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Paulo Jose Martins Bispo, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EY032231 (BISPO, PAULO J. M.) Sep 30, 2021 - Jul 31, 2023
    Advancing Diagnostics of Infectious Uveitis with MetagenomicAnalysis
    Role: Principal Investigator
  2. Massachusetts Lions Eye Research Fund (BISPO, PAULO J) Sep 9, 2019 - May 31, 2021
    Emergence of Multidrug Resistant Bacterial Keratitis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nicole L. Belanger, Robbie Barbero, Robert Barclay, Benjamin Lepene, Lucia Sobrin and Paulo J. M. Bispo . Improved Detection of Herpesviruses from Diluted Vitreous Specimens Using Hydrogel Particles. 2022; 12(12):3016. View Publication.
  2. André C, Islam MM, Paschalis E, Bispo PJM. Comparative In Vitro Activity of New Lipoglycopeptides and Vancomycin Against Ocular Staphylococci and Their Toxicity on the Human Corneal Epithelium. Cornea. 2022 Dec 01. PMID: 36455096.
    Citations:    Fields:    
  3. Silva MD, André C, Bispo PJM . Targeted killing of ocular Streptococcus pneumoniae by the phage endolysin MSlys. Ophthalmology Science. In press. 2022.
  4. Andre C, Rouhana J, Scarpa de Mello S, Rosa da Cunha G, Van Camp AG, Gilmore MS, Bispo PJM. Population structure of ocular Streptococcus pneumoniae is highly diverse and formed by lineages that escape current vaccines. Microb Genom. 2022 03; 8(3). PMID: 35254235; PMCID: PMC9176286.
    Citations:    Fields:    Translation:HumansCells
  5. Bispo PJM, Sahm DF, Asbell PA. A Systematic Review of Multi-decade Antibiotic Resistance Data for Ocular Bacterial Pathogens in the United States. Ophthalmol Ther. 2022 Apr; 11(2):503-520. PMID: 35113406; PMCID: PMC8927494.
    Citations: 3     
  6. Ung L, Belanger NL, Chodosh J, Gilmore MS, Bispo PJM. Novel Molecular Barcoding for Rapid Pathogen Detection in Infectious Keratitis. Ophthalmol Sci. 2021 Dec; 1(4):100066. PMID: 36246949.
  7. Shanbhag SS, Shih G, Bispo PJM, Chodosh J, Jacobs DS, Saeed HN. Diphtheroids as Corneal Pathogens in Chronic Ocular Surface Disease in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Cornea. 2021 06 01; 40(6):774-779. PMID: 33758140; PMCID: PMC8102355.
    Citations: 2     Fields:    Translation:HumansCells
  8. Leme RCP, Bispo PJM, Salles MJ. Community-genotype methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Latin America: a systematic review. Braz J Infect Dis. 2021 Jan-Feb; 25(1):101539. PMID: 33607082; PMCID: PMC9392117.
    Citations: 2     Fields:    Translation:HumansCells
  9. André C, Durand ML, Buckley T, Cadorette J, Gilmore MS, Ciolino JB, Bispo PJM. A Cluster of Corneal Donor Rim Cultures Positive for Achromobacter Species Associated With Contaminated Eye Solution. Cornea. 2021 Feb 01; 40(2):223-227. PMID: 33395117.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  10. Kim S, Bispo PJM, Tanner EEL, Mitragotri S, E Silva RN, Gipson I, Chodosh J, Behlau I, Paschalis EI, Gilmore MS, Dohlman CH. The Search for Antifungal Prophylaxis After Artificial Corneal Surgery-An In Vitro Study. Cornea. 2020 Dec; 39(12):1547-1555. PMID: 32769678.
    Citations: 1     Fields:    Translation:Animals
  11. Santin K, Bispo PJM, Rocchetti TT, Denadai L, Martins WMBDS, Carmo MSD, Hofling-Lima AL. Characterization and distribution of viridans group streptococci isolated from infectious endophthalmitis and keratitis. Arq Bras Oftalmol. 2020 Nov-Dec; 83(6):463-472. PMID: 33470272.
    Citations: 1     Fields:    Translation:HumansCells
  12. Almeida LM, Gaca A, Bispo PM, Lebreton F, Saavedra JT, Silva RA, Basílio-Júnior ID, Zorzi FM, Filsner PH, Moreno AM, Gilmore MS. Coexistence of the Oxazolidinone Resistance-Associated Genes cfr and optrA in Enterococcus faecalis From a Healthy Piglet in Brazil. Front Public Health. 2020; 8:518. PMID: 33102417.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Valdes L, Bispo P, Sobrin L. Application of Metagenomic Sequencing in the Diagnosis of Infectious Uveitis. Semin Ophthalmol. 2020 Aug 17; 35(5-6):276-279. PMID: 33073643.
    Citations: 3     Fields:    Translation:Humans
  14. Bispo PJM, Ung L, Chodosh J, Gilmore MS. Hospital-Associated Multidrug-Resistant MRSA Lineages Are Trophic to the Ocular Surface and Cause Severe Microbial Keratitis. Front Public Health. 2020; 8:204. PMID: 32582610.
    Citations: 2     Fields:    Translation:HumansCells
  15. Almeida LM, Lebreton F, Gaca A, Bispo PM, Saavedra JT, Calumby RN, Grillo LM, Nascimento TG, Filsner PH, Moreno AM, Gilmore MS. Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil. Antimicrob Agents Chemother. 2020 05 21; 64(6). PMID: 32253215; PMCID: PMC7269498.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Ung L, Wang Y, Vangel M, Davies EC, Gardiner M, Bispo PJM, Gilmore MS, Chodosh J. Validation of a Comprehensive Clinical Algorithm for the Assessment and Treatment of Microbial Keratitis. Am J Ophthalmol. 2020 06; 214:97-109. PMID: 31899203.
    Citations: 4     Fields:    Translation:HumansCells
  17. Ung L, Bispo PJM, Bryan NC, Andre C, Chodosh J, Gilmore MS. The Best of All Worlds: Streptococcus pneumoniae Conjunctivitis through the Lens of Community Ecology and Microbial Biogeography. Microorganisms. 2019 Dec 25; 8(1). PMID: 31881682.
    Citations: 4     
  18. Ung L, Acharya NR, Agarwal T, Alfonso EC, Bagga B, Bispo PJ, Burton MJ, Dart JK, Doan T, Fleiszig SM, Garg P, Gilmore MS, Gritz DC, Hazlett LD, Iovieno A, Jhanji V, Kempen JH, Lee CS, Lietman TM, Margolis TP, McLeod SD, Mehta JS, Miller D, Pearlman E, Prajna L, Prajna NV, Seitzman GD, Shanbhag SS, Sharma N, Sharma S, Srinivasan M, Stapleton F, Tan DT, Tandon R, Taylor HR, Tu EY, Tuli SS, Vajpayee RB, Van Gelder RN, Watson SL, Zegans ME, Chodosh J. Infectious corneal ulceration: a proposal for neglected tropical disease status. Bull World Health Organ. 2019 Dec 01; 97(12):854-856. PMID: 31819296; PMCID: PMC6883276.
    Citations: 13     Fields:    Translation:Humans
  19. Ung L, Bispo PJM, Doan T, Van Gelder RN, Gilmore MS, Lietman T, Margolis TP, Zegans ME, Lee CS, Chodosh J. Clinical metagenomics for infectious corneal ulcers: Rags to riches? Ocul Surf. 2020 01; 18(1):1-12. PMID: 31669750; PMCID: PMC9837861.
    Citations: 11     Fields:    Translation:Humans
  20. Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J. Authors' response: Povidone-Iodine for the Treatment of Microbial Keratitis. Surv Ophthalmol. 2019 Nov - Dec; 64(6):892-893. PMID: 31283923.
    Citations:    Fields:    Translation:Humans
  21. Minkus CL, Bispo PJM, Papaliodis GN, Sobrin L. Real-Time Multiplex PCR Analysis in Infectious Uveitis. Semin Ophthalmol. 2019; 34(4):252-255. PMID: 31177936.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J. The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019 May - Jun; 64(3):255-271. PMID: 30590103; PMCID: PMC7021355.
    Citations: 64     Fields:    Translation:Humans
  23. Wurster JI, Bispo PJM, Van Tyne D, Cadorette JJ, Boody R, Gilmore MS. Staphylococcus aureus from ocular and otolaryngology infections are frequently resistant to clinically important antibiotics and are associated with lineages of community and hospital origins. PLoS One. 2018; 13(12):e0208518. PMID: 30521630; PMCID: PMC6283574.
    Citations: 9     Fields:    Translation:HumansCells
  24. Zhai H, Bispo PJM, Kobashi H, Jacobs DS, Gilmore MS, Ciolino JB. Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery. Am J Ophthalmol Case Rep. 2018 Dec; 12:73-75. PMID: 30272036; PMCID: PMC6159334.
    Citations: 2     
  25. Bispo PJM, Davoudi S, Sahm ML, Ren A, Miller J, Romano J, Sobrin L, Gilmore MS. Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR. Invest Ophthalmol Vis Sci. 2018 01 01; 59(1):582-589. PMID: 29372257; PMCID: PMC5788046.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  26. Nascimento H, Viana-Niero C, Nogueira CL, Martins Bispo PJ, Pinto F, de Paula Pereira Uzam C, Matsumoto CK, Oliveira Machado AM, Leão SC, Höfling-Lima AL, de Freitas D. Identification of the Infection Source of an Outbreak of Mycobacterium Chelonae Keratitis After Laser in Situ Keratomileusis. Cornea. 2018 Jan; 37(1):116-122. PMID: 29111994.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  27. Duarte MJ, Kozin ED, Bispo PJM, Mitchell AH, Gilmore MS, Remenschneider AK. Methicillin-resistant Staphylococcus aureus in acute otitis externa. World J Otorhinolaryngol Head Neck Surg. 2018 Dec; 4(4):246-252. PMID: 30564786; PMCID: PMC6284227.
  28. Li D, Hodges RR, Bispo P, Gilmore MS, Gregory-Ksander M, Dartt DA. Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells. BMJ Open Ophthalmol. 2017; 2(1):e000101. PMID: 29354725; PMCID: PMC5751869.
    Citations: 5     
  29. Nascimento H, Watanabe A, Vieira ACC, Pelegrini A, Yu MC, Bispo PJM, Granato CFH, Höfling-Lima AL. Detection of herpes simplex-1 and -2 and varicella zoster virus by quantitative real-time polymerase chain reaction in corneas from patients with bacterial keratitis. Arq Bras Oftalmol. 2017 Mar-Apr; 80(2):84-87. PMID: 28591279.
    Citations:    Fields:    Translation:HumansCells
  30. Mazoteras P, Quiles MG, Martins Bispo PJ, Höfling-Lima AL, Pignatari AC, Casaroli-Marano RP. Analysis of Intraocular Lens Biofilms and Fluids After Long-Term Uncomplicated Cataract Surgery. Am J Ophthalmol. 2016 09; 169:46-57. PMID: 27318074.
    Citations: 1     Fields:    Translation:HumansCells
  31. Bispo PJ, Haas W, Gilmore MS. Biofilms in infections of the eye. Pathogens. 2015 Mar 23; 4(1):111-36. PMID: 25806622; PMCID: PMC4384075.
    Citations: 35     
  32. Camargo LF, Marra AR, Pignatari AC, Sukiennik T, Behar PP, Medeiros EA, Ribeiro J, Girão E, Correa L, Guerra C, Brites C, Pereira CA, Carneiro I, Reis M, Souza MA, Barata CU, Edmond MB. Nosocomial bloodstream infections in a nationwide study: comparison between solid organ transplant patients and the general population. Transpl Infect Dis. 2015 Apr; 17(2):308-13. PMID: 25726707.
    Citations: 8     Fields:    Translation:Humans
  33. Valentino MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C, Sanfilippo CM, Carter RA, Zegans ME, Beall B, Earl AM, Tuomanen EI, Morris TW, Haas W, Gilmore MS. Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster. Nat Commun. 2014 Nov 12; 5:5411. PMID: 25388376.
    Citations: 30     Fields:    Translation:HumansCells
  34. Mazoteras P, Bispo PJ, Höfling-Lima AL, Casaroli-Marano RP. DNA extraction methods for panbacterial and panfungal PCR detection in intraocular fluids. Curr Eye Res. 2015 Jul; 40(7):697-706. PMID: 25285466.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  35. Matsumoto CK, Bispo PJ, Santin K, Nogueira CL, Leão SC. Demonstration of plasmid-mediated drug resistance in Mycobacterium abscessus. J Clin Microbiol. 2014 May; 52(5):1727-9. PMID: 24574286.
    Citations: 1     Fields:    Translation:HumansCells
  36. Bispo PJ, Hofling-Lima AL, Pignatari AC. Characterization of ocular methicillin-resistant Staphylococcus epidermidis isolates belonging predominantly to clonal complex 2 subcluster II. J Clin Microbiol. 2014 May; 52(5):1412-7. PMID: 24523473.
    Citations: 9     Fields:    Translation:HumansCells
  37. Vola ME, Moriyama AS, Lisboa R, Vola MM, Hirai FE, Bispo PJ, Höfling-Lima AL. Prevalence and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus in ocular infections. Arq Bras Oftalmol. 2013 Nov-Dec; 76(6):350-3. PMID: 24510081.
    Citations: 19     Fields:    Translation:HumansCells
  38. Oechsler RA, Yamanaka TM, Bispo PJ, Sartori J, Yu MC, Melo AS, Miller D, Hofling-Lima AL. Fusarium keratitis in Brazil: genotyping, in vitro susceptibilities, and clinical outcomes. Clin Ophthalmol. 2013; 7:1693-701. PMID: 24039389.
    Citations: 10     
  39. Pereira CA, Marra AR, Camargo LF, Pignatari AC, Sukiennik T, Behar PR, Medeiros EA, Ribeiro J, Girão E, Correa L, Guerra C, Carneiro I, Brites C, Reis M, de Souza MA, Tranchesi R, Barata CU, Edmond MB. Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features. PLoS One. 2013; 8(7):e68144. PMID: 23861860.
    Citations: 17     Fields:    Translation:HumansCells
  40. Bispo PJ, Alfonso EC, Flynn HW, Miller D. Emerging 8-methoxyfluoroquinolone resistance among methicillin-susceptible Staphylococcus epidermidis isolates recovered from patients with endophthalmitis. J Clin Microbiol. 2013 Sep; 51(9):2959-63. PMID: 23824766.
    Citations: 8     Fields:    Translation:HumansCells
  41. Cariello AJ, Bispo PJ, de Souza GF, Pignatari AC, de Oliveira MG, Hofling-Lima AL. Bactericidal effect of S-nitrosothiols against clinical isolates from keratitis. Clin Ophthalmol. 2012; 6:1907-14. PMID: 23204833.
    Citations: 6     
  42. Belfort R, Gabriel L, Martins Bispo PJ, Muccioli C, Zacharias Serapicos PC, Clark L, Bell B, Bartell J, Stroman DW, Höfling-Lima AL. Safety and efficacy of moxifloxacin-dexamethasone eyedrops as treatment for bacterial ocular infection associated with bacterial blepharitis. Adv Ther. 2012 May; 29(5):416-26. PMID: 22562783.
    Citations: 3     Fields:    Translation:Humans
  43. Girardello R, Bispo PJ, Yamanaka TM, Gales AC. Cation concentration variability of four distinct Mueller-Hinton agar brands influences polymyxin B susceptibility results. J Clin Microbiol. 2012 Jul; 50(7):2414-8. PMID: 22553247.
    Citations: 21     Fields:    Translation:Cells
  44. Oguido AP, Casella AM, Hofling-Lima AL, Pacheco SA, Bispo PJ, Marques F. Pseudomonas aeruginosa endophthalmitis after penetrating keratoplasty transmitted from the same donor to two recipients confirmed by pulsed-field gel electrophoresis. J Clin Microbiol. 2011 Sep; 49(9):3346-7. PMID: 21775545.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  45. Melo GB, Bispo PJ, Campos Pignatari AC, Höfling-Lima AL. Real-time polymerase chain reaction test to discriminate between contamination and intraocular infection after cataract surgery. J Cataract Refract Surg. 2011 Jul; 37(7):1244-50. PMID: 21601416.
    Citations: 3     Fields:    Translation:HumansCells
  46. Marra AR, Camargo LF, Pignatari AC, Sukiennik T, Behar PR, Medeiros EA, Ribeiro J, Girão E, Correa L, Guerra C, Brites C, Pereira CA, Carneiro I, Reis M, de Souza MA, Tranchesi R, Barata CU, Edmond MB. Nosocomial bloodstream infections in Brazilian hospitals: analysis of 2,563 cases from a prospective nationwide surveillance study. J Clin Microbiol. 2011 May; 49(5):1866-71. PMID: 21411591.
    Citations: 73     Fields:    Translation:HumansCells
  47. Bispo PJ, de Melo GB, Hofling-Lima AL, Pignatari AC. Detection and gram discrimination of bacterial pathogens from aqueous and vitreous humor using real-time PCR assays. Invest Ophthalmol Vis Sci. 2011 Feb 22; 52(2):873-81. PMID: 20702819.
    Citations: 21     Fields:    Translation:HumansCells
  48. Melo GB, Bispo PJ, Yu MC, Pignatari AC, Höfling-Lima AL. Microbial profile and antibiotic susceptibility of culture-positive bacterial endophthalmitis. Eye (Lond). 2011 Mar; 25(3):382-7; quiz 388. PMID: 21336253.
    Citations: 22     Fields:    Translation:HumansCells
  49. Melo GB, Bispo PJ, Regatieri CV, Yu MC, Pignatari AC, Höfling-Lima AL. Incidence of endophthalmitis after cataract surgery (2002-2008) at a Brazilian university-hospital. Arq Bras Oftalmol. 2010 Nov-Dec; 73(6):505-7. PMID: 21271024.
    Citations: 7     Fields:    Translation:HumansCells
  50. Bispo PJ, Höfling-Lima AL, Pignatari AC. Molecular biology applied to the laboratory diagnosis of bacterial endophthalmitis. Arq Bras Oftalmol. 2009 Sep-Oct; 72(5):734-40. PMID: 20027421.
    Citations: 2     Fields:    Translation:Humans
  51. Andrade SS, Bispo PJ, Gales AC. Advances in the microbiological diagnosis of sepsis. Shock. 2008 Oct; 30 Suppl 1:41-6. PMID: 18704010.
    Citations: 13     Fields:    Translation:Humans
  52. Bispo PJ, Melo GB, d'Azevedo PA, Höfling-Lima AL, Yu MC, Pignatari AC. [Culture proven bacterial endophthalmitis: a 6-year review]. Arq Bras Oftalmol. 2008 Sep-Oct; 71(5):617-22. PMID: 19039452.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.