Harvard Catalyst Profiles

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Jeffrey Alan Gelfand, M.D.

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Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Gelfand, Jeffrey) Apr 10, 2020 - Mar 31, 2023
    DoD/USU/Geneva Foundation
    Photonic Antimicrobial Wound Dressing
    Role Description: Development of clinically adaptable device employing light based therapy and light-based enhancement of antimicrobial substances to highly resistant wound organisms and chronic infections.
    Role: Principal Investigator
  2. (Gelfand, Jeffrey) Apr 1, 2020 - Mar 31, 2023
    Air Force Office of Scientific Research
    Development of Light Based Antimicrobial Therapy for Negative Pressure Wound Therapy
    Role Description: The goal of this study is to develop a Negative Pressure Wound Therapy system enhanced by antimicrobial light systems
    Role: Principal Investigator
  3. (Hamblin, M) Dec 1, 2015 - Nov 30, 2017
    NIAID
    Synergistic Photodynamic Therapy for Catheter–Associated Urinary Tract Infections
    Role Description: Objective: Establish an animal model of UTI in order to study the utility of antimicrobial photodynamic therapy (PDT) as an all determinative therapy to the use of antibiotics. Examined different photosensitizers and their mechanism of action. The goal of this project is to develop a non-antibiotic approach to the treatment of urinary tract infections associated with chronic indwelling catheters by using a triple lumen catheter in which 1 lumen contains a fiberoptic conduit for the generation of 660 nm red light. A second lumen is used for the delivery of a combination of methylene blue and potassium iodide. When illuminated by the light source, the photosensitivity dye combination generates reactive species including superoxide and iodide. Role: Co-inventor and Co-PI
    Role: Co-PI
  4. R03AG018076 (GELFAND, JEFFREY A) Mar 15, 2000 - Feb 28, 2001
    NIH/NIA
    BABESIOSIS AS A PARADIGM FOR THE EFFECTS OF AGING
    Role: Principal Investigator
  5. P50GM021700 (TOMPKINS, RONALD GARY) Dec 1, 1977 - Nov 30, 2002
    NIH/NIGMS
    Overall Application: Burn Trauma Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Naranbhai V, Chang CC, Beltran WFG, Miller TE, Astudillo MG, Villalba JA, Yang D, Gelfand J, Bernstein BE, Feldman J, Hauser BM, Caradonna TM, Alter G, Murali MR, Jasrasaria R, Quinlan J, Xerras DC, Betancourt JR, Louis DN, Schmidt AG, Lennerz J, Poznansky MC, Iafrate AJ. High seroprevalence of anti-SARS-CoV-2 antibodies in Chelsea, Massachusetts. J Infect Dis. 2020 Sep 09. PMID: 32906151.
    Citations:    
  2. Miller TE, Garcia Beltran WF, Bard AZ, Gogakos T, Anahtar MN, Astudillo MG, Yang D, Thierauf J, Fisch AS, Mahowald GK, Fitzpatrick MJ, Nardi V, Feldman J, Hauser BM, Caradonna TM, Marble HD, Ritterhouse LL, Turbett SE, Batten J, Georgantas NZ, Alter G, Schmidt AG, Harris JB, Gelfand JA, Poznansky MC, Bernstein BE, Louis DN, Dighe A, Charles RC, Ryan ET, Branda JA, Pierce VM, Murali MR, Iafrate AJ, Rosenberg ES, Lennerz JK. Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital. FASEB J. 2020 Aug 28. PMID: 32856766.
    Citations:    
  3. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 Aug 27. PMID: 32855547.
    Citations:    
  4. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17. PMID: 32511497.
    Citations:    
  5. Meyerowitz EA, Vannier AGL, Friesen MGN, Schoenfeld S, Gelfand JA, Callahan MV, Kim AY, Reeves PM, Poznansky MC. Rethinking the role of hydroxychloroquine in the treatment of COVID-19. FASEB J. 2020 05; 34(5):6027-6037. PMID: 32350928.
    Citations:    
  6. Liu X, Chang Q, Ferrer-Espada R, Leanse LG, Goh XS, Wang X, Gelfand JA, Dai T. Photoinactivation of Moraxella catarrhalis Using 405-nm Blue Light: Implications for the Treatment of Otitis Media. Photochem Photobiol. 2020 05; 96(3):611-617. PMID: 32105346.
    Citations:    
  7. Wang Y, Ferrer-Espada R, Baglo Y, Goh XS, Held KD, Grad YH, Gu Y, Gelfand JA, Dai T. Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection. J Infect Dis. 2019 07 31; 220(5):873-881. PMID: 30629196.
    Citations:    Fields:    
  8. Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC. Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment. FASEB J. 2019 05; 33(5):6596-6608. PMID: 30802149.
    Citations:    
  9. Xuan W, He Y, Huang L, Huang YY, Bhayana B, Xi L, Gelfand JA, Hamblin MR. Antimicrobial Photodynamic Inactivation Mediated by Tetracyclines in Vitro and in Vivo: Photochemical Mechanisms and Potentiation by Potassium Iodide. Sci Rep. 2018 11 20; 8(1):17130. PMID: 30459451.
    Citations:    Fields:    
  10. Kimizuka Y, Katagiri W, Locascio JJ, Shigeta A, Sasaki Y, Shibata M, Morse K, Sîrbulescu RF, Miyatake M, Reeves P, Suematsu M, Gelfand J, Brauns T, Poznansky MC, Tsukada K, Kashiwagi S. Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response. J Immunol. 2018 12 15; 201(12):3587-3603. PMID: 30420435.
    Citations:    
  11. Gelfand JA, Nazarian RM, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Korek S, Botvinick E, Elkins K, Thomas L, Locascio J, Parry B, Kelly KM, Poznansky MC. A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking. FASEB J. 2019 02; 33(2):3074-3081. PMID: 30192655.
    Citations:    Fields:    
  12. He Y, Huang YY, Xi L, Gelfand JA, Hamblin MR. Tetracyclines function as dual-action light-activated antibiotics. PLoS One. 2018; 13(5):e0196485. PMID: 29742128.
    Citations: 2     Fields:    Translation:Cells
  13. Huang YY, Wintner A, Seed PC, Brauns T, Gelfand JA, Hamblin MR. Antimicrobial photodynamic therapy mediated by methylene blue and potassium iodide to treat urinary tract infection in a female rat model. Sci Rep. 2018 05 08; 8(1):7257. PMID: 29740035.
    Citations: 1     Fields:    
  14. Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC. AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression. Cancer Immunol Res. 2018 05; 6(5):539-551. PMID: 29511032.
    Citations: 3     Fields:    
  15. Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S. Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine. J Immunol. 2017 08 15; 199(4):1319-1332. PMID: 28710250.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  16. Kimizuka Y, Callahan JJ, Huang Z, Morse K, Katagiri W, Shigeta A, Bronson R, Takeuchi S, Shimaoka Y, Chan MPK, Zeng Y, Li B, Chen H, Tan RYY, Dwyer C, Mulley T, Leblanc P, Goudie C, Gelfand J, Tsukada K, Brauns T, Poznansky MC, Bean D, Kashiwagi S. Semiconductor diode laser device adjuvanting intradermal vaccine. Vaccine. 2017 04 25; 35(18):2404-2412. PMID: 28365253.
    Citations: 2     Fields:    Translation:AnimalsPHPublic Health
  17. Schlimgen R, Howard J, Wooley D, Thompson M, Baden LR, Yang OO, Christiani DC, Mostoslavsky G, Diamond DV, Duane EG, Byers K, Winters T, Gelfand JA, Fujimoto G, Hudson TW, Vyas JM. Risks Associated With Lentiviral Vector Exposures and Prevention Strategies. J Occup Environ Med. 2016 12; 58(12):1159-1166. PMID: 27930472.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  18. Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J. Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients. Neurology. 2015 Jun 16; 84(24):2403-12. PMID: 25979696.
    Citations: 33     Fields:    Translation:HumansCells
  19. Brauns T, Leblanc P, Gelfand JA, Poznanski M. Could mycobacterial Hsp70-containing fusion protein lead the way to an affordable therapeutic cancer vaccine? Expert Rev Vaccines. 2015 Mar; 14(3):435-46. PMID: 25496347.
    Citations:    Fields:    Translation:HumansCells
  20. Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol. 2014 Feb 24; 7:15. PMID: 24565018.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Kashiwagi S, Brauns T, Gelfand J, Poznansky MC. Laser vaccine adjuvants. History, progress, and potential. Hum Vaccin Immunother. 2014; 10(7):1892-907. PMID: 25424797.
    Citations: 5     Fields:    Translation:HumansCells
  22. Leblanc P, Moise L, Luza C, Chantaralawan K, Lezeau L, Yuan J, Field M, Richer D, Boyle C, Martin WD, Fishman JB, Berg EA, Baker D, Zeigler B, Mais DE, Taylor W, Coleman R, Warren HS, Gelfand JA, De Groot AS, Brauns T, Poznansky MC. VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever. Hum Vaccin Immunother. 2014; 10(10):3022-38. PMID: 25483693.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Kashiwagi S, Yuan J, Forbes B, Hibert ML, Lee EL, Whicher L, Goudie C, Yang Y, Chen T, Edelblute B, Collette B, Edington L, Trussler J, Nezivar J, Leblanc P, Bronson R, Tsukada K, Suematsu M, Dover J, Brauns T, Gelfand J, Poznansky MC. Near-infrared laser adjuvant for influenza vaccine. PLoS One. 2013; 8(12):e82899. PMID: 24349390.
    Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
  24. Gelfand JA. Case 12-2013: a woman with pulmonary infiltrates and respiratory failure. N Engl J Med. 2013 08 08; 369(6):584. PMID: 23924023.
    Citations:    Fields:    Translation:HumansCells
  25. Saavedra AP, Warth JA, Burke JF, Norton KJ, Gelfand JA. Increased dense erythrocytes in flame-burned patients. Clin Hemorheol Microcirc. 2013; 53(4):349-56. PMID: 22596230.
    Citations:    Fields:    Translation:HumansCells
  26. Leblanc PR, Yuan J, Brauns T, Gelfand JA, Poznansky MC. Accelerated vaccine development against emerging infectious diseases. Hum Vaccin Immunother. 2012 Jul; 8(7):1010-2. PMID: 22777091.
    Citations: 2     Fields:    Translation:Humans
  27. Chen X, Kim P, Farinelli B, Doukas A, Yun SH, Gelfand JA, Anderson RR, Wu MX. A novel laser vaccine adjuvant increases the motility of antigen presenting cells. PLoS One. 2010 Oct 29; 5(10):e13776. PMID: 21048884.
    Citations: 23     Fields:    Translation:AnimalsCells
  28. Krause PJ, Gewurz BE, Hill D, Marty FM, Vannier E, Foppa IM, Furman RR, Neuhaus E, Skowron G, Gupta S, McCalla C, Pesanti EL, Young M, Heiman D, Hsue G, Gelfand JA, Wormser GP, Dickason J, Bia FJ, Hartman B, Telford SR, Christianson D, Dardick K, Coleman M, Girotto JE, Spielman A. Persistent and relapsing babesiosis in immunocompromised patients. Clin Infect Dis. 2008 Feb 01; 46(3):370-6. PMID: 18181735.
    Citations: 51     Fields:    Translation:HumansAnimals
  29. Stowell CP, Gelfand JA, Shepard JA, Kratz A. Case records of the Massachusetts General Hospital. Case 17-2007. A 25-year-old woman with relapsing fevers and recent onset of dyspnea. N Engl J Med. 2007 May 31; 356(22):2313-9. PMID: 17538091.
    Citations: 3     Fields:    Translation:HumansCells
  30. Borggraefe I, Yuan J, Telford SR, Menon S, Hunter R, Shah S, Spielman A, Gelfand JA, Wortis HH, Vannier E. Babesia microti primarily invades mature erythrocytes in mice. Infect Immun. 2006 Jun; 74(6):3204-12. PMID: 16714547.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Shnayderman M, Mansfield B, Yip P, Clark HA, Krebs MD, Cohen SJ, Zeskind JE, Ryan ET, Dorkin HL, Callahan MV, Stair TO, Gelfand JA, Gill CJ, Hitt B, Davis CE. Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Anal Chem. 2005 Sep 15; 77(18):5930-7. PMID: 16159124.
    Citations: 17     Fields:    Translation:Cells
  32. Eichhorn JH, Brauns TA, Gelfand JA, Crothers BA, Wilbur DC. A novel automated screening and interpretation process for cervical cytology using the internet transmission of low-resolution images: a feasibility study. Cancer. 2005 Aug 25; 105(4):199-206. PMID: 15937917.
    Citations: 5     Fields:    Translation:HumansCells
  33. Takabayashi T, Shimizu S, Clark BD, Beinborn M, Burke JF, Gelfand JA. Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells. Surgery. 2004 May; 135(5):544-54. PMID: 15118592.
    Citations: 7     Fields:    Translation:HumansCells
  34. Vannier E, Borggraefe I, Telford SR, Menon S, Brauns T, Spielman A, Gelfand JA, Wortis HH. Age-associated decline in resistance to Babesia microti is genetically determined. J Infect Dis. 2004 May 01; 189(9):1721-8. PMID: 15116311.
    Citations: 15     Fields:    Translation:HumansAnimals
  35. Gelfand JA, Callahan MV. Babesiosis: An Update on Epidemiology and Treatment. Curr Infect Dis Rep. 2003 Feb; 5(1):53-58. PMID: 12525291.
    Citations: 1     
  36. Takabayashi T, Vannier E, Burke JF, Tompkins RG, Gelfand JA, Clark BD. Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells. J Infect Dis. 1998 Jun; 177(6):1622-8. PMID: 9607842.
    Citations: 17     Fields:    Translation:HumansCells
  37. Gelfand JA, Callahan MV. Babesiosis. Curr Clin Top Infect Dis. 1998; 18:201-16. PMID: 9779356.
    Citations: 1     Fields:    Translation:HumansAnimals
  38. Sant GR, Theoharides TC, Letourneau R, Gelfand J. Interstitial cystitis and bladder mastocytosis in a woman with chronic urticaria. Scand J Urol Nephrol. 1997 Oct; 31(5):497-500. PMID: 9406315.
    Citations: 1     Fields:    Translation:HumansCells
  39. Aiura K, Clark BD, Dinarello CA, Margolis NH, Kaplanski G, Burke JF, Tompkins RG, Gelfand JA. Interaction with autologous platelets multiplies interleukin-1 and tumor necrosis factor production in mononuclear cells. J Infect Dis. 1997 Jan; 175(1):123-9. PMID: 8985205.
    Citations: 2     Fields:    Translation:HumansCells
  40. Takabayashi T, Vannier E, Clark BD, Margolis NH, Dinarello CA, Burke JF, Gelfand JA. A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis. J Immunol. 1996 May 01; 156(9):3455-60. PMID: 8617973.
    Citations: 34     Fields:    Translation:HumansCells
  41. Boustani MR, Gelfand JA. Babesiosis. Clin Infect Dis. 1996 Apr; 22(4):611-5. PMID: 8729197.
    Citations: 9     Fields:    Translation:HumansAnimals
  42. Frautschi JR, Eberhart RC, Hubbell JA, Clark BD, Gelfand JA. Alkylation of cellulosic membranes results in reduced complement activation. J Biomater Sci Polym Ed. 1996; 7(8):707-14. PMID: 8639479.
    Citations:    Fields:    Translation:HumansCells
  43. Ryan CM, Atkins MB, Mier JW, Gelfand JA, Tompkins RG. Effects of malignancy and interleukin-2 infusion on gut macromolecular permeability. Crit Care Med. 1995 Nov; 23(11):1801-6. PMID: 7587254.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  44. Mileno MD, Margolis NH, Clark BD, Dinarello CA, Burke JF, Gelfand JA. Coagulation of whole blood stimulates interleukin-1 beta gene expression. J Infect Dis. 1995 Jul; 172(1):308-11. PMID: 7797938.
    Citations: 9     Fields:    Translation:HumansCells
  45. Harris BH, Gelfand JA. The immune response to trauma. Semin Pediatr Surg. 1995 May; 4(2):77-82. PMID: 7633853.
    Citations: 9     Fields:    Translation:Humans
  46. Knox TA, Kaplan MM, Gelfand JA, Wolff SM. Methotrexate treatment of idiopathic granulomatous hepatitis. Ann Intern Med. 1995 Apr 15; 122(8):592-5. PMID: 7887553.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  47. Dirkes K, Harris BH, Connolly RJ, Schwaitzberg SD, Dinarello CA, Gelfand JA. Platelet activating factor-antagonist improves survival in experimental staphylococcal septicemia. J Pediatr Surg. 1994 Aug; 29(8):1055-7; discussion 1057-8. PMID: 7965505.
    Citations:    Fields:    Translation:AnimalsCells
  48. Wakabayashi G, Cannon JG, Gelfand JA, Clark BD, Aiura K, Burke JF, Wolff SM, Dinarello CA. Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits. Am J Physiol. 1994 Jul; 267(1 Pt 2):R329-36. PMID: 8048640.
    Citations: 4     Fields:    Translation:AnimalsCells
  49. Boustani MR, Lepore TJ, Gelfand JA, Lazarus DS. Acute respiratory failure in patients treated for babesiosis. Am J Respir Crit Care Med. 1994 Jun; 149(6):1689-91. PMID: 8004331.
    Citations: 3     Fields:    Translation:HumansCells
  50. Mester M, Carter EA, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD. Thermal injury induces very early production of interleukin-1 alpha in the rat by mechanisms other than endotoxemia. Surgery. 1994 May; 115(5):588-96. PMID: 8178258.
    Citations: 18     Fields:    Translation:Animals
  51. Mandle R, Baron C, Roux E, Sundel R, Gelfand J, Aulak K, Davis AE, Rosen FS, Bing DH. Acquired C1 inhibitor deficiency as a result of an autoantibody to the reactive center region of C1 inhibitor. J Immunol. 1994 May 01; 152(9):4680-5. PMID: 7512602.
    Citations: 7     Fields:    Translation:HumansCells
  52. Granowitz EV, Porat R, Gelfand JA, Wolff SM, Dinarello CA. Administration of low-dose endotoxin to healthy humans increases C5a binding to circulating neutrophils. J Infect Dis. 1994 Feb; 169(2):480-2. PMID: 8106792.
    Citations: 2     Fields:    Translation:HumansCells
  53. Gelfand JA. Too little oxygen, too little interleukin-2: a link between hypoxemia and cellular immune dysfunction. Crit Care Med. 1994 Feb; 22(2):187-8. PMID: 8306669.
    Citations:    Fields:    Translation:AnimalsCells
  54. Aiura K, Gelfand JA, Burke JF, Thompson RC, Dinarello CA. Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits. Infect Immun. 1993 Aug; 61(8):3342-50. PMID: 8335365.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Mester M, Tompkins RG, Gelfand JA, Dinarello CA, Burke JF, Clark BD. Intestinal production of interleukin-1 alpha during endotoxemia in the mouse. J Surg Res. 1993 Jun; 54(6):584-91. PMID: 8412068.
    Citations: 6     Fields:    Translation:Animals
  56. Kaplanski G, Porat R, Aiura K, Erban JK, Gelfand JA, Dinarello CA. Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event. Blood. 1993 May 15; 81(10):2492-5. PMID: 8490165.
    Citations: 24     Fields:    Translation:HumansCells
  57. Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA. 1993 Apr 14; 269(14):1829-35. PMID: 8459516.
    Citations: 55     Fields:    Translation:HumansAnimals
  58. Shapiro L, Gelfand JA. Cytokines and sepsis: pathophysiology and therapy. New Horiz. 1993 Feb; 1(1):13-22. PMID: 7922386.
    Citations: 15     Fields:    Translation:HumansAnimals
  59. Kaplan E, Dinarello CA, Wakabayashi G, Burke JF, Connolly RS, Gelfand JA. Interleukin-1 pretreatment protects against endotoxin-induced hypotension in rabbits: association with decreased tumor necrosis factor levels. J Infect Dis. 1993 Jan; 167(1):244-7. PMID: 8418176.
    Citations:    Fields:    Translation:Animals
  60. Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA. Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans. Crit Care Med. 1992 Oct; 20(10):1414-9. PMID: 1395662.
    Citations: 19     Fields:    Translation:Humans
  61. Ho JL, Badaró R, Schwartz A, Dinarello CA, Gelfand JA, Sobel J, Barral A, Netto MB, Carvalho EM, Reed SG, et al. Diminished in vitro production of interleukin-1 and tumor necrosis factor-alpha during acute visceral leishmaniasis and recovery after therapy. J Infect Dis. 1992 Jun; 165(6):1094-102. PMID: 1583328.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  62. Perala DG, Chapman RJ, Gelfand JA, Callahan MV, Adams DF, Lie T. Relative production of IL-1 beta and TNF alpha by mononuclear cells after exposure to dental implants. J Periodontol. 1992 May; 63(5):426-30. PMID: 1527686.
    Citations: 2     Fields:    Translation:HumansCells
  63. Perala DG, Chapman RJ, Gelfand JA, Callahan MV, Adams DF, Lie T. Relative Production of IL-1ß and TNFa by Mononuclear Cells After Exposure to Dental Implants. J Periodontol. 1992 May; 63(5):426-430. PMID: 29539721.
    Citations:    Fields:    
  64. Vachino G, Gelfand JA, Atkins MB, Tamerius JD, Demchak P, Mier JW. Complement activation in cancer patients undergoing immunotherapy with interleukin-2 (IL-2): binding of complement and C-reactive protein by IL-2-activated lymphocytes. Blood. 1991 Nov 15; 78(10):2505-13. PMID: 1824247.
    Citations: 16     Fields:    Translation:HumansCells
  65. Stylianos S, Wakabayashi G, Gelfand JA, Harris BH. Experimental hemorrhage and blunt trauma do not increase circulating tumor necrosis factor. J Trauma. 1991 Aug; 31(8):1063-7. PMID: 1875432.
    Citations: 7     Fields:    Translation:Animals
  66. Wakabayashi G, Gelfand JA, Jung WK, Connolly RJ, Burke JF, Dinarello CA. Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli. J Clin Invest. 1991 Jun; 87(6):1925-35. PMID: 2040686.
    Citations: 60     Fields:    Translation:AnimalsCells
  67. Wakabayashi G, Gelfand JA, Burke JF, Thompson RC, Dinarello CA. A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J. 1991 Mar 01; 5(3):338-43. PMID: 1825816.
    Citations: 72     Fields:    Translation:AnimalsCells
  68. Morin M, Schindler R, Wakabayashi G, Daumy G, Dinarello CA, Gelfand JA. Picogram concentrations of endotoxin stimulate synthesis of IL-1 beta and TNF alpha by human peripheral blood mononuclear cells exposed to recombinant human C5a. Eur Cytokine Netw. 1991 Jan-Feb; 2(1):27-30. PMID: 1873491.
    Citations: 2     Fields:    Translation:HumansCells
  69. Perala D, Chapman R, Gelfand J. Complement activation by dental implants. Int J Oral Maxillofac Implants. 1991; 6(2):136-41. PMID: 1809667.
    Citations:    Fields:    Translation:Humans
  70. Schindler R, Gelfand JA, Dinarello CA. Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself. Blood. 1990 Oct 15; 76(8):1631-8. PMID: 2207333.
    Citations: 56     Fields:    Translation:HumansCells
  71. Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B, et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis. 1990 Jan; 161(1):79-84. PMID: 2295861.
    Citations: 123     Fields:    Translation:Humans
  72. Li JJ, Sanders RL, McAdam KP, Hales CA, Thompson BT, Gelfand JA, Burke JF. Impact of C-reactive protein (CRP) on surfactant function. J Trauma. 1989 Dec; 29(12):1690-7. PMID: 2593200.
    Citations: 3     Fields:    Translation:Humans
  73. Drapkin MS, Wisch JS, Gelfand JA, Cannon JG, Dinarello CA. Plasmapheresis for fulminant meningococcemia. Pediatr Infect Dis J. 1989 Jun; 8(6):399-400. PMID: 2501752.
    Citations: 6     Fields:    Translation:HumansCells
  74. Li JJ, Sanders RL, McAdam KP, Gelfand JA, Burke JF. Endotoxin suppresses surfactant synthesis in cultured rat lung cells. J Trauma. 1989 Feb; 29(2):180-8. PMID: 2645410.
    Citations: 2     Fields:    Translation:AnimalsCells
  75. Dinarello CA, Okusawa S, Gelfand JA. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of ibuprofen. Prog Clin Biol Res. 1989; 299:203-15. PMID: 2786217.
    Citations: 2     Fields:    Translation:Animals
  76. Kaplan E, Dinarello CA, Gelfand JA. Interleukin-1 and the response to injury. Immunol Res. 1989; 8(2):118-29. PMID: 2659688.
    Citations: 5     Fields:    Translation:HumansAnimals
  77. Dinarello CA, Okusawa S, Gelfand JA. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. Prog Clin Biol Res. 1989; 286:243-63. PMID: 2494673.
    Citations: 2     Fields:    Translation:HumansAnimals
  78. Tredget EE, Yu YM, Zhong S, Burini R, Okusawa S, Gelfand JA, Dinarello CA, Young VR, Burke JF. Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits. Am J Physiol. 1988 Dec; 255(6 Pt 1):E760-8. PMID: 3144180.
    Citations: 17     Fields:    Translation:HumansAnimals
  79. Vachino G, Heck LW, Gelfand JA, Kaplan MM, Burke JF, Berninger RW, McAdam KP. Inhibition of human neutrophil and Pseudomonas elastases by the amyloid P-component: a constituent of elastic fibers and amyloid deposits. J Leukoc Biol. 1988 Dec; 44(6):529-34. PMID: 3264008.
    Citations: 3     Fields:    Translation:HumansCells
  80. Okusawa S, Yancey KB, van der Meer JW, Endres S, Lonnemann G, Hefter K, Frank MM, Burke JF, Dinarello CA, Gelfand JA. C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alpha. J Exp Med. 1988 Jul 01; 168(1):443-8. PMID: 3260938.
    Citations: 36     Fields:    Translation:HumansCells
  81. Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA. Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest. 1988 Apr; 81(4):1162-72. PMID: 3258319.
    Citations: 188     Fields:    Translation:Animals
  82. van der Meer JW, Endres S, Lonnemann G, Cannon JG, Ikejima T, Okusawa S, Gelfand JA, Dinarello CA. Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro. J Leukoc Biol. 1988 Mar; 43(3):216-23. PMID: 3257788.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  83. Okusawa S, Dinarello CA, Yancey KB, Endres S, Lawley TJ, Frank MM, Burke JF, Gelfand JA. C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma. J Immunol. 1987 Oct 15; 139(8):2635-40. PMID: 3116090.
    Citations: 37     Fields:    Translation:HumansCells
  84. Yamada Y, Hefter K, Burke JF, Gelfand JA. An in vitro model of the wound microenvironment: local phagocytic cell abnormalities associated with in situ complement activation. J Infect Dis. 1987 May; 155(5):998-1004. PMID: 3031176.
    Citations:    Fields:    Translation:HumansCells
  85. Simon GL, Gelfand JA, Connolly RA, O'Donnell TF, Gorbach SL. Experimental Bacteroides fragilis bacteremia in a primate model: evidence that Bacteroides fragilis does not promote the septic shock syndrome. J Trauma. 1985 Dec; 25(12):1156-62. PMID: 4068069.
    Citations: 2     Fields:    Translation:AnimalsCells
  86. Gelfand JA. How do complement components and fragments affect cellular immunological function? J Trauma. 1984 Sep; 24(9 Suppl):S118-24. PMID: 6332921.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  87. Gelfand JA, Donelan M, Burke JF. Preferential activation and depletion of the alternative complement pathway by burn injury. Ann Surg. 1983 Jul; 198(1):58-62. PMID: 6859992.
    Citations: 8     Fields:    Translation:HumansAnimals
  88. Gelfand JA. Exploiting sex for therapeutic purposes. N Engl J Med. 1983 Jun 09; 308(23):1417-9. PMID: 6682485.
    Citations: 2     Fields:    Translation:Humans
  89. Gelfand JA, Donelan M, Hawiger A, Burke JF. Alternative complement pathway activation increases mortality in a model of burn injury in mice. J Clin Invest. 1982 Dec; 70(6):1170-6. PMID: 7174787.
    Citations: 7     Fields:    Translation:AnimalsCells
  90. Joiner KA, Hawiger A, Gelfand JA. Activation of the alternative complement pathway by blood culture isolates of Bacteroides fragilis. Infect Immun. 1981 Oct; 34(1):303-5. PMID: 6795126.
    Citations:    Fields:    Translation:HumansCells
  91. Joiner KA, Gelfand JA, Onderdonk AB, Bartlett JG, Gorbach SL. Host factors in the formation of abscesses. J Infect Dis. 1980 Jul; 142(1):40-9. PMID: 7400627.
    Citations: 7     Fields:    Translation:Animals
  92. Gadek JE, Hosea SW, Gelfand JA, Santaella M, Wickerhauser M, Triantaphyllopoulos DC, Frank MM. Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor. N Engl J Med. 1980 Mar 06; 302(10):542-6. PMID: 7351888.
    Citations: 28     Fields:    Translation:Humans
  93. Joiner KA, Shahon R, Gelfand JA. A sensitive microassay for the murine alternative complement pathway. J Immunol Methods. 1979; 31(3-4):283-90. PMID: 521632.
    Citations: 3     Fields:    Translation:AnimalsCells
  94. Gelfand JA, Hurley DL, Fauci AS, Frank MM. Role of complement in host defense against experimental disseminated candidiasis. J Infect Dis. 1978 Jul; 138(1):9-16. PMID: 355578.
    Citations: 25     Fields:    Translation:Animals
  95. Frank M, Gelfand JA, Alling DW, Sherins RJ. Epsilon aminocaproic acid for hereditary angioedema. N Engl J Med. 1977 May 26; 296(21):1235-6. PMID: 854067.
    Citations: 6     Fields:    Translation:Humans
  96. Gelfand JA, Sherins RJ, Alling DW, Frank MM. Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med. 1976 Dec 23; 295(26):1444-8. PMID: 792688.
    Citations: 88     Fields:    Translation:HumansCTClinical Trials
  97. Gelfand JA, Elin RJ, Berry FW, Frank MM. Endotoxemia associated with the Jarisch-Herxheimer reaction. N Engl J Med. 1976 Jul 22; 295(4):211-3. PMID: 775337.
    Citations: 19     Fields:    Translation:HumansCells
  98. Frank MM, Gelfand JA, Atkinson JP. Hereditary angioedema: the clinical syndrome and its management. Ann Intern Med. 1976 May; 84(5):580-93. PMID: 1275365.
    Citations: 95     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.