Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileLee Rubin, Ph.D.

TitleProfessor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressHarvard Stem Cell Center
Sherman Fairchild Biochemistry Bldg
7 Divinity Ave
Cambridge MA 02138
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Other Positions
TitleDirector of Translational Medicine of the Harvard Stem Cell Institute
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell Institute

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
RC4DK090781     (MELTON, DOUGLAS A)Sep 25, 2010 - Sep 30, 2013
Identification of Genes and Compounds That Control Beta Cell Replication
Role: Co-Principal Investigator

P01NS066888     (VAN VACTOR, DAVID L.)Aug 1, 2010 - Jul 31, 2015
Genetic Modeling for SMA Therapeutic Pathways
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rigamonti A, Repetti GG, Sun C, Price FD, Reny DC, Rapino F, Weisinger K, Benkler C, Peterson QP, Davidow LS, Hansson EM, Rubin LL. Large-Scale Production of Mature Neurons from Human Pluripotent Stem Cells in a Three-Dimensional Suspension Culture System. Stem Cell Reports. 2016 Jun 14; 6(6):993-1008. PMID: 27304920.
    View in: PubMed
  2. Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Circ Res. 2016 Apr 1; 118(7):1125-41; discussion 1142. PMID: 27034275.
    View in: PubMed
  3. Ng SY, Soh BS, Rodriguez-Muela N, Hendrickson DG, Price F, Rinn JL, Rubin LL. Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy. Cell Stem Cell. 2015 Nov 5; 17(5):569-84. PMID: 26321202.
    View in: PubMed
  4. Katsimpardi L, Rubin LL. Young systemic factors as a medicine for age-related neurodegenerative diseases. Neurogenesis (Austin). 2015; 2(1):e1004971. PMID: 27502604.
    View in: PubMed
  5. Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. PMID: 25437882; PMCID: PMC4329913.
  6. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066; PMCID: PMC4429606.
  7. Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Reversal of ß cell de-differentiation by a small molecule inhibitor of the TGFß pathway. Elife. 2014; 3:e02809. PMID: 25233132; PMCID: PMC4204634.
  8. Ichida JK, TCW J, T C W J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-9. PMID: 24952596; PMCID: PMC4310751.
  9. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 9; 344(6184):630-4. PMID: 24797482; PMCID: PMC4123747.
  10. Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2371-80. PMID: 23757500; PMCID: PMC3696827.
  11. Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 6; 12(6):713-26. PMID: 23602540; PMCID: PMC3707511.
  12. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 7; 12(2):238-51. PMID: 23246482; PMCID: PMC3570604.
  13. Wang Y, Davidow L, Arvanites AC, Blanchard J, Lam K, Xu K, Oza V, Yoo JW, Ng JM, Curran T, Rubin LL, McMahon AP. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012 Aug 24; 19(8):972-82. PMID: 22921064; PMCID: PMC3724998.
  14. Hayhurst M, Wagner AK, Cerletti M, Wagers AJ, Rubin LL. A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol. 2012 Aug 15; 368(2):323-34. PMID: 22705478; PMCID: PMC3851302.
  15. Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo JW, Coy S, Rubin LL, McMahon AP. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15; 7(6):1040-8. PMID: 22554036; PMCID: PMC3905677.
  16. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3915-20. PMID: 22345561; PMCID: PMC3309788.
  17. Makhortova NR, Hayhurst M, Cerqueira A, Sinor-Anderson AD, Zhao WN, Heiser PW, Arvanites AC, Davidow LS, Waldon ZO, Steen JA, Lam K, Ngo HD, Rubin LL. A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 2011 Aug; 7(8):544-52. PMID: 21685895; PMCID: PMC3236614.
  18. Rubin LL, Haston KM. Stem cell biology and drug discovery. BMC Biol. 2011; 9:42. PMID: 21649940; PMCID: PMC3110139.
  19. Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, Schier AF. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science. 2010 Jan 15; 327(5963):348-51. PMID: 20075256; PMCID: PMC2830481.
  20. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 6; 5(5):491-503. PMID: 19818703; PMCID: PMC3335195.
  21. Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65. PMID: 19287398.
    View in: PubMed
  22. Rubin LL. Stem cells and drug discovery: the beginning of a new era? Cell. 2008 Feb 22; 132(4):549-52. PMID: 18295572.
    View in: PubMed
  23. Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov. 2006 Dec; 5(12):1026-33. PMID: 17139287.
    View in: PubMed
  24. Lin LF, Rubin LL, Xu M. A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. J Neurochem. 2004 Jun; 89(6):1387-95. PMID: 15189341.
    View in: PubMed
  25. Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4616-21. PMID: 12679522; PMCID: PMC153604.
  26. Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol. 2002 Nov 6; 1(2):10. PMID: 12437772; PMCID: PMC137065.
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