Harvard Catalyst Profiles

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Juan Manuel Gonzalez Rosa, Ph.D.

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Travel Award
2019 - 2022
Career Development Award
2017 - 2017
Honorable Metion Award for Scientific Excellence
2016 - 2016
Funds for Medical Discovery Award
2014 - 2015
Long-Term Postdoctoral Fellowship


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1R01HL164749-01 (Juan Manuel Gonzalez-Rosa) Aug 15, 2022 - Jul 31, 2027
    Identifying new regulators of cardiac fibrosis and inflammation using zebrafishv
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. González-Rosa JM. Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine. Circ Res. 2022 Jun 10; 130(12):1803-1826. PMID: 35679360.
    Citations:    Fields:    Translation:HumansAnimals
  2. Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, González-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 04 19; 145(16):1218-1233. PMID: 35114812; PMCID: PMC9056949.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Sharpe M, González-Rosa JM, Wranitz F, Jeffrey S, Copenhaver K, Burns CG, Burns CE. Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration. Front Cell Dev Biol. 2022; 10:800594. PMID: 35178388; PMCID: PMC8844374.
  4. Andrés-Delgado L, Galardi-Castilla M, Münch J, Peralta M, Ernst A, González-Rosa JM, Tessadori F, Santamaría L, Bakkers J, Vermot J, de la Pompa JL, Mercader N. Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium. Dev Dyn. 2020 12; 249(12):1455-1469. PMID: 33103836; PMCID: PMC7754311.
    Citations: 5     Fields:    Translation:AnimalsCells
  5. Sanz-Morejón A, García-Redondo AB, Reuter H, Marques IJ, Bates T, Galardi-Castilla M, Große A, Manig S, Langa X, Ernst A, Piragyte I, Botos MA, González-Rosa JM, Ruiz-Ortega M, Briones AM, Salaices M, Englert C, Mercader N. Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish. Cell Rep. 2019 07 30; 28(5):1296-1306.e6. PMID: 31365871.
    Citations: 23     Fields:    Translation:AnimalsCells
  6. Andrés-Delgado L, Ernst A, Galardi-Castilla M, Bazaga D, Peralta M, Münch J, González-Rosa JM, Marques I, Tessadori F, de la Pompa JL, Vermot J, Mercader N. Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells. Development. 2019 07 04; 146(13). PMID: 31175121; PMCID: PMC6633599.
    Citations: 7     Fields:    Translation:AnimalsCells
  7. Guner-Ataman B, González-Rosa JM, Shah HN, Butty VL, Jeffrey S, Abrial M, Boyer LA, Burns CG, Burns CE. Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome. Cell Rep. 2018 07 31; 24(5):1342-1354.e5. PMID: 30067987.
    Citations: 8     Fields:    Translation:AnimalsCells
  8. Sánchez-Iranzo H, Galardi-Castilla M, Sanz-Morejón A, González-Rosa JM, Costa R, Ernst A, Sainz de Aja J, Langa X, Mercader N. Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):4188-4193. PMID: 29610343; PMCID: PMC5910827.
    Citations: 62     Fields:    Translation:AnimalsCells
  9. González-Rosa JM, Sharpe M, Field D, Soonpaa MH, Field LJ, Burns CE, Burns CG. Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. Dev Cell. 2018 02 26; 44(4):433-446.e7. PMID: 29486195; PMCID: PMC5830170.
    Citations: 98     Fields:    Translation:AnimalsCells
  10. Sánchez-Iranzo H, Galardi-Castilla M, Minguillón C, Sanz-Morejón A, González-Rosa JM, Felker A, Ernst A, Guzmán-Martínez G, Mosimann C, Mercader N. Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nat Commun. 2018 01 30; 9(1):428. PMID: 29382818; PMCID: PMC5789846.
    Citations: 26     Fields:    Translation:AnimalsCells
  11. Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018 05 15; 137(20):2152-2165. PMID: 29348261; PMCID: PMC5953786.
    Citations: 28     Fields:    Translation:AnimalsCells
  12. González-Rosa JM, Burns CE, Burns CG. Zebrafish heart regeneration: 15 years of discoveries. Regeneration (Oxf). 2017 06; 4(3):105-123. PMID: 28979788.
    Citations: 66     
  13. Manalo T, May A, Quinn J, Lafontant DS, Shifatu O, He W, Gonzalez-Rosa JM, Burns GC, Burns CE, Burns AR, Lafontant PJ. Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio ( Devario aequipinnatus) and Zebrafish ( Danio rerio) Hearts. J Histochem Cytochem. 2016 11; 64(11):687-714. PMID: 27680670; PMCID: PMC5084522.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Rodius S, Androsova G, Götz L, Liechti R, Crespo I, Merz S, Nazarov PV, de Klein N, Jeanty C, González-Rosa JM, Muller A, Bernardin F, Niclou SP, Vallar L, Mercader N, Ibberson M, Xenarios I, Azuaje F. Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Sci Rep. 2016 05 31; 6:26822. PMID: 27241320.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Jahangiri L, Sharpe M, Novikov N, González-Rosa JM, Borikova A, Nevis K, Paffett-Lugassy N, Zhao L, Adams M, Guner-Ataman B, Burns CE, Burns CG. The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development. 2016 Jan 01; 143(1):113-22. PMID: 26732840.
    Citations: 18     Fields:    Translation:AnimalsCells
  16. Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, Marques IJ, Galardi-Castilla M, de Diego I, Gómez MJ, Cortés A, Zapata A, Jiménez-Borreguero LJ, Mercader N, Flores I. Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Rep. 2015 Sep 08; 12(10):1691-703. PMID: 26321646; PMCID: PMC4589159.
    Citations: 35     Fields:    Translation:AnimalsCells
  17. González-Rosa JM, Guzmán-Martínez G, Marques IJ, Sánchez-Iranzo H, Jiménez-Borreguero LJ, Mercader N. Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the zebrafish. PLoS One. 2014; 9(12):e115604. PMID: 25532015; PMCID: PMC4274112.
    Citations: 23     Fields:    Translation:Animals
  18. Rodius S, Nazarov PV, Nepomuceno-Chamorro IA, Jeanty C, González-Rosa JM, Ibberson M, da Costa RM, Xenarios I, Mercader N, Azuaje F. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. BMC Genomics. 2014 Oct 03; 15:852. PMID: 25280539.
    Citations: 8     Fields:    Translation:AnimalsCells
  19. Peralta M, González-Rosa JM, Marques IJ, Mercader N. The Epicardium in the Embryonic and Adult Zebrafish. J Dev Biol. 2014 Apr 11; 2(2):101-116. PMID: 24926432; PMCID: PMC4050495.
    Citations: 21     
  20. Peralta M, Steed E, Harlepp S, González-Rosa JM, Monduc F, Ariza-Cosano A, Cortés A, Rayón T, Gómez-Skarmeta JL, Zapata A, Vermot J, Mercader N. Heartbeat-driven pericardiac fluid forces contribute to epicardium morphogenesis. Curr Biol. 2013 Sep 23; 23(18):1726-35. PMID: 23954432.
    Citations: 30     Fields:    Translation:AnimalsCells
  21. Espín R, Roca FJ, Candel S, Sepulcre MP, González-Rosa JM, Alcaraz-Pérez F, Meseguer J, Cayuela ML, Mercader N, Mulero V. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2013 Mar; 6(2):383-96. PMID: 22956347; PMCID: PMC3597020.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  22. González-Rosa JM, Peralta M, Mercader N. Pan-epicardial lineage tracing reveals that epicardium derived cells give rise to myofibroblasts and perivascular cells during zebrafish heart regeneration. Dev Biol. 2012 Oct 15; 370(2):173-86. PMID: 22877945.
    Citations: 72     Fields:    Translation:AnimalsCells
  23. González-Rosa JM, Mercader N. Cryoinjury as a myocardial infarction model for the study of cardiac regeneration in the zebrafish. Nat Protoc. 2012 Mar 29; 7(4):782-8. PMID: 22461067.
    Citations: 61     Fields:    Translation:Animals
  24. González-Rosa JM, Martín V, Peralta M, Torres M, Mercader N. Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish. Development. 2011 May; 138(9):1663-74. PMID: 21429987.
    Citations: 218     Fields:    Translation:AnimalsCells
  25. González-Rosa JM, Padrón-Barthe L, Torres M, Mercader N. [Lineage tracing of epicardial cells during development and regeneration]. Rev Esp Cardiol. 2010 Jun; 63 Suppl 2:36-48. PMID: 20540899.
    Citations:    Fields:    Translation:HumansAnimals
  26. Pérez-Pomares JM, González-Rosa JM, Muñoz-Chápuli R. Building the vertebrate heart - an evolutionary approach to cardiac development. Int J Dev Biol. 2009; 53(8-10):1427-43. PMID: 19247975.
    Citations: 15     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.