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profileHai Ning Shi, Ph.D., D.V.M.

TitleAssociate Professor of Pediatrics
InstitutionMassachusetts General Hospital
DepartmentPediatrics
AddressMassachusetts General Hospital
Mucosal Immunology Laboratory, Room 3504
55 Fruit St
Boston MA 02114
Phone617/726-7991
Fax617/726-4172
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AI121997     (SHI, HAI NING)Jan 15, 2017 - Dec 31, 2018
NIH/NIAID
Maternal effects on immune function in the offspring
Role: Principal Investigator

R01DK082427     (SHI, HAI NING)May 1, 2010 - Apr 30, 2015
NIH/NIDDK
Immunomodulatory effects of intestinal helminthes on mucosal immunity
Role: Principal Investigator

R21DK074727     (SHI, HAI NING)Sep 14, 2007 - Aug 31, 2010
NIH/NIDDK
Immunomodulation of bacteria-associated colitis by helminth infection
Role: Principal Investigator

K01DK059996     (SHI, HAI NING)Jul 1, 2003 - Jun 30, 2006
NIH/NIDDK
Triggering intestinal inflammation
Role: Principal Investigator

P30DK040561     (GRINSPOON, STEVEN K.)Sep 30, 1994 - Jul 31, 2022
NIH/NIDDK
Nutrition Obesity Research Center at Harvard
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Li Y, Lv M, Su C, Long S, Zhang W, Conway KL, Li W, Xavier RJ, Shi HN. p40 phox -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection. Front Immunol. 2017; 8:1270. PMID: 29062317.
    View in: PubMed
  2. Ward NL, Phillips CD, Nguyen DD, Shanmugam NK, Song Y, Hodin R, Shi HN, Cherayil BJ, Goldstein AM. Antibiotic Treatment Induces Long-lasting Changes in the Fecal Microbiota that Protect Against Colitis. Inflamm Bowel Dis. 2016 Oct; 22(10):2328-40. PMID: 27607336.
    View in: PubMed
  3. Meng D, Zhu W, Ganguli K, Shi HN, Walker WA. Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors. Am J Physiol Gastrointest Liver Physiol. 2016 Oct 01; 311(4):G744-G753. PMID: 27562058.
    View in: PubMed
  4. Trebicka E, Shanmugam NK, Chen K, Su CW, Shi HN, Cherayil BJ. Intestinal Inflammation Leads to a Long-lasting Increase in Resistance to Systemic Salmonellosis that Requires Macrophages But Not B or T Lymphocytes at the Time of Pathogen Challenge. Inflamm Bowel Dis. 2015 Dec; 21(12):2758-65. PMID: 26222341; PMCID: PMC4654659 [Available on 12/01/16].
  5. Long SR, Wang ZQ, Liu RD, Liu LN, Li LG, Jiang P, Zhang X, Zhang ZF, Shi HN, Cui J. Molecular identification of Trichinella spiralis nudix hydrolase and its induced protective immunity against trichinellosis in BALB/c mice. Parasit Vectors. 2014 Dec 19; 7:600. PMID: 25522912; PMCID: PMC4287505.
  6. Meng D, Zhu W, Shi HN, Lu L, Wijendran V, Xu W, Walker WA. Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis. Pediatr Res. 2015 Mar; 77(3):416-24. PMID: 25521917; PMCID: PMC4479150.
  7. Su L, Qi Y, Zhang M, Weng M, Zhang X, Su C, Shi HN. Development of fatal intestinal inflammation in MyD88 deficient mice co-infected with helminth and bacterial enteropathogens. PLoS Negl Trop Dis. 2014 Jul; 8(7):e2987. PMID: 25010669; PMCID: PMC4091940.
  8. Su L, Su CW, Qi Y, Yang G, Zhang M, Cherayil BJ, Zhang X, Shi HN. Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice. Infect Immun. 2014 Sep; 82(9):3855-66. PMID: 24980971; PMCID: PMC4187801.
  9. Shanmugam NK, Trebicka E, Fu LL, Shi HN, Cherayil BJ. Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota. J Immunol. 2014 Aug 01; 193(3):1398-407. PMID: 24973448; PMCID: PMC4108560.
  10. Tran HT, Lee IA, Low D, Kamba A, Mizoguchi A, Shi HN, Lee CG, Elias JA, Mizoguchi E. Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis. Inflamm Bowel Dis. 2014 May; 20(5):835-46. PMID: 24694795; PMCID: PMC4012618.
  11. Weng M, Ganguli K, Zhu W, Shi HN, Walker WA. Conditioned medium from Bifidobacteria infantis protects against Cronobacter sakazakii-induced intestinal inflammation in newborn mice. Am J Physiol Gastrointest Liver Physiol. 2014 May 01; 306(9):G779-87. PMID: 24627567; PMCID: PMC4010653.
  12. Whary MT, Muthupalani S, Ge Z, Feng Y, Lofgren J, Shi HN, Taylor NS, Correa P, Versalovic J, Wang TC, Fox JG. Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota. Microbes Infect. 2014 Apr; 16(4):345-55. PMID: 24513446; PMCID: PMC4030519.
  13. Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology. 2013 Dec; 145(6):1347-57. PMID: 23973919; PMCID: PMC3840157.
  14. Sokol H, Conway KL, Zhang M, Choi M, Morin B, Cao Z, Villablanca EJ, Li C, Wijmenga C, Yun SH, Shi HN, Xavier RJ. Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice. Gastroenterology. 2013 Sep; 145(3):591-601.e3. PMID: 23732773; PMCID: PMC3781941.
  15. Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ. ATG5 regulates plasma cell differentiation. Autophagy. 2013 Apr; 9(4):528-37. PMID: 23327930; PMCID: PMC3627668.
  16. Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN. Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. J Immunol. 2012 Aug 01; 189(3):1459-66. PMID: 22732589; PMCID: PMC3423331.
  17. Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN. Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol. 2012 Aug; 65(3):467-80. PMID: 22524476; PMCID: PMC4015462.
  18. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98. PMID: 22368036; PMCID: PMC3942786.
  19. Nishida A, Lau CW, Zhang M, Andoh A, Shi HN, Mizoguchi E, Mizoguchi A. The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice. Gastroenterology. 2012 Apr; 142(4):865-874.e2. PMID: 22202458; PMCID: PMC3441148.
  20. Chen CC, Lin WC, Kong MS, Shi HN, Walker WA, Lin CY, Huang CT, Lin YC, Jung SM, Lin TY. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue. Br J Nutr. 2012 Jun; 107(11):1623-34. PMID: 21992995.
    View in: PubMed
  21. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatr Res. 2011 Jun; 69(6):465-72. PMID: 21364495.
    View in: PubMed
  22. Su CW, Cao Y, Kaplan J, Zhang M, Li W, Conroy M, Walker WA, Shi HN. Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation. Infect Immun. 2011 Jun; 79(6):2285-94. PMID: 21444669; PMCID: PMC3125859.
  23. Srikanth CV, Wall DM, Maldonado-Contreras A, Shi H, Zhou D, Demma Z, Mumy KL, McCormick BA. Salmonella pathogenesis and processing of secreted effectors by caspase-3. Science. 2010 Oct 15; 330(6002):390-393. PMID: 20947770; PMCID: PMC4085780.
  24. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009 Nov; 119(11):3322-8. PMID: 19809161.
    View in: PubMed
  25. Conroy ME, Shi HN, Walker WA. The long-term health effects of neonatal microbial flora. Curr Opin Allergy Clin Immunol. 2009 Jun; 9(3):197-201. PMID: 19398905.
    View in: PubMed
  26. Chen CC, Chiu CH, Lin TY, Shi HN, Walker WA. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res. 2009 Feb; 65(2):169-75. PMID: 19262293; PMCID: PMC3206789.
  27. Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J Exp Med. 2009 Jan 16; 206(1):125-38. PMID: 19103880; PMCID: PMC2626685.
  28. Pazos M, Siccardi D, Mumy KL, Bien JD, Louie S, Shi HN, Gronert K, Mrsny RJ, McCormick BA. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. J Immunol. 2008 Dec 01; 181(11):8044-52. PMID: 19017997; PMCID: PMC2596662.
  29. Wang LJ, Cao Y, Shi HN. Helminth infections and intestinal inflammation. World J Gastroenterol. 2008 Sep 07; 14(33):5125-32. PMID: 18777588; PMCID: PMC2744001.
  30. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008 Aug 15; 181(4):2723-31. PMID: 18684963; PMCID: PMC2561261.
  31. Shimomura Y, Ogawa A, Kawada M, Sugimoto K, Mizoguchi E, Shi HN, Pillai S, Bhan AK, Mizoguchi A. A unique B2 B cell subset in the intestine. J Exp Med. 2008 Jun 09; 205(6):1343-55. PMID: 18519649; PMCID: PMC2413032.
  32. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun. 2008 Jul; 76(7):3045-53. PMID: 18426872; PMCID: PMC2446721.
  33. Shi HN, Walker WA. The role of TIM-4 in food allergy. Gastroenterology. 2007 Nov; 133(5):1723-6. PMID: 17983815.
    View in: PubMed
  34. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol. 2007 Oct 01; 179(7):4721-31. PMID: 17878371; PMCID: PMC3208515.
  35. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med Microbiol. 2007 Nov; 51(2):372-80. PMID: 17727655; PMCID: PMC3205980.
  36. Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J Immunol. 2007 Aug 15; 179(4):2270-81. PMID: 17675488.
    View in: PubMed
  37. Herrmann N, Gill SS, Bell CM, Anderson GM, Bronskill SE, Shulman KI, Fischer HD, Sykora K, Shi HS, Rochon PA. A population-based study of cholinesterase inhibitor use for dementia. J Am Geriatr Soc. 2007 Oct; 55(10):1517-23. PMID: 17697100.
    View in: PubMed
  38. Wall DM, Nadeau WJ, Pazos MA, Shi HN, Galyov EE, McCormick BA. Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium. Cell Microbiol. 2007 Sep; 9(9):2299-313. PMID: 17697195.
    View in: PubMed
  39. Chen CC, Louie S, McCormick BA, Walker WA, Shi HN. Helminth-primed dendritic cells alter the host response to enteric bacterial infection. J Immunol. 2006 Jan 01; 176(1):472-83. PMID: 16365440; PMCID: PMC4144328.
  40. Lewinger JP, Lee SS, Biernacka J, Wu LY, Shi HS, Bull SB. Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals. BMC Genet. 2005 Dec 30; 6 Suppl 1:S62. PMID: 16451675; PMCID: PMC1866720.
  41. Wu LY, Lee SS, Shi HS, Sun L, Bull SB. Resampling methods to reduce the selection bias in genetic effect estimation in genome-wide scans. BMC Genet. 2005 Dec 30; 6 Suppl 1:S24. PMID: 16451633; PMCID: PMC1866762.
  42. Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95. PMID: 16326999; PMCID: PMC4465784.
  43. Chen CC, Louie S, Shi HN, Walker WA. Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis. Pediatr Res. 2005 Dec; 58(6):1185-91. PMID: 16306191.
    View in: PubMed
  44. Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2006 Apr; 43(10):1694-9. PMID: 16256200.
    View in: PubMed
  45. Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity. 2005 Oct; 23(4):397-407. PMID: 16226505.
    View in: PubMed
  46. Chen CC, Louie S, McCormick B, Walker WA, Shi HN. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun. 2005 Sep; 73(9):5468-81. PMID: 16113263; PMCID: PMC1231118.
  47. Shi HN, Walker A. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 2004 Aug; 18(8):493-500. PMID: 15372112.
    View in: PubMed
  48. Bashir ME, Louie S, Shi HN, Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol. 2004 Jun 01; 172(11):6978-87. PMID: 15153518.
    View in: PubMed
  49. Shi HN, Walker WA. T helper cell subclasses and clinical disease states. Curr Opin Gastroenterol. 2002 Nov; 18(6):711-6. PMID: 17033353.
    View in: PubMed
  50. Bashir ME, Andersen P, Fuss IJ, Shi HN, Nagler-Anderson C. An enteric helminth infection protects against an allergic response to dietary antigen. J Immunol. 2002 Sep 15; 169(6):3284-92. PMID: 12218148.
    View in: PubMed
  51. Shi HN, Nagler-Anderson C. Mucosal T-cell responses to enteric infection. Curr Opin Gastroenterol. 1999 Nov; 15(6):529-33. PMID: 17024002.
    View in: PubMed
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