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Il-Kyu Choi, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Choi IK, Wang Z, Ke Q, Hong M, Paul DW, Fernandes SM, Hu Z, Stevens J, Guleria I, Kim HJ, Cantor H, Wucherpfennig KW, Brown JR, Ritz J, Zhang B. Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162. PMID: 33361812.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  2. Choi IK, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, Liu Y, Kim HJ, Ritz J, Cantor H, Rajewsky K, Wucherpfennig KW, Zhang B. Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695. PMID: 29311309.
    Citations: 6     Fields:    Translation:AnimalsCells
  3. Jung KH, Choi IK, Lee HS, Yan HH, Son MK, Ahn HM, Hong J, Yun CO, Hong SS. Corrigendum to "Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer" [Cancer Lett. 396 (2017) 155-166]. Cancer Lett. 2017 09 28; 404:93. PMID: 28646638.
    Citations:    Fields:    
  4. Jung KH, Choi IK, Lee HS, Yan HH, Son MK, Ahn HM, Hong J, Yun CO, Hong SS. Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer. Cancer Lett. 2017 06 28; 396:155-166. PMID: 28315430.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  5. Oh E, Choi IK, Hong J, Yun CO. Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model. Oncotarget. 2017 Jan 17; 8(3):4730-4746. PMID: 28002796.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  6. Wares JR, Crivelli JJ, Yun CO, Choi IK, Gevertz JL, Kim PS. Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections. Math Biosci Eng. 2015 Dec; 12(6):1237-56. PMID: 26775859.
    Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
  7. Kim PS, Crivelli JJ, Choi IK, Yun CO, Wares JR. Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics. Math Biosci Eng. 2015 Aug; 12(4):841-58. PMID: 25974336.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Jeon YR, Ahn HM, Choi IK, Yun CO, Rah DK, Lew DH, Lee WJ. Hepatocyte growth factor-expressing adenovirus upregulates matrix metalloproteinase-1 expression in keloid fibroblasts. Int J Dermatol. 2016 Mar; 55(3):356-61. PMID: 26234705.
    Citations: 1     Fields:    Translation:HumansCells
  9. Choi IK, Shin H, Oh E, Yoo JY, Hwang JK, Shin K, Yu DC, Yun CO. Potent and long-term antiangiogenic efficacy mediated by FP3-expressing oncolytic adenovirus. Int J Cancer. 2015 Nov 01; 137(9):2253-69. PMID: 25944623.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Lee WJ, Ahn HM, Roh H, Na Y, Choi IK, Lee JH, Kim YO, Lew DH, Yun CO. Decorin-expressing adenovirus decreases collagen synthesis and upregulates MMP expression in keloid fibroblasts and keloid spheroids. Exp Dermatol. 2015 Aug; 24(8):591-7. PMID: 25865370.
    Citations: 9     Fields:    Translation:HumansCells
  11. Ryu J, Kaul Z, Yoon AR, Liu Y, Yaguchi T, Na Y, Ahn HM, Gao R, Choi IK, Yun CO, Kaul SC, Wadhwa R. Identification and functional characterization of nuclear mortalin in human carcinogenesis. J Biol Chem. 2014 Sep 05; 289(36):24832-44. PMID: 25012652.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  12. Choi IK, Strauss R, Richter M, Yun CO, Lieber A. Strategies to increase drug penetration in solid tumors. Front Oncol. 2013; 3:193. PMID: 23898462.
    Citations: 40     
  13. Choi IK, Li Y, Oh E, Kim J, Yun CO. Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-?- and TNF-a-co-producing T cell-mediated antitumor immunity. PLoS One. 2013; 8(7):e67512. PMID: 23844018.
    Citations: 22     Fields:    Translation:AnimalsCells
  14. Lim SA, Kim TJ, Lee JE, Sonn CH, Kim K, Kim J, Choi JG, Choi IK, Yun CO, Kim JH, Yee C, Kumar V, Lee KM. Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res. 2013 Apr 15; 73(8):2598-607. PMID: 23580577.
    Citations: 22     Fields:    Translation:HumansCells
  15. Choi IK, Yun CO. Recent developments in oncolytic adenovirus-based immunotherapeutic agents for use against metastatic cancers. Cancer Gene Ther. 2013 Feb; 20(2):70-6. PMID: 23306610.
    Citations: 23     Fields:    Translation:HumansCells
  16. Lee WJ, Choi IK, Lee JH, Kim YO, Yun CO. A novel three-dimensional model system for keloid study: organotypic multicellular scar model. Wound Repair Regen. 2013 Jan-Feb; 21(1):155-65. PMID: 23231705.
    Citations: 4     Fields:    Translation:HumansCells
  17. Lee WJ, Choi IK, Lee JH, Lee JS, Kim YO, Rah DK, Yun CO. Relaxin-expressing adenovirus decreases collagen synthesis and up-regulates matrix metalloproteinase expression in keloid fibroblasts: in vitro experiments. Plast Reconstr Surg. 2012 Sep; 130(3):407e-417e. PMID: 22929264.
    Citations: 7     Fields:    Translation:HumansCells
  18. Koo T, Choi IK, Kim M, Lee JS, Oh E, Kim J, Yun CO. Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy. Hum Gene Ther. 2012 Jun; 23(6):609-22. PMID: 22248367.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Koom WS, Park SY, Kim W, Kim M, Kim JS, Kim H, Choi IK, Yun CO, Seong J. Combination of radiotherapy and adenovirus-mediated p53 gene therapy for MDM2-overexpressing hepatocellular carcinoma. J Radiat Res. 2012; 53(2):202-10. PMID: 22510592.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  20. Choi KJ, Zhang SN, Choi IK, Kim JS, Yun CO. Strengthening of antitumor immune memory and prevention of thymic atrophy mediated by adenovirus expressing IL-12 and GM-CSF. Gene Ther. 2012 Jul; 19(7):711-23. PMID: 21993173.
    Citations: 19     Fields:    Translation:AnimalsCells
  21. Lee WJ, Yun CO, Yun IS, Kim YO, Choi IK, Yun TJ, Rah DK. Augmentation of rat skin flap viability by relaxin-expressing adenovirus. Wound Repair Regen. 2011 Nov; 19(6):709-17. PMID: 22092841.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Lee WJ, Kim YO, Choi IK, Rah DK, Yun CO. Adenovirus-relaxin gene therapy for keloids: implication for reversing pathological fibrosis. Br J Dermatol. 2011 Sep; 165(3):673-7. PMID: 21623756.
    Citations: 5     Fields:    Translation:HumansCells
  23. Yoon AR, Gao R, Kaul Z, Choi IK, Ryu J, Noble JR, Kato Y, Saito S, Hirano T, Ishii T, Reddel RR, Yun CO, Kaul SC, Wadhwa R. MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res. 2011 Oct; 39(18):8078-91. PMID: 21724611.
    Citations: 21     Fields:    Translation:HumansCells
  24. Zhang SN, Choi IK, Huang JH, Yoo JY, Choi KJ, Yun CO. Optimizing DC vaccination by combination with oncolytic adenovirus coexpressing IL-12 and GM-CSF. Mol Ther. 2011 Aug; 19(8):1558-68. PMID: 21468000.
    Citations: 33     Fields:    Translation:AnimalsCellsPHPublic Health
  25. Choi IK, Lee JS, Zhang SN, Park J, Sonn CH, Lee KM, Yun CO. Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rß2 or IL-18Ra. Gene Ther. 2011 Sep; 18(9):898-909. PMID: 21451575.
    Citations: 43     Fields:    Translation:AnimalsCells
  26. Wadhwa R, Ryu J, Gao R, Choi IK, Morrow G, Kaur K, Kim I, Kaul SC, Yun CO, Tanguay RM. Proproliferative functions of Drosophila small mitochondrial heat shock protein 22 in human cells. J Biol Chem. 2010 Feb 05; 285(6):3833-3839. PMID: 19948727.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  27. Choi IK, Lee YS, Yoo JY, Yoon AR, Kim H, Kim DS, Seidler DG, Kim JH, Yun CO. Effect of decorin on overcoming the extracellular matrix barrier for oncolytic virotherapy. Gene Ther. 2010 Feb; 17(2):190-201. PMID: 19907500.
    Citations: 30     Fields:    Translation:AnimalsCells
  28. Huang JH, Zhang SN, Choi KJ, Choi IK, Kim JH, Lee MG, Lee M, Kim H, Yun CO. Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12 and 4-1BBL. Mol Ther. 2010 Feb; 18(2):264-74. PMID: 19738604.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  29. Lee YS, Kim JH, Choi KJ, Choi IK, Kim H, Cho S, Cho BC, Yun CO. Enhanced antitumor effect of oncolytic adenovirus expressing interleukin-12 and B7-1 in an immunocompetent murine model. Clin Cancer Res. 2006 Oct 01; 12(19):5859-68. PMID: 17020994.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.