Harvard Catalyst Profiles

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Juan Manuel Leyva-Castillo, Ph.D.

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Biography
2004 - 2006
Master Fellowship
2008 - 2012
PhD Fellowship
2011
Travel Grant XXII World Allergy Congress
2011
Outstanding Junior Abstract Award for XXII World Allergy Congress
2012 - 2013
Postdoctoral fellowship
2013
Travel grant for the EAACI Allergy School on Allergy Diagnosis in and beyond the Skin
2013 - 2015
EAACI JMA Mentorship Program
2014 - 2016
Postdoctoral Fellowship
2015
EAACI travel grant for EAACI 2015
2015
JMA Poster Session Award EAACI 2015

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 Apr 10. PMID: 31027995.
    Citations:    
  2. Leyva-Castillo JM, Yoon J, Geha RS. IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice. J Allergy Clin Immunol. 2019 Feb; 143(2):619-630.e7. PMID: 29920352.
    Citations:    Fields:    
  3. Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS. RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). PMID: 29500225.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Badran YR, Dedeoglu F, Leyva Castillo JM, Bainter W, Ohsumi TK, Bousvaros A, Goldsmith JD, Geha RS, Chou J. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. PMID: 28600438.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. PMID: 27551155.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Malhotra N, Yoon J, Leyva-Castillo JM, Galand C, Archer N, Miller LS, Geha RS. IL-22 derived from ?d T cells restricts Staphylococcus aureus infection of mechanically injured skin. J Allergy Clin Immunol. 2016 10; 138(4):1098-1107.e3. PMID: 27543072.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Galand C, Leyva-Castillo JM, Yoon J, Han A, Lee MS, McKenzie ANJ, Stassen M, Oyoshi MK, Finkelman FD, Geha RS. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016 11; 138(5):1356-1366. PMID: 27372570.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  8. Li J, Leyva-Castillo JM, Hener P, Eisenmann A, Zaafouri S, Jonca N, Serre G, Birling MC, Li M. Counterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects. J Allergy Clin Immunol. 2016 07; 138(1):150-161.e13. PMID: 26993035.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Leyva-Castillo JM and Li M. Thymic stromal lymphopoietin and atopic diseases. Revue Française d'Allergologie. 2014; 54(5):364–376.
  10. Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M. Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat Commun. 2013; 4:2847. PMID: 24284909.
    Citations: 22     Fields:    Translation:AnimalsCells
  11. Leyva-Castillo JM, Hener P, Jiang H, Li M. TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice. J Invest Dermatol. 2013 Jan; 133(1):154-63. PMID: 22832486.
    Citations: 31     Fields:    Translation:AnimalsCellsPHPublic Health
  12. Leyva-Castillo JM, Cavazos-Adame H, Rojas-Martínez A, Fernandez-Espinoza MC, Ortiz-López R. . Difficulties in Mutation Screening of the Plasminogen (PLG) Gene in Patients With Ligneous Conjunctivitis and Severe Hypoplasminogenemia—Reply. Arch Ophthalmol. 2007; 125(9):1303.
  13. Leyva-Castillo JM, Cavazos-Adame H, Rojas-Martínez A, López-Garza R, Espinoza MC, Ortiz-López R. Ligneous conjunctivitis in a Mexican patient with a mutation in the plasminogen (PLG) gene. Arch Ophthalmol. 2006 Oct; 124(10):1500-1. PMID: 17030725.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.