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Xianjun Dong, Ph.D.

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2021 - 2022
American Parkinson's Disease Association Research Award
2019 - 2020
American Parkinson's Disease Association Research Award
Advanced Center for Parkinson’s Disease Research (ACEPD) Seed Award
Research Excellence Award, Brigham and Women's Hospital
BRI NextGen Award, Brigham Research Institute
2017 - 2018
American Parkinson's Disease Association Research Award
Chinese Government Award for Outstanding Self-financed Students Abroad;
MCB Travel Fellowship, University of Bergen
First prize in the 2002 National Undergraduate Electronic Design Contest, China
Meritorious in the international Interdisciplinary Contest in Modelling (ICM), US

Xianjun Dong is an Assistant Professor in the Department of Neurology at Harvard Medical School, a Faculty member of the HMS Initiative for RNA Medicine, and an Associate Member of the Broad Institute. Since 2020, Dr. Dong has been appointed to direct this Genomics and Bioinformatics Hub at Brigham and Women’s Hospital (BWH) and also run his own research lab as an independent PI. Before taking this position, Dr. Dong has been serving as the Director of the Computational Neuroscience Unit of the Precision Neurology Program at BWH and an Instructor at Harvard Medical School for 7 years. He specialized in developing and applying computational methods to understand the transcriptional regulation of the human genome, by integrating genomic, transcriptomic, epigenetic, and clinical data from both healthy subjects and patients with neurological diseases. He is particularly interested in the non-coding RNAs (eRNA, circRNA, miRNA, etc.) in the human brain. He has expertise in analyzing various NGS data, incl. ChIPseq, RNAseq, RNA-PET, CAGE, and WGS data.

Dr. Dong received his PhD degree in Bioinformatics at the University of Bergen (supervisor: Boris Lenhard) and a Postdoctoral Fellowship in Bioinformatics and Integrative Biology at the University of Massachusetts Medical School (supervisor: Zhiping Weng). He was an active member of the ENCODE consortium. He has 40+ publications with 20,000+ citations and an H-index of 24. He is recently awarded by the American Parkinson’s Disease Association (APDA), Aligning Science Across Parkinson’s (ASAP), and NIH (two R01, U01, R41, U19). In his spare time, he raises three kids and 15 chickens. See his website for more details: http://sterding.github.io.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19 1U19NS130617 (Dong) Dec 1, 2022 - Nov 30, 2027
    Human PRECISION Human Pain Center - Data Core
    Role Description: The goal of this core is to act as a data center for large-scale multiomics datasets generated by the U19 Center by building infrastructure, providing data management, coordination, analysis and sharing.
    Role: PI
  2. R01 AG078948-01 (Dong, Sun) Jul 1, 2022 - Jun 30, 2027
    Regulation mechanism and functional genomics of LINE1 RNA in TDP-43 linked neurodegeneration
    Role Description: The goal of this project is to study the regulation mechanism and functional genomics of LINE1 RNA in TDP-43 linked neurodegeneration.
    Role: PI
  3. R01 NS124916-01 (Lee, Dong) Dec 1, 2021 - Nov 30, 2026
    Systematic study of extracellular vesicles and their integrative analysis with Parkinson's organoids MAP
    Role Description: The goal of this study is to develop a new 3D mini-brain microphysiological analysis platform (MAP) to recapitulate the dopamine neurons’ interconnectivity and study molecular neurodegeneration systematically.
    Role: PI
  4. R41AG076098 (CHEN, YUCHAO) Sep 30, 2021 - Mar 29, 2022
    EXODUS-enabled High-throughput Multi-omics Profiling of Extracellular Vesicles for Diagnosis of Preclinical Alzheimer's Disease
    Role Description: The goal is to develop a collaborative hub providing genomics and bioinformatics service hub to the Neurology research community at Brigham and Women’s Hospital.
    Role: PI
  5. (Xianjun Dong) Sep 1, 2021 - Aug 31, 2021
    Developing RNA biomarkers of early PD pathology from brain organoids and extracellular vesicles
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.