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Albert Yung-Pai Hung, Ph.D., M.D.

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Research
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  1. K08NS041411 (HUNG, ALBERT Y) Aug 1, 2001 - Jul 31, 2006
    NIH/NINDS
    Activity-Dependent Regulation of Synapses by Shank
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huh YE, Ruby Chiang MS, Locascio JJ, Liao Z, Liu G, Choudhury K, Kuras YI, Tuncali I, Videnovic A, Hunt AL, Schwarzschild MA, Hung AY, Herrington TM, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Sardi SP, Scherzer CR. ß-Glucocerebrosidase Activity in GBA-linked Parkinson's Disease: The Type of Mutation Matters. Neurology. 2020 Jun 15. PMID: 32540937.
    Citations:    
  2. Bakshi R, Macklin EA, Hung AY, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Ascherio A, Scherzer CR, Schwarzschild MA. Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. J Parkinsons Dis. 2020; 10(2):505-510. PMID: 32250320.
    Citations:    
  3. Gajos KZ, Reinecke K, Donovan M, Stephen CD, Hung AY, Schmahmann JD, Gupta AS. Computer mouse use captures ataxia and parkinsonism, enabling accurate measurement and detection. Mov Disord. 2020 02; 35(2):354-358. PMID: 31769069.
    Citations:    
  4. Schwarzschild MA, Macklin EA, Bakshi R, Battacharyya S, Logan R, Espay AJ, Hung AY, Bwala G, Goetz CG, Russell DS, Goudreau JL, Parashos SA, Saint-Hilaire MH, Rudolph A, Hare JM, Curhan GC, Ascherio A. Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial. Neurology. 2019 10 01; 93(14):e1328-e1338. PMID: 31484712.
    Citations:    
  5. Baker JM, Hung AY. Movement Disorders in Women. Semin Neurol. 2017 12; 37(6):653-660. PMID: 29270938.
    Citations:    Fields:    Translation:HumansAnimals
  6. Chandran R, Williams L, Hung A, Nowlin K, LaJeunesse D. SEM characterization of anatomical variation in chitin organization in insect and arthropod cuticles. Micron. 2016 Mar; 82:74-85. PMID: 26774746.
    Citations: 3     Fields:    Translation:Animals
  7. Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR. Association between a-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain. 2015 Sep; 138(Pt 9):2659-71. PMID: 26220939.
    Citations: 16     Fields:    Translation:Humans
  8. de Gusmäo CM, Berkowitz AL, Hung AY, Westover MB. Cerebrospinal fluid shunt-induced chorea: case report and review of the literature on shunt-related movement disorders. Pract Neurol. 2015 Feb; 15(1):42-4. PMID: 24997172.
    Citations:    Fields:    Translation:Humans
  9. Schwarzschild MA, Ascherio A, Beal MF, Cudkowicz ME, Curhan GC, Hare JM, Hooper DC, Kieburtz KD, Macklin EA, Oakes D, Rudolph A, Shoulson I, Tennis MK, Espay AJ, Gartner M, Hung A, Bwala G, Lenehan R, Encarnacion E, Ainslie M, Castillo R, Togasaki D, Barles G, Friedman JH, Niles L, Carter JH, Murray M, Goetz CG, Jaglin J, Ahmed A, Russell DS, Cotto C, Goudreau JL, Russell D, Parashos SA, Ede P, Saint-Hilaire MH, Thomas CA, James R, Stacy MA, Johnson J, Gauger L, Antonelle de Marcaida J, Thurlow S, Isaacson SH, Carvajal L, Rao J, Cook M, Hope-Porche C, McClurg L, Grasso DL, Logan R, Orme C, Ross T, Brocht AF, Constantinescu R, Sharma S, Venuto C, Weber J, Eaton K. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014 Feb; 71(2):141-50. PMID: 24366103.
    Citations: 44     Fields:    Translation:Humans
  10. Hung AY, Schwarzschild MA. Treatment of Parkinson's disease: what's in the non-dopaminergic pipeline? Neurotherapeutics. 2014 Jan; 11(1):34-46. PMID: 24310604.
    Citations: 7     Fields:    Translation:HumansAnimals
  11. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7. PMID: 24068787.
    Citations: 22     Fields:    Translation:Humans
  12. Stella SL, Vila A, Hung AY, Rome ME, Huynh U, Sheng M, Kreienkamp HJ, Brecha NC. Association of shank 1A scaffolding protein with cone photoreceptor terminals in the mammalian retina. PLoS One. 2012; 7(9):e43463. PMID: 22984429.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol. 2012 Mar; 71(3):370-84. PMID: 22451204.
    Citations: 80     Fields:    Translation:Humans
  14. Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, Unni VK, Hung AY, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Sudarsky LR, Growdon JH, Ivinson AJ, Hyman BT, Scherzer CR. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Mov Disord. 2011 Oct; 26(12):2283-6. PMID: 21953863.
    Citations: 9     Fields:    Translation:Humans
  15. Palada V, Terzic J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D. Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiol Aging. 2012 Apr; 33(4):836.e1-3. PMID: 21794955.
    Citations: 10     Fields:    Translation:Humans
  16. Wöhr M, Roullet FI, Hung AY, Sheng M, Crawley JN. Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior. PLoS One. 2011; 6(6):e20631. PMID: 21695253.
    Citations: 60     Fields:    Translation:Animals
  17. Silverman JL, Turner SM, Barkan CL, Tolu SS, Saxena R, Hung AY, Sheng M, Crawley JN. Sociability and motor functions in Shank1 mutant mice. Brain Res. 2011 Mar 22; 1380:120-37. PMID: 20868654.
    Citations: 80     Fields:    Translation:Animals
  18. Hung AY, Sung CC, Brito IL, Sheng M. Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons. PLoS One. 2010 Mar 24; 5(3):e9842. PMID: 20352094.
    Citations: 43     Fields:    Translation:AnimalsCells
  19. Hung AY, Futai K, Sala C, Valtschanoff JG, Ryu J, Woodworth MA, Kidd FL, Sung CC, Miyakawa T, Bear MF, Weinberg RJ, Sheng M. Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci. 2008 Feb 13; 28(7):1697-708. PMID: 18272690.
    Citations: 124     Fields:    Translation:AnimalsCells
  20. Hung AY, Schwarzschild MA. Clinical trials for neuroprotection in Parkinson's disease: overcoming angst and futility? Curr Opin Neurol. 2007 Aug; 20(4):477-83. PMID: 17620885.
    Citations: 16     Fields:    Translation:HumansAnimals
  21. Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M. Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development. Dev Cell. 2007 Apr; 12(4):587-602. PMID: 17419996.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  22. Hung AY, Sala C, Valtschanoff JG, Ryu J, Burgoon M, Miyakawa T, Weinberg RJ, Sheng M. Functional role of the Shank1 postsynaptic scaffold protein in synapse structure and in learning and memory. Society for Neuroscience. 2005; 501.9.
  23. Huang YJ, Sun YM, Chang FL, Hung AY, Wang CT. The feasibility study of the octane-enhancing process: isobutylene dimerization using C4 mixture. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003; 38(11):2661-78. PMID: 14533931.
    Citations:    Fields:    Translation:CellsPHPublic Health
  24. Hung AY, Sheng M. PDZ domains: structural modules for protein complex assembly. J Biol Chem. 2002 Feb 22; 277(8):5699-702. PMID: 11741967.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  25. Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. J Biol Chem. 1997 Jan 17; 272(3):1896-903. PMID: 8999878.
    Citations: 9     Fields:    Translation:HumansCells
  26. Haas C, Hung AY, Citron M, Teplow DB, Selkoe DJ. beta-Amyloid, protein processing and Alzheimer's disease. Arzneimittelforschung. 1995 Mar; 45(3A):398-402. PMID: 7763333.
    Citations: 11     Fields:    Translation:Humans
  27. Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. J Biol Chem. 1994 Jul 01; 269(26):17741-8. PMID: 8021287.
    Citations: 53     Fields:    Translation:HumansCells
  28. Hung AY, Selkoe DJ. Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. EMBO J. 1994 Feb 01; 13(3):534-42. PMID: 8313898.
    Citations: 28     Fields:    Translation:HumansCells
  29. Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem. 1993 Nov 05; 268(31):22959-62. PMID: 8226807.
    Citations: 64     Fields:    Translation:HumansCells
  30. Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann N Y Acad Sci. 1993 Sep 24; 695:109-16. PMID: 8239267.
    Citations: 25     Fields:    Translation:HumansCells
  31. Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem. 1993 Feb 15; 268(5):3021-4. PMID: 8428976.
    Citations: 97     Fields:    Translation:HumansCells
  32. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 1992 Dec 17; 360(6405):672-4. PMID: 1465129.
    Citations: 335     Fields:    Translation:HumansCells
  33. Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9439-43. PMID: 1409654.
    Citations: 34     Fields:    Translation:AnimalsCells
  34. Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 1992 Sep 24; 359(6393):322-5. PMID: 1383826.
    Citations: 361     Fields:    Translation:HumansCells
  35. Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 1992 Jun 11; 357(6378):500-3. PMID: 1608449.
    Citations: 165     Fields:    Translation:HumansCells
  36. Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J Neurosci. 1991 Dec; 11(12):3783-93. PMID: 1744690.
    Citations: 59     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.