Harvard Catalyst Profiles

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Jui Cheng Tai, Ph.D.


National Yang-Ming University, Taipei, TaiwanB.S.07/2000Life Sciences
National Yang-Ming University, Taipei, TaiwanM.S.07/2002Biochemistry
National Defense Medical Center, Taipei, TaiwanPh.D.01/2009Neurosciences
Center for Genomic Medicine, Massachusetts General Hospital, BostonResearch Fellow08/2018Neurogenetics
2012 - 2015
Postdoctoral Research Abroad Program Awards
Postdoctoral Fellow Outstanding Publication Awards
2015 - 2016
Fund for Medical Discovery (FMD) Postdoctoral Fellowship Award


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mohajeri K, Yadav R, D'haene E, Boone PM, Erdin S, Gao D, Moyses-Oliveira M, Bhavsar R, Currall BB, O'Keefe K, Burt ND, Lowther C, Lucente D, Salani M, Larson M, Redin C, Dudchenko O, Aiden EL, Menten B, Tai DJC, Gusella JF, Vergult S, Talkowski ME. Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models. Am J Hum Genet. 2022 Nov 03; 109(11):2049-2067. PMID: 36283406; PMCID: PMC9674968.
    Citations:    Fields:    Translation:HumansCells
  2. Weiner DJ, Ling E, Erdin S, Tai DJC, Yadav R, Grove J, Fu JM, Nadig A, Carey CE, Baya N, Bybjerg-Grauholm J, Berretta S, Macosko EZ, Sebat J, O'Connor LJ, Hougaard DM, Børglum AD, Talkowski ME, McCarroll SA, Robinson EB. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p. Nat Genet. 2022 Nov; 54(11):1630-1639. PMID: 36280734; PMCID: PMC9649437.
    Citations: 1     Fields:    Translation:HumansCells
  3. Tai DJC, Razaz P, Erdin S, Gao D, Wang J, Nuttle X, de Esch CE, Collins RL, Currall BB, O'Keefe K, Burt ND, Yadav R, Wang L, Mohajeri K, Aneichyk T, Ragavendran A, Stortchevoi A, Morini E, Ma W, Lucente D, Hastie A, Kelleher RJ, Perlis RH, Talkowski ME, Gusella JF. Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models. Am J Hum Genet. 2022 Oct 06; 109(10):1789-1813. PMID: 36152629.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Tai JH, Sun HY, Tseng YC, Li G, Chang SY, Yeh SH, Chen PJ, Chaw SM, Wang HY. Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and Minks. Mol Biol Evol. 2022 09 01; 39(9). PMID: 35934827; PMCID: PMC9384665.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  5. Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder. Nat Commun. 2022 06 10; 13(1):3243. PMID: 35688811; PMCID: PMC9187732.
    Citations:    Fields:    Translation:HumansCells
  6. Sundberg M, Pinson H, Smith RS, Winden KD, Venugopal P, Tai DJC, Gusella JF, Talkowski ME, Walsh CA, Tegmark M, Sahin M. 16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro. Nat Commun. 2021 05 18; 12(1):2897. PMID: 34006844; PMCID: PMC8131375.
    Citations: 2     Fields:    Translation:HumansCells
  7. Seabra CM, Aneichyk T, Erdin S, Tai DJC, De Esch CEF, Razaz P, An Y, Manavalan P, Ragavendran A, Stortchevoi A, Abad C, Young JI, Maciel P, Talkowski ME, Gusella JF. Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons. Mol Autism. 2020 06 05; 11(1):45. PMID: 32503625; PMCID: PMC7275313.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Hsu WL, Ma YL, Liu YC, Tai DJC, Lee EHY. Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome. Sci Rep. 2020 01 23; 10(1):1074. PMID: 31974426.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  9. Boone PM, Paterson S, Mohajeri K, Zhu W, Genetti CA, Tai DJC, Nori N, Agrawal PB, Bacino CA, Bi W, Talkowski ME, Hogan BM, Rodan LH. Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome. Am J Med Genet A. 2020 01; 182(1):189-194. PMID: 31633297.
    Citations: 6     Fields:    Translation:HumansAnimals
  10. Tai DJ, Liu YC, Hsu WL, Ma YL, Cheng SJ, Liu SY, Lee EH. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016 Feb 04; 7:10552. PMID: 26842955.
    Citations: 32     Fields:    Translation:AnimalsCells
  11. Tai DJ, Ragavendran A, Manavalan P, Stortchevoi A, Seabra CM, Erdin S, Collins RL, Blumenthal I, Chen X, Shen Y, Sahin M, Zhang C, Lee C, Gusella JF, Talkowski ME. Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR. Nat Neurosci. 2016 Mar; 19(3):517-22. PMID: 26829649; PMCID: PMC4903018.
    Citations: 22     Fields:    Translation:HumansCells
  12. Chen YC, Hsu WL, Ma YL, Tai DJ, Lee EH. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. J Neurosci. 2014 Jul 16; 34(29):9574-89. PMID: 25031400.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  13. Tai DJ, Hsu WL, Liu YC, Ma YL, Lee EH. Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning. EMBO J. 2011 Jan 05; 30(1):205-20. PMID: 21102409.
    Citations: 22     Fields:    Translation:AnimalsCells
  14. Hsu WL, Chiu TH, Tai DJ, Ma YL, Lee EH. A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling. Cell Death Differ. 2009 Nov; 16(11):1515-29. PMID: 19609277.
    Citations: 12     Fields:    Translation:AnimalsCells
  15. Tai DJ, Su CC, Ma YL, Lee EH. SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. J Biol Chem. 2009 Feb 13; 284(7):4073-89. PMID: 19088076.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.