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Bobby J. Cherayil, M.D., M.B.,B.S.

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Overview
Research in my laboratory is broadly directed at elucidating the molecular details of mammalian innate immunity, particularly in the gastrointestinal tract. We use a combination of in vitro and in vivo approaches to analyze the host factors that influence the response to infection with Salmonella typhimurium, an important agent of acute gastroenteritis in humans. In an on-going series of experiments, we are attempting to elucidate the effects of altered iron metabolism on macrophage function in salmonellosis. These studies have revealed a novel role for intracellular iron in the regulation of inflammatory cytokine biosynthesis, and have important implications for our understanding of host-pathogen interactions in conditions such as hemochromatosis.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI089700 (CHERAYIL, BOBBY JOSEPH) Jun 15, 2011 - May 31, 2021
    NIH/NIAID
    Cross-talk between iron metabolism and intestinal inflammation
    Role: Principal Investigator
  2. R56AI089700 (CHERAYIL, BOBBY JOSEPH) Jun 21, 2010 - May 31, 2012
    NIH/NIAID
    Cross-talk between iron metabolism and intestinal inflammation
    Role: Principal Investigator
  3. R21AI065619 (CHERAYIL, BOBBY JOSEPH) Jul 1, 2005 - Jun 30, 2008
    NIH/NIAID
    Mammalian metal transporters &Salmonella infection
    Role: Principal Investigator
  4. R01AI048815 (CHERAYIL, BOBBY JOSEPH) Dec 1, 2001 - Nov 30, 2007
    NIH/NIAID
    Induction of Macrophage iNOS by Salmonella
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Su C, Su L, Li Y, Long SR, Chang J, Zhang W, Walker WA, Xavier RJ, Cherayil BJ, Shi HN. Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis. Mucosal Immunol. 2018 01; 11(1):144-157. PMID: 28352104.
    Citations: 9     Fields:    Translation:AnimalsCells
  2. Verma S, Cherayil BJ. Iron and inflammation - the gut reaction. Metallomics. 2017 02 22; 9(2):101-111. PMID: 28067386.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Ward NL, Phillips CD, Nguyen DD, Shanmugam NK, Song Y, Hodin R, Shi HN, Cherayil BJ, Goldstein AM. Antibiotic Treatment Induces Long-lasting Changes in the Fecal Microbiota that Protect Against Colitis. Inflamm Bowel Dis. 2016 10; 22(10):2328-40. PMID: 27607336.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Chen K, Shanmugam NK, Pazos MA, Hurley BP, Cherayil BJ. Commensal Bacteria-Induced Inflammasome Activation in Mouse and Human Macrophages Is Dependent on Potassium Efflux but Does Not Require Phagocytosis or Bacterial Viability. PLoS One. 2016; 11(8):e0160937. PMID: 27505062; PMCID: PMC4978417.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Trebicka E, Shanmugam NK, Chen K, Su CW, Shi HN, Cherayil BJ. Intestinal Inflammation Leads to a Long-lasting Increase in Resistance to Systemic Salmonellosis that Requires Macrophages But Not B or T Lymphocytes at the Time of Pathogen Challenge. Inflamm Bowel Dis. 2015 Dec; 21(12):2758-65. PMID: 26222341.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Shanmugam NK, Chen K, Cherayil BJ. Commensal Bacteria-induced Interleukin 1ß (IL-1ß) Secreted by Macrophages Up-regulates Hepcidin Expression in Hepatocytes by Activating the Bone Morphogenetic Protein Signaling Pathway. J Biol Chem. 2015 Dec 18; 290(51):30637-47. PMID: 26515063; PMCID: PMC4683283.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  7. Cherayil BJ. Pathophysiology of Iron Homeostasis during Inflammatory States. J Pediatr. 2015 Oct; 167(4 Suppl):S15-9. PMID: 26364019; PMCID: PMC4568438.
    Citations: 3     Fields:    Translation:Humans
  8. Kortman GA, Mulder ML, Richters TJ, Shanmugam NK, Trebicka E, Boekhorst J, Timmerman HM, Roelofs R, Wiegerinck ET, Laarakkers CM, Swinkels DW, Bolhuis A, Cherayil BJ, Tjalsma H. Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens. Eur J Immunol. 2015 Sep; 45(9):2553-67. PMID: 26046550; PMCID: PMC4618841.
    Citations: 10     Fields:    Translation:AnimalsCells
  9. Belkind-Gerson J, Hotta R, Nagy N, Thomas AR, Graham H, Cheng L, Solorzano J, Nguyen D, Kamionek M, Dietrich J, Cherayil BJ, Goldstein AM. Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism. Inflamm Bowel Dis. 2015 Apr; 21(4):870-8. PMID: 25742399.
    Citations: 13     Fields:    Translation:AnimalsCells
  10. Cherayil BJ. Response to comment on "Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota". J Immunol. 2014 Dec 15; 193(12):5763. PMID: 25480954.
    Citations:    Fields:    Translation:Animals
  11. Trebicka E, Shanmugam NK, Mikhailova A, Alter G, Cherayil BJ. Effect of human immunodeficiency virus infection on plasma bactericidal activity against Salmonella enterica serovar Typhimurium. Clin Vaccine Immunol. 2014 Oct; 21(10):1437-42. PMID: 25121777; PMCID: PMC4266356.
    Citations: 3     Fields:    Translation:HumansCells
  12. Su L, Su CW, Qi Y, Yang G, Zhang M, Cherayil BJ, Zhang X, Shi HN. Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice. Infect Immun. 2014 Sep; 82(9):3855-66. PMID: 24980971; PMCID: PMC4187801.
    Citations: 11     Fields:    Translation:AnimalsCells
  13. Shanmugam NK, Trebicka E, Fu LL, Shi HN, Cherayil BJ. Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota. J Immunol. 2014 Aug 01; 193(3):1398-407. PMID: 24973448; PMCID: PMC4108560.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Shanmugam NK, Cherayil BJ. Serum-induced up-regulation of hepcidin expression involves the bone morphogenetic protein signaling pathway. Biochem Biophys Res Commun. 2013 Nov 15; 441(2):383-6. PMID: 24157792; PMCID: PMC3850278.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Trebicka E, Jacob S, Pirzai W, Hurley BP, Cherayil BJ. Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States. Clin Vaccine Immunol. 2013 Oct; 20(10):1491-8. PMID: 23803904; PMCID: PMC3807195.
    Citations: 18     Fields:    Translation:HumansCells
  16. Karagiannis AK, Ziogas DC, Gras-Miralles B, Geiger BM, Nagel J, Trebicka E, Najarian R, Cherayil BJ, Kokkotou E. Increased susceptibility of melanin-concentrating hormone-deficient mice to infection with Salmonella enterica serovar Typhimurium. Infect Immun. 2013 Jan; 81(1):166-72. PMID: 23115043; PMCID: PMC3536128.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN. Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. J Immunol. 2012 Aug 01; 189(3):1459-66. PMID: 22732589; PMCID: PMC3423331.
    Citations: 15     Fields:    Translation:AnimalsCells
  18. Shanmugam NK, Ellenbogen S, Trebicka E, Wang L, Mukhopadhyay S, Lacy-Hulbert A, Gallini CA, Garrett WS, Cherayil BJ. Tumor necrosis factor a inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One. 2012; 7(5):e38136. PMID: 22675442.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  19. Cherayil BJ, Ellenbogen S, Shanmugam NN. Iron and intestinal immunity. Curr Opin Gastroenterol. 2011 Oct; 27(6):523-8. PMID: 21785351; PMCID: PMC3734539.
    Citations: 8     Fields:    Translation:HumansAnimals
  20. Cherayil BJ. The role of iron in the immune response to bacterial infection. Immunol Res. 2011 May; 50(1):1-9. PMID: 21161695; PMCID: PMC3085559.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  21. Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM. J Innate Immun. 2011; 3(5):437-46. PMID: 21494017; PMCID: PMC3186711.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis. 2012 Jan; 18(1):112-9. PMID: 21351217.
    Citations: 21     Fields:    Translation:AnimalsCells
  23. Cherayil BJ. Iron and immunity: immunological consequences of iron deficiency and overload. Arch Immunol Ther Exp (Warsz). 2010 Dec; 58(6):407-15. PMID: 20878249; PMCID: PMC3173740.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  24. Johnson EE, Sandgren A, Cherayil BJ, Murray M, Wessling-Resnick M. Role of ferroportin in macrophage-mediated immunity. Infect Immun. 2010 Dec; 78(12):5099-106. PMID: 20837712; PMCID: PMC2981308.
    Citations: 16     Fields:    Translation:AnimalsCells
  25. Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM. Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters. J Biol Chem. 2010 Jun 25; 285(26):20147-54. PMID: 20406817; PMCID: PMC2888427.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  26. Cherayil BJ. Cross-talk between iron homeostasis and intestinal inflammation. Gut Microbes. 2010 Jan; 1(1):65-69. PMID: 21327119.
    Citations: 2     Fields:    
  27. Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebicka E, Wang L, Borregaard N, Murray M, Cherayil BJ. Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages. FEMS Immunol Med Microbiol. 2010 Feb; 58(1):138-45. PMID: 19863663; PMCID: PMC2822896.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009 Nov; 119(11):3322-8. PMID: 19809161.
    Citations: 58     Fields:    Translation:AnimalsCells
  29. Cherayil BJ. Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation. Inflamm Bowel Dis. 2009 Sep; 15(9):1391-6. PMID: 19322906.
    Citations: 21     Fields:    Translation:HumansCells
  30. Wang L, Cherayil BJ. Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity. J Innate Immun. 2009; 1(5):455-64. PMID: 20375603; PMCID: PMC3969595.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  31. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008 Aug 15; 181(4):2723-31. PMID: 18684963; PMCID: PMC2561261.
    Citations: 51     Fields:    Translation:AnimalsCells
  32. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun. 2008 Jul; 76(7):3045-53. PMID: 18426872; PMCID: PMC2446721.
    Citations: 18     Fields:    Translation:AnimalsCells
  33. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol. 2007 Oct 01; 179(7):4721-31. PMID: 17878371; PMCID: PMC3208515.
    Citations: 50     Fields:    Translation:AnimalsCells
  34. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med Microbiol. 2007 Nov; 51(2):372-80. PMID: 17727655; PMCID: PMC3205980.
    Citations: 19     Fields:    Translation:AnimalsCells
  35. Srikanth CV, Cherayil BJ. Intestinal innate immunity and the pathogenesis of Salmonella enteritis. Immunol Res. 2007; 37(1):61-78. PMID: 17496347; PMCID: PMC3199302.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  36. Chlosta S, Fishman DS, Harrington L, Johnson EE, Knutson MD, Wessling-Resnick M, Cherayil BJ. The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect Immun. 2006 May; 74(5):3065-7. PMID: 16622252; PMCID: PMC1459754.
    Citations: 51     Fields:    Translation:AnimalsCells
  37. Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity. 2005 Oct; 23(4):397-407. PMID: 16226505.
    Citations: 46     Fields:    Translation:AnimalsCells
  38. Rhee SJ, Walker WA, Cherayil BJ. Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection. J Immunol. 2005 Jul 15; 175(2):1127-36. PMID: 16002714.
    Citations: 37     Fields:    Translation:AnimalsCells
  39. Huang FC, Li Q, Cherayil BJ. A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells. FEMS Microbiol Lett. 2005 Feb 01; 243(1):265-70. PMID: 15668028.
    Citations: 15     Fields:    Translation:HumansCells
  40. Li Q, Cherayil BJ. Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan. Biochem Biophys Res Commun. 2004 Dec 03; 325(1):91-6. PMID: 15522205.
    Citations: 2     Fields:    Translation:AnimalsCells
  41. Huang FC, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ. Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Infect Immun. 2004 Sep; 72(9):5052-62. PMID: 15321998; PMCID: PMC517448.
    Citations: 17     Fields:    Translation:HumansCells
  42. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8. PMID: 15123821; PMCID: PMC409931.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  43. Cherayil BJ, Sengupta N. Dispatch from India. N Engl J Med. 2004 Apr 01; 350(14):1471. PMID: 15070805.
    Citations:    Fields:    
  44. Cherayil BJ. How not to get bugged by bugs: mechanisms of cellular tolerance to microorganisms. Curr Opin Gastroenterol. 2003 Nov; 19(6):572-7. PMID: 15703607.
    Citations: 2     Fields:    
  45. Li Q, Cherayil BJ. Role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infection. Infect Immun. 2003 Sep; 71(9):4873-82. PMID: 12933828; PMCID: PMC187311.
    Citations: 17     Fields:    Translation:AnimalsCells
  46. Cherayil BJ, Antos D. Inducible nitric oxide synthase and Salmonella infection. Microbes Infect. 2001 Jul; 3(9):771-6. PMID: 11489426.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  47. Cherayil BJ, McCormick BA, Bosley J. Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2. Infect Immun. 2000 Oct; 68(10):5567-74. PMID: 10992455; PMCID: PMC101507.
    Citations: 13     Fields:    Translation:AnimalsCells
  48. Chaudhuri A, Orme S, Vo T, Wang W, Cherayil BJ. Phosphorylation of TRAF2 inhibits binding to the CD40 cytoplasmic domain. Biochem Biophys Res Commun. 1999 Mar 24; 256(3):620-5. PMID: 10080948.
    Citations: 7     Fields:    Translation:HumansCells
  49. Chaudhuri A, Orme S, Eilam S, Cherayil BJ. CD40-mediated signals inhibit the binding of TNF receptor-associated factor 2 to the CD40 cytoplasmic domain. J Immunol. 1997 Nov 01; 159(9):4244-51. PMID: 9379019.
    Citations: 2     Fields:    Translation:HumansCells
  50. Aoki Y, Isselbacher KJ, Cherayil BJ, Pillai S. Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4204-8. PMID: 7514299; PMCID: PMC43753.
    Citations: 12     Fields:    Translation:AnimalsCells
  51. Cherayil BJ, MacDonald K, Waneck GL, Pillai S. Surface transport and internalization of the membrane IgM H chain in the absence of the Mb-1 and B29 proteins. J Immunol. 1993 Jul 01; 151(1):11-9. PMID: 8326121.
    Citations: 6     Fields:    Translation:AnimalsCells
  52. Rosenberg IM, Iyer R, Cherayil B, Chiodino C, Pillai S. Structure of the murine Mac-2 gene. Splice variants encode proteins lacking functional signal peptides. J Biol Chem. 1993 Jun 15; 268(17):12393-400. PMID: 8509379.
    Citations: 3     Fields:    Translation:AnimalsCells
  53. Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S. Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. J Biol Chem. 1991 Oct 05; 266(28):18731-6. PMID: 1917996.
    Citations: 28     Fields:    Translation:HumansCells
  54. Cherayil BJ, Pillai S. The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow. J Exp Med. 1991 Jan 01; 173(1):111-6. PMID: 1898658; PMCID: PMC2118761.
    Citations: 14     Fields:    Translation:Cells
  55. Cherayil BJ, Chaitovitz S, Wong C, Pillai S. Molecular cloning of a human macrophage lectin specific for galactose. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7324-8. PMID: 2402511; PMCID: PMC54736.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  56. Cherayil BJ, Weiner SJ, Pillai S. The Mac-2 antigen is a galactose-specific lectin that binds IgE. J Exp Med. 1989 Dec 01; 170(6):1959-72. PMID: 2584931; PMCID: PMC2189532.
    Citations: 60     Fields:    Translation:AnimalsCells
  57. Cherayil BJ, Young RA. A 28-kDa protein from Mycobacterium leprae is a target of the human antibody response in lepromatous leprosy. J Immunol. 1988 Dec 15; 141(12):4370-5. PMID: 3058804.
    Citations: 17     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.