Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Malcolm Russell Whitman, Ph.D.


Malcolm Whitman received his undergraduate degree in Biology from Yale College and his PhD from the Biochemistry and Molecular Biology Department at Harvard University. His thesis work in the lab of Lew Cantley investigated the association of phosphatidylinositol kinases with oncogene and growth factor receptor tyrosine kinases, and culminated in the discovery of the phosphatidylinositol-3-kinase signal transduction pathway. In his postdoctoral work with Doug Melton, he developed the frog embryo as a tool for studying mechanisms of growth factor signaling during early development.

As an independent investigator, Dr. Whitman has focused on transduction of TGFß superfamily signals. The laboratory identified the first Smad-interacting transcription factor, FAST-1, and established that FAST-1 has a central role in the regulation of early developmental patterning by TGFß ligands. His current research interests continue to address the problem of how TGFß superfamily ligands signal in different contexts, and how TGFß signaling might be manipulated in vivo for therapeutic purposes.

The Whitman laboratory is also interested in how metabolic sensors regulate chronic inflammatory disease. The lab has recently established that a natural product derived small molecule, halofuginone, exerts anti-inflammatory effects by mimicking a lack of amino acid availability, thereby activating a metabolic sensor pathway known as the amino acid response.

Dr. Whitman is a Professor of Developmental Biology at the Harvard School of Dental Medicine and an affiliate member of the Department of Cell Biology at Harvard Medical School. He is a member of the BBS graduate program (http://www.hms.harvard.edu/dms/bbs/), an affiliate of the Harvard Stem Cell Institute (http://www.hsci.harvard.edu/) the Dana Farber/Harvard Cancer Center Cancer Cell Biology Program (http://www.dfhcc.harvard.edu/research-programs/discipline-based-programs/cancer-cell-biology/ ) and a member of the executive committee for the Harvard Developmental and Regenerative Biology program (https://drb.hms.harvard.edu/).

Dental Health Care for Special Needs Individuals: Trinidad and Tobago Summer Camp Case Study
International/Summer, 06/24/13 - 07/27/13
Menthol Cigarettes and Tobacco Dependence in Elderly Nursing Home Residents
Summer, 06/14/10 - 08/13/10
Breast Cancer Bone Metastasis: RANKL signalling and MMP-2 mediated invasion
Summer, 06/11/07 - 08/17/07

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI142343 (WHITMAN, MALCOLM R.) Nov 13, 2018 - Oct 31, 2020
    Novel Nutrient-sensing Pathway Suppresses Pathologic Tissue Remodeling
    Role: Principal Investigator
  2. R01GM115417 (WHITMAN, MALCOLM R.) Sep 17, 2015 - Aug 31, 2020
    The first secreted Tyrosine kinase
    Role: Principal Investigator
  3. R01AR066717 (WHITMAN, MALCOLM R.) Apr 1, 2015 - Mar 31, 2020
    Role of the first secreted tyrosine kinase in bone development, homeostasis, and repair.
    Role: Co-Principal Investigator
  4. R21DE024312 (WHITMAN, MALCOLM R.) Apr 9, 2014 - Mar 31, 2017
    Role of a Novel Secreted Protein Tyrosine Kinase in Development
    Role: Principal Investigator
  5. R01GM089885 (WHITMAN, MALCOLM R.) Apr 1, 2010 - Feb 28, 2015
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Whitman's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (230)
Co-Authors (21)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.