Harvard Catalyst Profiles

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Chih Chieh Yang, Ph.D., M.D.

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The Calvin & Rose G Hoffman Marlowe Memorial Trust Prize
Lifu Medical Research Foundation Award
Dr. Tsai Memorial Award
Travel Award, 20th European Congress of Psychiatry
Young Scientist Award, 11th World Congress of Biological Psychiatry

The major goal of Dr. Albert C. Yang's research is the detection of hidden information in neurophysiologic signals using techniques adapted from statistical physics and nonlinear dynamics. The major application of this on-going work is to develop novel techniques for identifying objective biomarkers of psychiatric disorders and for understanding the pathophysiology of the mental illness.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang AC, Peng CK, Huang NE. Causal decomposition in the mutual causation system. Nat Commun. 2018 08 23; 9(1):3378. PMID: 30140008.
    Citations:    Fields:    
  2. Yang AC, Tsai SJ, Lin CP, Peng CK, Huang NE. Frequency and amplitude modulation of resting-state fMRI signals and their functional relevance in normal aging. Neurobiol Aging. 2018 10; 70:59-69. PMID: 30007165.
    Citations:    Fields:    
  3. Yang AC, Tsai SJ. New Targets for Schizophrenia Treatment beyond the Dopamine Hypothesis. Int J Mol Sci. 2017 Aug 03; 18(8). PMID: 28771182.
    Citations: 4     Fields:    Translation:Humans
  4. Lin WC, Shen CC, Tsai SJ, Yang AC. Increased Risk of Myofascial Pain Syndrome Among Patients with Insomnia. Pain Med. 2017 Aug 01; 18(8):1557-1565. PMID: 28339643.
    Citations:    Fields:    Translation:Humans
  5. Ma Y, Shi W, Peng CK, Yang AC. Nonlinear dynamical analysis of sleep electroencephalography using fractal and entropy approaches. Sleep Med Rev. 2018 02; 37:85-93. PMID: 28392169.
    Citations: 3     Fields:    Translation:Humans
  6. Hager B, Yang AC, Brady R, Meda S, Clementz B, Pearlson GD, Sweeney JA, Tamminga C, Keshavan M. Neural complexity as a potential translational biomarker for psychosis. J Affect Disord. 2017 07; 216:89-99. PMID: 27814962.
    Citations: 2     Fields:    Translation:Humans
  7. Yang AC, Tsai SJ, Liu ME, Huang CC, Lin CP. The Association of Aging with White Matter Integrity and Functional Connectivity Hubs. Front Aging Neurosci. 2016; 8:143. PMID: 27378915.
    Citations: 4     
  8. Yang AC, Fuh JL, Huang NE, Shia BC, Wang SJ. Patients with migraine are right about their perception of temperature as a trigger: time series analysis of headache diary data. J Headache Pain. 2015; 16:533. PMID: 26018293.
    Citations: 1     Fields:    Translation:Humans
  9. Yang AC, Hong CJ, Liou YJ, Huang KL, Huang CC, Liu ME, Lo MT, Huang NE, Peng CK, Lin CP, Tsai SJ. Decreased resting-state brain activity complexity in schizophrenia characterized by both increased regularity and randomness. Hum Brain Mapp. 2015 Jun; 36(6):2174-86. PMID: 25664834.
    Citations: 5     Fields:    Translation:Humans
  10. Wang EH, Yang AC. Pisa syndrome after discontinuation of clotiapine in a patient with intractable insomnia. J Clin Psychopharmacol. 2014 Apr; 34(2):276-7. PMID: 24525650.
    Citations:    Fields:    Translation:Humans
  11. Yang AC, Huang CC, Liu ME, Liou YJ, Hong CJ, Lo MT, Huang NE, Peng CK, Lin CP, Tsai SJ. The APOE ?4 allele affects complexity and functional connectivity of resting brain activity in healthy adults. Hum Brain Mapp. 2014 Jul; 35(7):3238-48. PMID: 24193893.
    Citations: 12     Fields:    Translation:Humans
  12. Shen CC, Tsai SJ, Perng CL, Kuo BI, Yang AC. Risk of Parkinson disease after depression: a nationwide population-based study. Neurology. 2013 Oct 22; 81(17):1538-44. PMID: 24089392.
    Citations: 27     Fields:    Translation:Humans
  13. Yang AC, Wang SJ, Lai KL, Tsai CF, Yang CH, Hwang JP, Lo MT, Huang NE, Peng CK, Fuh JL. Cognitive and neuropsychiatric correlates of EEG dynamic complexity in patients with Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 02; 47:52-61. PMID: 23954738.
    Citations: 18     Fields:    Translation:Humans
  14. Wang EH, Yang AC. Reversible skin rash in a bipolar disorder patient on first use of lithium. Psychiatry Clin Neurosci. 2013 Jul; 67(5):365. PMID: 23859668.
    Citations: 1     Fields:    Translation:Humans
  15. Lin YH, Ho YC, Lin SH, Yeh YH, Liu CY, Kuo TB, Yang CC, Yang AC. On-call duty effects on sleep-state physiological stability in male medical interns. PLoS One. 2013; 8(6):e65072. PMID: 23750232.
    Citations: 2     Fields:    Translation:Humans
  16. Yang AC, Tsai SJ. Complexity of mental illness: a new research dimension. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 01; 45:251-2. PMID: 23380171.
    Citations: 2     Fields:    Translation:Humans
  17. Yang AC, Yang CH, Hong CJ, Liou YJ, Shia BC, Peng CK, Huang NE, Tsai SJ. Effects of age, sex, index admission, and predominant polarity on the seasonality of acute admissions for bipolar disorder: a population-based study. Chronobiol Int. 2013 May; 30(4):478-85. PMID: 23281718.
    Citations: 2     Fields:    Translation:Humans
  18. Yang AC, Tsai SJ. Is mental illness complex? From behavior to brain. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 01; 45:253-7. PMID: 23089053.
    Citations: 13     Fields:    Translation:Humans
  19. Yang AC, Tsai SJ, Yang CH, Shia BC, Fuh JL, Wang SJ, Peng CK, Huang NE. Suicide and media reporting: a longitudinal and spatial analysis. Soc Psychiatry Psychiatr Epidemiol. 2013 Mar; 48(3):427-35. PMID: 22878833.
    Citations: 4     Fields:    Translation:Humans
  20. Yang AC, Huang CC, Yeh HL, Liu ME, Hong CJ, Tu PC, Chen JF, Huang NE, Peng CK, Lin CP, Tsai SJ. Complexity of spontaneous BOLD activity in default mode network is correlated with cognitive function in normal male elderly: a multiscale entropy analysis. Neurobiol Aging. 2013 Feb; 34(2):428-38. PMID: 22683008.
    Citations: 38     Fields:    Translation:Humans
  21. Yang AC, Tsai SJ, Hong CJ, Wang C, Chen TJ, Liou YJ, Peng CK. Clustering heart rate dynamics is associated with ß-adrenergic receptor polymorphisms: analysis by information-based similarity index. PLoS One. 2011 May 04; 6(5):e19232. PMID: 21573230.
    Citations: 1     Fields:    Translation:Humans
  22. Chen SP, Fuh JL, Wang SJ, Tsai SJ, Hong CJ, Yang AC. Brain-derived neurotrophic factor gene Val66Met polymorphism modulates reversible cerebral vasoconstriction syndromes. PLoS One. 2011 Mar 18; 6(3):e18024. PMID: 21437208.
    Citations: 12     Fields:    Translation:Humans
  23. Yang AC, Tsai SJ, Huang NE, Peng CK. Association of Internet search trends with suicide death in Taipei City, Taiwan, 2004-2009. J Affect Disord. 2011 Jul; 132(1-2):179-84. PMID: 21371755.
    Citations: 18     Fields:    Translation:Humans
  24. Yang AC, Yang CH, Hong CJ, Tsai SJ, Kuo CH, Peng CK, Mietus JE, Goldberger AL, Thomas RJ. Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis. Psychophysiology. 2011 Feb; 48(2):285-91. PMID: 20624250.
    Citations: 15     Fields:    Translation:Humans
  25. Yang AC, Fuh JL, Huang NE, Shia BC, Peng CK, Wang SJ. Temporal associations between weather and headache: analysis by empirical mode decomposition. PLoS One. 2011 Jan 31; 6(1):e14612. PMID: 21297940.
    Citations: 11     Fields:    Translation:Humans
  26. Yang AC, Tsai SJ, Yang CH, Kuo CH, Chen TJ, Hong CJ. Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia. J Affect Disord. 2011 Jun; 131(1-3):179-85. PMID: 21195485.
    Citations: 17     Fields:    Translation:Humans
  27. Yang AC, Huang NE, Peng CK, Tsai SJ. Do seasons have an influence on the incidence of depression? The use of an internet search engine query data as a proxy of human affect. PLoS One. 2010 Oct 28; 5(10):e13728. PMID: 21060851.
    Citations: 25     Fields:    Translation:Humans
  28. Yang AC, Tsai SJ, Yeh HL, Chen JY, Liou YJ, Hwang JP, Hong CJ. Association between renal function and cognitive performance in elderly community-dwelling men without dementia. J Am Geriatr Soc. 2010 Oct; 58(10):2046-8. PMID: 20929489.
    Citations: 1     Fields:    Translation:Humans
  29. Yang AC, Tsai SJ, Huang NE. Decomposing the association of completed suicide with air pollution, weather, and unemployment data at different time scales. J Affect Disord. 2011 Mar; 129(1-3):275-81. PMID: 20828830.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  30. Yang AC, Chen TJ, Tsai SJ, Hong CJ, Kuo CH, Yang CH, Kao KP. BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects. Am J Med Genet B Neuropsychiatr Genet. 2010 Jul; 153B(5):1024-30. PMID: 20213725.
    Citations: 16     Fields:    Translation:Humans
  31. Cheng D, Tsai SJ, Hong CJ, Yang AC. Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele. PLoS One. 2009 Nov 05; 4(11):e7733. PMID: 19890394.
    Citations: 7     Fields:    Translation:Humans
  32. Yang AC, Goldberger AL, Peng CK. Genomic classification using an information-based similarity index: application to the SARS coronavirus. J Comput Biol. 2005 Oct; 12(8):1103-16. PMID: 16241900.
    Citations: 5     Fields:    Translation:HumansCells
  33. Novak V, Yang AC, Lepicovsky L, Goldberger AL, Lipsitz LA, Peng CK. Multimodal pressure-flow method to assess dynamics of cerebral autoregulation in stroke and hypertension. Biomed Eng Online. 2004 Oct 25; 3(1):39. PMID: 15504235.
    Citations: 36     Fields:    Translation:Humans
  34. Yang AC, Hseu SS, Yien HW, Goldberger AL, Peng CK. Linguistic analysis of the human heartbeat using frequency and rank order statistics. Phys Rev Lett. 2003 Mar 14; 90(10):108103. PMID: 12689038.
    Citations: 12     Fields:    Translation:Humans
  35. Yang AC, Peng CK, Yien HW, Goldberger AL. Information categorization approach to literary authorship disputes. Physica A. (329):473-483. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.