Harvard Catalyst Profiles

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Lei Gao, M.D.

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Society for Neuroscience Trainee Professional Development Award
Sleep Research Society Trainee Merit Based Award
Sleep Research Society Grant Writing Workshop Award

I am an anesthesiologist who specializes in the care of general surgery, off-site and neurosurgical patients. After completing residency training at the MGH, I joined the faculty at the MGH/Harvard Medical School while conducting research as part of the Harvard Anesthesia T-32 training grant. My area of expertise is in disorders of cognition, sleep and circadian rhythm, and neurotrauma. I have a background in computational neurosciences and non-linear dynamics that have enabled me to develop new prognostic tools in traumatic brain injury and further define mechanisms of anesthesia using electroencephalography. I currently work with Drs Kun Hu and Frank Scheer at the Brigham and Women’s Hospital Sleep Medicine group, Dr Oluwaseun Johnson-Akeju at the MGH, as well as Dr Richa Saxena at the Broad Institute to explore environmental (e.g. shiftwork), behavioral (e.g. sleep hygiene, meal timing, social jetlag) and genetic markers of poor cardiovascular (e.g. metabolic syndrome and diabetes), neurological (e.g. postoperative delirium), and pain outcomes. My hope is to integrate these disciplines to improve the early detection and treatment of perioperative neurocognitive disorders).

Available: 12/01/22, Expires: 12/31/24

Sleep health and medicine are relevant to all medical and surgical specialties. Postoperative delirium (POD), cognitive decline, and Alzheimer's disease (AD) may be of particular interest to future anesthesiologists, intensivists, surgeons, or neurologists. We have opportunities for a student interested in both large database analysis and/or clinical data collection for sleep/circadian rhythms (our 24-h body clock status) prior to major surgery. We will provide all training needed depending on the work and goals to be accomplished. Our lab has an excellent track record for previous students to present at national/international conferences that have resulted in publications to support the students' next steps.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Comparative Effectiveness Research (CER) Award (SUBRAMANIAM, BALACHUNDHAR; GAO, LEI) Mar 1, 2024 - Feb 28, 2029
    The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-Cardiac for Postoperative Delirium
    Role: Co-Principal Investigator
  2. AACSF-23-1148490 (GAO, LEI) Oct 1, 2023 - Sep 30, 2026
    Alzheimer's Association
    Sleep/Circadian Regulation and Progression to Postoperative Dementia
    Role: Principal Investigator
  3. GEMSSTAR-04-15-2021 (GAO, LEI) Apr 15, 2021 - Apr 14, 2023
    Foundation for Anesthesia Education and Research (FAER)
    Clinical and Translational Research Methods
    Role: Principal Investigator
  4. R03AG067985 (GAO, LEI) Sep 15, 2020 - May 31, 2023
    Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized Patients
    Role: Principal Investigator
  5. A2020886S (LI, PENG) Sep 1, 2020 - Aug 31, 2023
    The BrightFocus Foundation
    Circadian regulation, autonomic function, and Alzheimer’s disease
    Role: Site-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.