Harvard Catalyst Profiles

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Rona Stephanie Carroll, Ph.D.

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Mentoring
Available: 10/15/18, Expires: 10/30/20

Our laboratory provides a rich intellectual environment of physicians and scientists focused on neuroendocrinology and reproductive endocrinology. An elaborate neural network integrating internal and external signals governs the onset of puberty and subsequent fertility. The precise nature and components of this network are not well established, but it is clear that puberty is triggered by the central increase in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which stimulates the secretion of the pituitary gonadotropins, necessary for the activation of gonadal function. Our laboratory uses a translational approach to study the hormones and genes involved in the neuroendocrine regulation of reproductive development, puberty onset and subsequent fertility. Out approaches include studies of: 1. Hypothalamic and pituitary cell models and in vitro studies; 2. In vivo mouse models; and 3. Patients with clinical reproductive disorders. Potential Student Roles: (1) Assist with reproductive phenotyping of genetically modified mouse models (e.g., pubertal markers, estrous cyclicity); (2) Assist with human genetic studies, including review of human patient clinical data to correlate with genetic findings with clinical phenotypes, and DNA sequencing and sequence analysis, including analyses of exome sequence data; (3) Contribute to laboratory studies of human inducible pluripotent stem cell (hiPSC)-derived hypothalamic neurons that have been genetically modified by CRISPR-Cas9.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32HD007159 (CARROLL, RONA S) Sep 30, 1988
    NIH/NICHD
    HORMONAL REGULATION OF GONADOTROPIN BIOSYNTHESIS
    Role: Principal Investigator
  2. F31MH009259 (CARROLL, RONA S) Dec 1, 1986
    NIH/NIMH
    BEHAVORIAL CONTROL OF LH IN
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Roberts SA, Abreu AP, Navarro VM, Liang JN, Maguire CA, Kim HK, Carroll RS, Kaiser UB. The Peripubertal Decline in Makorin Ring Finger Protein 3 Expression is Independent of Leptin Action. J Endocr Soc. 2020 Jul 01; 4(7):bvaa059. PMID: 32587933.
    Citations:    
  2. Abreu AP, Toro CA, Song YB, Navarro VM, Bosch MA, Eren A, Liang JN, Carroll RS, Latronico AC, Ronnekleiv OK, Aylwin CF, Lomniczi A, Ojeda SR, Kaiser UB. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons. J Clin Invest. 2020 May 14. PMID: 32407292.
    Citations:    
  3. Valadares LP, Meireles CG, De Toledo IP, Santarem de Oliveira R, Gonçalves de Castro LC, Abreu AP, Carroll RS, Latronico AC, Kaiser UB, Guerra ENS, Lofrano-Porto A. MKRN3 Mutations in Central Precocious Puberty: A Systematic Review and Meta-Analysis. J Endocr Soc. 2019 May 01; 3(5):979-995. PMID: 31041429.
    Citations:    
  4. Zhao Y, Huang W, Kim TM, Jung Y, Menon LG, Xing H, Li H, Carroll RS, Park PJ, Yang HW, Johnson MD. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma. J Exp Clin Cancer Res. 2019 Jan 25; 38(1):36. PMID: 30683134.
    Citations:    Fields:    
  5. Stamatiades GA, Carroll RS, Kaiser UB. GnRH-A Key Regulator of FSH. Endocrinology. 2019 01 01; 160(1):57-67. PMID: 30517625.
    Citations:    Fields:    
  6. Masterson TA, Arora H, Kulandavelu S, Carroll RS, Kaiser UB, Gultekin SH, Hare JM, Ramasamy R. S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism. J Sex Med. 2018 05; 15(5):654-661. PMID: 29606625.
    Citations: 1     Fields:    
  7. Lee H, Hodi FS, Giobbie-Hurder A, Ott PA, Buchbinder EI, Haq R, Tolaney S, Barroso-Sousa R, Zhang K, Donahue H, Davis M, Gargano ME, Kelley KM, Carroll RS, Kaiser UB, Min L. Characterization of Thyroid Disorders in Patients Receiving Immune Checkpoint Inhibition Therapy. Cancer Immunol Res. 2017 12; 5(12):1133-1140. PMID: 29079654.
    Citations: 2     Fields:    Translation:HumansCells
  8. Maguire CA, Song YB, Wu M, León S, Carroll RS, Alreja M, Kaiser UB, Navarro VM. Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology. 2017 07 01; 158(7):2319-2329. PMID: 28444173.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Dauber A, Cunha-Silva M, Macedo DB, Brito VN, Abreu AP, Roberts SA, Montenegro LR, Andrew M, Kirby A, Weirauch MT, Labilloy G, Bessa DS, Carroll RS, Jacobs DC, Chappell PE, Mendonca BB, Haig D, Kaiser UB, Latronico AC. Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty. J Clin Endocrinol Metab. 2017 05 01; 102(5):1557-1567. PMID: 28324015.
    Citations: 7     Fields:    Translation:Humans
  10. Hickman TT, Shuman ME, Johnson TA, Yang F, Rice RR, Rice IM, Chung EH, Wiemann R, Tinl M, Iracheta C, Chen G, Flynn P, Mondello MB, Thompson J, Meadows ME, Carroll RS, Yang HW, Xing H, Pilgrim D, Chiocca EA, Dunn IF, Golby AJ, Johnson MD. Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248. PMID: 27689463.
    Citations:    Fields:    
  11. Simavli S, Abreu AP, Kwaan MR, Dluhy RG, Yanushpolsky EH, Feltmate C, Cerda SR, Carroll RS, Kaiser UB, Kuohung W. Candidate gene analysis in a case of congenital absence of the endometrium. Fertil Res Pract. 2016; 2:3. PMID: 28620530.
    Citations:    
  12. Thompson IR, Ciccone NA, Zhou Q, Xu S, Khogeer A, Carroll RS, Kaiser UB. GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER. Mol Endocrinol. 2016 Mar; 30(3):348-60. PMID: 26835742.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Min L, Leon S, Li H, Pinilla L, Carroll RS, Tena-Sempere M, Kaiser UB. RF9 Acts as a KISS1R Agonist In Vivo and In Vitro. Endocrinology. 2015 Dec; 156(12):4639-48. PMID: 26418326.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB. GnRH Neuron-Specific Ablation of Gaq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gaq/11-Independent GnRH Secretion. J Neurosci. 2015 Sep 16; 35(37):12903-16. PMID: 26377475.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Min L, Nie M, Zhang A, Wen J, Noel SD, Lee V, Carroll RS, Kaiser UB. Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction. Neuroendocrinology. 2016; 103(3-4):230-9. PMID: 26088945.
    Citations: 2     Fields:    Translation:Humans
  16. Simavli S, Thompson IR, Maguire CA, Gill JC, Carroll RS, Wolfe A, Kaiser UB, Navarro VM. Substance p regulates puberty onset and fertility in the female mouse. Endocrinology. 2015 Jun; 156(6):2313-22. PMID: 25856429.
    Citations: 9     Fields:    Translation:Animals
  17. Min L, Hodi FS, Giobbie-Hurder A, Ott PA, Luke JJ, Donahue H, Davis M, Carroll RS, Kaiser UB. Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study. Clin Cancer Res. 2015 Feb 15; 21(4):749-55. PMID: 25538262.
    Citations: 22     Fields:    Translation:Humans
  18. Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015 Feb; 156(2):627-37. PMID: 25422875.
    Citations: 19     Fields:    Translation:Animals
  19. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, Carroll RS, Glidewell-Kenney CA, Mellon PL, Bhattacharya M, Tobet SA, Kaiser UB, Babwah AV. KISS1R signals independently of Gaq/11 and triggers LH secretion via the ß-arrestin pathway in the male mouse. Endocrinology. 2014 Nov; 155(11):4433-46. PMID: 25147978.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Beneduzzi D, Trarbach EB, Min L, Jorge AA, Garmes HM, Renk AC, Fichna M, Fichna P, Arantes KA, Costa EM, Zhang A, Adeola O, Wen J, Carroll RS, Mendonça BB, Kaiser UB, Latronico AC, Silveira LF. Role of gonadotropin-releasing hormone receptor mutations in patients with a wide spectrum of pubertal delay. Fertil Steril. 2014 Sep; 102(3):838-846.e2. PMID: 25016926.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23; 34(17):6047-56. PMID: 24760864.
    Citations: 16     Fields:    Translation:AnimalsCells
  22. Macedo DB, Abreu AP, Reis AC, Montenegro LR, Dauber A, Beneduzzi D, Cukier P, Silveira LF, Teles MG, Carroll RS, Junior GG, Filho GG, Gucev Z, Arnhold IJ, de Castro M, Moreira AC, Martinelli CE, Hirschhorn JN, Mendonca BB, Brito VN, Antonini SR, Kaiser UB, Latronico AC. Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3. J Clin Endocrinol Metab. 2014 Jun; 99(6):E1097-103. PMID: 24628548.
    Citations: 22     Fields:    Translation:Humans
  23. Noel SD, Abreu AP, Xu S, Muyide T, Gianetti E, Tusset C, Carroll J, Latronico AC, Seminara SB, Carroll RS, Kaiser UB. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients. FASEB J. 2014 Apr; 28(4):1924-37. PMID: 24376026.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  24. Min L, Soltis K, Reis AC, Xu S, Kuohung W, Jain M, Carroll RS, Kaiser UB. Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling. Mol Endocrinol. 2014 Jan; 28(1):16-27. PMID: 24295737.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  25. Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27; 368(26):2467-75. PMID: 23738509.
    Citations: 69     Fields:    Translation:HumansAnimals
  26. Thompson IR, Ciccone NA, Xu S, Zaytseva S, Carroll RS, Kaiser UB. GnRH pulse frequency-dependent stimulation of FSHß transcription is mediated via activation of PKA and CREB. Mol Endocrinol. 2013 Apr; 27(4):606-18. PMID: 23393127.
    Citations: 17     Fields:    Translation:AnimalsCells
  27. Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB. Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology. 2012 Oct; 153(10):4883-93. PMID: 22893725.
    Citations: 20     Fields:    Translation:AnimalsCells
  28. Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, Park PJ, Carroll RS, Johnson MD. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells. 2012 Jul; 30(7):1313-26. PMID: 22553175.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  29. Abreu AP, Noel SD, Xu S, Carroll RS, Latronico AC, Kaiser UB. Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol. 2012 Aug; 26(8):1417-27. PMID: 22745195.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  30. Yang HW, Kim TM, Song SS, Shrinath N, Park R, Kalamarides M, Park PJ, Black PM, Carroll RS, Johnson MD. Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma. Neoplasia. 2012 Jan; 14(1):20-8. PMID: 22355270.
    Citations: 14     Fields:    Translation:HumansCells
  31. Menon LG, Pratt J, Yang HW, Black PM, Sorensen GA, Carroll RS. Imaging of human mesenchymal stromal cells: homing to human brain tumors. J Neurooncol. 2012 Apr; 107(2):257-67. PMID: 22081298.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  32. Leinonen V, Menon LG, Carroll RS, Dello Iacono D, Grevet J, Jääskeläinen JE, Black PM. Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. Int J Alzheimers Dis. 2011; 2011:312526. PMID: 21660204.
    Citations: 13     
  33. Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res. 2010 Aug 15; 16(16):4155-64. PMID: 20682713.
    Citations: 21     Fields:    Translation:Humans
  34. Gill JC, Wang O, Kakar S, Martinelli E, Carroll RS, Kaiser UB. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One. 2010 Jul 30; 5(7):e11911. PMID: 20689830.
    Citations: 32     Fields:    Translation:Animals
  35. Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD. SNAI2/Slug promotes growth and invasion in human gliomas. BMC Cancer. 2010 Jun 17; 10:301. PMID: 20565806.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  36. Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, Carroll RS, Black PM. Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes. Anticancer Res. 2010 Apr; 30(4):1057-64. PMID: 20530409.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Lee YB, Polio S, Lee W, Dai G, Menon L, Carroll RS, Yoo SS. Bio-printing of collagen and VEGF-releasing fibrin gel scaffolds for neural stem cell culture. Exp Neurol. 2010 Jun; 223(2):645-52. PMID: 20211178.
    Citations: 18     Fields:    Translation:AnimalsCells
  38. Schmidt NO, Ziu M, Cargioli T, Westphal M, Giese A, Black PM, Carroll RS. Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy. Transl Oncol. 2010 Feb; 3(1):43-9. PMID: 20165694.
    Citations: 3     
  39. Ciccone NA, Xu S, Lacza CT, Carroll RS, Kaiser UB. Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors. Mol Cell Biol. 2010 Feb; 30(4):1028-40. PMID: 20008557.
    Citations: 30     Fields:    Translation:AnimalsCells
  40. Menon LG, Kelly K, Yang HW, Kim SK, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009 Sep; 27(9):2320-30. PMID: 19544410.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  41. Lee DH, Ahn Y, Kim SU, Wang KC, Cho BK, Phi JH, Park IH, Black PM, Carroll RS, Lee J, Kim SK. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res. 2009 Aug 01; 15(15):4925-34. PMID: 19638465.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  42. Jeong KH, Gill JC, Nosé V, Parlow AF, Carroll RS, Kaiser UB. Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis. Endocrinology. 2009 Jul; 150(7):3383-91. PMID: 19282386.
    Citations: 1     Fields:    Translation:AnimalsCells
  43. Schmidt NO, Koeder D, Messing M, Mueller FJ, Aboody KS, Kim SU, Black PM, Carroll RS, Westphal M, Lamszus K. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Res. 2009 May 01; 1268:24-37. PMID: 19285048.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  44. Benny O, Menon LG, Ariel G, Goren E, Kim SK, Stewman C, Black PM, Carroll RS, Machluf M. Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. Clin Cancer Res. 2009 Feb 15; 15(4):1222-31. PMID: 19190128.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  45. Claus EB, Park PJ, Carroll R, Chan J, Black PM. Specific genes expressed in association with progesterone receptors in meningioma. Cancer Res. 2008 Jan 01; 68(1):314-22. PMID: 18172325.
    Citations: 15     Fields:    Translation:HumansCells
  46. Kalamarides M, Stemmer-Rachamimov AO, Takahashi M, Han ZY, Chareyre F, Niwa-Kawakita M, Black PM, Carroll RS, Giovannini M. Natural history of meningioma development in mice reveals: a synergy of Nf2 and p16(Ink4a) mutations. Brain Pathol. 2008 Jan; 18(1):62-70. PMID: 17924978.
    Citations: 12     Fields:    Translation:HumansAnimals
  47. Benny O, Kim SK, Gvili K, Radzishevsky IS, Mor A, Verduzco L, Menon LG, Black PM, Machluf M, Carroll RS. In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model. FASEB J. 2008 Feb; 22(2):488-99. PMID: 17873103.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  48. Agar NY, Yang HW, Carroll RS, Black PM, Agar JN. Matrix solution fixation: histology-compatible tissue preparation for MALDI mass spectrometry imaging. Anal Chem. 2007 Oct 01; 79(19):7416-23. PMID: 17822313.
    Citations: 14     Fields:    Translation:Animals
  49. Tzika AA, Astrakas L, Cao H, Mintzopoulos D, Andronesi OC, Mindrinos M, Zhang J, Rahme LG, Blekas KD, Likas AC, Galatsanos NP, Carroll RS, Black PM. Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. Int J Mol Med. 2007 Aug; 20(2):199-208. PMID: 17611638.
    Citations: 13     Fields:    Translation:Humans
  50. Cargioli TG, Ugur HC, Ramakrishna N, Chan J, Black PM, Carroll RS. Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. Neurosurgery. 2007 Apr; 60(4):750-9; discussion 759-60. PMID: 17415213.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  51. Ugur HC, Ramakrishna N, Bello L, Menon LG, Kim SK, Black PM, Carroll RS. Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model. J Neurooncol. 2007 Jul; 83(3):267-75. PMID: 17310267.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  52. Yu Y, Jiang X, Schoch BS, Carroll RS, Black PM, Johnson MD. Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. Cancer Res. 2007 Jan 01; 67(1):130-8. PMID: 17210692.
    Citations: 25     Fields:    Translation:HumansCells
  53. Black P, Morokoff A, Zauberman J, Claus E, Carroll R. Meningiomas: science and surgery. Clin Neurosurg. 2007; 54:91-9. PMID: 18504903.
    Citations: 5     Fields:    Translation:Humans
  54. Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res. 2006 Nov 15; 66(22):10815-23. PMID: 17090523.
    Citations: 40     Fields:    Translation:HumansCells
  55. Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC, Cho BK, Kim M, Menon LG, Black PM, Carroll RS. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res. 2006 Sep 15; 12(18):5550-6. PMID: 17000692.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  56. Ziu M, Schmidt NO, Cargioli TG, Aboody KS, Black PM, Carroll RS. Glioma-produced extracellular matrix influences brain tumor tropism of human neural stem cells. J Neurooncol. 2006 Sep; 79(2):125-33. PMID: 16598423.
    Citations: 24     Fields:    Translation:HumansCells
  57. Aboody KS, Najbauer J, Schmidt NO, Yang W, Wu JK, Zhuge Y, Przylecki W, Carroll R, Black PM, Perides G. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neuro Oncol. 2006 Apr; 8(2):119-26. PMID: 16524944.
    Citations: 50     Fields:    Translation:AnimalsCells
  58. Kim SK, Cargioli TG, Machluf M, Yang W, Sun Y, Al-Hashem R, Kim SU, Black PM, Carroll RS. PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model. Clin Cancer Res. 2005 Aug 15; 11(16):5965-70. PMID: 16115940.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  59. Schmidt NO, Przylecki W, Yang W, Ziu M, Teng Y, Kim SU, Black PM, Aboody KS, Carroll RS. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. Neoplasia. 2005 Jun; 7(6):623-9. PMID: 16036113.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  60. Kirsch M, Weigel P, Pinzer T, Carroll RS, Black PM, Schackert HK, Schackert G. Therapy of hematogenous melanoma brain metastases with endostatin. Clin Cancer Res. 2005 Feb 01; 11(3):1259-67. PMID: 15709197.
    Citations: 6     Fields:    Translation:AnimalsCells
  61. Benny O, Duvshani-Eshet M, Cargioli T, Bello L, Bikfalvi A, Carroll RS, Machluf M. Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):768-76. PMID: 15701867.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  62. Schmidt KF, Ziu M, Schmidt NO, Vaghasia P, Cargioli TG, Doshi S, Albert MS, Black PM, Carroll RS, Sun Y. Volume reconstruction techniques improve the correlation between histological and in vivo tumor volume measurements in mouse models of human gliomas. J Neurooncol. 2004 Jul; 68(3):207-15. PMID: 15332323.
    Citations: 32     Fields:    Translation:Animals
  63. Tfelt-Hansen J, Yano S, Bandyopadhyay S, Carroll R, Brown EM, Chattopadhyay N. Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Endocrinology. 2004 Sep; 145(9):4222-31. PMID: 15178645.
    Citations: 14     Fields:    Translation:HumansCells
  64. Sun Y, Schmidt NO, Schmidt K, Doshi S, Rubin JB, Mulkern RV, Carroll R, Ziu M, Erkmen K, Poussaint TY, Black P, Albert M, Burstein D, Kieran MW. Perfusion MRI of U87 brain tumors in a mouse model. Magn Reson Med. 2004 May; 51(5):893-9. PMID: 15122670.
    Citations: 15     Fields:    Translation:Animals
  65. Schmidt NO, Ziu M, Carrabba G, Giussani C, Bello L, Sun Y, Schmidt K, Albert M, Black PM, Carroll RS. Antiangiogenic therapy by local intracerebral microinfusion improves treatment efficiency and survival in an orthotopic human glioblastoma model. Clin Cancer Res. 2004 Feb 15; 10(4):1255-62. PMID: 14977823.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  66. Brown AB, Yang W, Schmidt NO, Carroll R, Leishear KK, Rainov NG, Black PM, Breakefield XO, Aboody KS. Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin. Hum Gene Ther. 2003 Dec 10; 14(18):1777-85. PMID: 14670128.
    Citations: 54     Fields:    Translation:AnimalsCells
  67. Giussani C, Carrabba G, Pluderi M, Lucini V, Pannacci M, Caronzolo D, Costa F, Minotti M, Tomei G, Villani R, Carroll RS, Bikfalvi A, Bello L. Local intracerebral delivery of endogenous inhibitors by osmotic minipumps effectively suppresses glioma growth in vivo. Cancer Res. 2003 May 15; 63(10):2499-505. PMID: 12750272.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  68. Machluf M, Carroll RS. Cell-based delivery systems for antiangiogenic therapy. Biotechnol Genet Eng Rev. 2003; 20:183-95. PMID: 14997852.
    Citations: 1     Fields:    Translation:HumansAnimals
  69. Bello L, Lucini V, Giussani C, Carrabba G, Pluderi M, Scaglione F, Tomei G, Villani R, Black PM, Bikfalvi A, Carroll RS. IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo. Neurosurgery. 2003 Jan; 52(1):177-85; discussion 185-6. PMID: 12493116.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  70. Bello L, Giussani C, Carrabba G, Pluderi M, Lucini V, Pannacci M, Caronzolo D, Tomei G, Villani R, Scaglione F, Carroll RS, Bikfalvi A. Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors. Clin Cancer Res. 2002 Nov; 8(11):3539-48. PMID: 12429645.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.