Harvard Catalyst Profiles

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Bobby J. Cherayil, M.B.,B.S., M.D.

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Overview
overview
Research in my laboratory is broadly directed at elucidating the molecular details of mammalian innate immunity, particularly in the gastrointestinal tract. We use a combination of in vitro and in vivo approaches to analyze the host factors that influence the response to infection with Salmonella typhimurium, an important agent of acute gastroenteritis in humans. In an on-going series of experiments, we are attempting to elucidate the effects of altered iron metabolism on macrophage function in salmonellosis. These studies have revealed a novel role for intracellular iron in the regulation of inflammatory cytokine biosynthesis, and have important implications for our understanding of host-pathogen interactions in conditions such as hemochromatosis.

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21AI155593 (CHERAYIL, BOBBY JOSEPH) May 14, 2021 - Oct 31, 2023
    NIH
    Effects of Salmonella infection on bone marrow macrophage progenitors
    Role: Principal Investigator
  2. R01AI089700 (CHERAYIL, BOBBY JOSEPH) Jun 15, 2011 - May 31, 2021
    NIH
    Cross-talk between iron metabolism and intestinal inflammation
    Role: Principal Investigator
  3. R56AI089700 (CHERAYIL, BOBBY JOSEPH) Jun 21, 2010 - May 31, 2012
    NIH
    Cross-talk between iron metabolism and intestinal inflammation
    Role: Principal Investigator
  4. R21AI065619 (CHERAYIL, BOBBY JOSEPH) Jul 1, 2005 - Jun 30, 2008
    NIH
    Mammalian metal transporters &Salmonella infection
    Role: Principal Investigator
  5. R01AI048815 (CHERAYIL, BOBBY JOSEPH) Dec 1, 2001 - Nov 30, 2007
    NIH
    Induction of Macrophage iNOS by Salmonella
    Role: Principal Investigator

Bibliographic
selected publications
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.