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Pengxiang Huang, Ph.D.


University of Virginia, Charlottesville, VAPh.D.12/2009Biophysics
Tsinghua University, Beijing, ChinaB.S.07/2002Biology

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang DY, Xu H, He T, Younis MR, Zeng L, Liu H, Jiang C, Lin J, Huang P. Cobalt carbide-based theranostic agents for in vivo multimodal imaging guided photothermal therapy. Nanoscale. 2020 Apr 03; 12(13):7174-7179. PMID: 32195531.
  2. Lu Z, Zou J, Li S, Topper MJ, Tao Y, Zhang H, Jiao X, Xie W, Kong X, Vaz M, Li H, Cai Y, Xia L, Huang P, Rodgers K, Lee B, Riemer JB, Day CP, Yen RC, Cui Y, Wang Y, Wang Y, Zhang W, Easwaran H, Hulbert A, Kim K, Juergens RA, Yang SC, Battafarano RJ, Bush EL, Broderick SR, Cattaneo SM, Brahmer JR, Rudin CM, Wrangle J, Mei Y, Kim YJ, Zhang B, Wang KK, Forde PM, Margolick JB, Nelkin BD, Zahnow CA, Pardoll DM, Housseau F, Baylin SB, Shen L, Brock MV. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020 03; 579(7798):284-290. PMID: 32103175.
  3. He T, Xu H, Zhang Y, Yi S, Cui R, Xing S, Wei C, Lin J, Huang P. Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy. Theranostics. 2020; 10(4):1544-1554. PMID: 32042321.
  4. Zeng L, Ma G, Xu H, Mu J, Li F, Gao X, Deng Z, Qu J, Huang P, Lin J. In Vivo Chemoselective Photoacoustic Imaging of Copper(II) in Plant and Animal Subjects. Small. 2019 02; 15(6):e1803866. PMID: 30645025.
    Citations:    Fields:    
  5. Cheng T, Li X, Huang P, Wang H, Wang M, Yang W. Colorimetric and electrochemical (dual) thrombin assay based on the use of a platinum nanoparticle modified metal-organic framework (type Fe-MIL-88) acting as a peroxidase mimic. Mikrochim Acta. 2019 01 10; 186(2):94. PMID: 30631938.
    Citations:    Fields:    
  6. Li Z, Hu Y, Miao Z, Xu H, Li C, Zhao Y, Li Z, Chang M, Ma Z, Sun Y, Besenbacher F, Huang P, Yu M. Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy. Nano Lett. 2018 11 14; 18(11):6778-6788. PMID: 30288978.
    Citations:    Fields:    Translation:HumansCells
  7. Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell. 2018 09 20; 175(1):295-297. PMID: 30241610.
    Citations:    Fields:    
  8. Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell. 2018 07 12; 174(2):312-324.e16. PMID: 29804838.
    Citations: 2     Fields:    
  9. Wang J, Li XB, Huang P, Huang MY, Gu XJ. Change of Peripheral Blood Treg/Thl7 in Cognitive Impairment with Chronic Renal Failure Patients. Cell Physiol Biochem. 2018; 45(1):281-290. PMID: 29402868.
    Citations:    Fields:    Translation:HumansCells
  10. Zhang S, Xiao Q, Shi Z, Yu G, Ma XP, Chen H, Zhang P, Shen S, Sai-Yin HG, Chen TY, Lu PX, Wang NJ, Ren W, Huang P, Xie J, Conran C, Zheng SL, Yu L, Xu J, Jiang DK. Caspase polymorphisms and prognosis of hepatocellular carcinoma. PLoS One. 2017; 12(4):e0176802. PMID: 28453560.
    Citations:    Fields:    Translation:Humans
  11. Kim YH, Min KH, Wang Z, Kim J, Jacobson O, Huang P, Zhu G, Liu Y, Yung B, Niu G, Chen X. Development of Sialic Acid-coated Nanoparticles for Targeting Cancer and Efficient Evasion of the Immune System. Theranostics. 2017; 7(4):962-973. PMID: 28382168.
    Citations:    Fields:    Translation:AnimalsCells
  12. Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, Salic A. Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell. 2016 Aug 25; 166(5):1176-1187.e14. PMID: 27545348.
    Citations: 23     Fields:    Translation:AnimalsCells
  13. Lin X, You Y, Wang J, Qin Y, Huang P, Yang F. MicroRNA-155 deficiency promotes nephrin acetylation and attenuates renal damage in hyperglycemia-induced nephropathy. Inflammation. 2015 Apr; 38(2):546-54. PMID: 24969676.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Santori FR, Huang P, van de Pavert SA, Douglass EF, Leaver DJ, Haubrich BA, Keber R, Lorbek G, Konijn T, Rosales BN, Rozman D, Horvat S, Rahier A, Mebius RE, Rastinejad F, Nes WD, Littman DR. Identification of natural ROR? ligands that regulate the development of lymphoid cells. Cell Metab. 2015 Feb 03; 21(2):286-298. PMID: 25651181.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  15. Wang YT, Lu XM, Zhu F, Huang P, Yu Y, Long ZY, Wu YM. Ameliorative Effects of p75NTR-ED-Fc on Axonal Regeneration and Functional Recovery in Spinal Cord-Injured Rats. Mol Neurobiol. 2015 Dec; 52(3):1821-1834. PMID: 25394381.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin CP, Maddocks K, Byrd J, Melnick A, Huang P, Wiestner A, Bhalla KN. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res. 2014 May 01; 74(9):2520-32. PMID: 24599128.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  17. Huang P, Chandra V, Rastinejad F. Retinoic acid actions through mammalian nuclear receptors. Chem Rev. 2014 Jan 08; 114(1):233-54. PMID: 24308533.
    Citations: 18     Fields:    Translation:AnimalsCells
  18. Rastinejad F, Huang P, Chandra V, Khorasanizadeh S. Understanding nuclear receptor form and function using structural biology. J Mol Endocrinol. 2013 Dec; 51(3):T1-T21. PMID: 24103914.
    Citations: 25     Fields:    Translation:HumansAnimals
  19. Xiong F, Tentner AR, Huang P, Gelas A, Mosaliganti KR, Souhait L, Rannou N, Swinburne IA, Obholzer ND, Cowgill PD, Schier AF, Megason SG. Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell. 2013 Apr 25; 153(3):550-61. PMID: 23622240.
    Citations: 40     Fields:    Translation:AnimalsCells
  20. Chandra V, Huang P, Potluri N, Wu D, Kim Y, Rastinejad F. Multidomain integration in the structure of the HNF-4a nuclear receptor complex. Nature. 2013 Mar 21; 495(7441):394-8. PMID: 23485969.
    Citations: 45     Fields:    Translation:HumansCells
  21. Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR. Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors. ACS Med Chem Lett. 2013 Jan 10; 4(1):79-84. PMID: 24040486.
    Citations: 11     
  22. Huang P, Xiong F, Megason SG, Schier AF. Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet. 2012; 8(6):e1002762. PMID: 22685423.
    Citations: 20     Fields:    Translation:AnimalsCells
  23. Wang YT, Lu XM, Zhu F, Huang P, Yu Y, Zeng L, Long ZY, Wu YM. The use of a gold nanoparticle-based adjuvant to improve the therapeutic efficacy of hNgR-Fc protein immunization in spinal cord-injured rats. Biomaterials. 2011 Nov; 32(31):7988-98. PMID: 21784510.
    Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  24. Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing ROR?t activity. Nature. 2011 Apr 28; 472(7344):486-90. PMID: 21441909.
    Citations: 156     Fields:    Translation:HumansAnimalsCells
  25. Kim D, Blus BJ, Chandra V, Huang P, Rastinejad F, Khorasanizadeh S. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Nat Struct Mol Biol. 2010 Aug; 17(8):1027-9. PMID: 20657587.
    Citations: 36     Fields:    Translation:AnimalsCells
  26. Huang P, Chandra V, Rastinejad F. Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. Annu Rev Physiol. 2010; 72:247-72. PMID: 20148675.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  27. Huang P, Schier AF. Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development. 2009 Sep; 136(18):3089-98. PMID: 19700616.
  28. Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr; 16(4):600-6. PMID: 19386268.
    Citations: 52     Fields:    Translation:AnimalsCells
  29. Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008 Nov 20; 456(7220):350-6. PMID: 19043829.
    Citations: 205     Fields:    Translation:HumansCells
  30. Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol. 2007 Dec; 14(12):1207-13. PMID: 18037887.
    Citations: 182     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.