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Mary C Whitman, M.D., Ph.D.


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  1. K08EY027850 (WHITMAN, MARY CATHERINE) Jul 1, 2017 - Jun 30, 2020
    Oculomotor axon guidance in normal and abnormal development
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vemula SK, Kim SA, Muvavarirwa T, Bell JL, Whitman MC. Impaired Extraocular Muscle Innervation Is Present Before Eye Opening in a Mouse Model of Infantile Nystagmus Syndrome. Invest Ophthalmol Vis Sci. 2022 09 01; 63(10):4. PMID: 36083589; PMCID: PMC9469029.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Whitman MC, Gilette NM, Bell JL, Kim SA, Tischfield M, Engle EC. TWIST1, a gene associated with Saethre-Chotzen syndrome, regulates extraocular muscle organization in mouse. Dev Biol. 2022 10; 490:126-133. PMID: 35944701; PMCID: PMC9765759.
    Citations:    Fields:    Translation:Animals
  3. Nwanaji-Enwerem JC, Gateman T, Whitecross S, Whitman MC. First Visit Characteristics Associated with Future Surgery in Intermittent Exotropia. J Binocul Vis Ocul Motil. 2022 Jan-Mar; 72(1):22-28. PMID: 35049416.
    Citations:    Fields:    Translation:Humans
  4. Whitman MC, Barry BJ, Robson CD, Facio FM, Van Ryzin C, Chan WM, Lehky TJ, Thurm A, Zalewski C, King KA, Brewer C, Almpani K, Lee JS, Delaney A, FitzGibbon EJ, Lee PR, Toro C, Paul SM, Abdul-Rahman OA, Webb BD, Jabs EW, Moller HU, Larsen DA, Antony JH, Troedson C, Ma A, Ragnhild G, Wirgenes KV, Tham E, Kvarnung M, Maarup TJ, MacKinnon S, Hunter DG, Collins FS, Manoli I, Engle EC. TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy. Hum Genet. 2021 Dec; 140(12):1709-1731. PMID: 34652576; PMCID: PMC8656246.
    Citations:    Fields:    Translation:Humans
  5. Whitman MC. Axonal Growth Abnormalities Underlying Ocular Cranial Nerve Disorders. Annu Rev Vis Sci. 2021 09 15; 7:827-850. PMID: 34081534; PMCID: PMC9002938.
    Citations:    Fields:    Translation:HumansCells
  6. Jurgens JA, Barry BJ, Lemire G, Chan WM, Whitman MC, Shaaban S, Robson CD, MacKinnon S, England EM, McMillan HJ, Kelly C, Pratt BM, O'Donnell-Luria A, MacArthur DG, Boycott KM, Hunter DG, Engle EC. Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development. Eur J Hum Genet. 2021 05; 29(5):816-826. PMID: 33649541; PMCID: PMC8110841.
    Citations: 1     Fields:    Translation:HumansCells
  7. Whitman MC, Di Gioia SA, Chan WM, Gelber A, Pratt BM, Bell JL, Collins TE, Knowles JA, Armoskus C, Pato M, Pato C, Shaaban S, Staffieri S, MacKinnon S, Maconachie GDE, Elder JE, Traboulsi EI, Gottlob I, Mackey DA, Hunter DG, Engle EC. Recurrent Rare Copy Number Variants Increase Risk for Esotropia. Invest Ophthalmol Vis Sci. 2020 08 03; 61(10):22. PMID: 32780866.
    Citations: 2     Fields:    Translation:Humans
  8. Collett G, Elhusseiny AM, Scelfo C, Whitman MC, VanderVeen DK. Ocular injury via epinephrine auto-injector. J AAPOS. 2020 06; 24(3):179-181. PMID: 32502635.
    Citations:    Fields:    Translation:Humans
  9. Fujiki R, Lee JY, Jurgens JA, Whitman MC, Engle EC. Isolation and Culture of Oculomotor, Trochlear, and Spinal Motor Neurons from Prenatal Islmn:GFP Transgenic Mice. J Vis Exp. 2019 11 12; (153). PMID: 31789317; PMCID: PMC7036286.
    Citations:    Fields:    Translation:AnimalsCells
  10. Tenney AP, Livet J, Belton T, Prochazkova M, Pearson EM, Whitman MC, Kulkarni AB, Engle EC, Henderson CE. Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Cell Rep. 2019 10 08; 29(2):437-452.e4. PMID: 31597102.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Whitman MC, Miyake N, Nguyen EH, Bell JL, Matos Ruiz PM, Chan WM, Di Gioia SA, Mukherjee N, Barry BJ, Bosley TM, Khan AO, Engle EC. Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans. Hum Mol Genet. 2019 09 15; 28(18):3113-3125. PMID: 31211835; PMCID: PMC6737292.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Whitman MC, Bell JL, Nguyen EH, Engle EC. Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth. J Vis Exp. 2019 07 16; (149). PMID: 31380850; PMCID: PMC6771922.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Drack AV, Miraldi Utz V, Wang K, Alcorn DM, Brooks BP, Costakos DM, Couser NL, Heon E, Levin AV, Lloyd IC, Morse CL, Schmitt MA, Whitman MC, Traboulsi EI. Survey of practice patterns for the management of ophthalmic genetic disorders among AAPOS members: report by the AAPOS Genetic Eye Disease Task Force. J AAPOS. 2019 08; 23(4):226-228.e1. PMID: 31233830.
    Citations: 1     Fields:    Translation:Humans
  14. Whitman MC, Nguyen EH, Bell JL, Tenney AP, Gelber A, Engle EC. Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis. Invest Ophthalmol Vis Sci. 2018 10 01; 59(12):5201-5209. PMID: 30372748; PMCID: PMC6204880.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Latremoliere A, Cheng L, DeLisle M, Wu C, Chew S, Hutchinson EB, Sheridan A, Alexandre C, Latremoliere F, Sheu SH, Golidy S, Omura T, Huebner EA, Fan Y, Whitman MC, Nguyen E, Hermawan C, Pierpaoli C, Tischfield MA, Woolf CJ, Engle EC. Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration. Cell Rep. 2018 08 14; 24(7):1865-1879.e9. PMID: 30110642; PMCID: PMC6155462.
    Citations: 42     Fields:    Translation:AnimalsCells
  16. Shaaban S, MacKinnon S, Andrews C, Staffieri SE, Maconachie GDE, Chan WM, Whitman MC, Morton SU, Yazar S, MacGregor S, Elder JE, Traboulsi EI, Gottlob I, Hewitt AW, Hunter DG, Mackey DA, Engle EC. Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect. Invest Ophthalmol Vis Sci. 2018 08 01; 59(10):4054-4064. PMID: 30098192; PMCID: PMC6088800.
    Citations: 7     Fields:    Translation:Humans
  17. Whitman MC, Engle EC. Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance. Hum Mol Genet. 2017 08 01; 26(R1):R37-R44. PMID: 28459979; PMCID: PMC5886468.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  18. Michalak SM, Whitman MC, Park JG, Tischfield MA, Nguyen EH, Engle EC. Ocular Motor Nerve Development in the Presence and Absence of Extraocular Muscle. Invest Ophthalmol Vis Sci. 2017 04 01; 58(4):2388-2396. PMID: 28437527; PMCID: PMC5403115.
    Citations: 10     Fields:    Translation:AnimalsCells
  19. Whitman MC, MacNeill K, Hunter DG. Reply. Ophthalmology. 2017 01; 124(1):e11. PMID: 27993270; PMCID: PMC8906057.
    Citations:    Fields:    
  20. Whitman MC, MacNeill K, Hunter DG. Bifocals Fail to Improve Stereopsis Outcomes in High AC/A Accommodative Esotropia. Ophthalmology. 2016 Apr; 123(4):690-6. PMID: 26854034.
    Citations: 4     Fields:    Translation:Humans
  21. Whitman MC, Andrews C, Chan WM, Tischfield MA, Stasheff SF, Brancati F, Ortiz-Gonzalez X, Nuovo S, Garaci F, MacKinnon SE, Hunter DG, Grant PE, Engle EC. Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development. Am J Med Genet A. 2016 Feb; 170A(2):297-305. PMID: 26639658; PMCID: PMC4770801.
    Citations: 17     Fields:    Translation:HumansCells
  22. Whitman MC, Vanderveen DK. Complications of pediatric cataract surgery. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):414-20. PMID: 25325868.
    Citations: 15     Fields:    Translation:Humans
  23. Gelman R, Whitman MC, Horowitz J. Retinal vasculature remodeling in a case of systemic lupus erythematosus vaso-occlusive retinopathy. Retin Cases Brief Rep. 2014; 8(1):77-82. PMID: 25372215.
    Citations:    Fields:    Translation:Humans
  24. Whitman MC, Kazim M. Dent in the forehead: a rare manifestation of metastatic cancer. Arch Ophthalmol. 2012 Oct; 130(10):1349-51. PMID: 23044962.
    Citations:    Fields:    Translation:Humans
  25. Whitman MC, Walker DM. A case of lower extremity venous thrombosis in the pediatric emergency department: associations with May-Thurner syndrome and isotretinoin use. Pediatr Emerg Care. 2011 Feb; 27(2):125-8. PMID: 21293221.
    Citations: 1     Fields:    Translation:Humans
  26. Nihalani BR, Whitman MC, Salgado CM, Loudon SE, Hunter DG. Short tag noose technique for optional and late suture adjustment in strabismus surgery. Arch Ophthalmol. 2009 Dec; 127(12):1584-90. PMID: 20008711.
    Citations: 13     Fields:    Translation:Humans
  27. Whitman MC, Fan W, Rela L, Rodriguez-Gil DJ, Greer CA. Blood vessels form a migratory scaffold in the rostral migratory stream. J Comp Neurol. 2009 Sep 10; 516(2):94-104. PMID: 19575445.
    Citations: 73     Fields:    Translation:AnimalsCells
  28. Whitman MC, Greer CA. Adult neurogenesis and the olfactory system. Prog Neurobiol. 2009 Oct; 89(2):162-75. PMID: 19615423.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  29. Maresh A, Rodriguez Gil D, Whitman MC, Greer CA. Principles of glomerular organization in the human olfactory bulb--implications for odor processing. PLoS One. 2008 Jul 09; 3(7):e2640. PMID: 18612420.
    Citations: 57     Fields:    Translation:HumansCells
  30. Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD, Eisch AJ. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci. 2007 Nov 14; 27(46):12623-9. PMID: 18003841.
    Citations: 276     Fields:    Translation:AnimalsCells
  31. Whitman MC, Greer CA. Synaptic integration of adult-generated olfactory bulb granule cells: basal axodendritic centrifugal input precedes apical dendrodendritic local circuits. J Neurosci. 2007 Sep 12; 27(37):9951-61. PMID: 17855609; PMCID: PMC6672649.
    Citations: 90     Fields:    Translation:AnimalsCells
  32. Whitman MC, Greer CA. Adult-generated neurons exhibit diverse developmental fates. Dev Neurobiol. 2007 Jul; 67(8):1079-93. PMID: 17565001.
    Citations: 41     Fields:    Translation:AnimalsCells
  33. Kolk SM, Whitman MC, Yun ME, Shete P, Donoghue MJ. A unique subpopulation of Tbr1-expressing deep layer neurons in the developing cerebral cortex. Mol Cell Neurosci. 2006 May-Jun; 32(1-2):200-14. PMID: 16858776.
    Citations: 15     Fields:    Translation:AnimalsCells
  34. Kolk SM, Whitman MC, Yun ME, Shete P, Donoghue MJ. A unique subpopulation of Tbr1-expressing deep layer neurons in the developing cerebral cortex. Mol Cell Neurosci. 2005 Dec; 30(4):538-51. PMID: 16188453.
    Citations: 10     Fields:    Translation:AnimalsCells
  35. Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL. Disulfide bond-mediated dimerization of HLA-G on the cell surface. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16180-5. PMID: 12454284; PMCID: PMC138585.
    Citations: 66     Fields:    Translation:HumansCells
  36. Wang J, Whitman MC, Natarajan K, Tormo J, Mariuzza RA, Margulies DH. Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin. J Biol Chem. 2002 Jan 11; 277(2):1433-42. PMID: 11696552.
    Citations: 28     Fields:    Translation:AnimalsCells
  37. Hebert AM, Strohmaier J, Whitman MC, Chen T, Gubina E, Hill DM, Lewis MS, Kozlowski S. Kinetics and thermodynamics of beta 2-microglobulin binding to the alpha 3 domain of major histocompatibility complex class I heavy chain. Biochemistry. 2001 May 01; 40(17):5233-42. PMID: 11318646.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  38. Whitman MC, Strohmaier J, O'Boyle K, Tingem JM, Wilkinson Y, Goldstein J, Chen T, Brorson K, Brunswick M, Kozlowski S. The isolated major histocompatibility complex class I alpha3 domain binds beta2m and CD8alphaalpha dimers. Mol Immunol. 2000 Feb-Mar; 37(3-4):141-9. PMID: 10865113.
    Citations: 1     Fields:    Translation:Cells
  39. Chen T, Goldstein JS, O'Boyle K, Whitman MC, Brunswick M, Kozlowski S. ICAM-1 co-stimulation has differential effects on the activation of CD4+ and CD8+ T cells. Eur J Immunol. 1999 03; 29(3):809-14. PMID: 10092083.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Barry BJ, Whitman MC, Hunter DG, Engle EC. Duane Syndrome. GeneReviews®. 1993. View Publication.
  41. Whitman M, Hunter DG, Engle EC. Congenital Fibrosis of the Extraocular Muscles. GeneReviews®. 1993. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.