award
2015
Best Young Investigators
2014
The Bernard Lown Scholarship in Cardiovascular Health Program

Overview
Dr. Jun Li is a research scientist in Departments of Nutrition and Epidemiology at Harvard T.H. Chan School of Public Health (HSPH). The main area of her research focuses on the identification of risk factors for prevention of type 2 diabetes (T2D) and cardiovascular disease (CVD), with particular interest and skills on high-dimensional omics research.

Dr. Li is currently leading several projects identifying genomic, metabolomic, dietary, and lifestyle risk factors for T2D and CVD in the Nurses' Health Studies (NHS), Health Professional Follow-up Study, PREDIMED study, Hispanic Community Health Study/Study of Latinos, and the UK Biobank. Her research interests also extend to the new area of systems epidemiology and multi-omics integration. She is adopting new methodologies to integrate multi-omics data (including genetics, epigenetics, metabolomics, and gut microbiome) for the interpretation of disease etiology and identification of mechanisms through which diet/lifestyle factors impact cardiometabolic health.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99DK122128 (LI, JUN) Sep 1, 2019 - Aug 31, 2021
    NIH
    Chronic Inflammation and Type 2 Diabetes: A Multi-omics Approach
    Role Description: This project seeks to systematically examine the relationship between chronic inflammation and type 2 diabetes (T2D) by incorporating multi-omics data from several large prospective cohort studies.
    Role: Principal Investigator
  2. 2P30DK046200-26 (LI, JUN) Dec 1, 2018 - Nov 30, 2020
    Boston Nutrition Obesity Research Center
    Chronic Inflammation and Obesity: Genetic Susceptibility and the Role of Diet
    Role Description: This study will combine new genomic approaches with epidemiological studies, to examine the relations between chronic inflammation with obesity and its co-morbidities, and whether dietary inflammatory potentials interact with polygenic risk in influencing long-term weight gain.
    Role: Principal Investigator
  3. 9-17-CMF-011 (LI, JUN) Sep 1, 2017 - Aug 31, 2019
    American Diabetes Association
    Mediterranean diet, metabolites, and cardiovascular disease in patients with diabetes
    Role Description: This projects aimed to examine metabolic mechanisms through which the Mediterranean diet is associated with lower CVD risk among diabetic patients.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li J, Guasch-Ferré M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martínez-González MÁ, Salas-Salvadó J, Hu FB, Liang L. The Mediterranean diet, plasma metabolome, and cardiovascular disease risk. Eur Heart J. 2020 Jul 21; 41(28):2645-2656. PMID: 32406924.
    Citations:    
  2. Li J, Guasch-Ferré M, Li Y, Hu FB. Dietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studies. Am J Clin Nutr. 2020 07 01; 112(1):150-167. PMID: 32020162.
    Citations:    
  3. Guasch-Ferré M, Santos JL, Martínez-González MA, Clish CB, Razquin C, Wang D, Liang L, Li J, Dennis C, Corella D, Muñoz-Bravo C, Romaguera D, Estruch R, Santos-Lozano JM, Castañer O, Alonso-Gómez A, Serra-Majem L, Ros E, Canudas S, Asensio EM, Fitó M, Pierce K, Martínez JA, Salas-Salvadó J, Toledo E, Hu FB, Ruiz-Canela M. Glycolysis/gluconeogenesis- and tricarboxylic acid cycle-related metabolites, Mediterranean diet, and type 2 diabetes. Am J Clin Nutr. 2020 04 01; 111(4):835-844. PMID: 32060497.
    Citations:    
  4. Long P, Liu X, Li J, He S, Chen H, Yuan Y, Qiu G, Yu K, Liu K, Jiang J, Yang H, Xu C, Zhang X, He M, Guo H, Liang L, Hu FB, Wu T, Pan A. Circulating folate concentrations and risk of coronary artery disease: a prospective cohort study in Chinese adults and a Mendelian randomization analysis. Am J Clin Nutr. 2020 03 01; 111(3):635-643. PMID: 31927564.
    Citations:    
  5. Yuan Y, Long P, Liu K, Xiao Y, He S, Li J, Mo T, Liu Y, Yu Y, Wang H, Zhou L, Liu X, Yang H, Li X, Min X, Zhang C, Zhang X, Pan A, He M, Hu FB, Navas-Acien A, Wu T. Multiple plasma metals, genetic risk and serum C-reactive protein: A metal-metal and gene-metal interaction study. Redox Biol. 2020 01; 29:101404. PMID: 31926627.
    Citations:    
  6. Ding M, Li J, Qi L, Ellervik C, Zhang X, Manson JE, Stampfer M, Chavarro JE, Rexrode KM, Kraft P, Chasman D, Willett WC, Hu FB. Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies. BMJ. 2019 11 27; 367:l6204. PMID: 31776125.
    Citations:    
  7. Razquin C, Ruiz-Canela M, Clish CB, Li J, Toledo E, Dennis C, Liang L, Salas-Huetos A, Pierce KA, Guasch-Ferré M, Corella D, Ros E, Estruch R, Gómez-Gracia E, Fitó M, Lapetra J, Romaguera D, Alonso-Gómez A, Serra-Majem L, Salas-Salvadó J, Hu FB, Martínez-González MA. Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies. Cardiovasc Diabetol. 2019 11 13; 18(1):151. PMID: 31722714.
    Citations:    
  8. Guo Y, Chung W, Zhu Z, Shan Z, Li J, Liu S, Liang L. Genome-Wide Assessment for Resting Heart Rate and Shared Genetics With Cardiometabolic Traits and Type 2 Diabetes. J Am Coll Cardiol. 2019 10 29; 74(17):2162-2174. PMID: 31648709.
    Citations:    
  9. Hu J, Zhao H, Braun JM, Zheng T, Zhang B, Xia W, Zhang W, Li J, Zhou Y, Li H, Li J, Zhou A, Zhang Y, Buka SL, Liu S, Peng Y, Wu C, Jiang M, Huo W, Zhu Y, Shi K, Li Y, Cai Z, Xu S. Associations of Trimester-Specific Exposure to Bisphenols with Size at Birth: A Chinese Prenatal Cohort Study. Environ Health Perspect. 2019 10; 127(10):107001. PMID: 31573832.
    Citations:    
  10. Li J, Hu FB. Research digest: reshaping the gut microbiota. Lancet Diabetes Endocrinol. 2019 09; 7(9):671. PMID: 31439276.
    Citations:    
  11. Hu J, Li Y, Zhang B, Zheng T, Li J, Peng Y, Zhou A, Buka SL, Liu S, Zhang Y, Shi K, Xia W, Rexrode KM, Xu S. Impact of the 2017 ACC/AHA Guideline for High Blood Pressure on Evaluating Gestational Hypertension-Associated Risks for Newborns and Mothers. Circ Res. 2019 07 05; 125(2):184-194. PMID: 31104583.
    Citations:    
  12. Guasch-Ferré M, Ruiz-Canela M, Li J, Zheng Y, Bulló M, Wang DD, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J, Serra-Majem L, Liang L, Papandreou C, Dennis C, Martínez-González MA, Hu FB, Salas-Salvadó J. Plasma Acylcarnitines and Risk of Type 2 Diabetes in a Mediterranean Population at High Cardiovascular Risk. J Clin Endocrinol Metab. 2019 05 01; 104(5):1508-1519. PMID: 30423132.
    Citations:    Fields:    
  13. Yu K, Yang B, Jiang H, Li J, Yan K, Liu X, Zhou L, Yang H, Li X, Min X, Zhang C, Luo X, Mei W, Sun S, Zhang L, Cheng X, He M, Zhang X, Pan A, Hu FB, Wu T. A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity. Sci Rep. 2019 03 26; 9(1):5121. PMID: 30914768.
    Citations:    
  14. Papandreou C, Li J, Liang L, Bulló M, Zheng Y, Ruiz-Canela M, Yu E, Guasch-Ferré M, Razquin C, Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Serra-Majem L, Rosique N, Martínez-González MA, Hu FB, Salas-Salvadó J. Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Sci Rep. 2019 02 27; 9(1):2892. PMID: 30814579.
    Citations:    
  15. Li J, Sun Q. Consumption of saturated fatty acids and coronary heart disease risk. Int J Cardiol. 2019 03 15; 279:27-28. PMID: 30658924.
    Citations:    
  16. Ma Y, Sun L, Li J, Hu Y, Gan Z, Zong G, Zheng H, Jin Q, Li H, Hu FB, Zeng R, Sun Q, Lin X. Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese. J Lipid Res. 2019 02; 60(2):421-429. PMID: 30552288.
    Citations:    Fields:    
  17. Shan Z, Li Y, Zong G, Guo Y, Li J, Manson JE, Hu FB, Willett WC, Schernhammer ES, Bhupathiraju SN. Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses. BMJ. 2018 11 21; 363:k4641. PMID: 30464025.
    Citations:    Fields:    
  18. He S, Lei W, Li J, Yu K, Yu Y, Zhou L, Zhang X, He M, Guo H, Yang H, Wu T. Relation of Platelet Parameters With Incident Cardiovascular Disease (The Dongfeng-Tongji Cohort Study). Am J Cardiol. 2019 01 15; 123(2):239-248. PMID: 30413247.
    Citations:    
  19. Li J, Rice MS, Huang T, Hankinson SE, Clevenger CV, Hu FB, Tworoger SS. Circulating prolactin concentrations and risk of type 2 diabetes in US women. Diabetologia. 2018 12; 61(12):2549-2560. PMID: 30306190.
    Citations:    Fields:    
  20. Guasch-Ferré M, Li J, Hu FB, Salas-Salvadó J, Tobias DK. Effects of walnut consumption on blood lipids and other cardiovascular risk factors: an updated meta-analysis and systematic review of controlled trials. Am J Clin Nutr. 2018 07 01; 108(1):174-187. PMID: 29931130.
    Citations:    Fields:    
  21. Tobias DK, Clish C, Mora S, Li J, Liang L, Hu FB, Manson JE, Zhang C. Dietary Intakes and Circulating Concentrations of Branched-Chain Amino Acids in Relation to Incident Type 2 Diabetes Risk Among High-Risk Women with a History of Gestational Diabetes Mellitus. Clin Chem. 2018 08; 64(8):1203-1210. PMID: 29945965.
    Citations: 1     Fields:    
  22. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Wang B, Liu X, Deng S, Hu J, Deng Q, Sun H, Guo H, Zhang X, Chen W, Yuan J, He M, Bai Y, Han X, Liu B, Liu C, Guo Y, Zhang B, Zhang Z, Hu FB, Gao W, Li L, Lathrop M, Laprise C, Liang L, Wu T. Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. Environ Health Perspect. 2018 06; 126(6):067005. PMID: 29906262.
    Citations:    Fields:    
  23. Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS, Dorajoo R, Li H, Long J, Guo X, Xu M, Spracklen CN, Chen Y, Liu X, Zhang Y, Khor CC, Liu J, Sun L, Wang L, Gao YT, Hu Y, Yu K, Wang Y, Cheung CYY, Wang F, Huang J, Fan Q, Cai Q, Chen S, Shi J, Yang X, Zhao W, Sheu WH, Cherny SS, He M, Feranil AB, Adair LS, Gordon-Larsen P, Du S, Varma R, Chen YI, Shu XO, Lam KSL, Wong TY, Ganesh SK, Mo Z, Hveem K, Fritsche LG, Nielsen JB, Tse HF, Huo Y, Cheng CY, Chen YE, Zheng W, Tai ES, Gao W, Lin X, Huang W, Abecasis G, Kathiresan S, Mohlke KL, Wu T, Sham PC, Gu D, Willer CJ. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 2017 Dec; 49(12):1722-1730. PMID: 29083407.
    Citations: 5     Fields:    Translation:Humans
  24. Hu J, Xia W, Pan X, Zheng T, Zhang B, Zhou A, Buka SL, Bassig BA, Liu W, Wu C, Peng Y, Li J, Zhang C, Liu H, Jiang M, Wang Y, Zhang J, Huang Z, Zheng D, Shi K, Qian Z, Li Y, Xu S. Association of adverse birth outcomes with prenatal exposure to vanadium: a population-based cohort study. Lancet Planet Health. 2017 09; 1(6):e230-e241. PMID: 29851608.
    Citations:    Translation:HumansPHPublic Health
  25. Jiang H, Li J, Yu K, Yang H, Min X, Chen H, Wu T. Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study. Sci Rep. 2017 08 30; 7(1):9987. PMID: 28855533.
    Citations:    
  26. Li J, Zhu X, Yu K, Jiang H, Zhang Y, Deng S, Cheng L, Liu X, Zhong J, Zhang X, He M, Chen W, Yuan J, Gao M, Bai Y, Han X, Liu B, Luo X, Mei W, He X, Sun S, Zhang L, Zeng H, Sun H, Liu C, Guo Y, Zhang B, Zhang Z, Huang J, Pan A, Yuan Y, Angileri F, Ming B, Zheng F, Zeng Q, Mao X, Peng Y, Mao Y, He P, Wang QK, Qi L, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. Circ Res. 2017 May 26; 120(11):1754-1767. PMID: 28348007.
    Citations: 4     Fields:    Translation:HumansCells
  27. Zhong J, Karlsson O, Wang G, Li J, Guo Y, Lin X, Zemplenyi M, Sanchez-Guerra M, Trevisi L, Urch B, Speck M, Liang L, Coull BA, Koutrakis P, Silverman F, Gold DR, Wu T, Baccarelli AA. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3503-3508. PMID: 28289216.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  28. Lu X, Li J, Li H, Chen Y, Wang L, He M, Wang Y, Sun L, Hu Y, Huang J, Wang F, Liu X, Chen S, Yu K, Yang X, Mo Z, Lin X, Wu T, Gu D. Coding-sequence variants are associated with blood lipid levels in 14,473 Chinese. Hum Mol Genet. 2016 09 15; 25(18):4107-4116. PMID: 27516387.
    Citations:    
  29. Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, Chen W, Yuan J, Zhang B, Kuang D, He X, Bai Y, Han X, Liu B, Li X, Yang L, Jiang H, Zhang Y, Hu J, Cheng L, Luo X, Mei W, Zhou Z, Sun S, Zhang L, Liu C, Guo Y, Zhang Z, Hu FB, Liang L, Wu T. Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. Environ Health Perspect. 2016 07; 124(7):966-73. PMID: 26756918.
    Citations: 12     Fields:    Translation:HumansCells
  30. Han X, Gui L, Liu B, Wang J, Li Y, Dai X, Li J, Yang B, Qiu G, Feng J, Zhang X, Wu T, He M. Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk. BMC Genet. 2015 Jan 30; 16:4. PMID: 25634581.
    Citations:    
  31. He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet. 2015 Mar 15; 24(6):1791-800. PMID: 25429064.
    Citations: 12     Fields:    Translation:Humans
  32. Feng W, He X, Chen M, Deng S, Qiu G, Li X, Liu C, Li J, Deng Q, Huang S, Wang T, Dai X, Yang B, Yuan J, He M, Zhang X, Chen W, Kan H, Wu T. Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China. Environ Health Perspect. 2015 Mar; 123(3):217-22. PMID: 25356836.
    Citations:    
  33. Gui L, Wu F, Han X, Dai X, Qiu G, Li J, Wang J, Zhang X, Wu T, He M. A multilocus genetic risk score predicts coronary heart disease risk in a Chinese Han population. Atherosclerosis. 2014 Dec; 237(2):480-5. PMID: 25463077.
    Citations:    
  34. Feng J, Huang S, He M, Dai X, Li J, Deng Q, Qiu G, Yang B, Wu T. [Analysis on the association of single nucleotide polymorphism in the promoter region of pre-miR-320b-2 with coronary heart disease risk and factors influencing circulating microRNA-320b level]. Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Oct; 48(10):893-9. PMID: 25573129.
    Citations:    
  35. Deng S, Deng Q, Hu D, Li J, Zhu X, Guo H, Wu T. [Association between urinary polycyclic aromatic hydrocarbon metabolites and elevated serum uric acid levels in coke oven workers]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Jun; 32(6):406-10. PMID: 25169220.
    Citations:    
  36. Dai X, Deng S, Wang T, Qiu G, Li J, Yang B, Feng W, He X, Deng Q, Ye J, Zhang W, He M, Zhang X, Guo H, Wu T. Associations between 25 lung cancer risk-related SNPs and polycyclic aromatic hydrocarbon-induced genetic damage in coke oven workers. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):986-96. PMID: 24692499.
    Citations:    
  37. Deng Q, Huang S, Zhang X, Zhang W, Feng J, Wang T, Hu D, Guan L, Li J, Dai X, Deng H, Zhang X, Wu T. Plasma microRNA expression and micronuclei frequency in workers exposed to polycyclic aromatic hydrocarbons. Environ Health Perspect. 2014 Jul; 122(7):719-25. PMID: 24633190.
    Citations:    
  38. Huang S, Chen M, Li L, He M, Hu D, Zhang X, Li J, Tanguay RM, Feng J, Cheng L, Zeng H, Dai X, Deng Q, Hu FB, Wu T. Circulating MicroRNAs and the occurrence of acute myocardial infarction in Chinese populations. Circ Cardiovasc Genet. 2014 Apr; 7(2):189-98. PMID: 24627568.
    Citations: 12     Fields:    Translation:Humans
  39. Yang B, Mo Z, Wu C, Yang H, Yang X, He Y, Gui L, Zhou L, Guo H, Zhang X, Yuan J, Dai X, Li J, Qiu G, Huang S, Deng Q, Feng Y, Guan L, Hu D, Zhang X, Wang T, Zhu J, Min X, Lang M, Li D, Hu FB, Lin D, Wu T, He M. A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC Med Genomics. 2014 Feb 11; 7:10. PMID: 24513273.
    Citations: 19     Fields:    Translation:Humans
  40. Li J, Gui L, Wu C, He Y, Zhou L, Guo H, Yuan J, Yang B, Dai X, Deng Q, Huang S, Guan L, Hu D, Deng S, Wang T, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T, He M. Genome-wide association study on serum alkaline phosphatase levels in a Chinese population. BMC Genomics. 2013 Oct 05; 14:684. PMID: 24094242.
    Citations: 4     Fields:    Translation:HumansCells
  41. Dai X, Wu C, He Y, Gui L, Zhou L, Guo H, Yuan J, Yang B, Li J, Deng Q, Huang S, Guan L, Hu D, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T, He M. A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Genet Epidemiol. 2013 Apr; 37(3):293-300. PMID: 23371916.
    Citations: 11     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.