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William Eimer, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD. Alzheimer's Disease-Associated ß-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 2018 Dec 19; 100(6):1527-1532. PMID: 30571943.
    Citations:    Fields:    
  2. Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD. Alzheimer's Disease-Associated ß-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 2018 Jul 11; 99(1):56-63.e3. PMID: 30001512.
    Citations: 3     Fields:    
  3. Kumar DK, Eimer WA, Tanzi RE, Moir RD. Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-ß peptide. Neurodegener Dis Manag. 2016 10; 6(5):345-8. PMID: 27599536.
    Citations: 5     Fields:    Translation:HumansAnimals
  4. Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. Amyloid-ß peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci Transl Med. 2016 05 25; 8(340):340ra72. PMID: 27225182.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  5. Vijaya Kumar DK, Eimer WA, Ramakrishnan S. Specificity of Toll-Like Receptor 2 and Dectin-1 Signaling in CNS Macrophages. J Neurosci. 2015 Dec 09; 35(49):16015-7. PMID: 26658855.
    Citations:    Fields:    Translation:AnimalsCells
  6. Sadleir KR, Eimer WA, Cole SL, Vassar R. Aß reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Mol Neurodegener. 2015 Jan 07; 10:1. PMID: 25567526.
    Citations: 18     Fields:    Translation:HumansAnimals
  7. Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2a does not block Aß-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS One. 2014; 9(7):e101643. PMID: 24992504.
    Citations: 12     Fields:    Translation:AnimalsCells
  8. Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. Erratum to: The Alzheimer's ß-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 2013 Oct; 126(4):623. PMID: 24005893.
    Citations:    
  9. Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. The Alzheimer's ß-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 2013 Sep; 126(3):329-52. PMID: 23820808.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  10. Eimer WA, Vassar R. Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aß42 accumulation and Caspase-3 activation. Mol Neurodegener. 2013 Jan 14; 8:2. PMID: 23316765.
    Citations: 52     Fields:    Translation:AnimalsCells
  11. Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. APOE4-specific changes in Aß accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem. 2012 Dec 07; 287(50):41774-86. PMID: 23060451.
    Citations: 58     Fields:    Translation:HumansAnimals
  12. Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R. ß-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J Biol Chem. 2012 Nov 09; 287(46):38408-25. PMID: 22988240.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  13. Youmans KL, Tai LM, Kanekiyo T, Stine WB, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ. Intraneuronal Aß detection in 5xFAD mice by a new Aß-specific antibody. Mol Neurodegener. 2012 Mar 16; 7:8. PMID: 22423893.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  14. Rajapaksha TW, Eimer WA, Bozza TC, Vassar R. The Alzheimer's ß-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb. Mol Neurodegener. 2011 Dec 28; 6:88. PMID: 22204380.
    Citations: 33     Fields:    Translation:AnimalsCells
  15. O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009. PMID: 19109907.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  16. Jones EW, Berget PB, Burnette JM, Anderson C, Asafu-Adjei D, Avetisian S, Barrie F, Chen R, Chu B, Conroy S, Conroy S, Dill A, Eimer W, Garrity D, Greenwood A, Hamilton T, Hucko S, Jackson C, Livesey K, Monaco T, Onorato C, Otsuka M, Pai S, Schaeffer G, Shung S, Spath S, Stahlman J, Sweeney B, Wiltrout E, Yurovsky D, Zonneveld A. The spectrum of Trp- mutants isolated as 5-fluoroanthranilate-resistant clones in Saccharomyces bayanus, S. mikatae and S. paradoxus. Yeast. 2008 Jan; 25(1):41-6. PMID: 17924454.
    Citations: 7     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.