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Huan Yang, Ph.D.

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Norman Bethune College of Medicine, Jilin University, ChinaM.B.07/2006Bachelor in Medicine
Michigan Technological University, Houghton, MIPh.D.08/2013Biological Science, Integrative Physiology
Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MAPostdoc08/2018Neurology, Sleep Physiology
The Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award
College of Sciences and Arts’ Outstanding Teachers (Top 10%)
Dean's Award for Outstanding Scholarship
Doctoral Finishing Fellowship (summer) from Graduate School (Top 5)
Sleep Research Society Abstract Merit Based Award
Gordon Conference Travel Award (Abstract Merit Based Award)

My research interests include understanding the mechanisms relating sleep, stress and cardiovascular risks. My long-term goal is incorporating behavior intervention relate to sleep and BP regulation to develop novel and effective methods to prevent cardiovascular diseases. My short-term goal is investigating the importance of sleep in both autonomic and renal regulations of BP, and cardiovascular health. I have more than 10 years of research experience on autonomic regulation of blood pressure (BP) at rest and under challenges (stress tests) in humans.
I have been involved with five NIH funded R01 sleep studies in the Mullington group, which I played the key role in autonomic function data acquisition, analysis, and interpretation. In these projects, I primarily performed beat-to-beat BP recordings, autonomic stress testing, heart rate variability and beroreflex sensitivity analysis. I recently received two Career Development Awards from American Heart Association and Sleep Research Society Foundation to support me to expand my area to the renal field, especially the renal regulation of BP. The Career Development Awards will provide me the opportunity to gain additional trainings, and help me to develop independency.

2009-2015 American Physiological Society (APS)
2012-Present American Heart Association (AHA)
2013-Present Sleep Research Society (SRS)

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Pilot Research Grant (Huan Yang) Sep 1, 2020 - Aug 31, 2021
    Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women’s Hospital.
    Examining the interactive effects of mindfulness and slow-paced breathing on stress physiology
    Role Description: The goal of this pilot project is to compare the separate and combined effects of slow-paced breathing and mindfulness on autonomic function.
    Role: Principal Investigator
  2. Career Development Award (Huan Yang) Aug 1, 2019 - Jul 31, 2020
    Sleep Research Society Foundation (SRSF)
    RAAS biomarkers of renal function and blood pressure response to repetitive sleep restriction.
    Role Description: Under conditions of repeated exposure to repeated bouts of short sleep (with recovery night of sleep between each bout), RAAS and renal biomarkers will be examined to test the hypothesis that renal mechanisms are implicated in the BP changes associated with insufficient sleep. This project will also investigate the relationship between renal and other physiological system markers in this unique repetitive sleep restriction model that mimic the daily life.
    Role: Principle Investigator
  3. Career Development Award (19CDA34760094) (Huan Yang) Apr 1, 2019 - Mar 31, 2022
    American Heart Association (AHA)
    RAAS biomarkers of renal function and blood pressure response to sleep loss.
    Role: Principle Investigator
  4. R01 HL125379-01A1 (Janet M. Mullington) Aug 19, 2016 - Jun 30, 2021
    Mechanisms Underlying the Blood Pressure Lowering Effect of Sleep Extension
    Role Description: An individualized, translational, randomized clinical trial to test the efficacy of a behavioral sleep extension intervention to reduce blood pressure in hypertensive and pre-hypertensive men and women; and to test the underlying mechanisms involved in response to treatment. If successful, this intervention will join first-line strategies such as diet and exercise, for controlling or reversing pre-hypertension and stage-1 hypertension.
    Role: Co-Investigator
  5. Postdoctoral Fellowship (15POST25280013) (Huan Yang) Jul 1, 2015 - Jun 30, 2017
    American Heart Association (AHA)
    Does sleep mediate the blood pressure lowering effects of low-dose aspirin?
    Role Description: This project will systematically investigate the essential role of sleep in the BP lowering effect of bedtime administration of low dose aspirin. We hypothesize that sleep mediates the BP lowering effects of bedtime administration of low-dose aspirin via both central and peripheral systems, and that sleep disruption may block this beneficial BP effect. This project will lead to the applications of bedtime low-dose aspirin administration in cardiovascular populations and emphasize the importance of good sleep that will potentially decrease the incidence of cardiovascular events, morbidity and mortality.
    Role: Principle Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang H, Vazquez M, Haack M and Mullington JM. Sleep. Increased Plasma Renin Activity During Wake in A Repetitive Sleep Restriction Protocol. 2021; 44(Suppl_1):A125.
  2. Vazquez M, Yang H, Dang R, Haack M and Mullington JM. Sleep. Sleep Hygiene as an Intervention to Lower Blood Pressure. 2021; 44(Suppl_1):A061.
  3. Mullington JM, Cunningham TJ, Haack M, Yang H. Causes and Consequences of Chronic Sleep Deficiency and the Role of Orexin. Front Neurol Neurosci. 2021; 45:128-138. PMID: 34052807.
    Citations:    Fields:    
  4. Yang H, Baltzis D, Bhatt V, Haack M, Meier-Ewert HK, Gautam S, Veves A, Mullington JM. Macro- and microvascular reactivity during repetitive exposure to shortened sleep: sex differences. Sleep. 2021 05 14; 44(5). PMID: 33249482.
    Citations:    Fields:    Translation:Humans
  5. Yang H, Goldstein MR, Vazquez M, Williams JP, and Mullington JM. Effects of sleep and sleep deficiency on autonomic function in humans. Curr Opin Endocr Metab Res. 2021; 18:268-274. View Publication.
  6. Holwerda SW, Carter JR, Yang H, Wang J, Pierce GL, Fadel PJ. CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans. Am J Physiol Heart Circ Physiol. 2021 02 01; 320(2):H762-H771. PMID: 33275522.
    Citations: 1     Fields:    Translation:Humans
  7. Yang H, Haack M, Dang R, Gautam S, Simpson NS, Mullington JM. Heart rate variability rebound following exposure to persistent and repetitive sleep restriction. Sleep. 2019 02 01; 42(2). PMID: 30476269.
    Citations: 5     Fields:    Translation:Humans
  8. Yang H, Haack M, Bhatt V, Meier-Ewert H, Veves A, and Mullington JM. . Circulation. Sex Differences In Microcirculation Due To Repetitive Exposure To Bouts Of Insufficient Nocturnal Sleep. 2019; 140(Suppl_1):A10696.
  9. Devine JK, Bertisch SM, Yang H, Scott-Sutherland J, Wilkins A, Molina V, Henrikson K, Haack M. Glucocorticoid and inflammatory reactivity to a repeated physiological stressor in insomnia disorder. Neurobiol Sleep Circadian Rhythms. 2019 Jan; 6:77-84. PMID: 31236523.
    Citations: 1     
  10. Yang H, Olia K, Haack M, and Mullington JM. . Sleep. Cardiovascular reactivity during repetitive experimentally induced insomnia symptoms in humans. 2018; Suppl_1(41):A93-A94.
  11. Besedovsky L, Yang H, Ciulla M, Jeffery M, Mullington J, and Haack M. . Sleep. Inflammatory response to experimentally-induced insomnia symptoms in healthy participants. 2018; Suppl_1(41):A93.
  12. Yang H, Haack M, Gautam S, Meier-Ewert HK, Mullington JM. Repetitive exposure to shortened sleep leads to blunted sleep-associated blood pressure dipping. J Hypertens. 2017 06; 35(6):1187-1194. PMID: 28169885.
    Citations: 16     Fields:    Translation:Humans
  13. Yang H, Haack, M and Mullington JM. . Journal of Hypertension. Sleep as a mediator of the blood pressure lowering effects of low dose aspirin. 2017; (35):e122.
  14. Yang H, Haack, M and Mullington JM. . Sleep. Repetitive sleep disruption, and experimental model of insomnia, leads to increased sympathetic activity. 2017; Suppl_1(40):B397.
  15. Devine JK, Haack M, Yang H, and Mullington JM. . Sleep. Repetitive sleep restriction and sleep disruption leads to elevated sleepiness and fatigue that fail to resolve with a single night of recovery sleep. 2017; Suppl_1(40):B753.
  16. Simpson NS, Diolombi M, Scott-Sutherland J, Yang H, Bhatt V, Gautam S, Mullington J, Haack M. Repeating patterns of sleep restriction and recovery: Do we get used to it? Brain Behav Immun. 2016 Nov; 58:142-151. PMID: 27263430.
    Citations: 15     Fields:    Translation:HumansCells
  17. Yang H, Durocher JJ, Larson RA, Carter JR. Role of the ovarian cycle on neural cardiovascular control in sleep-deprived women. J Appl Physiol (1985). 2015 Feb 15; 118(4):419-26. PMID: 25539931.
    Citations:    Fields:    Translation:Humans
  18. Ross AJ, Yang H, Larson RA, Carter JR. Sleep efficiency and nocturnal hemodynamic dipping in young, normotensive adults. . 2014 Oct 01; 307(7):R888-92. PMID: 25031228.
    Citations: 8     Translation:Humans
  19. Yang H, Carter JR. Baroreflex sensitivity analysis: spontaneous methodology vs. Valsalva's maneuver. Clin Auton Res. 2013 Jun; 23(3):133-9. PMID: 23677496.
    Citations: 6     Fields:    Translation:Humans
  20. Carter JR, Schwartz CE, Yang H, Joyner MJ. Fish oil and neurovascular reactivity to mental stress in humans. Am J Physiol Regul Integr Comp Physiol. 2013 Apr 01; 304(7):R523-30. PMID: 23408034.
    Citations: 15     Fields:    Translation:Humans
  21. Yang H, Drummer TD, Carter JR. Sex differences in sympathetic neural and limb vascular reactivity to mental stress in humans. . 2013 Feb 01; 304(3):H436-43. PMID: 23203970.
    Citations: 10     Translation:HumansCells
  22. Yang H, Durocher JJ, Larson RA, Dellavalla JP, Carter JR. Total sleep deprivation alters cardiovascular reactivity to acute stressors in humans. J Appl Physiol (1985). 2012 Sep; 113(6):903-8. PMID: 22815387.
    Citations: 19     Fields:    Translation:Humans
  23. Carter JR, Schwartz CE, Yang H, Joyner MJ. Fish oil and neurovascular control in humans. Am J Physiol Heart Circ Physiol. 2012 Aug 15; 303(4):H450-6. PMID: 22707560.
    Citations: 6     Fields:    Translation:Humans
  24. Carter JR, Durocher JJ, Larson RA, DellaValla JP, Yang H. Sympathetic neural responses to 24-hour sleep deprivation in humans: sex differences. Am J Physiol Heart Circ Physiol. 2012 May 15; 302(10):H1991-7. PMID: 22408018.
    Citations: 40     Fields:    Translation:Humans
  25. Yang H, Cooke WH, Reed KS, Carter JR. Sex differences in hemodynamic and sympathetic neural firing patterns during orthostatic challenge in humans. J Appl Physiol (1985). 2012 May; 112(10):1744-51. PMID: 22403351.
    Citations: 18     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.