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MIchael S Placzek, Ph.D.

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  1. K01DA046520 (PLACZEK, MICHAEL STEPHEN) Aug 1, 2019 - Jul 31, 2023
    Assessing brain activation and neurochemistry of kappa opioid agonists through in vivo imaging
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Alshelh Z, Brusaferri L, Saha A, Morrissey E, Knight P, Kim M, Zhang Y, Hooker JM, Albrecht D, Torrado-Carvajal A, Placzek MS, Akeju O, Price J, Edwards RR, Lee J, Sclocco R, Catana C, Napadow V, Loggia ML. Neuro-immune signatures in chronic low back pain subtypes. Brain. 2021 Sep 16. PMID: 34528069.
    Citations:    Fields:    
  2. Placzek MS. Imaging Kappa Opioid Receptors in the Living Brain with Positron Emission Tomography. Handb Exp Pharmacol. 2021 Aug 07. PMID: 34363128.
    Citations:    Fields:    
  3. Bai P, Bai S, Placzek MS, Lu X, Fiedler SA, Ntaganda B, Wey HY, Wang C. A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging. Molecules. 2020 Feb 25; 25(5). PMID: 32106419.
    Citations: 2     Fields:    Translation:Humans
  4. Lan Y, Bai P, Chen Z, Neelamegam R, Placzek MS, Wang H, Fiedler SA, Yang J, Yuan G, Qu X, Schmidt HR, Song J, Normandin MD, Ran C, Wang C. Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET). Acta Pharm Sin B. 2019 Nov; 9(6):1204-1215. PMID: 31867166.
    Citations: 5     
  5. Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging. ACS Chem Neurosci. 2019 01 16; 10(1):384-395. PMID: 30212182.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Larimer BM, Dubois F, Bloch E, Nesti S, Placzek M, Zadra G, Hooker JM, Loda M, Mahmood U. Specific 18F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone-Binding Globulin. J Nucl Med. 2018 10; 59(10):1538-1543. PMID: 29853654.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Krishnan HS, Bernard-Gauthier V, Placzek MS, Dahl K, Narayanaswami V, Livni E, Chen Z, Yang J, Collier TL, Ran C, Hooker JM, Liang SH, Vasdev N. Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2. Mol Pharm. 2018 02 05; 15(2):695-702. PMID: 29298483.
    Citations: 2     Fields:    Translation:HumansAnimals
  8. Liu W, Huang X, Placzek MS, Krska SW, McQuade P, Hooker JM, Groves JT. Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin. Chem Sci. 2018 Feb 07; 9(5):1168-1172. PMID: 29675161.
    Citations: 8     
  9. Schoenberger M, Schroeder FA, Placzek MS, Carter RL, Rosen BR, Hooker JM, Sander CY. In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates. ACS Chem Neurosci. 2018 02 21; 9(2):298-305. PMID: 29050469.
    Citations: 6     Fields:    Translation:AnimalsCells
  10. Ma L, Placzek MS, Hooker JM, Vasdev N, Liang SH. [11C]Cyanation of arylboronic acids in aqueous solutions. Chem Commun (Camb). 2017 Jun 21; 53(49):6597-6600. PMID: 28580477.
    Citations: 7     Fields:    
  11. Rotstein BH, Placzek MS, Krishnan HS, Pekošak A, Collier TL, Wang C, Liang SH, Burstein ES, Hooker JM, Vasdev N. Preclinical PET Neuroimaging of [11C]Bexarotene. Mol Imaging. 2016; 15. PMID: 27553293.
    Citations: 1     Fields:    Translation:Animals
  12. Rotstein BH, Liang SH, Placzek MS, Hooker JM, Gee AD, Dollé F, Wilson AA, Vasdev N. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals. Chem Soc Rev. 2016 Aug 22; 45(17):4708-26. PMID: 27276357.
    Citations: 26     Fields:    Translation:HumansCells
  13. Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM. A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. ACS Chem Neurosci. 2016 Apr 20; 7(4):484-9. PMID: 26694017.
    Citations: 12     Fields:    Translation:Animals
  14. Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM. PET Neurochemical Imaging Modes. Semin Nucl Med. 2016 Jan; 46(1):20-7. PMID: 26687854.
    Citations: 5     Fields:    Translation:HumansAnimals
  15. Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. ACS Chem Neurosci. 2016 05 18; 7(5):528-33. PMID: 26675505.
    Citations: 8     Fields:    Translation:Animals
  16. Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM. Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET. Neuropsychopharmacology. 2015 Dec; 40(13):2865-72. PMID: 26058662.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Lee HG, Milner PJ, Placzek MS, Buchwald SL, Hooker JM. Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes. J Am Chem Soc. 2015 Jan 21; 137(2):648-51. PMID: 25565277.
    Citations: 18     Fields:    
  18. Fabio K, Guillon C, Lacey CJ, Lu SF, Heindel ND, Ferris CF, Placzek M, Jones G, Brownstein MJ, Simon NG. Synthesis and evaluation of potent and selective human V1a receptor antagonists as potential ligands for PET or SPECT imaging. Bioorg Med Chem. 2012 Feb 01; 20(3):1337-45. PMID: 22249122.
    Citations: 1     Fields:    Translation:HumansCells
  19. Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. J Med Chem. 2007 Sep 06; 50(18):4419-30. PMID: 17696418.
    Citations: 21     Fields:    Translation:HumansCells
  20. Morrell A, Placzek M, Parmley S, Grella B, Antony S, Pommier Y, Cushman M. Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors. J Med Chem. 2007 Sep 06; 50(18):4388-404. PMID: 17676830.
    Citations: 24     Fields:    Translation:HumansCells
  21. Morrell A, Placzek MS, Steffen JD, Antony S, Agama K, Pommier Y, Cushman M. Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures. J Med Chem. 2007 May 03; 50(9):2040-8. PMID: 17402722.
    Citations: 19     Fields:    Translation:HumansCells
  22. Degitz K, Placzek M, Arnold B, Schmidt H, Plewig G. Congenital adrenal hyperplasia and acne in male patients. Br J Dermatol. 2003 Jun; 148(6):1263-6. PMID: 12828760.
    Citations: 3     Fields:    Translation:Humans
  23. Placzek M, Degitz K, Schmidt H, Plewig G. Acne fulminans in late-onset congenital adrenal hyperplasia. Lancet. 1999 Aug 28; 354(9180):739-40. PMID: 10475188.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.