Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Hai Ning Shi, Ph.D., D.V.M.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI121997 (SHI, HAI NING) Jan 15, 2017 - Dec 31, 2019
    Maternal effects on immune function in the offspring
    Role: Principal Investigator
  2. R01DK082427 (SHI, HAI NING) May 1, 2010 - Apr 30, 2016
    Immunomodulatory effects of intestinal helminthes on mucosal immunity
    Role: Principal Investigator
  3. R21DK074727 (SHI, HAI NING) Sep 14, 2007 - Aug 31, 2010
    Immunomodulation of bacteria-associated colitis by helminth infection
    Role: Principal Investigator
  4. K01DK059996 (SHI, HAI NING) Jul 1, 2003 - Jun 30, 2006
    Triggering intestinal inflammation
    Role: Principal Investigator
  5. P30DK040561 (GRINSPOON, STEVEN K.) Sep 30, 1994 - Jul 31, 2022
    Nutrition Obesity Research Center at Harvard
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Long SR, Lanter BB, Pazos MA, Mou H, Barrios J, Su CW, Wang ZQ, Walker WA, Hurley BP, Shi HN. Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace. Sci Rep. 2019 10 31; 9(1):15703. PMID: 31673002.
    Citations: 6     Fields:    Translation:AnimalsCells
  2. Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):696-708.e9. PMID: 31618654.
    Citations: 57     Fields:    Translation:AnimalsCells
  3. Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018 11 15; 175(5):1307-1320.e22. PMID: 30392957.
    Citations: 158     Fields:    Translation:AnimalsCells
  4. Su CW, Chen CY, Li Y, Long SR, Massey W, Kumar DV, Walker WA, Shi HN. Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages. Sci Rep. 2018 03 15; 8(1):4607. PMID: 29545532.
    Citations: 25     Fields:    Translation:AnimalsCells
  5. Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury R, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A. A single-cell survey of the small intestinal epithelium. Nature. 2017 11 16; 551(7680):333-339. PMID: 29144463.
    Citations: 467     Fields:    Translation:AnimalsCells
  6. Li Y, Lv M, Su C, Long S, Zhang W, Conway KL, Li W, Xavier RJ, Shi HN. p40 phox -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection. Front Immunol. 2017; 8:1270. PMID: 29062317.
    Citations: 3     Fields:    
  7. Ward NL, Phillips CD, Nguyen DD, Shanmugam NK, Song Y, Hodin R, Shi HN, Cherayil BJ, Goldstein AM. Antibiotic Treatment Induces Long-lasting Changes in the Fecal Microbiota that Protect Against Colitis. Inflamm Bowel Dis. 2016 10; 22(10):2328-40. PMID: 27607336; PMCID: PMC5689073.
    Citations: 8     Fields:    Translation:AnimalsCells
  8. Meng D, Zhu W, Ganguli K, Shi HN, Walker WA. Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G744-G753. PMID: 27562058; PMCID: PMC5142200.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. Trebicka E, Shanmugam NK, Chen K, Su CW, Shi HN, Cherayil BJ. Intestinal Inflammation Leads to a Long-lasting Increase in Resistance to Systemic Salmonellosis that Requires Macrophages But Not B or T Lymphocytes at the Time of Pathogen Challenge. Inflamm Bowel Dis. 2015 Dec; 21(12):2758-65. PMID: 26222341; PMCID: PMC4654659.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Long SR, Wang ZQ, Liu RD, Liu LN, Li LG, Jiang P, Zhang X, Zhang ZF, Shi HN, Cui J. Molecular identification of Trichinella spiralis nudix hydrolase and its induced protective immunity against trichinellosis in BALB/c mice. Parasit Vectors. 2014 Dec 19; 7:600. PMID: 25522912.
    Citations: 28     Fields:    Translation:AnimalsPHPublic Health
  11. Meng D, Zhu W, Shi HN, Lu L, Wijendran V, Xu W, Walker WA. Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis. Pediatr Res. 2015 Mar; 77(3):416-24. PMID: 25521917; PMCID: PMC4479150.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  12. Su L, Qi Y, Zhang M, Weng M, Zhang X, Su C, Shi HN. Development of fatal intestinal inflammation in MyD88 deficient mice co-infected with helminth and bacterial enteropathogens. PLoS Negl Trop Dis. 2014 Jul; 8(7):e2987. PMID: 25010669.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Su L, Su CW, Qi Y, Yang G, Zhang M, Cherayil BJ, Zhang X, Shi HN. Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice. Infect Immun. 2014 Sep; 82(9):3855-66. PMID: 24980971.
    Citations: 25     Fields:    Translation:AnimalsCells
  14. Shanmugam NK, Trebicka E, Fu LL, Shi HN, Cherayil BJ. Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota. J Immunol. 2014 Aug 01; 193(3):1398-407. PMID: 24973448; PMCID: PMC4108560.
    Citations: 20     Fields:    Translation:AnimalsCells
  15. Tran HT, Lee IA, Low D, Kamba A, Mizoguchi A, Shi HN, Lee CG, Elias JA, Mizoguchi E. Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis. Inflamm Bowel Dis. 2014 May; 20(5):835-46. PMID: 24694795.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Weng M, Ganguli K, Zhu W, Shi HN, Walker WA. Conditioned medium from Bifidobacteria infantis protects against Cronobacter sakazakii-induced intestinal inflammation in newborn mice. Am J Physiol Gastrointest Liver Physiol. 2014 May 01; 306(9):G779-87. PMID: 24627567.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  17. Whary MT, Muthupalani S, Ge Z, Feng Y, Lofgren J, Shi HN, Taylor NS, Correa P, Versalovic J, Wang TC, Fox JG. Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota. Microbes Infect. 2014 Apr; 16(4):345-55. PMID: 24513446.
    Citations: 17     Fields:    Translation:Animals
  18. Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology. 2013 Dec; 145(6):1347-57. PMID: 23973919; PMCID: PMC3840157.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  19. Sokol H, Conway KL, Zhang M, Choi M, Morin B, Cao Z, Villablanca EJ, Li C, Wijmenga C, Yun SH, Shi HN, Xavier RJ. Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Gastroenterology. 2013 Sep; 145(3):591-601.e3. PMID: 23732773; PMCID: PMC3781941.
    Citations: 73     Fields:    Translation:AnimalsCells
  20. Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ. ATG5 regulates plasma cell differentiation. Autophagy. 2013 Apr; 9(4):528-37. PMID: 23327930.
    Citations: 72     Fields:    Translation:AnimalsCells
  21. Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN. Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. J Immunol. 2012 Aug 01; 189(3):1459-66. PMID: 22732589; PMCID: PMC3423331.
    Citations: 25     Fields:    Translation:AnimalsCells
  22. Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN. Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol. 2012 Aug; 65(3):467-80. PMID: 22524476.
    Citations: 29     Fields:    Translation:AnimalsCells
  23. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98. PMID: 22368036.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  24. Nishida A, Lau CW, Zhang M, Andoh A, Shi HN, Mizoguchi E, Mizoguchi A. The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice. Gastroenterology. 2012 Apr; 142(4):865-874.e2. PMID: 22202458; PMCID: PMC3441148.
    Citations: 31     Fields:    Translation:AnimalsCells
  25. Chen CC, Lin WC, Kong MS, Shi HN, Walker WA, Lin CY, Huang CT, Lin YC, Jung SM, Lin TY. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue. Br J Nutr. 2012 Jun; 107(11):1623-34. PMID: 21992995.
    Citations: 41     Fields:    Translation:AnimalsCells
  26. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatr Res. 2011 Jun; 69(6):465-72. PMID: 21364495.
    Citations: 73     Fields:    Translation:HumansAnimals
  27. Su CW, Cao Y, Kaplan J, Zhang M, Li W, Conroy M, Walker WA, Shi HN. Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation. Infect Immun. 2011 Jun; 79(6):2285-94. PMID: 21444669.
    Citations: 24     Fields:    Translation:AnimalsCells
  28. Srikanth CV, Wall DM, Maldonado-Contreras A, Shi H, Zhou D, Demma Z, Mumy KL, McCormick BA. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010 Oct 15; 330(6002):390-393. PMID: 20947770.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  29. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009 Nov; 119(11):3322-8. PMID: 19809161; PMCID: PMC2769199.
    Citations: 76     Fields:    Translation:AnimalsCells
  30. Conroy ME, Shi HN, Walker WA. The long-term health effects of neonatal microbial flora. Curr Opin Allergy Clin Immunol. 2009 Jun; 9(3):197-201. PMID: 19398905.
    Citations: 28     Fields:    Translation:Humans
  31. Chen CC, Chiu CH, Lin TY, Shi HN, Walker WA. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res. 2009 Feb; 65(2):169-75. PMID: 19262293.
    Citations: 16     Fields:    Translation:AnimalsCells
  32. Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J Exp Med. 2009 Jan 16; 206(1):125-38. PMID: 19103880.
    Citations: 60     Fields:    Translation:AnimalsCells
  33. Pazos M, Siccardi D, Mumy KL, Bien JD, Louie S, Shi HN, Gronert K, Mrsny RJ, McCormick BA. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. J Immunol. 2008 Dec 01; 181(11):8044-52. PMID: 19017997; PMCID: PMC2596662.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  34. Wang LJ, Cao Y, Shi HN. Helminth infections and intestinal inflammation. World J Gastroenterol. 2008 Sep 07; 14(33):5125-32. PMID: 18777588.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  35. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008 Aug 15; 181(4):2723-31. PMID: 18684963; PMCID: PMC2561261.
    Citations: 72     Fields:    Translation:AnimalsCells
  36. Shimomura Y, Ogawa A, Kawada M, Sugimoto K, Mizoguchi E, Shi HN, Pillai S, Bhan AK, Mizoguchi A. A unique B2 B cell subset in the intestine. J Exp Med. 2008 Jun 09; 205(6):1343-55. PMID: 18519649.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  37. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun. 2008 Jul; 76(7):3045-53. PMID: 18426872.
    Citations: 32     Fields:    Translation:AnimalsCells
  38. Shi HN, Walker WA. The role of TIM-4 in food allergy. Gastroenterology. 2007 Nov; 133(5):1723-6. PMID: 17983815.
    Citations: 1     Fields:    Translation:AnimalsCells
  39. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol. 2007 Oct 01; 179(7):4721-31. PMID: 17878371; PMCID: PMC3208515.
    Citations: 64     Fields:    Translation:AnimalsCells
  40. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med Microbiol. 2007 Nov; 51(2):372-80. PMID: 17727655; PMCID: PMC3205980.
    Citations: 24     Fields:    Translation:AnimalsCells
  41. Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J Immunol. 2007 Aug 15; 179(4):2270-81. PMID: 17675488.
    Citations: 37     Fields:    Translation:AnimalsCells
  42. Herrmann N, Gill SS, Bell CM, Anderson GM, Bronskill SE, Shulman KI, Fischer HD, Sykora K, Shi HS, Rochon PA. A population-based study of cholinesterase inhibitor use for dementia. J Am Geriatr Soc. 2007 Oct; 55(10):1517-23. PMID: 17697100.
    Citations: 24     Fields:    Translation:HumansPHPublic Health
  43. Wall DM, Nadeau WJ, Pazos MA, Shi HN, Galyov EE, McCormick BA. Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cell Microbiol. 2007 Sep; 9(9):2299-313. PMID: 17697195.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  44. Chen CC, Louie S, McCormick BA, Walker WA, Shi HN. Helminth-primed dendritic cells alter the host response to enteric bacterial infection. J Immunol. 2006 Jan 01; 176(1):472-83. PMID: 16365440; PMCID: PMC4144328.
    Citations: 43     Fields:    Translation:AnimalsCells
  45. Lewinger JP, Lee SS, Biernacka J, Wu LY, Shi HS, Bull SB. Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals. BMC Genet. 2005 Dec 30; 6 Suppl 1:S62. PMID: 16451675; PMCID: PMC1866720.
    Citations: 2     Fields:    Translation:HumansCells
  46. Wu LY, Lee SS, Shi HS, Sun L, Bull SB. Resampling methods to reduce the selection bias in genetic effect estimation in genome-wide scans. BMC Genet. 2005 Dec 30; 6 Suppl 1:S24. PMID: 16451633; PMCID: PMC1866762.
    Citations: 2     Fields:    Translation:HumansCells
  47. Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95. PMID: 16326999; PMCID: PMC4465784.
    Citations: 13     Fields:    Translation:HumansCells
  48. Chen CC, Louie S, Shi HN, Walker WA. Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis. Pediatr Res. 2005 Dec; 58(6):1185-91. PMID: 16306191.
    Citations: 34     Fields:    Translation:AnimalsCells
  49. Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2006 Apr; 43(10):1694-9. PMID: 16256200.
    Citations:    Fields:    Translation:AnimalsCells
  50. Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity. 2005 Oct; 23(4):397-407. PMID: 16226505.
    Citations: 58     Fields:    Translation:AnimalsCells
  51. Chen CC, Louie S, McCormick B, Walker WA, Shi HN. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun. 2005 Sep; 73(9):5468-81. PMID: 16113263; PMCID: PMC1231118.
    Citations: 76     Fields:    Translation:AnimalsCells
  52. Shi HN, Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 2004 Aug; 18(8):493-500. PMID: 15372112.
    Citations: 18     Fields:    Translation:HumansCells
  53. Bashir ME, Louie S, Shi HN, Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol. 2004 Jun 01; 172(11):6978-87. PMID: 15153518.
    Citations: 124     Fields:    Translation:AnimalsCells
  54. Shi HN, Walker WA. T helper cell subclasses and clinical disease states. Curr Opin Gastroenterol. 2002 Nov; 18(6):711-6. PMID: 17033353.
    Citations:    Fields:    
  55. Bashir ME, Andersen P, Fuss IJ, Shi HN, Nagler-Anderson C. An enteric helminth infection protects against an allergic response to dietary antigen. J Immunol. 2002 Sep 15; 169(6):3284-92. PMID: 12218148.
    Citations: 75     Fields:    Translation:AnimalsCells
  56. Shi HN, Nagler-Anderson C. Mucosal T-cell responses to enteric infection. Curr Opin Gastroenterol. 1999 Nov; 15(6):529-33. PMID: 17024002.
    Citations:    Fields:    
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Shi's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (328)
Co-Authors (39)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.