Harvard Catalyst Profiles

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Jeong Hyun Yun, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL146972 (YUN, JEONG) Apr 1, 2020 - Mar 31, 2025
    The role of COPD genetic risk factor HHIP on lymphocytic inflammation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yun JH, Lee S, Srinivasa P, Morrow J, Chase R, Saferali A, Xu Z, Cho M, Castaldi P, Hersh CP. An interferon-inducible signature of airway disease from blood gene expression profiling. Eur Respir J. 2022 05; 59(5). PMID: 34649980; PMCID: PMC9245457.
    Citations:    Fields:    Translation:Humans
  2. Ghosh AJ, Hobbs BD, Yun JH, Saferali A, Moll M, Xu Z, Chase RP, Morrow J, Ziniti J, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, McGoldrick D, Cho MH, DeMeo DL, Silverman EK, Castaldi PJ, Hersh CP. Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Respir Res. 2022 Apr 21; 23(1):97. PMID: 35449067; PMCID: PMC9026726.
    Citations:    Fields:    Translation:HumansCells
  3. Ghosh AJ, Hobbs BD, Moll M, Saferali A, Boueiz A, Yun JH, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, Lomas D, Castaldi PJ, Carey VJ, DeMeo DL, Cho MH, Silverman EK, Hersh CP. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323. PMID: 34762809; PMCID: PMC8886988.
    Citations: 3     Fields:    Translation:Humans
  4. Moll M, Boueiz A, Ghosh AJ, Saferali A, Lee S, Xu Z, Yun JH, Hobbs BD, Hersh CP, Sin DD, Tal-Singer R, Silverman EK, Cho MH, Castaldi PJ. Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 01 15; 205(2):161-170. PMID: 34739356; PMCID: PMC8787248.
    Citations: 2     Fields:    Translation:Humans
  5. Morrow JD, Castaldi PJ, Chase RP, Yun JH, Lee S, Liu YY, Hersh CP. Peripheral blood microbial signatures in current and former smokers. Sci Rep. 2021 10 06; 11(1):19875. PMID: 34615932; PMCID: PMC8494912.
    Citations: 1     Fields:    Translation:Humans
  6. Yun JH, Lee C, Liu T, Liu S, Kim EY, Xu S, Curtis JL, Pinello L, Bowler RP, Silverman EK, Hersh CP, Zhou X. Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice. JCI Insight. 2021 09 08; 6(17). PMID: 34375314; PMCID: PMC8492352.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Lin X, Li Y, Gong L, Yun JH, Xu S, Tesfaigzi Y, Qiao D, Zhou X. Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors. EBioMedicine. 2021 Jul; 69:103463. PMID: 34224973; PMCID: PMC8264115.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  8. Saferali A, Yun JH, Lee S, Chase RP, Bowler RP, Castaldi PJ, Hersh CP. Transcriptomic Signature of Asthma-Chronic Obstructive Pulmonary Disease Overlap in Whole Blood. Am J Respir Cell Mol Biol. 2021 02; 64(2):268-271. PMID: 33522883; PMCID: PMC7874396.
    Citations: 1     Fields:    Translation:HumansCells
  9. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 11 01; 202(9):1225-1236. PMID: 32551799; PMCID: PMC7605184.
    Citations: 7     Fields:    Translation:HumansCells
  10. Castaldi PJ, Boueiz A, Yun J, Estepar RSJ, Ross JC, Washko G, Cho MH, Hersh CP, Kinney GL, Young KA, Regan EA, Lynch DA, Criner GJ, Dy JG, Rennard SI, Casaburi R, Make BJ, Crapo J, Silverman EK, Hokanson JE. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study. Chest. 2020 05; 157(5):1147-1157. PMID: 31887283; PMCID: PMC7242638.
    Citations: 13     Fields:    Translation:Humans
  11. Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2019 11 18; 12(1):166. PMID: 31739789.
    Citations:    Fields:    
  12. Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sánchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399. PMID: 31710793; PMCID: PMC7020846.
    Citations: 53     
  13. Yun JH, Chase R, Parker MM, Saferali A, Castaldi PJ, Silverman EK, Hersh CP. Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 09; 61(3):398-401. PMID: 31469299; PMCID: PMC6839929.
    Citations: 2     Fields:    Translation:HumansCells
  14. Saferali A, Yun JH, Parker MM, Sakornsakolpat P, Chase RP, Lamb A, Hobbs BD, Boezen MH, Dai X, de Jong K, Beaty TH, Wei W, Zhou X, Silverman EK, Cho MH, Castaldi PJ, Hersh CP. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 07; 15(7):e1008229. PMID: 31269066.
    Citations: 9     Fields:    Translation:HumansCells
  15. Seo M, Qiu W, Bailey W, Criner GJ, Dransfield MT, Fuhlbrigge AL, Reilly JJ, Scholand MB, Castaldi P, Chase R, Parker M, Saferali A, Yun JH, Crapo JD, Cho MH, Beaty TH, Silverman EK, Hersh CP. Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease. J Mol Med (Berl). 2018 12; 96(12):1375-1385. PMID: 30353303; PMCID: PMC6240374.
    Citations: 5     Fields:    Translation:Humans
  16. Yun JH, Hersh CP. Reply. J Allergy Clin Immunol. 2018 12; 142(6):2013-2014. PMID: 30316523.
    Citations:    Fields:    Translation:HumansCells
  17. Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018 06; 141(6):2037-2047.e10. PMID: 29709670.
    Citations: 58     Fields:    Translation:HumansCells
  18. Halper-Stromberg E, Yun JH, Parker MM, Singer RT, Gaggar A, Silverman EK, Leach S, Bowler RP, Castaldi PJ. Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression. Am J Respir Cell Mol Biol. 2018 04; 58(4):500-509. PMID: 29206476.
    Citations: 15     Fields:    Translation:HumansCells
  19. Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2017 10 06; 10(1):58. PMID: 28985737.
    Citations: 32     Fields:    Translation:Humans
  20. Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP. Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 07; 57(1):47-58. PMID: 28248572; PMCID: PMC5516276.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  21. Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4681-7. PMID: 27444019; PMCID: PMC4987811.
    Citations: 28     Fields:    Translation:Animals
  22. Nwakile C, Purushottam B, Bhalla V, Ukpong D, Shah M, Yun J, Morris DL, Figueredo VM. Significance of QRS duration in non-ST elevation myocardial infarction. Int J Cardiol. 2015; 187:146-7. PMID: 25828339.
    Citations:    Fields:    Translation:Humans
  23. Chae YK, Khemasuwan D, Dimou A, Neagu S, Chebrolu L, Gupta S, Carpio A, Kim J, Yun JH, Smyrlis A, Friedman A, Tester W. Inhibition of renin angiotensin axis may be associated with reduced risk of developing venous thromboembolism in patients with atherosclerotic disease. PLoS One. 2014; 9(1):e87813. PMID: 24498202.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  24. Slipczuk L, Codolosa JN, Davila CD, Romero-Corral A, Yun J, Pressman GS, Figueredo VM. Infective endocarditis epidemiology over five decades: a systematic review. PLoS One. 2013; 8(12):e82665. PMID: 24349331.
    Citations: 126     Fields:    Translation:HumansPHPublic Health
  25. Khemasuwan D, Chae YK, Gupta S, Carpio A, Yun JH, Neagu S, Lucca AB, Valsecchi ME, Mora JI. Dose-related effect of statins in venous thrombosis risk reduction. Am J Med. 2011 Sep; 124(9):852-9. PMID: 21783169.
    Citations: 14     Fields:    Translation:Humans
  26. Yun JH, Henson PM, Tuder RM. Phagocytic clearance of apoptotic cells: role in lung disease. Expert Rev Respir Med. 2008 Dec; 2(6):753-65. PMID: 20477237.
    Citations: 12     Fields:    
  27. Tuder RM, Yun JH. It takes two to tango: cigarette smoke partners with viruses to promote emphysema. J Clin Invest. 2008 Aug; 118(8):2689-93. PMID: 18654673; PMCID: PMC2483690.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  28. Tuder RM, Yun JH. Vascular endothelial growth factor of the lung: friend or foe. Curr Opin Pharmacol. 2008 Jun; 8(3):255-60. PMID: 18468486.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  29. Tuder RM, Yun JH, Graham BB. Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):1-6. PMID: 18441278.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Tuder RM, Yun JH, Bhunia A, Fijalkowska I. Hypoxia and chronic lung disease. J Mol Med (Berl). 2007 Dec; 85(12):1317-24. PMID: 18040654.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  31. Chae YK, Yun JH. Folic acid and prevention of colorectal adenomas. JAMA. 2007 Sep 26; 298(12):1397; author reply 1397. PMID: 17895454.
    Citations: 5     Fields:    Translation:Humans
  32. Chae YK, Yun JH. Early supplementation with high-dose vitamin A in The Gambia. Lancet. 2007 Sep 22; 370(9592):1030; author reply 1030-1. PMID: 17889234.
    Citations:    Fields:    Translation:Humans
  33. Chae YK, Yun JH. Risk of cancer from blood donated by people with cancer. Lancet. 2007 Aug 18; 370(9587):563; author reply 563-4. PMID: 17707745.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.