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Ata Kiapour, Ph.D.

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Mentoring
Available: 12/02/19, Expires: 12/31/20

Many anatomical features of human joints and bones have shown to be associated with acute musculoskeletal injuries as well as degenerative joint diseases (e.g. OA). Several intrinsic (e.g. genetic factors) and extrinsic (i.e. sports participation) have shown to influence bone and soft tissue development. However, little is know on how these factors influence the detailed morphological features of human joints. The purpose of this project is to study the effect of early sports participation and obesity (as two main contributors to joint biomechanics) on development of the knee and hip joints.

The student scholar will be trained on quantitative techniques to measure key morphological features of the human knee and hip from MRI and CT images in 2D and 3D. Following training, student will take the lead on anatomy measurements and work with our research team to analyze the data to isolate the effect of sports participation and/or obesity on joint morphology.

Selected candidate is expected to present their findings in 1 peer-reviewed manuscript as well as a conference abstract. The project is designed in a way to assure the completion of all these milestones within 1 year.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Morris WZ, Riccio AI, Podeszwa DA, Pierce WA, Standefer KD, Kiapour A, Liu RW, Novais EN. The point of epiphyseal penetration affects rotational stability of screw fixation in slipped capital femoral epiphysis: A biomechanical study. J Orthop Res. 2020 May 19. PMID: 32427362.
    Citations:    
  2. Hosseinzadeh S, Kiapour AM. Age-related changes in ACL morphology during skeletal growth and maturation are different between females and males. J Orthop Res. 2020 May 19. PMID: 32427346.
    Citations:    
  3. Murray MM, Fleming BC, Badger GJ, Freiberger C, Henderson R, Barnett S, Kiapour A, Ecklund K, Proffen B, Sant N, Kramer DE, Micheli LJ, Yen YM. Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial. Am J Sports Med. 2020 May; 48(6):1305-1315. PMID: 32298131.
    Citations:    
  4. Massaad E, Fatima N, Kiapour A, Hadzipasic M, Shankar GM, Shin JH. Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature. Neurospine. 2020 Mar; 17(1):125-135. PMID: 32252163.
    Citations:    
  5. Richard D, Liu Z, Cao J, Kiapour AM, Willen J, Yarlagadda S, Jagoda E, Kolachalama VB, Sieker JT, Chang GH, Muthuirulan P, Young M, Masson A, Konrad J, Hosseinzadeh S, Maridas DE, Rosen V, Krawetz R, Roach N, Capellini TD. Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk. Cell. 2020 Apr 16; 181(2):362-381.e28. PMID: 32220312.
    Citations:    
  6. Hosseinzadeh S, Novais EN, Maranho DA, Emami SA, Portilla G, Kim YJ, Kiapour AM. Age- and sex-specific morphologic changes in the metaphyseal fossa adjacent to epiphyseal tubercle in children and adolescents without hip disorders. J Orthop Res. 2020 Feb 24. PMID: 32091139.
    Citations:    
  7. Kiapour A, Joukar A, Elgafy H, Erbulut DU, Agarwal AK, Goel VK. Biomechanics of the Sacroiliac Joint: Anatomy, Function, Biomechanics, Sexual Dimorphism, and Causes of Pain. Int J Spine Surg. 2020 Feb; 14(Suppl 1):3-13. PMID: 32123652.
    Citations:    
  8. Novais EN, Maranho DA, Vairagade A, Kim YJ, Kiapour A. Smaller Epiphyseal Tubercle and Larger Peripheral Cupping in Slipped Capital Femoral Epiphysis Compared with Healthy Hips: A 3-Dimensional Computed Tomography Study. J Bone Joint Surg Am. 2020 Jan 02; 102(1):29-36. PMID: 31596801.
    Citations:    
  9. Perrone GS, Webster KE, Imbriaco C, Portilla GM, Vairagade A, Murray MM, Kiapour AM. Risk of Secondary ACL Injury in Adolescents Prescribed Functional Bracing After ACL Reconstruction. Orthop J Sports Med. 2019 Nov; 7(11):2325967119879880. PMID: 31763340.
    Citations:    
  10. Beveridge JE, Proffen BL, Karamchedu NP, Chin KE, Sieker JT, Badger GJ, Kiapour AM, Murray MM, Fleming BC. Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair. J Orthop Res. 2019 10; 37(10):2249-2257. PMID: 31125133.
    Citations:    
  11. Kiapour AM, Ecklund K, Murray MM, Flutie B, Freiberger C, Henderson R, Kramer D, Micheli L, Thurber L, Yen YM, Fleming BC. Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery. Am J Sports Med. 2019 07; 47(8):1831-1843. PMID: 31166701.
    Citations:    
  12. Murray MM, Kiapour AM, Kalish LA, Ecklund K, Freiberger C, Henderson R, Kramer D, Micheli L, Yen YM, Fleming BC. Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair. Am J Sports Med. 2019 05; 47(6):1361-1369. PMID: 30986359.
    Citations:    
  13. Kiapour AM, Kiapour A, Maranho DA, Kim YJ, Novais EN. Relative contribution of epiphyseal tubercle and peripheral cupping to capital femoral epiphysis stability during daily activities. J Orthop Res. 2019 07; 37(7):1571-1579. PMID: 30908729.
    Citations:    
  14. Kiapour AM, Sieker JT, Proffen BL, Lam TT, Fleming BC, Murray MM. Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PLoS One. 2019; 14(3):e0212662. PMID: 30822327.
    Citations:    
  15. Kiapour AM, Yang DS, Badger GJ, Karamchedu NP, Murray MM, Fadale PD, Hulstyn MJ, Shalvoy RM, Fleming BC. Anatomic Features of the Tibial Plateau Predict Outcomes of ACL Reconstruction Within 7 Years After Surgery. Am J Sports Med. 2019 02; 47(2):303-311. PMID: 30640519.
    Citations:    Fields:    
  16. Seyed Vosoughi A, Joukar A, Kiapour A, Parajuli D, Agarwal AK, Goel VK, Zavatsky J. Optimal satellite rod constructs to mitigate rod failure following pedicle subtraction osteotomy (PSO): a finite element study. Spine J. 2019 05; 19(5):931-941. PMID: 30414992.
    Citations:    Fields:    
  17. Kiapour AM, Cao J, Young M, Capellini TD. The role of Gdf5 regulatory regions in development of hip morphology. PLoS One. 2018; 13(11):e0202785. PMID: 30388100.
    Citations:    Fields:    
  18. Joukar A, Shah A, Kiapour A, Vosoughi AS, Duhon B, Agarwal AK, Elgafy H, Ebraheim N, Goel VK. Sex Specific Sacroiliac Joint Biomechanics During Standing Upright: A Finite Element Study. Spine (Phila Pa 1976). 2018 09 15; 43(18):E1053-E1060. PMID: 29509655.
    Citations:    Fields:    Translation:Humans
  19. Novais EN, Maranho DA, Kim YJ, Kiapour A. Age- and Sex-Specific Morphologic Variations of Capital Femoral Epiphysis Growth in Children and Adolescents Without Hip Disorders. Orthop J Sports Med. 2018 Jun; 6(6):2325967118781579. PMID: 30090833.
    Citations:    
  20. Lindsey DP, Kiapour A, Yerby SA, Goel VK. Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length. World J Orthop. 2018 Mar 18; 9(3):14-23. PMID: 29564210.
    Citations:    
  21. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Fleming BC, Murray MM. Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Feb 20. PMID: 29460983.
    Citations:    Fields:    
  22. Pregizer SK, Kiapour AM, Young M, Chen H, Schoor M, Liu Z, Cao J, Rosen V, Capellini TD. Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis. Ann Rheum Dis. 2018 03; 77(3):450. PMID: 29311146.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Beveridge JE, Machan JT, Walsh EG, Kiapour AM, Karamchedu NP, Chin KE, Proffen BL, Sieker JT, Murray MM, Fleming BC. Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. J Orthop Res. 2018 06; 36(6):1701-1709. PMID: 29227559.
    Citations:    Fields:    
  24. Kiapour AM, Fleming BC, Murray MM. Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage. Orthop J Sports Med. 2017 Aug; 5(8):2325967117723886. PMID: 28875154.
    Citations: 1     
  25. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Murray MM, Fleming BC. Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 01; 36(1):318-329. PMID: 28671352.
    Citations: 1     Fields:    
  26. Perrone GS, Proffen BL, Kiapour AM, Sieker JT, Fleming BC, Murray MM. Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair. J Orthop Res. 2017 12; 35(12):2606-2612. PMID: 28608618.
    Citations:    Fields:    Translation:HumansAnimals
  27. Capellini TD, Chen H, Cao J, Doxey AC, Kiapour AM, Schoor M, Kingsley DM. Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nat Genet. 2017 Aug; 49(8):1202-1210. PMID: 28671685.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  28. Kiapour AM. CORR Insights®: Knee Abduction Affects Greater Magnitude of Change in ACL and MCL Strains Than Matched Internal Tibial Rotation In Vitro. Clin Orthop Relat Res. 2017 10; 475(10):2397-2400. PMID: 28578498.
    Citations:    Fields:    
  29. Camathias C, Studer K, Kiapour A, Rutz E, Vavken P. Trochleoplasty as a Solitary Treatment for Recurrent Patellar Dislocation Results in Good Clinical Outcome in Adolescents. Am J Sports Med. 2016 Nov; 44(11):2855-2863. PMID: 27436719.
    Citations: 5     Fields:    Translation:Humans
  30. Sieker JT, Ayturk UM, Proffen BL, Weissenberger MH, Kiapour AM, Murray MM. Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol. 2016 07; 68(7):1637-47. PMID: 26866935.
    Citations: 4     Fields:    Translation:Animals
  31. Kiapour AM, Demetropoulos CK, Kiapour A, Quatman CE, Wordeman SC, Goel VK, Hewett TE. Strain Response of the Anterior Cruciate Ligament to Uniplanar and Multiplanar Loads During Simulated Landings: Implications for Injury Mechanism. Am J Sports Med. 2016 Aug; 44(8):2087-96. PMID: 27159285.
    Citations: 10     Fields:    Translation:Humans
  32. Ata M. Kiapour, Constantine K. Demetropoulos, Ali Kiapour, Carmen E. Quatman, Samuel C. Wordeman, Vijay K. Goel, and Timothy E. Hewett. Strain Response of the Anterior Cruciate Ligament to Uniplanar and Multiplanar Loads During Simulated Landings: Implications for Injury Mechanism. Am J Sports Med. 2016.
  33. Blanke F, Kiapour AM, Haenle M, Fischer J, Majewski M, Vogt S, Camathias C. Risk of Noncontact Anterior Cruciate Ligament Injuries Is Not Associated With Slope and Concavity of the Tibial Plateau in Recreational Alpine Skiers: A Magnetic Resonance Imaging-Based Case-Control Study of 121 Patients. Am J Sports Med. 2016 Jun; 44(6):1508-14. PMID: 26957218.
    Citations: 1     Fields:    Translation:Humans
  34. Lindsey DP, Kiapour A, Yerby SA, Goel VK. Sacroiliac Joint Fusion Minimally Affects Adjacent Lumbar Segment Motion: A Finite Element Study. Int J Spine Surg. 2015; 9:64. PMID: 26767156.
    Citations: 3     
  35. Kiapour AM, Fleming BC, Murray MM. Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model. Clin Orthop Relat Res. 2015 Aug; 473(8):2599-608. PMID: 25742916.
    Citations: 3     Fields:    Translation:Animals
  36. Kiapour AM, Kiapour A, Goel VK, Quatman CE, Wordeman SC, Hewett TE, Demetropoulos CK. Uni-directional coupling between tibiofemoral frontal and axial plane rotation supports valgus collapse mechanism of ACL injury. J Biomech. 2015 Jul 16; 48(10):1745-51. PMID: 26070647.
    Citations:    
  37. Kiapour AM, Fleming BC, Proffen BL, Murray MM. Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. Am J Sports Med. 2015 Jul; 43(7):1623-31. PMID: 25939612.
    Citations:    
  38. Karami KJ, Buckenmeyer LE, Kiapour AM, Kelkar PS, Goel VK, Demetropoulos CK, Soo TM. Biomechanical evaluation of the pedicle screw insertion depth effect on screw stability under cyclic loading and subsequent pullout. J Spinal Disord Tech. 2015 Apr; 28(3):E133-9. PMID: 25310387.
    Citations: 3     Fields:    Translation:Humans
  39. Kiapour AM, Shalvoy MR, Murray MM, Fleming BC. Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res. 2015 Feb; 473(2):639-50. PMID: 25269532.
    Citations: 8     Fields:    Translation:HumansAnimals
  40. Faizan A, Kiapour A, Kiapour AM, Goel VK. Biomechanical analysis of various footprints of transforaminal lumbar interbody fusion devices. J Spinal Disord Tech. 2014 Jun; 27(4):E118-27. PMID: 24869985.
    Citations: 2     Fields:    Translation:Humans
  41. Erbulut DU, Kiapour A, Oktenoglu T, Ozer AF, Goel VK. A computational biomechanical investigation of posterior dynamic instrumentation: combination of dynamic rod and hinged (dynamic) screw. J Biomech Eng. 2014 May; 136(5):051007. PMID: 24599026.
    Citations: 4     Fields:    
  42. Kiapour AM, Kaul V, Kiapour A, Quatman CE, Wordeman SC, Hewett TE, Demetropoulos CK, Goel VK. The Effect of Ligament Modeling Technique on Knee Joint Kinematics: A Finite Element Study. Appl Math (Irvine). 2014 May; 4(5A):91-97. PMID: 25221727.
    Citations: 7     
  43. Oktenoglu T, Erbulut DU, Kiapour A, Ozer AF, Lazoglu I, Kaner T, Sasani M, Goel VK. Pedicle screw-based posterior dynamic stabilisation of the lumbar spine: in vitro cadaver investigation and a finite element study. Comput Methods Biomech Biomed Engin. 2015 Aug; 18(11):1252-1261. PMID: 24708377.
    Citations: 1     Fields:    
  44. Dreischarf M, Zander T, Shirazi-Adl A, Puttlitz CM, Adam CJ, Chen CS, Goel VK, Kiapour A, Kim YH, Labus KM, Little JP, Park WM, Wang YH, Wilke HJ, Rohlmann A, Schmidt H. Comparison of eight published static finite element models of the intact lumbar spine: predictive power of models improves when combined together. J Biomech. 2014 Jun 03; 47(8):1757-66. PMID: 24767702.
    Citations: 8     Fields:    Translation:Humans
  45. Palepu V, Kiapour A, Goel VK, Moran JM. A unique modular implant system enhances load sharing in anterior cervical interbody fusion: a finite element study. Biomed Eng Online. 2014 Mar 11; 13(1):26. PMID: 24618205.
    Citations: 2     Fields:    Translation:Humans
  46. Kiapour AM, Murray MM. Basic science of anterior cruciate ligament injury and repair. Bone Joint Res. 2014; 3(2):20-31. PMID: 24497504.
    Citations: 35     
  47. Kiapour A, Kiapour AM, Kaul V, Quatman CE, Wordeman SC, Hewett TE, Demetropoulos CK, Goel VK. Finite element model of the knee for investigation of injury mechanisms: development and validation. J Biomech Eng. 2014 Jan; 136(1):011002. PMID: 24763546.
    Citations: 15     Fields:    Translation:Humans
  48. Kiapour AM, Wordeman SC, Paterno MV, Quatman CE, Levine JW, Goel VK, Demetropoulos CK, Hewett TE. Diagnostic value of knee arthrometry in the prediction of anterior cruciate ligament strain during landing. Am J Sports Med. 2014 Feb; 42(2):312-9. PMID: 24275863.
    Citations: 9     Fields:    Translation:Humans
  49. Kiapour AM, Quatman CE, Goel VK, Wordeman SC, Hewett TE, Demetropoulos CK. Timing sequence of multi-planar knee kinematics revealed by physiologic cadaveric simulation of landing: implications for ACL injury mechanism. Clin Biomech (Bristol, Avon). 2014 Jan; 29(1):75-82. PMID: 24238957.
    Citations: 6     Fields:    Translation:Humans
  50. Quatman CE, Kiapour AM, Demetropoulos CK, Kiapour A, Wordeman SC, Levine JW, Goel VK, Hewett TE. Preferential loading of the ACL compared with the MCL during landing: a novel in sim approach yields the multiplanar mechanism of dynamic valgus during ACL injuries. Am J Sports Med. 2014 Jan; 42(1):177-86. PMID: 24124198.
    Citations: 24     Fields:    Translation:Humans
  51. Levine JW, Kiapour AM, Quatman CE, Wordeman SC, Goel VK, Hewett TE, Demetropoulos CK. Clinically relevant injury patterns after an anterior cruciate ligament injury provide insight into injury mechanisms. Am J Sports Med. 2013 Feb; 41(2):385-95. PMID: 23144366.
    Citations: 32     Fields:    Translation:Humans
  52. Kiapour A, Anderson DG, Spenciner DB, Ferrara L, Goel VK. Kinematic effects of a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis. J Neurosurg Spine. 2012 Oct; 17(4):314-20. PMID: 22860875.
    Citations: 4     Fields:    Translation:Humans
  53. Kiapour A, Kiapour AM, Kodigudla M, Hill GM, Mishra S and Goel VK. A Biomechanical Finite Element Study of Subsidence and Migration Tendencies in Stand-Alone Fusion Procedures – Comparison of an in situ Expandable Device with a Rigid Device. J Spine. 2012; 120(1). View Publication.
  54. Kiapour A, Ambati D, Hoy RW, Goel VK. Effect of graded facetectomy on biomechanics of Dynesys dynamic stabilization system. Spine (Phila Pa 1976). 2012 May 01; 37(10):E581-9. PMID: 22198353.
    Citations: 6     Fields:    
  55. Kiapour A, Abdelgawad AA, Goel VK, Souccar A, Terai T, Ebraheim NA. Relationship between limb length discrepancy and load distribution across the sacroiliac joint--a finite element study. J Orthop Res. 2012 Oct; 30(10):1577-80. PMID: 22488899.
    Citations: 7     Fields:    Translation:Humans
  56. Bhattacharya S, Goel VK, Liu X, Kiapour A, Serhan HA. Models that incorporate spinal structures predict better wear performance of cervical artificial discs. Spine J. 2011 Aug; 11(8):766-76. PMID: 21802999.
    Citations: 2     Fields:    
  57. Quatman CE, Kiapour A, Myer GD, Ford KR, Demetropoulos CK, Goel VK, Hewett TE. Cartilage pressure distributions provide a footprint to define female anterior cruciate ligament injury mechanisms. Am J Sports Med. 2011 Aug; 39(8):1706-13. PMID: 21487121.
    Citations: 13     Fields:    Translation:Humans
  58. Terai T, Sairyo K, Goel VK, Ebraheim N, Biyani A, Ahmad F, Kiapour A, Higashino K, Sakai T, Yasui N. Biomechanical rationale of sacral rounding deformity in pediatric spondylolisthesis: a clinical and biomechanical study. Arch Orthop Trauma Surg. 2011 Sep; 131(9):1187-94. PMID: 21221610.
    Citations: 3     Fields:    Translation:Humans
  59. Ivanov AA, Kiapour A, Ebraheim NA, Goel V. Lumbar fusion leads to increases in angular motion and stress across sacroiliac joint: a finite element study. Spine (Phila Pa 1976). 2009 Mar 01; 34(5):E162-9. PMID: 19247155.
    Citations: 17     Fields:    Translation:Humans
  60. Sairyo K, Sakai T, Yasui N, Kiapour A, Biyani A, Ebraheim N, Goel VK. Newly occurred L4 spondylolysis in the lumbar spine with pre-existence L5 spondylolysis among sports players: case reports and biomechanical analysis. Arch Orthop Trauma Surg. 2009 Oct; 129(10):1433-9. PMID: 19084979.
    Citations: 3     Fields:    Translation:Humans
  61. Goel VK, Kiapour A, Faizan A, Krishna M, Friesem T. Finite element study of matched paired posterior disc implant and dynamic stabilizer (360° motion preservation system). SAS J. 2007; 1(1):55-61. PMID: 25802579.
    Citations: 3     
  62. Goel VK, Mehta A, Jangra J, Faizan A, Kiapour A, Hoy RW, Fauth AR. Anatomic Facet Replacement System (AFRS) Restoration of Lumbar Segment Mechanics to Intact: A Finite Element Study and In Vitro Cadaver Investigation. SAS J. 2007; 1(1):46-54. PMID: 25802578.
    Citations: 6     
  63. Grauer JN, Biyani A, Faizan A, Kiapour A, Sairyo K, Ivanov A, Ebraheim NA, Patel TCh, Goel VK. Biomechanics of two-level Charité artificial disc placement in comparison to fusion plus single-level disc placement combination. Spine J. 2006 Nov-Dec; 6(6):659-66. PMID: 17088196.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.