Harvard Catalyst Profiles

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Carlos M Diaz Garcia, Ph.D.

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Biography
awards and honors
2018
Postdoc awardee presentation and travel award. 13th Intl Conference on Brain Energy Metabolim
2017 - 2020
Ruth L. Kirschstein National Research Service Award (NRSA) individual postdoctoral fellowship (F32)
2016 - 2017
Fix Fund Postdoctoral Fellowship, Department of Neurobiology, Harvard Medical School
2014
Ph.D. awarded with Honorific Mention, National Autonomous University of Mexico
2013
International Travel Award, 57th Annual Meeting of the Biophysical Society
2012
Travel Award, 1st Congress of the Federation of Neuroscience Societies from Latin-America
2010 - 2014
Ph.D. Scholarship, National Council of Science and Technology of Mexico CONACyT
2010
Scholarship, Institute of Science and Technology of Mexico City ICyTDF
2009
Scholarship, Network of Public MacroUniversities of Latin America and the Caribbean
2006
Award for the Best Academic Performance, University of La Habana, Cuba
2006
B.S. in Biochemistry awarded with High Honors, University of La Habana, Cuba

Overview
overview
Dr. Diaz Garcia will be collaborating with Dr. Gary Yellen on studying the control of glycolysis by energy state, and the metabolic responses to stimulation throughout the neuronal anatomy. These projects will involve the design and testing of plasmids encoding the genetic information for fluorescent biosensors, the production of AAV particles to deliver these plasmids to brain tissue, and the deployment and imaging of these biosensors in several cellular compartments. These projects also involve measuring the concentration of several metabolites in individual neurons within hippocampal slices, using multiphoton excitation and fluorescence lifetime imaging. These activities are related to his previous work as a postdoctoral researcher, which has paved the way for a collaboration between the laboratory of Professor Gary Yellen and his new laboratory at The University of Oklahoma Health Sciences Center.

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. F32NS100331 (DIAZ GARCIA, CARLOS MANLIO) Apr 1, 2017 - Mar 31, 2020
    NIH
    Defining the cellular metabolic responses to brain activity using fluorescent biosensors
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Díaz-García CM, Meyer DJ, Nathwani N, Rahman M, Martínez-François JR, Yellen G. The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle. Elife. 2021 02 08; 10. PMID: 33555254; PMCID: PMC7870136.
    Citations: 13     Fields:    Translation:AnimalsCells
  2. Koveal D, Díaz-García CM, Yellen G. Fluorescent Biosensors for Neuronal Metabolism and the Challenges of Quantitation. Curr Opin Neurobiol. 2020 08; 63:111-121. PMID: 32559637.
    Citations: 10     Fields:    Translation:Cells
  3. Díaz-García CM, Lahmann C, Martínez-François JR, Li B, Koveal D, Nathwani N, Rahman M, Keller JP, Marvin JS, Looger LL, Yellen G. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor. J Neurosci Res. 2019 08; 97(8):946-960. PMID: 31106909; PMCID: PMC6565483.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  4. Díaz-García CM, Yellen G. Neurons rely on glucose rather than astrocytic lactate during stimulation. J Neurosci Res. 2019 08; 97(8):883-889. PMID: 30575090; PMCID: PMC6565458.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  5. García-Delgado N, Velasco M, Sánchez-Soto C, Díaz-García CM, Hiriart M. Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion. Front Endocrinol (Lausanne). 2018; 9:40. PMID: 29556214.
    Citations: 6     Fields:    
  6. Velasco M, Larqué C, Díaz-García CM, Sanchez-Soto C, Hiriart M. Rat Pancreatic Beta-Cell Culture. Methods Mol Biol. 2018; 1727:261-273. PMID: 29222788.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Carbajal-Ramírez A, García-Macedo R, Díaz-García CM, Sanchez-Soto C, Padrón AM, de la Peña JE, Cruz M, Hiriart M. Neuropathy-specific alterations in a Mexican population of diabetic patients. BMC Neurol. 2017 Aug 25; 17(1):161. PMID: 28841856; PMCID: PMC6389277.
    Citations: 1     Fields:    Translation:Humans
  8. Díaz-García CM, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab. 2017 Aug 01; 26(2):361-374.e4. PMID: 28768175; PMCID: PMC5559896.
    Citations: 155     Fields:    Translation:AnimalsCells
  9. Velasco M, Díaz-García CM, Larqué C, Hiriart M. Modulation of Ionic Channels and Insulin Secretion by Drugs and Hormones in Pancreatic Beta Cells. Mol Pharmacol. 2016 Sep; 90(3):341-57. PMID: 27436126.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Diaz-Garcia CM, Agüero-Chapín G, Antunes A, Vasconcelos V. Biological toxins and medicinal chemistry: research and therapeutic tools. Curr Top Med Chem. 2015; 15(7):580. PMID: 25686736.
    Citations:    Fields:    
  11. Hiriart M, Sanchez-Soto C, Diaz-Garcia CM, Castanares DT, Avitia M, Velasco M, Mas-Oliva J, Macias-Silva M, González-Villalpando C, Delgado-Coello B, Sosa-Garrocho M, Vidaltamayo R, Fuentes-Silva D. Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes. Front Endocrinol (Lausanne). 2014; 5:95. PMID: 24995000.
    Citations: 6     Fields:    
  12. Diaz-Garcia CM, Morales-Lázaro SL, Sánchez-Soto C, Velasco M, Rosenbaum T, Hiriart M. Role for the TRPV1 channel in insulin secretion from pancreatic beta cells. J Membr Biol. 2014 Jun; 247(6):479-91. PMID: 24676478.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Marcia Hiriart, Myrian Velasco, Carlos Manlio Diaz-Garcia, Carlos Larqué, Carmen Sánchez-Soto, Alondra Albarado-Ibáñez, Juan Pablo Chávez-Maldonado, Alicia Toledo, Neivys García-Delgado. Islets of Langerhans. Pancreatic Beta Cells in Metabolic Syndrome. 2014; 1-25. View Publication.
  14. Hiriart M, Velasco M, Larqué C, Diaz-Garcia CM. Metabolic syndrome and ionic channels in pancreatic beta cells. Vitam Horm. 2014; 95:87-114. PMID: 24559915.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Domínguez-Pérez D, Diaz-Garcia CM, García-Delgado N, Sierra-Gómez Y, Castañeda O, Antunes A. Insights into the toxicological properties of a low molecular weight fraction from Zoanthus sociatus (Cnidaria). Mar Drugs. 2013 Aug 13; 11(8):2873-81. PMID: 23945599.
    Citations: 3     Fields:    Translation:Animals
  16. Diaz-Garcia CM. The TRPA1 channel and oral hypoglycemic agents: is there complicity in ß-cell exhaustion? Channels (Austin). 2013 Nov-Dec; 7(6):420-2. PMID: 23921548.
    Citations: 2     Fields:    Translation:HumansAnimals
  17. Diaz-Garcia CM, Sanchez-Soto C, Hiriart M. TRPM channels phosphorylation as a potential bridge between old signals and novel regulatory mechanisms of insulin secretion. Curr Diabetes Rev. 2013 Mar 01; 9(2):117-25. PMID: 23092333.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Alvarez-Collazo J, Díaz-García CM, López-Medina AI, Vassort G, Alvarez JL. Zinc modulation of basal and ß-adrenergically stimulated L-type Ca2+ current in rat ventricular cardiomyocytes: consequences in cardiac diseases. Pflugers Arch. 2012 Nov; 464(5):459-70. PMID: 23007464.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Diaz-Garcia CM, Fuentes-Silva D, Sanchez-Soto C, Domínguez-Pérez D, García-Delgado N, Varela C, Mendoza-Hernández G, Rodriguez-Romero A, Castaneda O, Hiriart M. Toxins from Physalia physalis (Cnidaria) raise the intracellular Ca(2+) of beta-cells and promote insulin secretion. Curr Med Chem. 2012; 19(31):5414-23. PMID: 22830340.
    Citations: 7     Fields:    Translation:AnimalsCells
  20. Diaz-Garcia CM, Sanchez-Soto C, Fuentes-Silva D, Leon-Pinzon C, Dominguez-Perez D, Varela C, Rodriguez-Romero A, Castañeda O, Hiriart M. Low molecular weight compounds from Zoanthus sociatus impair insulin secretion via Ca(+2) influx blockade and cause glucose intolerance in vivo. Toxicon. 2012 Feb; 59(2):306-14. PMID: 22155304.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Diaz-Garcia CM, Sanchez-Soto C, Hiriart M. Toxins that modulate ionic channels as tools for exploring insulin secretion. Cell Mol Neurobiol. 2010 Nov; 30(8):1275-81. PMID: 21046453.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.