Malcolm Russell Whitman, Ph.D.
Title Professor of Developmental Biology Institution Harvard School of Dental Medicine Department Developmental Biology Address Harvard School of Dental Medicine REB 505 188 Longwood Ave Boston MA 02115
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Overview
Malcolm Whitman received his undergraduate degree in Biology from Yale College and his PhD from the Biochemistry and Molecular Biology Department at Harvard University. His thesis work in the lab of Lew Cantley investigated the association of phosphatidylinositol kinases with oncogene and growth factor receptor tyrosine kinases, and culminated in the discovery of the phosphatidylinositol-3-kinase signal transduction pathway. In his postdoctoral work with Doug Melton, he developed the frog embryo as a tool for studying mechanisms of growth factor signaling during early development.
As an independent investigator, Dr. Whitman has focused on transduction of TGFß superfamily signals. The laboratory identified the first Smad-interacting transcription factor, FAST-1, and established that FAST-1 has a central role in the regulation of early developmental patterning by TGFß ligands. His current research interests continue to address the problem of how TGFß superfamily ligands signal in different contexts, and how TGFß signaling might be manipulated in vivo for therapeutic purposes.
The Whitman laboratory is also interested in how metabolic sensors regulate chronic inflammatory disease. The lab has recently established that a natural product derived small molecule, halofuginone, exerts anti-inflammatory effects by mimicking a lack of amino acid availability, thereby activating a metabolic sensor pathway known as the amino acid response.
Dr. Whitman is a Professor of Developmental Biology at the Harvard School of Dental Medicine and an affiliate member of the Department of Cell Biology at Harvard Medical School. He is a member of the BBS graduate program (http://www.hms.harvard.edu/dms/bbs/), an affiliate of the Harvard Stem Cell Institute (http://www.hsci.harvard.edu/) the Dana Farber/Harvard Cancer Center Cancer Cell Biology Program (http://www.dfhcc.harvard.edu/research-programs/discipline-based-programs/cancer-cell-biology/ ) and a member of the executive committee for the Harvard Developmental and Regenerative Biology program (https://drb.hms.harvard.edu/).

Mentoring
Dental Health Care for Special Needs Individuals: Trinidad and Tobago Summer Camp Case Study
International/Summer, 06/24/13 - 07/27/13
Menthol Cigarettes and Tobacco Dependence in Elderly Nursing Home Residents
Summer, 06/14/10 - 08/13/10
Breast Cancer Bone Metastasis: RANKL signalling and MMP-2 mediated invasion
Summer, 06/11/07 - 08/17/07

Research
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R21AI142343
(WHITMAN, MALCOLM R.)
Nov 13, 2018 - Oct 31, 2020
Novel Nutrient-sensing Pathway Suppresses Pathologic Tissue Remodeling
Role: Principal Investigator
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R01GM115417
(WHITMAN, MALCOLM R.)
Sep 17, 2015 - Aug 31, 2020
The first secreted Tyrosine kinase
Role: Principal Investigator
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R01AR066717
(WHITMAN, MALCOLM R.)
Apr 1, 2015 - Mar 31, 2020
Role of the first secreted tyrosine kinase in bone development, homeostasis, and repair.
Role: Co-Principal Investigator
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R21DE024312
(WHITMAN, MALCOLM R.)
Apr 9, 2014 - Mar 31, 2017
Role of a Novel Secreted Protein Tyrosine Kinase in Development
Role: Principal Investigator
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R01GM089885
(WHITMAN, MALCOLM R.)
Apr 1, 2010 - Feb 28, 2015
MECHANISM OF ACTION OF HALOFUGINONE AS A NOVEL THERAPEUTIC
Role: Principal Investigator
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R01HD029468
(WHITMAN, MALCOLM R.)
Aug 5, 1992 - Aug 31, 2012
Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM
Role: Principal Investigator
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P01HD024926
(STILES, CHARLES)
Sep 1, 1989 - Nov 30, 2004
SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYO DEVELOPMENT
Role: Co-Principal Investigator

Bibliographic
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