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Lei Gao, M.D.

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Overview
I am an anesthesiologist who specializes in the care of general surgery, off-site and neurosurgical patients. After completing residency training at the MGH, I joined the faculty at the MGH/Harvard Medical School while conducting research as part of the Harvard Anesthesia T-32 training grant. My area of expertise is in disorders of cognition, sleep and circadian rhythm, and neurotrauma. I have a background in computational neurosciences and non-linear dynamics that have enabled me to develop new prognostic tools in traumatic brain injury and further define mechanisms of anesthesia using electroencephalography. I currently work with Drs Kun Hu and Frank Scheer at the Brigham and Women’s Hospital Sleep Medicine group, Dr Oluwaseun Johnson-Akeju at the MGH, as well as Dr Richa Saxena at the Broad Institute to explore environmental (e.g. shiftwork), behavioral (e.g. sleep hygiene, meal timing, social jetlag) and genetic markers of poor cardiovascular (e.g. metabolic syndrome and diabetes), neurological (e.g. Alzheimer’s disease), and pain outcomes. My hope is to integrate these disciplines to improve the early detection and treatment of poor outcomes in the perioperative period (e.g. delirium, and post-operative cognitive dysfunction).

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu K. Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 May 01; 42(5). PMID: 30722058.
    Citations:    
  2. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 2     
  3. Gao L, Smielewski P, Czosnyka M, Ercole A. Early Asymmetric Cardio-Cerebral Causality and Outcome after Severe Traumatic Brain Injury. J Neurotrauma. 2017 10 01; 34(19):2743-2752. PMID: 28330412.
    Citations: 1     Fields:    Translation:Humans
  4. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    Citations: 3     Fields:    Translation:Humans
  5. Gao L, Smielewski P, Czosnyka M, Ercole A. Cerebrovascular Signal Complexity Six Hours after Intensive Care Unit Admission Correlates with Outcome after Severe Traumatic Brain Injury. J Neurotrauma. 2016 11 15; 33(22):2011-2018. PMID: 26916703.
    Citations: 1     Fields:    Translation:Humans
  6. Mahalingam S, Gao L, Nageshwaran S, Vickers C, Bottomley T, Grewal P. Improving pressure ulcer risk assessment and management using the Waterlow scale at a London teaching hospital. J Wound Care. 2014 Dec; 23(12):613-22. PMID: 25492277.
    Citations: 1     Fields:    Translation:Humans
  7. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999.
    Citations: 26     Fields:    Translation:Humans
  8. Gao L, Elwellelwell CE, Kohl-Bareis M, Gramer M, Cooper CE, Leung TS, Tachtsidis I. Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva manoeuvre. Adv Exp Med Biol. 2011; 701:15-20. PMID: 21445764.
    Citations: 4     Fields:    Translation:Humans
  9. Tachtsidis I, Gao L, Leung TS, Kohl-Bareis M, Cooper CE, Elwell CE. A hybrid multi-distance phase and broadband spatially resolved spectrometer and algorithm for resolving absolute concentrations of chromophores in the near-infrared light spectrum. Adv Exp Med Biol. 2010; 662:169-75. PMID: 20204788.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.