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Lee Rubin, Ph.D.

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Other Positions
Title
Institution
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. RC4DK090781 (MELTON, DOUGLAS A) Sep 25, 2010 - Sep 30, 2013
    NIH
    Identification of Genes and Compounds That Control Beta Cell Replication
    Role: Co-Principal Investigator
  2. P01NS066888 (VAN VACTOR, DAVID L.) Aug 1, 2010 - Jul 31, 2016
    NIH
    Genetic Modeling for SMA Therapeutic Pathways
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rapino F, Natoli T, Limone F, O'Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O'Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes. Stem Cell Reports. 2023 01 10; 18(1):237-253. PMID: 36563689; PMCID: PMC9860128.
    Citations:    Fields:    Translation:Cells
  2. Spetz JKE, Florido MHC, Fraser CS, Qin X, Choiniere J, Yu SJ, Singh R, Friesen M, Rubin LL, Salem JE, Moslehi JJ, Sarosiek KA. Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities. Sci Adv. 2022 11 11; 8(45):eabn6579. PMID: 36351019; PMCID: PMC9645721.
    Citations:    Fields:    Translation:HumansCells
  3. Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJ. Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Sci Transl Med. 2022 08 31; 14(660):eabj1531. PMID: 36044597; PMCID: PMC9985140.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Gardezi M, Moore HG, Rubin LE, Grauer JN. Predictors of Physical Abuse in Elder Patients With Fracture. J Am Acad Orthop Surg Glob Res Rev. 2022 07 01; 6(7). PMID: 35819835; PMCID: PMC9278940.
    Citations:    Fields:    Translation:Humans
  5. Moore HG, Burroughs PJ, Rubin LE, Frumberg DB, Sculco PK, Grauer JN. Patients With Ehlers-Danlos Syndromes Experience Higher Rates of Prosthetic Dislocation After Total Hip Arthroplasty and Worse Implant Survival at 5 Years. J Am Acad Orthop Surg. 2022 Feb 15; 30(4):177-183. PMID: 34967762.
    Citations: 1     Fields:    Translation:Humans
  6. Mercier MR, Galivanche AR, Brand JP, Pathak N, Medvecky MJ, Varthi AG, Rubin LE, Grauer JN. COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery. PLoS One. 2021; 16(12):e0262115. PMID: 34972190; PMCID: PMC8719674.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  7. Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R. Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep. 2021 12 28; 37(13):110176. PMID: 34965416; PMCID: PMC8763642.
    Citations: 1     Fields:    Translation:HumansCells
  8. Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, Ivanis J, Huebner EA, Arvanites A, Oza V, Davidow L, Maeda R, Sakuma M, Grantham A, Wang Q, Chang AN, Pfaff K, Costigan M, Coppola G, Rubin LL, Schwer B, Alt FW, Woolf CJ. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Rep. 2021 09 07; 36(10):109666. PMID: 34496254; PMCID: PMC8462619.
    Citations:    Fields:    Translation:AnimalsCells
  9. Mayweather BA, Buchanan SM, Rubin LL. GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis. Mol Brain. 2021 09 06; 14(1):134. PMID: 34488822; PMCID: PMC8422669.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Sadegh C, Ebina W, Arvanites AC, Davidow LS, Rubin LL, Macklis JD. Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells. PLoS One. 2021; 16(9):e0254113. PMID: 34473715.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Tomov ML, O'Neil A, Abbasi HS, Cimini BA, Carpenter AE, Rubin LL, Bathe M. Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Commun Biol. 2021 06 24; 4(1):786. PMID: 34168275.
    Citations: 2     Translation:HumansAnimalsCells
  12. Yuan W, Beaulieu-Jones B, Krolewski R, Palmer N, Veyrat-Follet C, Frau F, Cohen C, Bozzi S, Cogswell M, Kumar D, Coulouvrat C, Leroy B, Fischer TZ, Sardi SP, Chandross KJ, Rubin LL, Wills AM, Kohane I, Lipnick SL. Accelerating diagnosis of Parkinson's disease through risk prediction. BMC Neurol. 2021 May 18; 21(1):201. PMID: 34006233; PMCID: PMC8130278.
    Citations: 2     Fields:    Translation:Humans
  13. Kebaish KJ, Galivanche AR, Varthi AG, Ottesen TD, Rubin LE, Grauer JN. Long-term Corticosteroid Use Independently Correlates With Complications After Posterior Lumbar Spine Surgery. Orthopedics. 2021 May-Jun; 44(3):172-179. PMID: 34039214.
    Citations:    Fields:    Translation:Humans
  14. Almada AE, Horwitz N, Price FD, Gonzalez AE, Ko M, Bolukbasi OV, Messemer KA, Chen S, Sinha M, Rubin LL, Wagers AJ. FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Rep. 2021 01 26; 34(4):108656. PMID: 33503437; PMCID: PMC9112118.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Buchanan SM, Price FD, Castiglioni A, Gee AW, Schneider J, Matyas MN, Hayhurst M, Tabebordbar M, Wagers AJ, Rubin LL. Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells. Skelet Muscle. 2020 10 09; 10(1):28. PMID: 33036659.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Walsh MB, Janzen E, Wingrove E, Hosseinibarkooie S, Muela NR, Davidow L, Dimitriadi M, Norabuena EM, Rubin LL, Wirth B, Hart AC. Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy. BMC Biol. 2020 09 16; 18(1):127. PMID: 32938453.
    Citations: 4     Fields:    Translation:Animals
  17. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 Jul 02; 27(1):178-180. PMID: 32619513.
    Citations: 2     Fields:    
  18. Malpani R, Mclynn RP, Bovonratwet P, Bagi PS, Yurter A, Mercier MR, Rubin LE, Grauer JN. Coagulopathies Are a Risk Factor for Adverse Events Following Total Hip and Total Knee Arthroplasty. Orthopedics. 2020 Jul 01; 43(4):233-238. PMID: 32674174.
    Citations:    Fields:    Translation:Humans
  19. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020 07 02; 27(1):147-157.e7. PMID: 32413331.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Ahfeldt T, Ordureau A, Bell C, Sarrafha L, Sun C, Piccinotti S, Grass T, Parfitt GM, Paulo JA, Yanagawa F, Uozumi T, Kiyota Y, Harper JW, Rubin LL. Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons. Stem Cell Reports. 2020 01 14; 14(1):75-90. PMID: 31902706.
    Citations: 14     Fields:    Translation:HumansCells
  21. Koutmani Y, Gampierakis IA, Polissidis A, Ximerakis M, Koutsoudaki PN, Polyzos A, Agrogiannis G, Karaliota S, Thomaidou D, Rubin LL, Politis PK, Karalis KP. CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus. Cell Rep. 2019 10 22; 29(4):932-945.e7. PMID: 31644914.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Ximerakis M, Lipnick SL, Innes BT, Simmons SK, Adiconis X, Dionne D, Mayweather BA, Nguyen L, Niziolek Z, Ozek C, Butty VL, Isserlin R, Buchanan SM, Levine SS, Regev A, Bader GD, Levin JZ, Rubin LL. Single-cell transcriptomic profiling of the aging mouse brain. Nat Neurosci. 2019 10; 22(10):1696-1708. PMID: 31551601.
    Citations: 108     Fields:    Translation:AnimalsCells
  23. Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, Agar NYR, Rubin LL, Qi J, Merk DJ, Segal RA. A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma. Neuro Oncol. 2019 09 06; 21(9):1150-1163. PMID: 31111916.
    Citations: 12     Fields:    Translation:AnimalsCells
  24. Watts ME, Wu C, Rubin LL. Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics. J Exp Neurosci. 2019; 13:1179069519862798. PMID: 31320806; PMCID: PMC6624916.
    Citations: 5     
  25. Yang SJ, Lipnick SL, Makhortova NR, Venugopalan S, Fan M, Armstrong Z, Schlaeger TM, Deng L, Chung WK, O'Callaghan L, Geraschenko A, Whye D, Berndl M, Hazard J, Williams B, Narayanaswamy A, Ando DM, Nelson P, Rubin LL. Applying Deep Neural Network Analysis to High-Content Image-Based Assays. SLAS Discov. 2019 09; 24(8):829-841. PMID: 31284814; PMCID: PMC6710615.
    Citations: 6     Fields:    Translation:Humans
  26. Idkowiak-Baldys J, Santhanam U, Buchanan SM, Pfaff KL, Rubin LL, Lyga J. Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology. PLoS One. 2019; 14(6):e0218035. PMID: 31181098; PMCID: PMC6557520.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Lipnick SL, Agniel DM, Aggarwal R, Makhortova NR, Finlayson SG, Brocato A, Palmer N, Darras BT, Kohane I, Rubin LL. Systemic nature of spinal muscular atrophy revealed by studying insurance claims. PLoS One. 2019; 14(3):e0213680. PMID: 30870495.
    Citations: 19     Fields:    Translation:Humans
  28. Howell K, Gibbs RM, Rubin LL. Spinal Muscular Atrophy: Huge Steps. Cerebrum. 2019 Mar-Apr; 2019. PMID: 32206168; PMCID: PMC7075499.
    Citations:    
  29. Wu C, Watts ME, Rubin LL. MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis. Cell Rep. 2019 01 29; 26(5):1143-1156.e5. PMID: 30699345.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  30. Ozek C, Krolewski RC, Buchanan SM, Rubin LL. Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. Sci Rep. 2018 11 23; 8(1):17293. PMID: 30470794; PMCID: PMC6251885.
    Citations: 28     Fields:    Translation:AnimalsCells
  31. Benkler C, O'Neil AL, Slepian S, Qian F, Weinreb PH, Rubin LL. Aggregated SOD1 causes selective death of cultured human motor neurons. Sci Rep. 2018 11 06; 8(1):16393. PMID: 30401824.
    Citations: 15     Fields:    Translation:HumansCells
  32. Darnell M, O'Neil A, Mao A, Gu L, Rubin LL, Mooney DJ. Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8368-E8377. PMID: 30120125; PMCID: PMC6130338.
    Citations: 33     Fields:    Translation:AnimalsCells
  33. Shin HY, Pfaff KL, Davidow LS, Sun C, Uozumi T, Yanagawa F, Yamazaki Y, Kiyota Y, Rubin LL. Using Automated Live Cell Imaging to Reveal Early Changes during Human Motor Neuron Degeneration. eNeuro. 2018 May-Jun; 5(3). PMID: 29971247.
    Citations: 3     Fields:    Translation:HumansCells
  34. Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL. Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest. 2018 07 02; 128(7):3008-3023. PMID: 29672276; PMCID: PMC6025996.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. Gibbs RM, Lipnick S, Bateman JW, Chen L, Cousins HC, Hubbard EG, Jowett G, LaPointe DS, McGredy MJ, Odonkor MN, Repetti G, Thomas E, Rubin LL. Toward Precision Medicine for Neurological and Neuropsychiatric Disorders. Cell Stem Cell. 2018 07 05; 23(1):21-24. PMID: 29887317.
    Citations: 14     Fields:    Translation:HumansCells
  36. Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW. Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. 2018 04 19; 70(2):211-227.e8. PMID: 29656925.
    Citations: 60     Fields:    Translation:HumansCells
  37. Christiansen EM, Yang SJ, Ando DM, Javaherian A, Skibinski G, Lipnick S, Mount E, O'Neil A, Shah K, Lee AK, Goyal P, Fedus W, Poplin R, Esteva A, Berndl M, Rubin LL, Nelson P, Finkbeiner S. In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images. Cell. 2018 04 19; 173(3):792-803.e19. PMID: 29656897.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  38. Paik EJ, O'Neil AL, Ng SY, Sun C, Rubin LL. Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture. Sci Rep. 2018 01 16; 8(1):804. PMID: 29339826.
    Citations: 9     Fields:    Translation:HumansCells
  39. Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger JR, Moran MF, Rubin LL, Miller FD, Kaplan DR. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017 11 06; 216(11):3655-3675. PMID: 28877995; PMCID: PMC5674898.
    Citations: 10     Fields:    Translation:AnimalsCells
  40. Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-ß1. Stem Cell Reports. 2017 08 08; 9(2):667-680. PMID: 28712846; PMCID: PMC5549875.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  41. Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez A. Subtly Modulating Glycogen Synthase Kinase 3 ß: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 2017 06 22; 60(12):4983-5001. PMID: 28548834.
    Citations: 22     Fields:    Translation:HumansCells
  42. Rodriguez-Muela N, Litterman NK, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LL. Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease. Cell Rep. 2017 02 07; 18(6):1484-1498. PMID: 28178525.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  43. d'Ydewalle C, Ramos DM, Pyles NJ, Ng SY, Gorz M, Pilato CM, Ling K, Kong L, Ward AJ, Rubin LL, Rigo F, Bennett CF, Sumner CJ. The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy. Neuron. 2017 Jan 04; 93(1):66-79. PMID: 28017471.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  44. Rigamonti A, Repetti GG, Sun C, Price FD, Reny DC, Rapino F, Weisinger K, Benkler C, Peterson QP, Davidow LS, Hansson EM, Rubin LL. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016 06 14; 6(6):993-1008. PMID: 27304920.
    Citations: 35     Fields:    Translation:HumansCells
  45. Ahfeldt T, Litterman NK, Rubin LL. Studying human disease using human neurons. Brain Res. 2017 02 01; 1656:40-48. PMID: 27060768; PMCID: PMC5053850.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  46. Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 01; 118(7):1125-41; discussion 1142. PMID: 27034275; PMCID: PMC4818972.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  47. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945. PMID: 26610635; PMCID: PMC4881284.
    Citations: 34     Fields:    Translation:HumansCells
  48. Ng SY, Soh BS, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LL. Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell. 2015 Nov 05; 17(5):569-84. PMID: 26321202.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  49. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015 Jul; 21(7):760-8. PMID: 26076036; PMCID: PMC4496292.
    Citations: 121     Fields:    Translation:HumansCells
  50. Katsimpardi L, Rubin LL. Young systemic factors as a medicine for age-related neurodegenerative diseases. Neurogenesis (Austin). 2015; 2(1):e1004971. PMID: 27502604; PMCID: PMC4973601.
    Citations: 4     
  51. Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. PMID: 25437882.
    Citations: 194     Fields:    Translation:HumansCells
  52. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066; PMCID: PMC4429606.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  53. Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, Brock M, Lipnick S, Rao M, Chang S, Li A, Noggle SA. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Rep. 2014 Nov 20; 9(4):1173-82. PMID: 25456120.
    Citations: 103     Fields:    Translation:HumansCells
  54. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Reversal of ß cell de-differentiation by a small molecule inhibitor of the TGFß pathway. Elife. 2014 Sep 16; 3:e02809. PMID: 25233132; PMCID: PMC4204634.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  55. Naryshkin NA, Weetall M, Dakka A, Narasimhan J, Zhao X, Feng Z, Ling KK, Karp GM, Qi H, Woll MG, Chen G, Zhang N, Gabbeta V, Vazirani P, Bhattacharyya A, Furia B, Risher N, Sheedy J, Kong R, Ma J, Turpoff A, Lee CS, Zhang X, Moon YC, Trifillis P, Welch EM, Colacino JM, Babiak J, Almstead NG, Peltz SW, Eng LA, Chen KS, Mull JL, Lynes MS, Rubin LL, Fontoura P, Santarelli L, Haehnke D, McCarthy KD, Schmucki R, Ebeling M, Sivaramakrishnan M, Ko CP, Paushkin SV, Ratni H, Gerlach I, Ghosh A, Metzger F. Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014 Aug 08; 345(6197):688-93. PMID: 25104390.
    Citations: 204     Fields:    Translation:HumansAnimalsCells
  56. Cherry JJ, Kobayashi DT, Lynes MM, Naryshkin NN, Tiziano FD, Zaworski PG, Rubin LL, Jarecki J. Assays for the identification and prioritization of drug candidates for spinal muscular atrophy. Assay Drug Dev Technol. 2014 Aug; 12(6):315-41. PMID: 25147906.
    Citations: 13     Fields:    Translation:HumansAnimals
  57. Ichida JK, Tcw J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-639. PMID: 24952596; PMCID: PMC4310751.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  58. Gould SE, Low JA, Marsters JC, Robarge K, Rubin LL, de Sauvage FJ, Sutherlin DP, Wong H, Yauch RL. Discovery and preclinical development of vismodegib. Expert Opin Drug Discov. 2014 Aug; 9(8):969-84. PMID: 24857041.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  59. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 09; 344(6184):630-4. PMID: 24797482.
    Citations: 394     Fields:    Translation:AnimalsCells
  60. Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2371-80. PMID: 23757500.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  61. Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 06; 12(6):713-26. PMID: 23602540; PMCID: PMC3707511.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  62. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 07; 12(2):238-51. PMID: 23246482.
    Citations: 235     Fields:    Translation:HumansCells
  63. Wang Y, Davidow L, Arvanites AC, Blanchard J, Lam K, Xu K, Oza V, Yoo JW, Ng JM, Curran T, Rubin LL, McMahon AP. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012 Aug 24; 19(8):972-82. PMID: 22921064.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  64. Hayhurst M, Wagner AK, Cerletti M, Wagers AJ, Rubin LL. A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol. 2012 Aug 15; 368(2):323-34. PMID: 22705478.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  65. Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo JW, Coy S, Rubin LL, McMahon AP. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15; 7(6):1040-8. PMID: 22554036.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  66. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3915-20. PMID: 22345561; PMCID: PMC3309788.
    Citations: 72     Fields:    Translation:AnimalsCells
  67. Chen PC, Gaisina IN, El-Khodor BF, Ramboz S, Makhortova NR, Rubin LL, Kozikowski AP. Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of ?7 SMA KO Mouse Model of Spinal Muscular Atrophy. ACS Chem Neurosci. 2012 Jan 18; 3(1):5-11. PMID: 22348181.
    Citations: 14     Fields:    
  68. Makhortova NR, Hayhurst M, Cerqueira A, Sinor-Anderson AD, Zhao WN, Heiser PW, Arvanites AC, Davidow LS, Waldon ZO, Steen JA, Lam K, Ngo HD, Rubin LL. A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 2011 Jun 19; 7(8):544-52. PMID: 21685895.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  69. Rubin LL, Haston KM. Stem cell biology and drug discovery. BMC Biol. 2011 Jun 07; 9:42. PMID: 21649940.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  70. Tang T, Tang JY, Li D, Reich M, Callahan CA, Fu L, Yauch RL, Wang F, Kotkow K, Chang KS, Shpall E, Wu A, Rubin LL, Marsters JC, Epstein EH, Caro I, de Sauvage FJ. Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res. 2011 May 15; 17(10):3378-87. PMID: 21558397.
    Citations: 29     Fields:    Translation:HumansAnimalsCTClinical Trials
  71. Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, Rubin LL, Misawa H, Tabin CJ, Brown R, Chen A, Hornstein E. miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13111-6. PMID: 20616011.
    Citations: 157     Fields:    Translation:AnimalsCells
  72. Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, Schier AF. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science. 2010 Jan 15; 327(5963):348-51. PMID: 20075256.
    Citations: 268     Fields:    Translation:AnimalsCells
  73. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503. PMID: 19818703.
    Citations: 344     Fields:    Translation:AnimalsCells
  74. Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC, Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, Xie M. GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5576-81. PMID: 19716296.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  75. Brunton SA, Stibbard JH, Rubin LL, Guicherit OM, Kruse LI, Price S, di Lucrezia R, MacKinnon CH, Avery A, Park Y, Buxton D, Boyd EA. Potent agonists of the Hedgehog signaling pathway. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4308-11. PMID: 19500978.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  76. Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65. PMID: 19287398.
    Citations: 199     Fields:    Translation:HumansAnimalsCells
  77. Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ. A paracrine requirement for hedgehog signalling in cancer. Nature. 2008 Sep 18; 455(7211):406-10. PMID: 18754008.
    Citations: 455     Fields:    Translation:HumansAnimalsCells
  78. Rubin LL. Stem cells and drug discovery: the beginning of a new era? Cell. 2008 Feb 22; 132(4):549-52. PMID: 18295572.
    Citations: 56     Fields:    Translation:AnimalsCells
  79. Brunton SA, Stibbard JH, Rubin LL, Kruse LI, Guicherit OM, Boyd EA, Price S. Potent inhibitors of the hedgehog signaling pathway. J Med Chem. 2008 Mar 13; 51(5):1108-10. PMID: 18275133.
    Citations: 6     Fields:    Translation:AnimalsCells
  80. Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov. 2006 Dec; 5(12):1026-33. PMID: 17139287.
    Citations: 316     Fields:    Translation:HumansAnimalsCells
  81. Deshpande DM, Kim YS, Martinez T, Carmen J, Dike S, Shats I, Rubin LL, Drummond J, Krishnan C, Hoke A, Maragakis N, Shefner J, Rothstein JD, Kerr DA. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol. 2006 Jul; 60(1):32-44. PMID: 16802299.
    Citations: 74     Fields:    Translation:AnimalsCells
  82. Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF. Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J Neurosci. 2006 Mar 22; 26(12):3256-68. PMID: 16554476; PMCID: PMC6674087.
    Citations: 45     Fields:    Translation:AnimalsCells
  83. Dellovade T, Romer JT, Curran T, Rubin LL. The hedgehog pathway and neurological disorders. Annu Rev Neurosci. 2006; 29:539-63. PMID: 16776596.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  84. Paladini RD, Saleh J, Qian C, Xu GX, Rubin LL. Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. J Invest Dermatol. 2005 Oct; 125(4):638-46. PMID: 16185261.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  85. Schnapp E, Kragl M, Rubin L, Tanaka EM. Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration. Development. 2005 Jul; 132(14):3243-53. PMID: 15983402.
    Citations: 57     Fields:    Translation:AnimalsCells
  86. Dvash T, Mayshar Y, Darr H, McElhaney M, Barker D, Yanuka O, Kotkow KJ, Rubin LL, Benvenisty N, Eiges R. Temporal gene expression during differentiation of human embryonic stem cells and embryoid bodies. Hum Reprod. 2004 Dec; 19(12):2875-83. PMID: 15375076.
    Citations: 35     Fields:    Translation:HumansCells
  87. Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran T. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell. 2004 Sep; 6(3):229-40. PMID: 15380514.
    Citations: 197     Fields:    Translation:AnimalsCells
  88. Lin LF, Rubin LL, Xu M. A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. J Neurochem. 2004 Jun; 89(6):1387-95. PMID: 15189341.
    Citations:    Fields:    Translation:AnimalsCells
  89. Kessaris N, Jamen F, Rubin LL, Richardson WD. Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development. 2004 Mar; 131(6):1289-98. PMID: 14960493.
    Citations: 48     Fields:    Translation:AnimalsCells
  90. Gabay L, Lowell S, Rubin LL, Anderson DJ. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron. 2003 Oct 30; 40(3):485-99. PMID: 14642274.
    Citations: 103     Fields:    Translation:AnimalsCells
  91. Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron. 2003 Sep 11; 39(6):937-50. PMID: 12971894.
    Citations: 256     Fields:    Translation:AnimalsCells
  92. Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4616-21. PMID: 12679522.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  93. Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14. PMID: 12588889; PMCID: PMC151919.
    Citations: 33     Fields:    Translation:HumansAnimals
  94. Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol. 2002 Nov 06; 1(2):10. PMID: 12437772; PMCID: PMC137065.
    Citations: 176     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.