Harvard Catalyst Profiles

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David Spector, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yu AT, Aggarwal D, Pappin D, Spector DL. Single Oligonucleotide Capture of RNA And Temperature Elution Series ( SOCRATES ) for Identification of RNA-binding Proteins. Bio Protoc. 2022 Dec 20; 12(24). PMID: 36618090; PMCID: PMC9797359.
  2. Hazra R, Brine L, Garcia L, Benz B, Chirathivat N, Shen MM, Wilkinson JE, Lyons SK, Spector DL. Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022 11 07; 57(21):2450-2468.e7. PMID: 36347239; PMCID: PMC9680017.
    Citations:    Fields:    Translation:AnimalsCells
  3. Balasooriya GI, Spector DL. Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage. Nat Commun. 2022 Oct 10; 13(1):5984. PMID: 36216821; PMCID: PMC9550772.
    Citations:    Fields:    Translation:AnimalsCells
  4. Hazra R, Spector DL. Simultaneous visualization of RNA transcripts and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence in situ hybridization and immunofluorescence microscopy. Front Cell Dev Biol. 2022; 10:986261. PMID: 36268512; PMCID: PMC9577017.
  5. Angelo J, Soto M, Dai D, Spector D, Orav EJ, Tavakkoli A, Tsai TC. Impact of the COVID-19 Pandemic on Inpatient and Outpatient Utilization of Bariatric Surgery. Surg Endosc. 2022 Sep 27. PMID: 36167873; PMCID: PMC9514883.
    Citations:    Fields:    
  6. Bhatia S, Kramer M, Russo S, Naik P, Arun G, Brophy K, Andrews P, Fan C, Perou CM, Preall J, Ha T, Plenker D, Tuveson DA, Rishi A, Wilkinson JE, McCombie WR, Kostroff K, Spector DL. Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics. Cancer Res. 2022 04 01; 82(7):1174-1192. PMID: 35180770; PMCID: PMC9135475.
    Citations: 2     Fields:    Translation:HumansCells
  7. Senturk JC, Sharma R, Tavakkoli A, Vernon A, Spector D, Robinson M, Sheu E, Shikora S. Safety and effectiveness of 1-stage conversion of adjustable gastric band-to-sleeve gastrectomy: a single-institution case-control study. Surg Obes Relat Dis. 2022 Jan; 18(1):95-101. PMID: 34666948.
    Citations:    Fields:    Translation:Humans
  8. Sun L, Kees T, Almeida AS, Liu B, He XY, Ng D, Han X, Spector DL, McNeish IA, Gimotty P, Adams S, Egeblad M. Activating a collaborative innate-adaptive immune response to control metastasis. Cancer Cell. 2021 10 11; 39(10):1361-1374.e9. PMID: 34478639; PMCID: PMC8981964.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  9. Yu AT, Berasain C, Bhatia S, Rivera K, Liu B, Rigo F, Pappin DJ, Spector DL. PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR. Elife. 2021 05 18; 10. PMID: 34002693.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Edgerton C, Heshmati K, Herman A, Dey T, Dehkharghani R, Ramsis R, Robinson M, Vernon A, Ghushe N, Spector D, Shikora S, Tavakkoli A, Sheu EG. Fellowship training influences learning curves for laparoscopic sleeve gastrectomy. Surg Endosc. 2022 02; 36(2):1601-1608. PMID: 33620566.
    Citations:    Fields:    Translation:Humans
  11. Chang KC, Spector DL. MaTAR25: a long non-coding RNA involved in breast cancer progression. Mol Cell Oncol. 2021; 8(2):1882286. PMID: 33860086; PMCID: PMC8018362.
  12. Chang KC, Diermeier SD, Yu AT, Brine LD, Russo S, Bhatia S, Alsudani H, Kostroff K, Bhuiya T, Brogi E, Pappin DJ, Bennett CF, Rigo F, Spector DL. MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression. Nat Commun. 2020 12 22; 11(1):6438. PMID: 33353933.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  13. Arun G, Spector DL. MALAT1 long non-coding RNA and breast cancer. RNA Biol. 2019 06; 16(6):860-863. PMID: 30874469; PMCID: PMC6546402.
    Citations: 48     Fields:    Translation:HumansCells
  14. Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M, Shi J, Vakoc CR. POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev. 2018 07 01; 32(13-14):915-928. PMID: 29945888; PMCID: PMC6075037.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  15. Arun G, Diermeier SD, Spector DL. Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol Med. 2018 03; 24(3):257-277. PMID: 29449148; PMCID: PMC5840027.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  16. Diermeier SD, Spector DL. Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids. Bio Protoc. 2017 Aug 20; 7(16). PMID: 28932764; PMCID: PMC5602589.
    Citations: 3     
  17. Zhang B, Mao YS, Diermeier SD, Novikova IV, Nawrocki EP, Jones TA, Lazar Z, Tung CS, Luo W, Eddy SR, Sanbonmatsu KY, Spector DL. Identification and Characterization of a Class of MALAT1-like Genomic Loci. Cell Rep. 2017 05 23; 19(8):1723-1738. PMID: 28538188.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  18. Pernar LI, Lockridge R, McCormack C, Chen J, Shikora SA, Spector D, Tavakkoli A, Vernon AH, Robinson MK. An Effort to Develop an Algorithm to Target Abdominal CT Scans for Patients After Gastric Bypass. Obes Surg. 2016 10; 26(10):2543-6. PMID: 27523471.
    Citations: 2     Fields:    Translation:Humans
  19. Diermeier SD, Chang KC, Freier SM, Song J, El Demerdash O, Krasnitz A, Rigo F, Bennett CF, Spector DL. Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. Cell Rep. 2016 09 27; 17(1):261-274. PMID: 27681436.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  20. Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, Brogi E, Egeblad M, Spector DL. Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev. 2016 Jan 01; 30(1):34-51. PMID: 26701265; PMCID: PMC4701977.
    Citations: 270     Fields:    Translation:HumansAnimalsCells
  21. Zepeda-Mendoza CJ, Mukhopadhyay S, Wong ES, Harder N, Splinter E, de Wit E, Eckersley-Maslin MA, Ried T, Eils R, Rohr K, Mills A, de Laat W, Flicek P, Sengupta AM, Spector DL. Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. BMC Genomics. 2015 Nov 21; 16:982. PMID: 26589460.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Bergmann JH, Li J, Eckersley-Maslin MA, Rigo F, Freier SM, Spector DL. Regulation of the ESC transcriptome by nuclear long noncoding RNAs. Genome Res. 2015 Sep; 25(9):1336-46. PMID: 26048247; PMCID: PMC4561492.
    Citations: 42     Fields:    Translation:AnimalsCells
  23. Hogan MS, Parfitt DE, Zepeda-Mendoza CJ, Shen MM, Spector DL. Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation. Cell Stem Cell. 2015 Mar 05; 16(3):275-88. PMID: 25748933.
    Citations: 29     Fields:    Translation:AnimalsCells
  24. Tektonidis M, Kim IH, Chen YC, Eils R, Spector DL, Rohr K. Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data. Med Image Anal. 2015 Jan; 19(1):1-14. PMID: 25181702.
    Citations: 1     Fields:    Translation:Cells
  25. Spector D, Perry Z, Shah S, Kim JJ, Tarnoff ME, Shikora SA. Roux-en-Y gastric bypass: hyperamylasemia is associated with small bowel obstruction. Surg Obes Relat Dis. 2015 Jan-Feb; 11(1):38-43. PMID: 25264325.
    Citations: 9     Fields:    Translation:Humans
  26. Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, Zhou Q, Han Y, Spector DL, Zheng D, Miano JM. Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1249-59. PMID: 24578380.
    Citations: 127     Fields:    Translation:HumansCells
  27. Eckersley-Maslin MA, Thybert D, Bergmann JH, Marioni JC, Flicek P, Spector DL. Random monoallelic gene expression increases upon embryonic stem cell differentiation. Dev Cell. 2014 Feb 24; 28(4):351-65. PMID: 24576421.
    Citations: 61     Fields:    Translation:AnimalsCells
  28. Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, Muhar M, Haslinger C, Yu M, Roeder RG, Wigler MH, Blobel GA, Zuber J, Spector DL, Young RA, Vakoc CR. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev. 2013 Dec 15; 27(24):2648-62. PMID: 24285714; PMCID: PMC3877755.
    Citations: 240     Fields:    Translation:HumansCells
  29. Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA. Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem Cell Reports. 2013; 1(5):371-8. PMID: 24286025.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  30. Bergmann JH, Spector DL. Long non-coding RNAs: modulators of nuclear structure and function. Curr Opin Cell Biol. 2014 Feb; 26:10-8. PMID: 24529241.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  31. Chen Z, Jaafar L, Agyekum DG, Xiao H, Wade MF, Kumaran RI, Spector DL, Bao G, Porteus MH, Dynan WS, Meiler SE. Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic Acids Res. 2013 Oct; 41(19):e182. PMID: 23956220.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  32. Eckersley-Maslin MA, Bergmann JH, Lazar Z, Spector DL. Lamin A/C is expressed in pluripotent mouse embryonic stem cells. Nucleus. 2013 Jan-Feb; 4(1):53-60. PMID: 23324457.
    Citations: 58     Fields:    Translation:AnimalsCells
  33. Hübner MR, Eckersley-Maslin MA, Spector DL. Chromatin organization and transcriptional regulation. Curr Opin Genet Dev. 2013 Apr; 23(2):89-95. PMID: 23270812.
    Citations: 74     Fields:    Translation:HumansCells
  34. Zhang B, Arun G, Mao YS, Lazar Z, Hung G, Bhattacharjee G, Xiao X, Booth CJ, Wu J, Zhang C, Spector DL. The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Rep. 2012 Jul 26; 2(1):111-23. PMID: 22840402.
    Citations: 297     Fields:    Translation:AnimalsCells
  35. Zhao R, Nakamura T, Fu Y, Lazar Z, Spector DL. Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nat Cell Biol. 2011 Oct 09; 13(11):1295-304. PMID: 21983563.
    Citations: 136     Fields:    Translation:HumansCells
  36. Mao YS, Zhang B, Spector DL. Biogenesis and function of nuclear bodies. Trends Genet. 2011 Aug; 27(8):295-306. PMID: 21680045.
    Citations: 289     Fields:    Translation:HumansCells
  37. Spector DL, Lamond AI. Nuclear speckles. Cold Spring Harb Perspect Biol. 2011 Feb 01; 3(2). PMID: 20926517.
    Citations: 341     Fields:    Translation:Cells
  38. Hübner MR, Spector DL. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol. 2010; 75:43-9. PMID: 21209387.
    Citations: 32     Fields:    Translation:HumansCells
  39. Mao YS, Sunwoo H, Zhang B, Spector DL. Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nat Cell Biol. 2011 Jan; 13(1):95-101. PMID: 21170033.
    Citations: 212     Fields:    Translation:HumansAnimalsCells
  40. Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell. 2010 Nov 12; 40(3):364-76. PMID: 21035370.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  41. Prasanth KV, Camiolo M, Chan G, Tripathi V, Denis L, Nakamura T, Hübner MR, Spector DL. Nuclear organization and dynamics of 7SK RNA in regulating gene expression. Mol Biol Cell. 2010 Dec; 21(23):4184-96. PMID: 20881057.
    Citations: 38     Fields:    Translation:HumansCells
  42. Kim IH, Chen YC, Spector DL, Eils R, Rohr K. Nonrigid registration of 2-D and 3-D dynamic cell nuclei images for improved classification of subcellular particle motion. IEEE Trans Image Process. 2011 Apr; 20(4):1011-22. PMID: 20840894.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  43. Spector D, Perry Z, Konobeck T, Mooradian D, Shikora S. Comparison of hemostatic properties between collagen and synthetic buttress materials used in staple line reinforcement in a swine splenic hemorrhage model. Surg Endosc. 2011 Apr; 25(4):1148-52. PMID: 20835722.
    Citations: 4     Fields:    Translation:Animals
  44. Spector D, Shikora S. Neuro-modulation and bariatric surgery for type 2 diabetes mellitus. Int J Clin Pract Suppl. 2010 Feb; (166):53-8. PMID: 20377665.
    Citations: 9     Fields:    Translation:HumansAnimals
  45. Hübner MR, Spector DL. Chromatin dynamics. Annu Rev Biophys. 2010; 39:471-89. PMID: 20462379.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  46. Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009 Jul 01; 23(13):1494-504. PMID: 19571179; PMCID: PMC3152381.
    Citations: 1071     Fields:    Translation:AnimalsCells
  47. Wilusz JE, Freier SM, Spector DL. 3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell. 2008 Nov 28; 135(5):919-32. PMID: 19041754.
    Citations: 331     Fields:    Translation:HumansAnimalsCells
  48. Dimitrova N, Chen YC, Spector DL, de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 2008 Nov 27; 456(7221):524-8. PMID: 18931659.
    Citations: 311     Fields:    Translation:HumansAnimalsCells
  49. Chen YC, Kappel C, Beaudouin J, Eils R, Spector DL. Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. Mol Biol Cell. 2008 Jul; 19(7):3147-62. PMID: 18480407.
    Citations: 30     Fields:    Translation:HumansCells
  50. Kumaran RI, Thakar R, Spector DL. Chromatin dynamics and gene positioning. Cell. 2008 Mar 21; 132(6):929-34. PMID: 18358806.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  51. Kumaran RI, Spector DL. A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. J Cell Biol. 2008 Jan 14; 180(1):51-65. PMID: 18195101; PMCID: PMC2213611.
    Citations: 199     Fields:    Translation:HumansCells
  52. Fang Y, Spector DL. Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Curr Biol. 2007 May 01; 17(9):818-23. PMID: 17442570; PMCID: PMC1950788.
    Citations: 180     Fields:    Translation:AnimalsCells
  53. Prasanth KV, Spector DL. Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. Genes Dev. 2007 Jan 01; 21(1):11-42. PMID: 17210785.
    Citations: 201     Fields:    Translation:HumansCells
  54. Spector DL. SnapShot: Cellular bodies. Cell. 2006 Dec 01; 127(5):1071. PMID: 17129789.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  55. Spector DJ. Default assembly of early adenovirus chromatin. Virology. 2007 Mar 01; 359(1):116-25. PMID: 17034827.
    Citations: 3     Fields:    Translation:HumansCells
  56. May BP, Lippman ZB, Fang Y, Spector DL, Martienssen RA. Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats. PLoS Genet. 2005 Dec; 1(6):e79. PMID: 16389298; PMCID: PMC1317654.
    Citations: 89     Fields:    Translation:AnimalsCells
  57. Prasanth KV, Prasanth SG, Xuan Z, Hearn S, Freier SM, Bennett CF, Zhang MQ, Spector DL. Regulating gene expression through RNA nuclear retention. Cell. 2005 Oct 21; 123(2):249-63. PMID: 16239143.
    Citations: 331     Fields:    Translation:AnimalsCells
  58. Fang Y, Spector DL. Centromere positioning and dynamics in living Arabidopsis plants. Mol Biol Cell. 2005 Dec; 16(12):5710-8. PMID: 16195344; PMCID: PMC1289415.
    Citations: 48     Fields:    Translation:AnimalsCells
  59. Bubulya PA, Prasanth KV, Deerinck TJ, Gerlich D, Beaudouin J, Ellisman MH, Ellenberg J, Spector DL. Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei. J Cell Biol. 2004 Oct 11; 167(1):51-63. PMID: 15479736; PMCID: PMC2172523.
    Citations: 33     Fields:    Translation:HumansCells
  60. Spector DL. Stopping for FISH and chips along the chromatin fiber superhighway. Mol Cell. 2004 Sep 24; 15(6):844-6. PMID: 15383273.
    Citations: 2     Fields:    Translation:HumansCells
  61. Prasanth SG, Prasanth KV, Siddiqui K, Spector DL, Stillman B. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 2004 Jul 07; 23(13):2651-63. PMID: 15215892; PMCID: PMC449767.
    Citations: 136     Fields:    Translation:HumansCells
  62. Saitoh N, Spahr CS, Patterson SD, Bubulya P, Neuwald AF, Spector DL. Proteomic analysis of interchromatin granule clusters. Mol Biol Cell. 2004 Aug; 15(8):3876-90. PMID: 15169873; PMCID: PMC491843.
    Citations: 127     Fields:    Translation:AnimalsCells
  63. Bubulya PA, Spector DL. "On the move"ments of nuclear components in living cells. Exp Cell Res. 2004 May 15; 296(1):4-11. PMID: 15120987.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  64. Ono T, Fang Y, Spector DL, Hirano T. Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell. 2004 Jul; 15(7):3296-308. PMID: 15146063; PMCID: PMC452584.
    Citations: 188     Fields:    Translation:HumansCells
  65. Fang Y, Hearn S, Spector DL. Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis. Mol Biol Cell. 2004 Jun; 15(6):2664-73. PMID: 15034145; PMCID: PMC420091.
    Citations: 40     Fields:    Translation:AnimalsCells
  66. Janicki SM, Tsukamoto T, Salghetti SE, Tansey WP, Sachidanandam R, Prasanth KV, Ried T, Shav-Tal Y, Bertrand E, Singer RH, Spector DL. From silencing to gene expression: real-time analysis in single cells. Cell. 2004 Mar 05; 116(5):683-98. PMID: 15006351; PMCID: PMC4942132.
    Citations: 302     Fields:    Translation:HumansAnimalsCells
  67. Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 2003 Jun 13; 113(6):703-16. PMID: 12809602.
    Citations: 894     Fields:    Translation:HumansCells
  68. Janicki SM, Spector DL. Nuclear choreography: interpretations from living cells. Curr Opin Cell Biol. 2003 Apr; 15(2):149-57. PMID: 12648670.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  69. Prasanth KV, Sacco-Bubulya PA, Prasanth SG, Spector DL. Sequential entry of components of the gene expression machinery into daughter nuclei. Mol Biol Cell. 2003 Mar; 14(3):1043-57. PMID: 12631722; PMCID: PMC151578.
    Citations: 72     Fields:    Translation:HumansCells
  70. Spector DL. The dynamics of chromosome organization and gene regulation. Annu Rev Biochem. 2003; 72:573-608. PMID: 14527325.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  71. Spector DL, Gasser SM. A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications. EMBO Rep. 2003 Jan; 4(1):18-23. PMID: 12524514.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  72. Sacco-Bubulya P, Spector DL. Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. J Cell Biol. 2002 Feb 04; 156(3):425-36. PMID: 11827980; PMCID: PMC2173333.
    Citations: 53     Fields:    Translation:HumansCells
  73. Muratani M, Gerlich D, Janicki SM, Gebhard M, Eils R, Spector DL. Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nat Cell Biol. 2002 Feb; 4(2):106-10. PMID: 11753375.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  74. Heard E, Rougeulle C, Arnaud D, Avner P, Allis CD, Spector DL. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell. 2001 Dec 14; 107(6):727-38. PMID: 11747809.
    Citations: 163     Fields:    Translation:AnimalsCells
  75. Spector DL. Nuclear domains. J Cell Sci. 2001 Aug; 114(Pt 16):2891-3. PMID: 11686292.
    Citations: 121     Fields:    Translation:Cells
  76. Tsukamoto T, Hashiguchi N, Janicki SM, Tumbar T, Belmont AS, Spector DL. Visualization of gene activity in living cells. Nat Cell Biol. 2000 Dec; 2(12):871-8. PMID: 11146650.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  77. Eils R, Gerlich D, Tvaruskó W, Spector DL, Misteli T. Quantitative imaging of pre-mRNA splicing factors in living cells. Mol Biol Cell. 2000 Feb; 11(2):413-8. PMID: 10679003; PMCID: PMC14782.
    Citations: 17     Fields:    Translation:AnimalsCells
  78. Lorenz P, Misteli T, Baker BF, Bennett CF, Spector DL. Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides. Nucleic Acids Res. 2000 Jan 15; 28(2):582-92. PMID: 10606658; PMCID: PMC102511.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  79. Tvaruskó W, Bentele M, Misteli T, Rudolf R, Kaether C, Spector DL, Gerdes HH, Eils R. Time-resolved analysis and visualization of dynamic processes in living cells. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7950-5. PMID: 10393928; PMCID: PMC22168.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  80. Misteli T, Cáceres JF, Clement JQ, Krainer AR, Wilkinson MF, Spector DL. Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol. 1998 Oct 19; 143(2):297-307. PMID: 9786943; PMCID: PMC2132840.
    Citations: 112     Fields:    Translation:HumansCells
  81. Misteli T, Spector DL. The cellular organization of gene expression. Curr Opin Cell Biol. 1998 Jun; 10(3):323-31. PMID: 9640532.
    Citations: 66     Fields:    Translation:AnimalsCells
  82. Lorenz P, Baker BF, Bennett CF, Spector DL. Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies. Mol Biol Cell. 1998 May; 9(5):1007-23. PMID: 9571236; PMCID: PMC25326.
    Citations: 27     Fields:    Translation:HumansCells
  83. Misteli T, Spector DL. Applications of the green fluorescent protein in cell biology and biotechnology. Nat Biotechnol. 1997 Oct; 15(10):961-4. PMID: 9335045.
    Citations: 64     Fields:    Translation:AnimalsCells
  84. Cáceres JF, Misteli T, Screaton GR, Spector DL, Krainer AR. Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol. 1997 Jul 28; 138(2):225-38. PMID: 9230067; PMCID: PMC2138183.
    Citations: 187     Fields:    Translation:HumansCells
  85. Huang S, Deerinck TJ, Ellisman MH, Spector DL. The dynamic organization of the perinucleolar compartment in the cell nucleus. J Cell Biol. 1997 Jun 02; 137(5):965-74. PMID: 9166399; PMCID: PMC2136227.
    Citations: 52     Fields:    Translation:HumansCells
  86. Huang S, Mayeda A, Krainer AR, Spector DL. RCC1 and nuclear organization. Mol Biol Cell. 1997 Jun; 8(6):1143-57. PMID: 9201722; PMCID: PMC305720.
    Citations: 3     Fields:    Translation:AnimalsCells
  87. Misteli T, Cáceres JF, Spector DL. The dynamics of a pre-mRNA splicing factor in living cells. Nature. 1997 May 29; 387(6632):523-7. PMID: 9168118.
    Citations: 223     Fields:    Translation:Cells
  88. Spector DL. Nuclear organization and gene expression. Exp Cell Res. 1996 Dec 15; 229(2):189-97. PMID: 8986596.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  89. Misteli T, Spector DL. Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors. Mol Biol Cell. 1996 Oct; 7(10):1559-72. PMID: 8898362; PMCID: PMC276006.
    Citations: 48     Fields:    Translation:HumansCells
  90. Huang S, Spector DL. Dynamic organization of pre-mRNA splicing factors. J Cell Biochem. 1996 Aug; 62(2):191-7. PMID: 8844399.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  91. Henderson S, Allsopp R, Spector D, Wang SS, Harley C. In situ analysis of changes in telomere size during replicative aging and cell transformation. J Cell Biol. 1996 Jul; 134(1):1-12. PMID: 8698806; PMCID: PMC2120915.
    Citations: 27     Fields:    Translation:HumansCells
  92. Huang S, Spector DL. Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription. J Cell Biol. 1996 May; 133(4):719-32. PMID: 8666659; PMCID: PMC2120843.
    Citations: 75     Fields:    Translation:HumansCells
  93. Tani T, Derby RJ, Hiraoka Y, Spector DL. Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. Mol Biol Cell. 1996 Jan; 7(1):173-92. PMID: 8741848; PMCID: PMC278621.
    Citations: 15     Fields:    Translation:AnimalsCells
  94. Tani T, Derby RJ, Hiraoka Y, Spector DL. Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. Mol Biol Cell. 1995 Nov; 6(11):1515-34. PMID: 8589453; PMCID: PMC301308.
    Citations: 23     Fields:    Translation:AnimalsCells
  95. Huang S, Deerinck TJ, Ellisman MH, Spector DL. In vivo analysis of the stability and transport of nuclear poly(A)+ RNA. J Cell Biol. 1994 Aug; 126(4):877-99. PMID: 7519622; PMCID: PMC2120126.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  96. O'Keefe RT, Mayeda A, Sadowski CL, Krainer AR, Spector DL. Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol. 1994 Feb; 124(3):249-60. PMID: 8294510; PMCID: PMC2119927.
    Citations: 86     Fields:    Translation:HumansCells
  97. Spector DL, Landon S, O'Keefe RT. Organization of RNA polymerase II transcription and pre-mRNA splicing within the mammalian cell nucleus. Biochem Soc Trans. 1993 Nov; 21(4):918-20. PMID: 8132093.
    Citations: 6     Fields:    Translation:AnimalsCells
  98. Jiménez-García LF, Green SR, Mathews MB, Spector DL. Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells. J Cell Sci. 1993 Sep; 106 ( Pt 1):11-22. PMID: 7903669.
    Citations: 32     Fields:    Translation:HumansCells
  99. Spector DL. Nuclear organization of pre-mRNA processing. Curr Opin Cell Biol. 1993 Jun; 5(3):442-7. PMID: 8352961.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  100. Jiménez-García LF, Spector DL. In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell. 1993 Apr 09; 73(1):47-59. PMID: 8462102.
    Citations: 115     Fields:    Translation:HumansCells
  101. Spector DL. Macromolecular domains within the cell nucleus. Annu Rev Cell Biol. 1993; 9:265-315. PMID: 8280462.
    Citations: 222     Fields:    Translation:AnimalsCells
  102. Spector DL, O'Keefe RT, Jiménez-García LF. Dynamics of transcription and pre-mRNA splicing within the mammalian cell nucleus. Cold Spring Harb Symp Quant Biol. 1993; 58:799-805. PMID: 7956094.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  103. Spector DL, Lark G, Huang S. Differences in snRNP localization between transformed and nontransformed cells. Mol Biol Cell. 1992 May; 3(5):555-69. PMID: 1535243; PMCID: PMC275608.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  104. Huang S, Spector DL. Will the real splicing sites please light up? Curr Biol. 1992 Apr; 2(4):188-90. PMID: 15335973.
    Citations: 8     Fields:    
  105. O'Keefe RT, Henderson SC, Spector DL. Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. J Cell Biol. 1992 Mar; 116(5):1095-110. PMID: 1740468; PMCID: PMC2289349.
    Citations: 194     Fields:    Translation:HumansAnimalsCells
  106. Huang S, Spector DL. U1 and U2 small nuclear RNAs are present in nuclear speckles. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):305-8. PMID: 1530887; PMCID: PMC48225.
    Citations: 67     Fields:    Translation:HumansCells
  107. Huang S, Spector DL. Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. Genes Dev. 1991 Dec; 5(12A):2288-302. PMID: 1748285.
    Citations: 81     Fields:    Translation:AnimalsCells
  108. Spector DL, Fu XD, Maniatis T. Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J. 1991 Nov; 10(11):3467-81. PMID: 1833187; PMCID: PMC453075.
    Citations: 195     Fields:    Translation:HumansCells
  109. Yu IJ, Spector DL, Bae YS, Marshak DR. Immunocytochemical localization of casein kinase II during interphase and mitosis. J Cell Biol. 1991 Sep; 114(6):1217-32. PMID: 1894695; PMCID: PMC2289133.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  110. Potashkin JA, Derby RJ, Spector DL. Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus. Mol Cell Biol. 1990 Jul; 10(7):3524-34. PMID: 2192258.
    Citations: 22     Fields:    Translation:AnimalsCells
  111. Spector DL. Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):147-51. PMID: 2136950; PMCID: PMC53217.
    Citations: 77     Fields:    Translation:AnimalsCells
  112. Conway GC, Krainer AR, Spector DL, Roberts RJ. Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Mol Cell Biol. 1989 Dec; 9(12):5273-80. PMID: 2531283.
    Citations: 6     Fields:    Translation:HumansCells
  113. Efrat S, Linde S, Kofod H, Spector D, Delannoy M, Grant S, Hanahan D, Baekkeskov S. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9037-41. PMID: 2848253; PMCID: PMC282658.
    Citations: 158     Fields:    Translation:AnimalsCells
  114. White E, Spector D, Welch W. Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells. J Virol. 1988 Nov; 62(11):4153-66. PMID: 2971821; PMCID: PMC253847.
    Citations: 29     Fields:    Translation:HumansCells
  115. Scolnik PA, Hinton P, Greenblatt IM, Giuliano G, Delanoy MR, Spector DL, Pollock D. Somatic instability of carotenoid biosynthesis in the tomato ghost mutant and its effect on plastid development. Planta. 1987 May; 171(1):11-8. PMID: 24227266.
    Citations: 10     Fields:    
  116. Spector DL, Watt RA, Sullivan NF. The v- and c-myc oncogene proteins colocalize in situ with small nuclear ribonucleoprotein particles. Oncogene. 1987 Mar; 1(1):5-12. PMID: 2963988.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.