Harvard Catalyst Profiles

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Neil McDonald, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Thomas AM, Brolih S, McGouran JF, El-Sagheer AH, Ptchelkine D, Jones M, McDonald NQ, McHugh PJ, Brown T. Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chem Commun (Camb). 2019 Sep 26; 55(78):11671-11674. PMID: 31497827.
    Citations: 1     Fields:    Translation:HumansCells
  2. Plaza-Menacho I, Barnouin K, Barry R, Borg A, Orme M, Chauhan R, Mouilleron S, Martínez-Torres RJ, Meier P, McDonald NQ. RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep. 2016 12 20; 17(12):3319-3332. PMID: 28009299; PMCID: PMC5199340.
    Citations: 16     Fields:    Translation:AnimalsCells
  3. Soriano EV, Ivanova ME, Fletcher G, Riou P, Knowles PP, Barnouin K, Purkiss A, Kostelecky B, Saiu P, Linch M, Elbediwy A, Kjær S, O'Reilly N, Snijders AP, Parker PJ, Thompson BJ, McDonald NQ. aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev Cell. 2016 08 22; 38(4):384-98. PMID: 27554858; PMCID: PMC4998004.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  4. Gabreski NA, Vaghasia JK, Novakova SS, McDonald NQ, Pierchala BA. Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction. J Biol Chem. 2016 07 29; 291(31):16249-62. PMID: 27226544; PMCID: PMC4965573.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  5. Krstajic N, Akram AR, Choudhary TR, McDonald N, Tanner MG, Pedretti E, Dalgarno PA, Scholefield E, Girkin JM, Moore A, Bradley M, Dhaliwal K. Two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue. J Biomed Opt. 2016 Apr 30; 21(4):46009. PMID: 27121475.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  6. Ivanova ME, Fletcher GC, O'Reilly N, Purkiss AG, Thompson BJ, McDonald NQ. Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove. Acta Crystallogr D Biol Crystallogr. 2015 Mar; 71(Pt 3):555-64. PMID: 25760605; PMCID: PMC4356366.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Fisher R, Horswell S, Rowan A, Salm MP, de Bruin EC, Gulati S, McGranahan N, Stares M, Gerlinger M, Varela I, Crockford A, Favero F, Quidville V, André F, Navas C, Grönroos E, Nicol D, Hazell S, Hrouda D, O'Brien T, Matthews N, Phillimore B, Begum S, Rabinowitz A, Biggs J, Bates PA, McDonald NQ, Stamp G, Spencer-Dene B, Hsieh JJ, Xu J, Pickering L, Gore M, Larkin J, Swanton C. Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution. Genome Biol. 2014 Aug 27; 15(8):433. PMID: 25159823; PMCID: PMC4166471.
    Citations: 35     Fields:    Translation:HumansCells
  8. Plaza-Menacho I, Mologni L, McDonald NQ. Mechanisms of RET signaling in cancer: current and future implications for targeted therapy. Cell Signal. 2014 Aug; 26(8):1743-52. PMID: 24705026.
    Citations: 37     Fields:    Translation:HumansCells
  9. Plaza-Menacho I, Barnouin K, Goodman K, Martínez-Torres RJ, Borg A, Murray-Rust J, Mouilleron S, Knowles P, McDonald NQ. Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol Cell. 2014 Mar 06; 53(5):738-51. PMID: 24560924; PMCID: PMC3988870.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  10. Linch M, Sanz-Garcia M, Soriano E, Zhang Y, Riou P, Rosse C, Cameron A, Knowles P, Purkiss A, Kjaer S, McDonald NQ, Parker PJ. A cancer-associated mutation in atypical protein kinase C? occurs in a substrate-specific recruitment motif. Sci Signal. 2013 Sep 17; 6(293):ra82. PMID: 24045153.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  11. Kjær S, Linch M, Purkiss A, Kostelecky B, Knowles PP, Rosse C, Riou P, Soudy C, Kaye S, Patel B, Soriano E, Murray-Rust J, Barton C, Dillon C, Roffey J, Parker PJ, McDonald NQ. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15; 451(2):329-42. PMID: 23418854.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  12. Mouilleron S, Wiezlak M, O'Reilly N, Treisman R, McDonald NQ. Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity. Structure. 2012 Nov 07; 20(11):1960-70. PMID: 23041370.
    Citations: 12     Fields:    Translation:Cells
  13. Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ, Treisman R. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci. 2012 Dec 01; 125(Pt 23):5860-72. PMID: 22976292.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  14. Bowles M, Lally J, Fadden AJ, Mouilleron S, Hammonds T, McDonald NQ. Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition. Nucleic Acids Res. 2012 Jul; 40(13):e101. PMID: 22457069; PMCID: PMC3401468.
    Citations: 14     Fields:    Translation:HumansCells
  15. Gerlinger M, Rowan AJ, Horswell S, Math M, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012 Mar 08; 366(10):883-892. PMID: 22397650; PMCID: PMC4878653.
    Citations: 3445     Fields:    Translation:Humans
  16. Mouilleron S, Langer CA, Guettler S, McDonald NQ, Treisman R. Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator. Sci Signal. 2011 Jun 14; 4(177):ra40. PMID: 21673315.
    Citations: 49     Fields:    Translation:AnimalsCells
  17. Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambacorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM. Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem. 2011 May 13; 286(19):17292-302. PMID: 21454698; PMCID: PMC3089571.
    Citations: 31     Fields:    Translation:HumansCells
  18. Boëda B, Knowles PP, Briggs DC, Murray-Rust J, Soriano E, Garvalov BK, McDonald NQ, Way M. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. J Biol Chem. 2011 Apr 01; 286(13):11543-54. PMID: 21278383; PMCID: PMC3064208.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  19. Kjaer S, Hanrahan S, Totty N, McDonald NQ. Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat Struct Mol Biol. 2010 Jun; 17(6):726-31. PMID: 20473317.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  20. Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ. Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep. 2009 Sep; 10(9):983-9. PMID: 19662078; PMCID: PMC2750047.
    Citations: 45     Fields:    Translation:HumansCells
  21. Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. Protein kinase C intervention: the state of play. Curr Opin Cell Biol. 2009 Apr; 21(2):268-79. PMID: 19233632.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  22. Mouilleron S, Guettler S, Langer CA, Treisman R, McDonald NQ. Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J. 2008 Dec 03; 27(23):3198-208. PMID: 19008859.
    Citations: 54     Fields:    Translation:Cells
  23. Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K, McDonald NQ. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. J Biol Chem. 2008 Aug 08; 283(32):22325-35. PMID: 18495667.
    Citations: 41     Fields:    Translation:HumansCells
  24. Ciccia A, McDonald N, West SC. Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem. 2008; 77:259-87. PMID: 18518821.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  25. Boëda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ, Way M. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol Cell. 2007 Dec 28; 28(6):1071-82. PMID: 18158903.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  26. Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA, McDonald N, Larijani B, Parker PJ. Protein kinases, from B to C. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1013-7. PMID: 17956266.
    Citations: 26     Fields:    Translation:Cells
  27. Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol. 2007 Nov; 9(11):1243-52. PMID: 17906618.
    Citations: 215     Fields:    Translation:HumansAnimalsCells
  28. Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJ, Keyse SM, McDonald NQ. Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases. Nature. 2007 May 24; 447(7143):487-92. PMID: 17495930.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  29. Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibáñez CF, McDonald NQ. Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem. 2006 Nov 03; 281(44):33577-87. PMID: 16928683.
    Citations: 97     Fields:    Translation:AnimalsCells
  30. Laman H, Funes JM, Ye H, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. EMBO J. 2005 Sep 07; 24(17):3104-16. PMID: 16096642; PMCID: PMC1201355.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  31. Nicastro G, Menon RP, Masino L, Knowles PP, McDonald NQ, Pastore A. The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10493-8. PMID: 16020535; PMCID: PMC1180765.
    Citations: 80     Fields:    Translation:Cells
  32. Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ. Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO J. 2005 Mar 09; 24(5):895-905. PMID: 15719018; PMCID: PMC554130.
    Citations: 53     Fields:    Translation:Cells
  33. Lally J, Newman M, Murray-Rust J, Fadden A, Kawarabayasi Y, McDonald N. Crystallization of the xeroderma pigmentosum group F endonuclease from Aeropyrum pernix. Acta Crystallogr D Biol Crystallogr. 2004 Sep; 60(Pt 9):1658-61. PMID: 15333947.
    Citations: 1     Fields:    Translation:Cells
  34. Lehmann A, Katayama S, Harrison C, Dhut S, Kitamura K, McDonald N, Toda T. Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint. Genes Cells. 2004 May; 9(5):367-82. PMID: 15147268.
    Citations: 22     Fields:    Translation:AnimalsCells
  35. Movahedzadeh F, Smith DA, Norman RA, Dinadayala P, Murray-Rust J, Russell DG, Kendall SL, Rison SC, McAlister MS, Bancroft GJ, McDonald NQ, Daffe M, Av-Gay Y, Stoker NG. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol. 2004 Feb; 51(4):1003-14. PMID: 14763976.
    Citations: 39     Fields:    Translation:AnimalsCells
  36. Leiper J, Murray-Rust J, McDonald N, Vallance P. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13527-32. PMID: 12370443; PMCID: PMC129707.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  37. Hornig NC, Knowles PP, McDonald NQ, Uhlmann F. The dual mechanism of separase regulation by securin. Curr Biol. 2002 Jun 25; 12(12):973-82. PMID: 12123570.
    Citations: 52     Fields:    Translation:AnimalsCells
  38. Norman RA, McAlister MS, Murray-Rust J, Movahedzadeh F, Stoker NG, McDonald NQ. Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis. Structure. 2002 Mar; 10(3):393-402. PMID: 12005437.
    Citations: 17     Fields:    Translation:Cells
  39. Card GL, Knowles P, Laman H, Jones N, McDonald NQ. Crystal structure of a gamma-herpesvirus cyclin-cdk complex. EMBO J. 2000 Jun 15; 19(12):2877-88. PMID: 10856233; PMCID: PMC203358.
    Citations: 15     Fields:    Translation:Cells
  40. Hughes WE, Woscholski R, Cooke FT, Patrick RS, Dove SK, McDonald NQ, Parker PJ. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J Biol Chem. 2000 Jan 14; 275(2):801-8. PMID: 10625610.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  41. Ruas M, Brookes S, McDonald NQ, Peters G. Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information. Oncogene. 1999 Sep 23; 18(39):5423-34. PMID: 10498896.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  42. Swanton C, Card GL, Mann D, McDonald N, Jones N. Overcoming inhibitions: subversion of CKI function by viral cyclins. Trends Biochem Sci. 1999 Mar; 24(3):116-20. PMID: 10203759.
    Citations: 12     Fields:    Translation:HumansCells
  43. Stewart AE, Dowd S, Keyse SM, McDonald NQ. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. Nat Struct Biol. 1999 Feb; 6(2):174-81. PMID: 10048930.
    Citations: 44     Fields:    Translation:Cells
  44. Pappa H, Dekker LV, Parker PJ, McDonald NQ. Preliminary X-ray analysis of a C2-like domain from protein kinase C-delta. Acta Crystallogr D Biol Crystallogr. 1998 Jul 01; 54(Pt 4):693-6. PMID: 9761878.
    Citations: 1     Fields:    Translation:AnimalsCells
  45. Pappa HS, Stewart AE, McDonald NQ. Incorporating anomalous scattering centres into macromolecules. Curr Opin Struct Biol. 1996 Oct; 6(5):611-6. PMID: 8913682.
    Citations:    Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.