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Ruisheng Wang, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cheng F, Zhao J, Wang Y, Lu W, Liu Z, Zhou Y, Martin WR, Wang R, Huang J, Hao T, Yue H, Ma J, Hou Y, Castrillon JA, Fang J, Lathia JD, Keri RA, Lightstone FC, Antman EM, Rabadan R, Hill DE, Eng C, Vidal M, Loscalzo J. Comprehensive characterization of protein-protein interactions perturbed by disease mutations. Nat Genet. 2021 03; 53(3):342-353. PMID: 33558758.
    Citations:    Fields:    Translation:Humans
  2. Maron BA, Wang RS, Shevtsov S, Drakos SG, Arons E, Wever-Pinzon O, Huggins GS, Samokhin AO, Oldham WM, Aguib Y, Yacoub MH, Rowin EJ, Maron BJ, Maron MS, Loscalzo J. Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes. Nat Commun. 2021 02 08; 12(1):873. PMID: 33558530.
    Citations:    Fields:    Translation:HumansCells
  3. Alba GA, Samokhin AO, Wang RS, Zhang YY, Wertheim BM, Arons E, Greenfield EA, Lundberg Slingsby MH, Ceglowski JR, Haley KJ, Bowman FP, Yu YR, Haney JC, Eng G, Mitchell RN, Sheets A, Vargas SO, Seo S, Channick RN, Leary PJ, Rajagopal S, Loscalzo J, Battinelli EM, Maron BA. NEDD9 is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. Am J Respir Crit Care Med. 2021 Feb 01. PMID: 33523764.
    Citations: 1     Fields:    
  4. Paci P, Fiscon G, Conte F, Wang RS, Farina L, Loscalzo J. Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery. NPJ Syst Biol Appl. 2021 01 21; 7(1):3. PMID: 33479222.
    Citations: 1     Fields:    
  5. Song JS, Wang RS, Leopold JA, Loscalzo J. Network determinants of cardiovascular calcification and repositioned drug treatments. FASEB J. 2020 08; 34(8):11087-11100. PMID: 32638415.
    Citations: 5     Fields:    Translation:HumansCells
  6. Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239. PMID: 31545648.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  7. Wang RS, Croteau-Chonka DC, Silverman EK, Loscalzo J, Weiss ST, Hall KT. Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma. Clin Pharmacol Ther. 2019 12; 106(6):1261-1267. PMID: 31557306.
    Citations: 2     Fields:    Translation:Humans
  8. Cheng F, Lu W, Liu C, Fang J, Hou Y, Handy DE, Wang R, Zhao Y, Yang Y, Huang J, Hill DE, Vidal M, Eng C, Loscalzo J. A genome-wide positioning systems network algorithm for in silico drug repurposing. Nat Commun. 2019 08 02; 10(1):3476. PMID: 31375661.
    Citations: 35     Fields:    Translation:HumansCells
  9. Musri MM, Coll-Bonfill N, Maron BA, Peinado VI, Wang RS, Altirriba J, Blanco I, Oldham WM, Tura-Ceide O, García-Lucio J, de la Cruz-Thea B, Meister G, Loscalzo J, Barberà JA. MicroRNA Dysregulation in Pulmonary Arteries from Chronic Obstructive Pulmonary Disease. Relationships with Vascular Remodeling. Am J Respir Cell Mol Biol. 2018 10; 59(4):490-499. PMID: 29757677.
    Citations: 9     Fields:    Translation:HumansCells
  10. Cheng F, Desai RJ, Handy DE, Wang R, Schneeweiss S, Barabási AL, Loscalzo J. Network-based approach to prediction and population-based validation of in silico drug repurposing. Nat Commun. 2018 07 12; 9(1):2691. PMID: 30002366.
    Citations: 87     Fields:    Translation:Humans
  11. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899023.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  12. Wang RS, Loscalzo J. Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications. J Mol Biol. 2018 09 14; 430(18 Pt A):2939-2950. PMID: 29791871.
    Citations: 7     Fields:    Translation:Humans
  13. Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA. Network Analysis to Risk Stratify Patients With Exercise Intolerance. Circ Res. 2018 03 16; 122(6):864-876. PMID: 29437835.
    Citations: 13     Fields:    Translation:Humans
  14. Wang RS, Oldham WM, Maron BA, Loscalzo J. Systems Biology Approaches to Redox Metabolism in Stress and Disease States. Antioxid Redox Signal. 2018 10 01; 29(10):953-972. PMID: 29121773.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Xiao W, Wang RS, Handy DE, Loscalzo J. NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism. Antioxid Redox Signal. 2018 Jan 20; 28(3):251-272. PMID: 28648096.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  16. Wang RS, Hall KT, Giulianini F, Passow D, Kaptchuk TJ, Loscalzo J. Network analysis of the genomic basis of the placebo effect. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570268.
    Citations: 13     Fields:    
  17. Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J. Endophenotype Network Models: Common Core of Complex Diseases. Sci Rep. 2016 06 09; 6:27414. PMID: 27278246.
    Citations: 28     Fields:    Translation:Humans
  18. Wang RS, Loscalzo J. Illuminating drug action by network integration of disease genes: a case study of myocardial infarction. Mol Biosyst. 2016 04 26; 12(5):1653-66. PMID: 27004607.
    Citations: 6     Fields:    Translation:HumansCells
  19. Wang RS, Maron BA, Loscalzo J. Systems medicine: evolution of systems biology from bench to bedside. Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug; 7(4):141-61. PMID: 25891169.
    Citations: 21     Fields:    Translation:Humans
  20. Wang RS, Oldham WM, Loscalzo J. Network-based association of hypoxia-responsive genes with cardiovascular diseases. New J Phys. 2014 Oct 24; 16(10):105014. PMID: 25530704.
    Citations: 7     
  21. Jones AM, Xuan Y, Xu M, Wang RS, Ho CH, Lalonde S, You CH, Sardi MI, Parsa SA, Smith-Valle E, Su T, Frazer KA, Pilot G, Pratelli R, Grossmann G, Acharya BR, Hu HC, Engineer C, Villiers F, Ju C, Takeda K, Su Z, Dong Q, Assmann SM, Chen J, Kwak JM, Schroeder JI, Albert R, Rhee SY, Frommer WB. Border control--a membrane-linked interactome of Arabidopsis. Science. 2014 May 16; 344(6185):711-6. PMID: 24833385.
    Citations: 66     Fields:    Translation:AnimalsCells
  22. Li Z, Zhang XS, Wang RS, Liu H, Zhang S. Discovering link communities in complex networks by an integer programming model and a genetic algorithm. PLoS One. 2013; 8(12):e83739. PMID: 24386268.
    Citations: 4     Fields:    Translation:Humans
  23. Jin X, Wang RS, Zhu M, Jeon BW, Albert R, Chen S, Assmann SM. Abscisic acid-responsive guard cell metabolomes of Arabidopsis wild-type and gpa1 G-protein mutants. Plant Cell. 2013 Dec; 25(12):4789-811. PMID: 24368793.
    Citations: 17     Fields:    Translation:Animals
  24. Wang RS, Albert R. Effects of community structure on the dynamics of random threshold networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jan; 87(1):012810. PMID: 23410391.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Wang RS, Saadatpour A, Albert R. Boolean modeling in systems biology: an overview of methodology and applications. Phys Biol. 2012 Oct; 9(5):055001. PMID: 23011283.
    Citations: 99     Fields:    Translation:AnimalsCells
  26. Chen C, Zhao JF, Huang Q, Wang RS, Zhang XS. Inferring domain-domain interactions from protein-protein interactions in the complex network conformation. BMC Syst Biol. 2012; 6 Suppl 1:S7. PMID: 23046795.
    Citations:    Fields:    Translation:Cells
  27. Saadatpour A, Wang RS, Liao A, Liu X, Loughran TP, Albert I, Albert R. Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. PLoS Comput Biol. 2011 Nov; 7(11):e1002267. PMID: 22102804.
    Citations: 52     Fields:    Translation:HumansCells
  28. Li Z, Wang RS, Zhang XS. Two-stage flux balance analysis of metabolic networks for drug target identification. BMC Syst Biol. 2011 Jun 20; 5 Suppl 1:S11. PMID: 21689470.
    Citations: 9     Fields:    Translation:HumansCells
  29. Wang RS, Pandey S, Li S, Gookin TE, Zhao Z, Albert R, Assmann SM. Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells. BMC Genomics. 2011 May 09; 12:216. PMID: 21554708.
    Citations: 68     Fields:    Translation:AnimalsCells
  30. Wang RS, Albert R. Elementary signaling modes predict the essentiality of signal transduction network components. BMC Syst Biol. 2011 Mar 22; 5:44. PMID: 21426566.
    Citations: 21     Fields:    Translation:Cells
  31. Pandey S, Wang RS, Wilson L, Li S, Zhao Z, Gookin TE, Assmann SM, Albert R. Boolean modeling of transcriptome data reveals novel modes of heterotrimeric G-protein action. Mol Syst Biol. 2010 Jun 08; 6:372. PMID: 20531402.
    Citations: 45     Fields:    Translation:AnimalsCells
  32. Wang RS, Jin G, Zhang XS, Chen L. Modeling post-transcriptional regulation activity of small non-coding RNAs in Escherichia coli. BMC Bioinformatics. 2009 Apr 29; 10 Suppl 4:S6. PMID: 19426454.
    Citations: 2     Fields:    Translation:Cells
  33. Zhao XM, Wang RS, Chen L, Aihara K. Automatic modeling of signaling pathways by network flow model. J Bioinform Comput Biol. 2009 Apr; 7(2):309-22. PMID: 19340917.
    Citations: 8     Fields:    Translation:Cells
  34. Albert R, Wang RS. Discrete dynamic modeling of cellular signaling networks. Methods Enzymol. 2009; 467:281-306. PMID: 19897097.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  35. Zhao XM, Wang RS, Chen L, Aihara K. Uncovering signal transduction networks from high-throughput data by integer linear programming. Nucleic Acids Res. 2008 May; 36(9):e48. PMID: 18411207.
    Citations: 42     Fields:    Translation:AnimalsCells
  36. Li Z, Zhang S, Wang RS, Zhang XS, Chen L. Quantitative function for community detection. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Mar; 77(3 Pt 2):036109. PMID: 18517463.
    Citations: 12     Fields:    
  37. Wang RS, Zhang XS, Chen L. Inferring transcriptional interactions and regulator activities from experimental data. Mol Cells. 2007 Dec 31; 24(3):307-15. PMID: 18182844.
    Citations: 6     Fields:    Translation:Cells
  38. Wang RS, Wang Y, Wu LY, Zhang XS, Chen L. Analysis on multi-domain cooperation for predicting protein-protein interactions. BMC Bioinformatics. 2007 Oct 16; 8:391. PMID: 17937822.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  39. Zhang S, Wang RS, Zhang XS. Uncovering fuzzy community structure in complex networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Oct; 76(4 Pt 2):046103. PMID: 17995056.
    Citations: 7     Fields:    
  40. Wang RS, Wang Y, Zhang XS, Chen L. Inferring transcriptional regulatory networks from high-throughput data. Bioinformatics. 2007 Nov 15; 23(22):3056-64. PMID: 17890736.
    Citations: 16     Fields:    Translation:Cells
  41. Wang Y, Feng E, Wang R, Zhang D. The haplotype assembly model with genotype information and iterative local-exhaustive search algorithm. Comput Biol Chem. 2007 Aug; 31(4):288-93. PMID: 17631422.
    Citations:    Fields:    
  42. Zhang XS, Wang RS, Wu LY, Zhang W. Minimum conflict individual haplotyping from SNP fragments and related genotype. Evol Bioinform Online. 2007 Feb 16; 2:261-70. PMID: 19455219.
    Citations: 2     
  43. Wang Y, Feng E, Wang R. A clustering algorithm based on two distance functions for MEC model. Comput Biol Chem. 2007 Apr; 31(2):148-50. PMID: 17363329.
    Citations: 5     Fields:    Translation:Humans
  44. Wang RS, Wu LY, Zhang XS, Chen L. A Markov chain model for haplotype assembly from SNP fragments. Genome Inform. 2006; 17(2):162-71. PMID: 17503389.
    Citations: 1     Fields:    Translation:HumansCells
  45. Zhao YY, Wu LY, Zhang JH, Wang RS, Zhang XS. Haplotype assembly from aligned weighted SNP fragments. Comput Biol Chem. 2005 Aug; 29(4):281-7. PMID: 16051522.
    Citations: 8     Fields:    Translation:Humans
  46. Wang RS, Wu LY, Li ZP, Zhang XS. Haplotype reconstruction from SNP fragments by minimum error correction. Bioinformatics. 2005 May 15; 21(10):2456-62. PMID: 15731204.
    Citations: 14     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.