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Joanna A Korecka-Roet, Ph.D.

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Biography
VU University of Amsterdam, The NetherlandsPhD01/2013Neuroscience
2019
The Alfred Pope Award
2022 - 2023
Silva Family Ataxia Scholar

Overview
I focus my research on understanding the functional interplay of aberrant cellular mechanisms in neurodegenerative diseases and gene therapy advancement

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brekk OR, Korecka JA, Crapart CC, Huebecker M, MacBain ZK, Rosenthal SA, Sena-Esteves M, Priestman DA, Platt FM, Isacson O, Hallett PJ. Upregulating ß-hexosaminidase activity in rodents prevents a-synuclein lipid associations and protects dopaminergic neurons from a-synuclein-mediated neurotoxicity. Acta Neuropathol Commun. 2020 08 06; 8(1):127. PMID: 32762772; PMCID: PMC7409708.
    Citations: 6     Fields:    Translation:AnimalsCells
  2. Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice. Mol Ther Nucleic Acids. 2020 Sep 04; 21:623-635. PMID: 32736291.
    Citations: 10     
  3. Korecka JA, Thomas R, Christensen DP, Hinrich AJ, Ferrari EJ, Levy SA, Hastings ML, Hallett PJ, Isacson O. Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts. Hum Mol Genet. 2019 10 01; 28(19):3232-3243. PMID: 31261377; PMCID: PMC6859523.
    Citations: 17     Fields:    Translation:HumansCells
  4. Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O. Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation. Stem Cell Reports. 2019 01 08; 12(1):29-41. PMID: 30595548; PMCID: PMC6335600.
    Citations: 22     Fields:    Translation:HumansCells
  5. Verhaagen J, Hobo B, Ehlert EME, Eggers R, Korecka JA, Hoyng SA, Attwell CL, Harvey AR, Mason MRJ. Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System. Methods Mol Biol. 2018; 1715:3-17. PMID: 29188502.
    Citations: 5     Fields:    Translation:HumansCells
  6. Korecka JA, Moloney EB, Eggers R, Hobo B, Scheffer S, Ras-Verloop N, Pasterkamp RJ, Swaab DF, Smit AB, van Kesteren RE, Bossers K, Verhaagen J. Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease. J Neurosci. 2017 09 27; 37(39):9361-9379. PMID: 28842419; PMCID: PMC6596765.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Korecka JA, Levy S, Isacson O. In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells. Mol Cell Neurosci. 2016 06; 73:3-12. PMID: 26691153.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  8. Korecka JA, van Kesteren RE, Blaas E, Spitzer SO, Kamstra JH, Smit AB, Swaab DF, Verhaagen J, Bossers K. Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013; 8(5):e63862. PMID: 23724009.
    Citations: 101     Fields:    Translation:HumansCells
  9. Korecka JA, Eggers R, Swaab DF, Bossers K, Verhaagen J. Modeling early Parkinson's disease pathology with chronic low dose MPTP treatment. Restor Neurol Neurosci. 2013; 31(2):155-67. PMID: 23271419.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. van den Berge SA, van Strien ME, Korecka JA, Dijkstra AA, Sluijs JA, Kooijman L, Eggers R, De Filippis L, Vescovi AL, Verhaagen J, van de Berg WD, Hol EM. The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain. Brain. 2011 Nov; 134(Pt 11):3249-63. PMID: 22075520.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  11. Korecka JA, Verhaagen J, Hol EM. Cell-replacement and gene-therapy strategies for Parkinson's and Alzheimer's disease. Regen Med. 2007 Jul; 2(4):425-46. PMID: 17635050.
    Citations: 20     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.