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Lei Gao, M.D.

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Society for Neuroscience Trainee Professional Development Award
Sleep Research Society Trainee Merit Based Award
Sleep Research Society Grant Writing Workshop Award

I am an anesthesiologist who specializes in the care of general surgery, off-site and neurosurgical patients. After completing residency training at the MGH, I joined the faculty at the MGH/Harvard Medical School while conducting research as part of the Harvard Anesthesia T-32 training grant. My area of expertise is in disorders of cognition, sleep and circadian rhythm, and neurotrauma. I have a background in computational neurosciences and non-linear dynamics that have enabled me to develop new prognostic tools in traumatic brain injury and further define mechanisms of anesthesia using electroencephalography. I currently work with Drs Kun Hu and Frank Scheer at the Brigham and Women’s Hospital Sleep Medicine group, Dr Oluwaseun Johnson-Akeju at the MGH, as well as Dr Richa Saxena at the Broad Institute to explore environmental (e.g. shiftwork), behavioral (e.g. sleep hygiene, meal timing, social jetlag) and genetic markers of poor cardiovascular (e.g. metabolic syndrome and diabetes), neurological (e.g. Alzheimer’s disease), and pain outcomes. My hope is to integrate these disciplines to improve the early detection and treatment of poor outcomes in the perioperative period (e.g. delirium, and post-operative cognitive dysfunction).

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03AG067985 (GAO, LEI) Sep 15, 2020 - May 31, 2022
    Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized Patients
    Role: Principal Investigator
  2. MRTG-02-15-2020 (GAO, LEI) Jul 1, 2020 - Jun 30, 2022
    FAER Mentored Research Training Grant
    Circadian/Sleep Disturbance and Systemic Inflammation in the Development of Delirium
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gao L, Lim ASP, Wong PM, Gaba A, Cui L, Yu L, Buchman AS, Bennett DA, Hu K, Li P. Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure. Nat Sci Sleep. 2020; 12:299-307. PMID: 32581616.
  2. Hashimoto DA, Witkowski E, Gao L, Meireles O, Rosman G. Artificial Intelligence in Anesthesiology: Current Techniques, Clinical Applications, and Limitations. Anesthesiology. 2020 02; 132(2):379-394. PMID: 31939856.
    Citations: 3     Fields:    Translation:Humans
  3. Gao L, Smielewski P, Li P, Czosnyka M, Ercole A. Signal Information Prediction of Mortality Identifies Unique Patient Subsets after Severe Traumatic Brain Injury: A Decision-Tree Analysis Approach. J Neurotrauma. 2020 04 01; 37(7):1011-1019. PMID: 31744382.
    Citations: 1     Fields:    
  4. Li P, Lim ASP, Gao L, Hu C, Yu L, Bennett DA, Buchman AS, Hu K. More random motor activity fluctuations predict incident frailty, disability, and mortality. Sci Transl Med. 2019 10 30; 11(516). PMID: 31666398.
    Citations: 2     Fields:    Translation:Humans
  5. Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu K. Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 05 01; 42(5). PMID: 30722058.
    Citations: 1     Fields:    Translation:Humans
  6. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2018 01; 129(1):69-78. PMID: 29154132.
    Citations: 6     Fields:    Translation:Humans
  7. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 8     
  8. Gao L, Smielewski P, Czosnyka M, Ercole A. Early Asymmetric Cardio-Cerebral Causality and Outcome after Severe Traumatic Brain Injury. J Neurotrauma. 2017 10 01; 34(19):2743-2752. PMID: 28330412.
    Citations: 3     Fields:    Translation:Humans
  9. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    Citations: 12     Fields:    Translation:Humans
  10. Gao L, Smielewski P, Czosnyka M, Ercole A. Cerebrovascular Signal Complexity Six Hours after Intensive Care Unit Admission Correlates with Outcome after Severe Traumatic Brain Injury. J Neurotrauma. 2016 11 15; 33(22):2011-2018. PMID: 26916703.
    Citations: 3     Fields:    Translation:Humans
  11. Mahalingam S, Gao L, Nageshwaran S, Vickers C, Bottomley T, Grewal P. Improving pressure ulcer risk assessment and management using the Waterlow scale at a London teaching hospital. J Wound Care. 2014 Dec; 23(12):613-22. PMID: 25492277.
    Citations: 1     Fields:    Translation:Humans
  12. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999.
    Citations: 37     Fields:    Translation:Humans
  13. Gao L, Angadi DS, Coleman NP. Lipoma Arborescens – Is it as benign as it sounds?. Current Orthopaedic Practice. 2014; 25(1):92-94. View Publication.
  14. Gao L, Elwellelwell CE, Kohl-Bareis M, Gramer M, Cooper CE, Leung TS, Tachtsidis I. Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva manoeuvre. Adv Exp Med Biol. 2011; 701:15-20. PMID: 21445764.
    Citations: 6     Fields:    Translation:Humans
  15. Tachtsidis I, Gao L, Leung TS, Kohl-Bareis M, Cooper CE, Elwell CE. A hybrid multi-distance phase and broadband spatially resolved spectrometer and algorithm for resolving absolute concentrations of chromophores in the near-infrared light spectrum. Adv Exp Med Biol. 2010; 662:169-75. PMID: 20204788.
    Citations: 7     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.