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Thomas John Dougherty, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lorenz C, Dougherty TJ, Lory S. Correct Sorting of Lipoproteins into the Inner and Outer Membranes of Pseudomonas aeruginosa by the Escherichia coli LolCDE Transport System. mBio. 2019 04 16; 10(2). PMID: 30992347.
    Citations:    
  2. Lorenz C, Dougherty TJ, Lory S. Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway. J Bacteriol. 2016 12 01; 198(23):3162-3175. PMID: 27645386.
    Citations:    Fields:    Translation:Cells
  3. Pucci MJ, Dougherty TJ. Editorial overview: Antimicrobials: fighting bacterial infections in the 21st century-thinking outside of the box. Curr Opin Microbiol. 2016 10; 33:v-vii. PMID: 27567402.
    Citations:    Fields:    Translation:HumansAnimals
  4. Nayar AS, Dougherty TJ, Ferguson KE, Granger BA, McWilliams L, Stacey C, Leach LJ, Narita S, Tokuda H, Miller AA, Brown DG, McLeod SM. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May; 197(10):1726-34. PMID: 25733621.
    Citations: 12     Fields:    Translation:Cells
  5. Nayar AS, Dougherty TJ, Reck F, Thresher J, Gao N, Shapiro AB, Ehmann DE. Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor. Antimicrob Agents Chemother. 2015 Jan; 59(1):331-7. PMID: 25348539.
    Citations: 2     Fields:    Translation:Cells
  6. Reck F, Ehmann DE, Dougherty TJ, Newman JV, Hopkins S, Stone G, Agrawal N, Ciaccio P, McNulty J, Barthlow H, O'Donnell J, Goteti K, Breen J, Comita-Prevoir J, Cornebise M, Cronin M, Eyermann CJ, Geng B, Carr GR, Pandarinathan L, Tang X, Cottone A, Zhao L, Bezdenejnih-Snyder N. Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. Bioorg Med Chem. 2014 Oct 01; 22(19):5392-409. PMID: 25155913.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE. NBTI 5463 Is a Novel Bacterial Type II Topoisomerase Inhibitor with Activity against Gram-Negative Bacteria and In Vivo Efficacy. Antimicrob Agents Chemother. 2014 Jul; 58(7):4250. PMID: 24926073.
    Citations:    
  8. Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE. NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy. Antimicrob Agents Chemother. 2014 May; 58(5):2657-64. PMID: 24566174.
    Citations: 7     Fields:    Translation:Cells
  9. Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009 Dec 10; 52(23):7446-57. PMID: 19775168.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Simons SP, McLellan TJ, Aeed PA, Zaniewski RP, Desbonnet CR, Wondrack LM, Marr ES, Subashi TA, Dougherty TJ, Xu Z, Wang IK, LeMotte PK, Maguire BA. Purification of the large ribosomal subunit via its association with the small subunit. Anal Biochem. 2009 Dec 01; 395(1):77-85. PMID: 19646947.
    Citations: 3     Fields:    Translation:Cells
  11. Tait-Kamradt AG, Cronan M, Dougherty TJ. Comparative genome analysis of high-level penicillin resistance in Streptococcus pneumoniae. Microb Drug Resist. 2009 Jun; 15(2):69-75. PMID: 19432519.
    Citations: 5     Fields:    Translation:Cells
  12. Zawadzke LE, Norcia M, Desbonnet CR, Wang H, Freeman-Cook K, Dougherty TJ. Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway. Assay Drug Dev Technol. 2008 Feb; 6(1):95-103. PMID: 18315498.
    Citations: 6     Fields:    Translation:Cells
  13. Pucci MJ, Dougherty TJ. A method to assay penicillin-binding proteins. Methods Mol Med. 2008; 142:131-41. PMID: 18437311.
    Citations: 1     Fields:    Translation:Cells
  14. Williams SP, Tait-Kamradt AG, Norton JE, Albert TJ, Dougherty TJ. Nucleotide sequence changes between Streptococcus pneumoniae R6 and D39 strains determined by an oligonucleotide hybridization DNA sequencing technology. J Microbiol Methods. 2007 Jul; 70(1):65-74. PMID: 17477996.
    Citations: 1     Fields:    Translation:Cells
  15. Sobral RG, Jones AE, Des Etages SG, Dougherty TJ, Peitzsch RM, Gaasterland T, Ludovice AM, de Lencastre H, Tomasz A. Extensive and genome-wide changes in the transcription profile of Staphylococcus aureus induced by modulating the transcription of the cell wall synthesis gene murF. J Bacteriol. 2007 Mar; 189(6):2376-91. PMID: 17194794.
    Citations: 30     Fields:    Translation:HumansCells
  16. Springer DM, Bunker A, Luh BY, Sorenson ME, Goodrich JT, Bronson JJ, DenBleyker K, Dougherty TJ, Fung-Tomc J. Cyclopentanone ring-cleaved pleuromutilin derivatives. Eur J Med Chem. 2007 Jan; 42(1):109-13. PMID: 17156897.
    Citations: 2     Fields:    Translation:Cells
  17. Dougherty TJ, Miller PF. Microbial genomics and drug discovery: exploring innovative routes of drug discovery in the postgenomic era. IDrugs. 2006 Jun; 9(6):420-2. PMID: 16752312.
    Citations: 1     Fields:    Translation:Cells
  18. Barrett JF, Dougherty TJ. Antibacterial drug discovery & development summit. Expert Opin Investig Drugs. 2004 Jun; 13(6):715-21. PMID: 15174958.
    Citations:    Fields:    Translation:Humans
  19. Thanassi JA, Hartman-Neumann SL, Dougherty TJ, Dougherty BA, Pucci MJ. Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae. Nucleic Acids Res. 2002 Jul 15; 30(14):3152-62. PMID: 12136097.
    Citations: 72     Fields:    Translation:Cells
  20. Dougherty TJ, Barrett JF, Pucci MJ. Microbial genomics and novel antibiotic discovery: new technology to search for new drugs. Curr Pharm Des. 2002; 8(13):1119-35. PMID: 12052223.
    Citations: 3     Fields:    Translation:Cells
  21. Pucci MJ, Dougherty TJ. Direct quantitation of the numbers of individual penicillin-binding proteins per cell in Staphylococcus aureus. J Bacteriol. 2002 Jan; 184(2):588-91. PMID: 11751840.
    Citations: 5     Fields:    Translation:Cells
  22. Hartman-Neumann S, DenBleyker K, Pelosi LA, Lawrence LE, Barrett JF, Dougherty TJ. Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6) quinolone BMS-284756. Antimicrob Agents Chemother. 2001 Oct; 45(10):2865-70. PMID: 11557482.
    Citations: 12     Fields:    Translation:Cells
  23. Dougherty TJ, Beaulieu D, Barrett JF. New quinolones and the impact on resistance. Drug Discov Today. 2001 May 01; 6(10):529-536. PMID: 11369292.
    Citations: 1     Fields:    
  24. Zheng G, Dougherty TJ, Pandey RK. A Simple and Short Synthesis of Divinyl Chlorophyll Derivatives. J Org Chem. 1999 May 14; 64(10):3751-3754. PMID: 11674511.
    Citations: 1     Fields:    
  25. Bruccoleri RE, Dougherty TJ, Davison DB. Concordance analysis of microbial genomes. Nucleic Acids Res. 1998 Oct 01; 26(19):4482-6. PMID: 9742253.
    Citations: 11     Fields:    Translation:Cells
  26. Pucci MJ, Dougherty TJ, Barrett JF. Why are there no new antibiotics? Expert Opin Investig Drugs. 1998 Aug; 7(8):1233-5. PMID: 15992026.
    Citations: 3     Fields:    
  27. Pucci MJ, Thanassi JA, Discotto LF, Kessler RE, Dougherty TJ. Identification and characterization of cell wall-cell division gene clusters in pathogenic gram-positive cocci. J Bacteriol. 1997 Sep; 179(17):5632-5. PMID: 9287029.
    Citations: 13     Fields:    Translation:Cells
  28. Dougherty TJ, Kennedy K, Kessler RE, Pucci MJ. Direct quantitation of the number of individual penicillin-binding proteins per cell in Escherichia coli. J Bacteriol. 1996 Nov; 178(21):6110-5. PMID: 8892807.
    Citations: 33     Fields:    Translation:Cells
  29. Fung-Tomc JC, Gradelski E, Huczko E, Dougherty TJ, Kessler RE, Bonner DP. Differences in the resistant variants of Enterobacter cloacae selected by extended-spectrum cephalosporins. Antimicrob Agents Chemother. 1996 May; 40(5):1289-93. PMID: 8723487.
    Citations: 6     Fields:    Translation:Cells
  30. Ho HT, Falk PJ, Ervin KM, Krishnan BS, Discotto LF, Dougherty TJ, Pucci MJ. UDP-N-acetylmuramyl-L-alanine functions as an activator in the regulation of the Escherichia coli glutamate racemase activity. Biochemistry. 1995 Feb 28; 34(8):2464-70. PMID: 7873525.
    Citations: 3     Fields:    Translation:Cells
  31. Leviton IM, Fraimow HS, Carrasco N, Dougherty TJ, Miller MH. Tobramycin uptake in Escherichia coli membrane vesicles. Antimicrob Agents Chemother. 1995 Feb; 39(2):467-75. PMID: 7726517.
    Citations: 2     Fields:    Translation:Cells
  32. Pucci MJ, Thanassi JA, Ho HT, Falk PJ, Dougherty TJ. Staphylococcus haemolyticus contains two D-glutamic acid biosynthetic activities, a glutamate racemase and a D-amino acid transaminase. J Bacteriol. 1995 Jan; 177(2):336-42. PMID: 7814322.
    Citations: 9     Fields:    Translation:Cells
  33. Dougherty TJ, Pucci MJ. Penicillin-binding proteins are regulated by rpoS during transitions in growth states of Escherichia coli. Antimicrob Agents Chemother. 1994 Feb; 38(2):205-10. PMID: 8192444.
    Citations: 9     Fields:    Translation:Cells
  34. Pucci MJ, Novotny J, Discotto LF, Dougherty TJ. The Escherichia coli Dga (MurI) protein shares biological activity and structural domains with the Pediococcus pentosaceus glutamate racemase. J Bacteriol. 1994 Jan; 176(2):528-30. PMID: 7904596.
    Citations: 2     Fields:    Translation:Cells
  35. Dougherty TJ, Thanassi JA, Pucci MJ. The Escherichia coli mutant requiring D-glutamic acid is the result of mutations in two distinct genetic loci. J Bacteriol. 1993 Jan; 175(1):111-6. PMID: 8093236.
    Citations: 12     Fields:    Translation:Cells
  36. Pucci MJ, Discotto LF, Dougherty TJ. Cloning and identification of the Escherichia coli murB DNA sequence, which encodes UDP-N-acetylenolpyruvoylglucosamine reductase. J Bacteriol. 1992 Mar; 174(5):1690-3. PMID: 1311302.
    Citations: 14     Fields:    Translation:Cells
  37. Pucci MJ, Boice-Sowek J, Kessler RE, Dougherty TJ. Comparison of cefepime, cefpirome, and cefaclidine binding affinities for penicillin-binding proteins in Escherichia coli K-12 and Pseudomonas aeruginosa SC8329. Antimicrob Agents Chemother. 1991 Nov; 35(11):2312-7. PMID: 1804003.
    Citations: 17     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.