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Jun Li, M.D., Ph.D.

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Biography
Tongji Medical College, Huazhong University of Science and Technology, ChinaMD06/2011Preventive Medicine
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, ChinaPhD06/2016Cardiovascular Epidemiology and Environmental Health
Harvard T.H. Chan School of Public Health, Boston, MAPostdoc fellow01/2020Cardiometabolic Disease Epidemiology, Integrated Omics
Harvard T.H. Chan School of Public Health, Boston, MAResearch Scientist03/2022Cardiometabolic Disease Epidemiology, Integrated Omics
2023
The Mark Bieber Award
2020
The “Reviewers’ Choice” Award
2020
Scott Grundy Fellowship Award for Excellence in Metabolism Research
2019
The Jeremiah and Rose Stamler Research Award winner
2019
The Barry R. and Irene Tilenius Bloom Fellowship Award
2018
The Postdoc Association Travel Award
2015
Best Young Investigators
2014
The Bernard Lown Scholarship in Cardiovascular Health Program

Overview
As an epidemiologist with medical training, Dr. Li is experienced and committed to the research of diabetes and cardiovascular disease prevention, with particular interests and expertise in integrating state-of-the-art multi-omics technologies and advanced analytics under the framework of systems epidemiology, aiming to identify novel risk factors, understand disease etiology and mechanisms through which risk factors impact health, and to inform the development of personalized preventive and therapeutic strategies. In the past few years, Dr. Li has been leading multiple projects in large population cohorts and interventional trials including the UK Biobank, Nurses’ Health Studies, Health Professionals Follow-up Study, the PREDIMED study, and the Hispanic Community Health Study/Study of Latinos, among others. Dr. Li was awarded the Jeremiah and Rose Stamler Research Award and the Mark Bieber Award by the American Heart Association. She is actively involved in teaching activities at the Harvard T.H. Chan School of Public Health. Her current research projects include:

1. integrating multi-omics data (transcriptomics, metabolomics, and metagenomics) to examine mechanisms through which diet and lifestyles affect risk of cardiovascular disease, diabetes, and cognitive decline;
2. employing large-scale genetic, transcriptomic, and proteomic data to examine biological risk factors and pathways relevant to the development cardiovascular disease and diabetes;
3. using polygenic risk prediction for complex disease to identify high-risk populations and examine effective diet/lifestyle intervention strategies for disease prevention among high genetic risk groups.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA272452 (TOBIAS, DEIRDRE K.; GIOVANNUCCI, EDWARD L.; ZHANG, XUEHONG) Sep 20, 2022 - Aug 31, 2027
    NIH
    Decoding mechanisms underlying metabolic dysregulation in obesity and digestive cancer risk
    Role Description: This project will identify novel inflammotypes for metabolically unhealthy obesity and examine their associations with risk of digestive cancers, in multiple large prospective cohort studies.
    Role: Co-Investigator
  2. R00DK122128 (LI, JUN) Mar 15, 2022 - Mar 14, 2025
    NIH
    Chronic Inflammation and Type 2 Diabetes: A Multi-omics Approach
    Role Description: This study aims to systematically examine the relationship between chronic inflammation and type 2 diabetes, integrating genomics, transcriptomics, metabolomics, and proteomics data in several large US and European prospective cohorts. Novel cutting-edge methodologies will be used for analyses to gain new insight into diabetes pathophysiology and individualized prevention.
    Role: Principal Investigator
  3. U2CDK129670 (HU, FRANK B) Aug 16, 2021 - Jun 30, 2026
    NIH
    Dietary Biomarkers Development Center at Harvard University
    Role Description: We will establish a state-of-the-art Dietary Biomarker Development Center at Harvard University to systematically catalog validated metabolomic signatures of important food sources of protein and carbohydrates in the US diets.
    Role: Co-Investigator
  4. K99DK122128 (LI, JUN) Sep 1, 2019 - May 31, 2022
    NIH
    Chronic Inflammation and Type 2 Diabetes: A Multi-omics Approach
    Role: Principal Investigator
  5. 2P30DK046200-26 (LI, JUN) Dec 1, 2018 - Nov 30, 2021
    Boston Nutrition Obesity Research Center - Pilot and Feasibility Award Program
    Chronic Inflammation and Obesity: Genetic Susceptibility and the Role of Diet
    Role Description: This pilot study will combine new genomic approaches with epidemiological studies, to examine the relations between chronic inflammation with obesity and its co-morbidities, and whether dietary inflammatory potentials interact with polygenic risk in influencing long-term weight gain.
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.