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Kirsi-Marja Zitting, Ph.D.

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Biography
education and training
University of Helsinki, Helsinki, FinlandMS05/2008Biology
University of Helsinki, Helsinki, FinlandPhD12/2012Biology: Physiol & Neurobiol
awards and honors
2008
Young Investigator Award
2010
Young Investigator Award
2011
Research Merit Award
2012
Doctoral Dissertation Award in Physiology
2021
Harvard University Certificate of Distinction in Teaching

Overview
overview
Society Memberships
American Academy of Sleep Medicine
Sleep Research Society
European Sleep Research Society

Editorial Activities
Reviewer for international journals including e.g., Journal of Sleep Research, Sleep Health, Journal of Physiology, PLOS Biology, and PLOS One

Research Interests
My research interests include both basic and applied aspects of sleep research and circadian physiology. Much of my work has focused on understanding the effects of sleep and circadian rhythms on human metabolism, including energy, lipid, and glucose metabolism. I have also examined the effects of chronic sleep loss and circadian disruption on sleep structure and neurobehavioral performance, as well as how the COVID-19 pandemic has changed sleep and daily rhythms globally. My other research interests include applying artificial intelligence to improve the diagnostic process for detecting and treating sleep disorders, and pursuing novel treatments for sleep and circadian rhythm disorders such as the shift work disorder.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. (Kirsi-Marja Zitting) Jan 15, 2020 - Jan 14, 2022
    The American Academy of Sleep Medicine Foundation
    Deep neural network model for automatic detection of sleep-disordered events from out-of-center level 3 sleep tests
    Role Description: The goal of this study is to develop a deep neural network model to automatically detect apneas and hypopneas from the electrocardiogram signal and apply his technique to the scoring of out-of-center sleep tests (OCSTs).
    Role: Principal Investigator
  2. (Kirsi-Marja Zitting) Jul 1, 2019 - Jun 30, 2020
    Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine (Harvard Medical School)
    Early vs. late time restricted feeding, circadian timing, and chronotype in overweight and obese adults: Impact on weight loss and cardiometabolic health
    Role Description: The goal of this study is to test in overweight and obese free-living adults the impact of early time-restricted feeding vs. late-time-restricted feeding on weight loss and cardiometabolic health, and to examine whether individual chronotype mediates these effects.
    Role: Principal Investigator
  3. (Kirsi-Marja Zitting) Jun 1, 2019 - May 31, 2020
    William F. Milton Fund, President and Fellows of Harvard College
    Automatic behavior in musicians
    Role Description: The goal of this study is to determine in highly trained musicians whether there is evidence that automatic behavior (AB), which occurs during highly learned behaviors such as playing an instrument and is characterized by a continuation of the behavior with amnesia, is due to local sleep where small areas of the brain go offline.
    Role: Principal Investigator
clinical trials
The clinical trials listed below are automatically derived from ClinicalTrials.gov and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
NCT Short Title Overall Status Start Completion

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zitting KM, Lockyer BJ, Azarbarzin A, Sands SA, Wang W, Wellman A, Quan SF. Association of cortical arousals with sleep-disordered breathing events. J Clin Sleep Med. 2023 Jan 28. PMID: 36708264.
    Citations:    Fields:    
  2. Wang W, Yuan RK, Mitchell JF, Zitting KM, St Hilaire MA, Wyatt JK, Scheer FAJL, Wright KP, Brown EN, Ronda JM, Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period. Nat Protoc. 2023 02; 18(2):579-603. PMID: 36376588.
    Citations: 1     Fields:    Translation:Humans
  3. Xin Q, Yuan RK, Zitting KM, Wang W, Purcell SM, Vujovic N, Ronda JM, Quan SF, Williams JS, Buxton OM, Duffy JF, Czeisler CA. Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance. Sleep. 2022 07 11; 45(7). PMID: 35218665; PMCID: PMC9272266.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  4. Yuan RK, Zitting KM, Maskati L, Huang J. Increased sleep duration and delayed sleep timing during the COVID-19 pandemic. Sci Rep. 2022 06 29; 12(1):10937. PMID: 35768461; PMCID: PMC9243067.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  5. Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, Wang W, Bandaru SS, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Duffy JF, Saper CB, Czeisler CA. Chronic circadian disruption on a high-fat diet impairs glucose tolerance. Metabolism. 2022 05; 130:155158. PMID: 35150732.
    Citations: 1     Fields:    Translation:HumansAnimals
  6. Yuan RK, Zitting KM, Duffy JF, Vujovic N, Wang W, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Czeisler CA. Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance. Front Physiol. 2021; 12:764737. PMID: 34744800.
    Citations: 3     
  7. Vellei M, Chinazzo G, Zitting KM, Hubbard J. Human thermal perception and time of day: A review. Temperature (Austin). 2021; 8(4):320-341. PMID: 34901316.
    Citations:    
  8. Zitting KM, Lammers-van der Holst HM, Yuan RK, Wang W, Quan SF, Duffy JF. Google Trends reveals increases in internet searches for insomnia during the 2019 coronavirus disease (COVID-19) global pandemic. J Clin Sleep Med. 2021 Feb 01; 17(2):177-184. PMID: 32975191; PMCID: PMC7853234.
    Citations: 25     Fields:    Translation:HumansCellsPHPublic Health
  9. Yuan RK, Zitting KM, Wang W, Buxton OM, Williams JS, Duffy JF, Czeisler CA. Fasting blood triglycerides vary with circadian phase in both young and older people. Physiol Rep. 2020 06; 8(11):e14453. PMID: 32519460.
    Citations: 4     Fields:    Translation:Humans
  10. Yuan RK, Pardilla-Delgado E, Zitting KM, Duffy JF. Tips for circadian sleep health while working from home. Southwest J Pulm Crit Care. 2020; 20(4):126-127. PMID: 32341887; PMCID: PMC7185226.
    Citations: 1     
  11. Zitting KM, Vujovic N, Yuan RK, Isherwood CM, Medina JE, Wang W, Buxton OM, Williams JS, Czeisler CA, Duffy JF. Human Resting Energy Expenditure Varies with Circadian Phase. Curr Biol. 2018 11 19; 28(22):3685-3690.e3. PMID: 30416064; PMCID: PMC6300153.
    Citations: 50     Fields:    Translation:Humans
  12. Zitting KM, Münch MY, Cain SW, Wang W, Wong A, Ronda JM, Aeschbach D, Czeisler CA, Duffy JF. Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep. 2018 07 23; 8(1):11052. PMID: 30038272.
    Citations: 21     Fields:    Translation:Humans
  13. Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT. Soluble interleukin-13ra1: a circulating regulator of glucose. Am J Physiol Endocrinol Metab. 2017 12 01; 313(6):E663-E671. PMID: 28874358; PMCID: PMC5814599.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Maurer L, Zitting KM, Elliott K, Czeisler CA, Ronda JM, Duffy JF. A new face of sleep: The impact of post-learning sleep on recognition memory for face-name associations. Neurobiol Learn Mem. 2015 Dec; 126:31-8. PMID: 26549626.
    Citations: 6     Fields:    Translation:Humans
  15. Duffy JF, Zitting KM, Chinoy ED. Aging and Circadian Rhythms. Sleep Med Clin. 2015 Dec; 10(4):423-34. PMID: 26568120; PMCID: PMC4648699.
    Citations: 91     Fields:    Translation:HumansAnimals
  16. Duffy JF, Zitting KM, Czeisler CA. The Case for Addressing Operator Fatigue. Rev Hum Factors Ergon. 2015 Jun; 10(1):29-78. PMID: 26056516; PMCID: PMC4457397.
    Citations: 6     
  17. Porkka-Heiskanen T, Zitting KM, Wigren HK. Sleep, its regulation and possible mechanisms of sleep disturbances. Acta Physiol (Oxf). 2013 Aug; 208(4):311-28. PMID: 23746394.
    Citations: 30     Fields:    Translation:Humans
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.