Bobby J. Cherayil, M.D., M.B.,B.S.
Title Associate Professor of Pediatrics Institution Massachusetts General Hospital Address Massachusetts General Hospital
Pediatric Gastroenterology, Rm 3400
114 16th Street
Charlestown MA 02129
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Overview
Research in my laboratory is broadly directed at elucidating the molecular details of mammalian innate immunity, particularly in the gastrointestinal tract. We use a combination of in vitro and in vivo approaches to analyze the host factors that influence the response to infection with Salmonella typhimurium, an important agent of acute gastroenteritis in humans. In an on-going series of experiments, we are attempting to elucidate the effects of altered iron metabolism on macrophage function in salmonellosis. These studies have revealed a novel role for intracellular iron in the regulation of inflammatory cytokine biosynthesis, and have important implications for our understanding of host-pathogen interactions in conditions such as hemochromatosis.
Research
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R21AI155593
(CHERAYIL, BOBBY JOSEPH)
May 14, 2021 - Apr 30, 2023
Effects of Salmonella infection on bone marrow macrophage progenitors
Role: Principal Investigator
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R01AI089700
(CHERAYIL, BOBBY JOSEPH)
Jun 15, 2011 - May 31, 2021
Cross-talk between iron metabolism and intestinal inflammation
Role: Principal Investigator
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R56AI089700
(CHERAYIL, BOBBY JOSEPH)
Jun 21, 2010 - May 31, 2012
Cross-talk between iron metabolism and intestinal inflammation
Role: Principal Investigator
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R21AI065619
(CHERAYIL, BOBBY JOSEPH)
Jul 1, 2005 - Jun 30, 2008
Mammalian metal transporters &Salmonella infection
Role: Principal Investigator
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R01AI048815
(CHERAYIL, BOBBY JOSEPH)
Dec 1, 2001 - Nov 30, 2007
Induction of Macrophage iNOS by Salmonella
Role: Principal Investigator
Bibliographic
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