Harvard Catalyst Profiles

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Juan Manuel Leyva-Castillo, Ph.D.


2004 - 2006
Master Fellowship
2008 - 2012
PhD Fellowship
Travel Grant XXII World Allergy Congress
Outstanding Junior Abstract Award for XXII World Allergy Congress
2012 - 2013
Postdoctoral fellowship
Travel grant for the EAACI Allergy School on Allergy Diagnosis in and beyond the Skin
2013 - 2015
EAACI JMA Mentorship Program
2014 - 2016
Postdoctoral Fellowship
EAACI travel grant for EAACI 2015
JMA Poster Session Award EAACI 2015

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Eichenseher F, Herpers BL, Badoux P, Leyva-Castillo JM, Geha RS, van der Zwart M, McKellar J, Janssen F, de Rooij B, Selvakumar L, Röhrig C, Frieling J, Offerhaus M, Loessner MJ, Schmelcher M. Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0227321. PMID: 35416713; PMCID: PMC9112974.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Leyva-Castillo JM, Sun L, Wu SY, Rockowitz S, Sliz P, Geha RS. Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions. J Allergy Clin Immunol. 2022 08; 150(2):373-384. PMID: 35300986; PMCID: PMC9378429.
    Citations: 1     Fields:    
  3. Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI Insight. 2021 11 08; 6(21). PMID: 34747366; PMCID: PMC8663570.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  4. Leyva-Castillo JM, Geha RS. Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors. JID Innov. 2021 Sep; 1(3):100059. PMID: 34909740.
  5. Das M, Leyva-Castillo JM, Geha RS. Basophil: The cell that itches. J Allergy Clin Immunol. 2021 09; 148(3):708-709. PMID: 34147536.
    Citations:    Fields:    Translation:HumansCells
  6. Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jun; 22(6):794-795. PMID: 33903767.
    Citations:    Fields:    
  7. Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jan; 22(1):100. PMID: 33214720.
    Citations:    Fields:    
  8. Leyva-Castillo JM, Das M, Artru E, Yoon J, Galand C, Geha RS. Mast cell-derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure. J Allergy Clin Immunol. 2021 06; 147(6):2305-2315.e3. PMID: 33316284; PMCID: PMC8184568.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Wilkie H, Janssen E, Leyva-Castillo JM, Geha RS. DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity. J Invest Dermatol. 2021 06; 141(6):1503-1511.e3. PMID: 33171169; PMCID: PMC8102650.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Harb H, Stephen-Victor E, Crestani E, Benamar M, Massoud A, Cui Y, Charbonnier LM, Arbag S, Baris S, Cunnigham A, Leyva-Castillo JM, Geha RS, Mousavi AJ, Guennewig B, Schmitz-Abe K, Sioutas C, Phipatanakul W, Chatila TA. A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2020 11; 21(11):1359-1370. PMID: 32929274; PMCID: PMC7578174.
    Citations: 24     Fields:    Translation:HumansCells
  11. Leyva-Castillo JM, Jabara HH, Wenzel J, McGurk A, Wong D, Bieber T, Geha RS. APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice. Clin Immunol. 2020 10; 219:108556. PMID: 32777271.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Leyva-Castillo JM, McGurk A, Geha MDR. Allergic skin inflammation and S. aureus skin colonization are mutually reinforcing. Clin Immunol. 2020 09; 218:108511. PMID: 32569845.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Leyva-Castillo JM, Galand C, Mashiko S, Bissonnette R, McGurk A, Ziegler SF, Dong C, McKenzie ANJ, Sarfati M, Geha RS. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. J Allergy Clin Immunol. 2020 06; 145(6):1606-1614.e4. PMID: 32179159; PMCID: PMC7282942.
    Citations: 21     Fields:    Translation:AnimalsCells
  14. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. PMID: 31027995; PMCID: PMC6531322.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  15. Leyva-Castillo JM, Yoon J, Geha RS. IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice. J Allergy Clin Immunol. 2019 02; 143(2):619-630.e7. PMID: 29920352; PMCID: PMC6298864.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  16. Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS. RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). PMID: 29500225; PMCID: PMC5912895.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  17. Badran YR, Dedeoglu F, Leyva Castillo JM, Bainter W, Ohsumi TK, Bousvaros A, Goldsmith JD, Geha RS, Chou J. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. PMID: 28600438; PMCID: PMC5502421.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  18. Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. PMID: 27551155; PMCID: PMC5032726.
    Citations: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  19. Malhotra N, Yoon J, Leyva-Castillo JM, Galand C, Archer N, Miller LS, Geha RS. IL-22 derived from ?d T cells restricts Staphylococcus aureus infection of mechanically injured skin. J Allergy Clin Immunol. 2016 10; 138(4):1098-1107.e3. PMID: 27543072; PMCID: PMC5056816.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  20. Galand C, Leyva-Castillo JM, Yoon J, Han A, Lee MS, McKenzie ANJ, Stassen M, Oyoshi MK, Finkelman FD, Geha RS. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016 11; 138(5):1356-1366. PMID: 27372570; PMCID: PMC5099088.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  21. Li J, Leyva-Castillo JM, Hener P, Eisenmann A, Zaafouri S, Jonca N, Serre G, Birling MC, Li M. Counterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects. J Allergy Clin Immunol. 2016 07; 138(1):150-161.e13. PMID: 26993035.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Leyva-Castillo JM and Li M. Thymic stromal lymphopoietin and atopic diseases. Revue Française d'Allergologie. 2014; 54(5):364–376.
  23. Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M. Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat Commun. 2013; 4:2847. PMID: 24284909.
    Citations: 51     Fields:    Translation:AnimalsCells
  24. Leyva-Castillo JM, Hener P, Jiang H, Li M. TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice. J Invest Dermatol. 2013 Jan; 133(1):154-63. PMID: 22832486.
    Citations: 81     Fields:    Translation:AnimalsCellsPHPublic Health
  25. Leyva-Castillo JM, Cavazos-Adame H, Rojas-Martínez A, Fernandez-Espinoza MC, Ortiz-López R. . Difficulties in Mutation Screening of the Plasminogen (PLG) Gene in Patients With Ligneous Conjunctivitis and Severe Hypoplasminogenemia—Reply. Arch Ophthalmol. 2007; 125(9):1303.
  26. Leyva-Castillo JM, Cavazos-Adame H, Rojas-Martínez A, López-Garza R, Espinoza MC, Ortiz-López R. Ligneous conjunctivitis in a Mexican patient with a mutation in the plasminogen (PLG) gene. Arch Ophthalmol. 2006 Oct; 124(10):1500-1. PMID: 17030725.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.