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Zdravka Ognyanova Medarova, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56CA214464 (MEDAROVA, ZDRAVKA O) Sep 13, 2018 - Aug 31, 2019
    NIH/NCI
    In vivo methodology for the discovery and validation of miRNA biomarkers in cancer
    Role: Principal Investigator
  2. R01CA221771 (MEDAROVA, ZDRAVKA O) Aug 1, 2018 - Jul 31, 2023
    NIH/NCI
    Therapy for Metastatic breast cancer based on micro RNA silencing
    Role: Principal Investigator
  3. R01CA163461 (MEDAROVA, ZDRAVKA O) Aug 14, 2012 - May 31, 2017
    NIH/NCI
    MicroRNA Therapy for Lymph Node Metastatic Breast Cancer
    Role: Principal Investigator
  4. R01CA135650 (MOORE, ANNA) Sep 22, 2008 - Dec 31, 2018
    NIH/NCI
    Predictive Cancer Diagnostics and Therapy Response
    Role: Principal Investigator
  5. R00CA129070 (MEDAROVA, ZDRAVKA O.) Jul 13, 2007 - Apr 30, 2013
    NIH/NCI
    Target-Specific Imaging and Delivery of siRNA to Tumors
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yoo B, Jordan VC, Sheedy P, Billig AM, Ross A, Pantazopoulos P, Medarova Z. RNAi-Mediated PD-L1 Inhibition for Pancreatic Cancer Immunotherapy. Sci Rep. 2019 Mar 18; 9(1):4712. PMID: 30886310.
    Citations:    
  2. Sheedy P, Medarova Z. The fundamental role of miR-10b in metastatic cancer. Am J Cancer Res. 2018; 8(9):1674-1688. PMID: 30323962.
    Citations:    
  3. Yoo B, Greninger P, Stein GT, Egan RK, McClanaghan J, Moore A, Benes CH, Medarova Z. Potent and selective effect of the mir-10b inhibitor MN-anti-mir10b in human cancer cells of diverse primary disease origin. PLoS One. 2018; 13(7):e0201046. PMID: 30028875.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Yoo B, Fuchs BC, Medarova Z. New Directions in the Study and Treatment of Metastatic Cancer. Front Oncol. 2018; 8:258. PMID: 30042926.
    Citations:    
  5. Yoo B, Billig AM, Medarova Z. Guidelines for Rational Cancer Therapeutics. Front Oncol. 2017; 7:310. PMID: 29312885.
    Citations:    
  6. Kumar AT, Carp SA, Yang J, Ross A, Medarova Z, Ran C. Fluorescence lifetime-based contrast enhancement of indocyanine green-labeled tumors. J Biomed Opt. 2017 04 01; 22(4):40501. PMID: 28397959.
    Citations:    Fields:    Translation:HumansAnimals
  7. Yoo B, Kavishwar A, Wang P, Ross A, Pantazopoulos P, Dudley M, Moore A, Medarova Z. Therapy targeted to the metastatic niche is effective in a model of stage IV breast cancer. Sci Rep. 2017 03 21; 7:45060. PMID: 28322342.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  8. Wang P, Ross A, Yoo B, Yang J, Farrar C, Ran C, Pantazopoulos P, Medarova Z, Moore A. Magnetic resonance imaging of intra-pancreatic ductal nanoparticle delivery to islet cells. Diabetes Metab Res Rev. 2017 07; 33(5). PMID: 28032446.
    Citations:    Fields:    Translation:Animals
  9. Yigit MV, Ghosh SK, Kumar M, Petkova V, Kavishwar A, Moore A, Medarova Z. Context-dependent differences in miR-10b breast oncogenesis can be targeted for the prevention and arrest of lymph node metastasis. Oncogene. 2017 05 04; 36(18):2628. PMID: 27841862.
    Citations: 1     Fields:    
  10. Lo ST, Pantazopouos P, Medarova Z, Moore A. Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages. Am J Cancer Res. 2016; 6(9):1986-1995. PMID: 27725904.
    Citations: 1     
  11. Wang P, Yoo B, Sherman S, Mukherjee P, Ross A, Pantazopoulos P, Petkova V, Farrar C, Medarova Z, Moore A. Predictive imaging of chemotherapeutic response in a transgenic mouse model of pancreatic cancer. Int J Cancer. 2016 08 01; 139(3):712-8. PMID: 26996122.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Yoo B, Kavishwar A, Ross A, Pantazopoulos P, Moore A, Medarova Z. In Vivo Detection of miRNA Expression in Tumors Using an Activatable Nanosensor. Mol Imaging Biol. 2016 Feb; 18(1):70-8. PMID: 25987466.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Medarova Z, Balcioglu M, Yigit MV. Controlling RNA Expression in Cancer Using Iron Oxide Nanoparticles Detectable by MRI and In Vivo Optical Imaging. Methods Mol Biol. 2016; 1372:163-79. PMID: 26530923.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Kavishwar A, Medarova Z. Sensing miRNA: Signal Amplification by Cognate RISC for Intracellular Detection of miRNA in Live Cells. Methods Mol Biol. 2016; 1372:121-7. PMID: 26530920.
    Citations:    Fields:    Translation:HumansCells
  15. Taylor RL, Medarova Z, Briles WE. Immune effects of chicken non-MHC alloantigens. Poult Sci. 2016 Feb; 95(2):447-57. PMID: 26527702.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Yoo B, Kavishwar A, Ross A, Wang P, Tabassum DP, Polyak K, Barteneva N, Petkova V, Pantazopoulos P, Tena A, Moore A, Medarova Z. Combining miR-10b-Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer. Cancer Res. 2015 Oct 15; 75(20):4407-15. PMID: 26359455.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Wang P, Schuetz C, Vallabhajosyula P, Medarova Z, Tena A, Wei L, Yamada K, Deng S, Markmann JF, Sachs DH, Moore A. Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI. Transplantation. 2015 Aug; 99(8):1574-81. PMID: 25806407.
    Citations: 2     Fields:    Translation:Animals
  18. Yoo B, Ifediba MA, Ghosh S, Medarova Z, Moore A. Combination treatment with theranostic nanoparticles for glioblastoma sensitization to TMZ. Mol Imaging Biol. 2014 Oct; 16(5):680-9. PMID: 24696184.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Medarova Z, Ghosh SK, Vangel M, Drake R, Moore A. Risk stratification of prostate cancer patients based on EPS-urine zinc content. Am J Cancer Res. 2014; 4(4):385-93. PMID: 25057441.
    Citations: 3     
  20. Yoo B, Ghosh SK, Kumar M, Moore A, Yigit MV, Medarova Z. Design of nanodrugs for miRNA targeting in tumor cells. J Biomed Nanotechnol. 2014 Jun; 10(6):1114-22. PMID: 24749405.
    Citations: 5     Fields:    Translation:HumansCells
  21. Yoo B, Kavishwar A, Ghosh SK, Barteneva N, Yigit MV, Moore A, Medarova Z. Detection of miRNA expression in intact cells using activatable sensor oligonucleotides. Chem Biol. 2014 Feb 20; 21(2):199-204. PMID: 24440078.
    Citations: 4     Fields:    Translation:HumansCells
  22. Ghosh SK, Yigit MV, Uchida M, Ross AW, Barteneva N, Moore A, Medarova Z. Sequence-dependent combination therapy with doxorubicin and a survivin-specific small interfering RNA nanodrug demonstrates efficacy in models of adenocarcinoma. Int J Cancer. 2014 Apr 01; 134(7):1758-66. PMID: 24114765.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  23. Ghosh SK, Pantazopoulos P, Medarova Z, Moore A. Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues. Clin Breast Cancer. 2013 Apr; 13(2):109-18. PMID: 23122537.
    Citations: 12     Fields:    Translation:HumansCells
  24. Ghosh SK, Uchida M, Yoo B, Ross AW, Gendler SJ, Gong J, Moore A, Medarova Z. Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model. Int J Cancer. 2013 Apr 15; 132(8):1860-7. PMID: 23015160.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Uppal R, Medarova Z, Farrar CT, Dai G, Moore A, Caravan P. Molecular imaging of fibrin in a breast cancer xenograft mouse model. Invest Radiol. 2012 Oct; 47(10):553-8. PMID: 22960948.
    Citations: 8     Fields:    Translation:Animals
  26. Wang P, Yigit MV, Ran C, Ross A, Wei L, Dai G, Medarova Z, Moore A. A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection. Diabetes. 2012 Dec; 61(12):3247-54. PMID: 22923469.
    Citations: 11     Fields:    Translation:HumansAnimals
  27. Yigit MV, Ghosh SK, Kumar M, Petkova V, Kavishwar A, Moore A, Medarova Z. Context-dependent differences in miR-10b breast oncogenesis can be targeted for the prevention and arrest of lymph node metastasis. Oncogene. 2013 Mar 21; 32(12):1530-8. PMID: 22580603.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  28. Yigit MV, Medarova Z. In vivo and ex vivo applications of gold nanoparticles for biomedical SERS imagingi. Am J Nucl Med Mol Imaging. 2012; 2(2):232-41. PMID: 23133814.
    Citations: 12     
  29. Yigit MV, Moore A, Medarova Z. Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res. 2012 May; 29(5):1180-8. PMID: 22274558.
    Citations: 18     Fields:    Translation:Humans
  30. Medarova Z, Greiner DL, Ifediba M, Dai G, Bolotin E, Castillo G, Bogdanov A, Kumar M, Moore A. Imaging the pancreatic vasculature in diabetes models. Diabetes Metab Res Rev. 2011 Nov; 27(8):767-72. PMID: 22069257.
    Citations: 6     Fields:    Translation:Animals
  31. Wang P, Medarova Z, Moore A. Molecular imaging: a promising tool to monitor islet transplantation. J Transplant. 2011; 2011:202915. PMID: 22013504.
    Citations: 6     
  32. Kavishwar A, Medarova Z, Moore A. Unique sphingomyelin patches are targets of a beta-cell-specific antibody. J Lipid Res. 2011 Sep; 52(9):1660-71. PMID: 21747097.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  33. Wang P, Yigit MV, Medarova Z, Wei L, Dai G, Schuetz C, Moore A. Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation. Diabetes. 2011 Feb; 60(2):565-71. PMID: 21270267.
    Citations: 15     Fields:    Translation:HumansAnimals
  34. Yigit MV, Zhu L, Ifediba MA, Zhang Y, Carr K, Moore A, Medarova Z. Noninvasive MRI-SERS imaging in living mice using an innately bimodal nanomaterial. ACS Nano. 2011 Feb 22; 5(2):1056-66. PMID: 21194236.
    Citations: 10     Fields:    Translation:Animals
  35. Kumar M, Yigit M, Dai G, Moore A, Medarova Z. Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer Res. 2010 Oct 01; 70(19):7553-61. PMID: 20702603.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  36. Ghosh SK, Kim P, Zhang XA, Yun SH, Moore A, Lippard SJ, Medarova Z. A novel imaging approach for early detection of prostate cancer based on endogenous zinc sensing. Cancer Res. 2010 Aug 01; 70(15):6119-27. PMID: 20610630.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  37. Ifediba MA, Medarova Z, Ng SW, Yang J, Moore A. siRNA delivery to CNS cells using a membrane translocation peptide. Bioconjug Chem. 2010 May 19; 21(5):803-6. PMID: 20420373.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Tsai S, Shameli A, Yamanouchi J, Clemente-Casares X, Wang J, Serra P, Yang Y, Medarova Z, Moore A, Santamaria P. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity. 2010 Apr 23; 32(4):568-80. PMID: 20381385.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  39. Kumar M, Medarova Z, Pantazopoulos P, Dai G, Moore A. Novel membrane-permeable contrast agent for brain tumor detection by MRI. Magn Reson Med. 2010 Mar; 63(3):617-24. PMID: 20146231.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  40. Ran C, Xu X, Raymond SB, Ferrara BJ, Neal K, Bacskai BJ, Medarova Z, Moore A. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28; 131(42):15257-61. PMID: 19807070.
    Citations: 40     Fields:    Translation:AnimalsCells
  41. Medarova Z, Moore A. MRI in diabetes: first results. AJR Am J Roentgenol. 2009 Aug; 193(2):295-303. PMID: 19620424.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  42. Medarova Z, Moore A. MRI as a tool to monitor islet transplantation. Nat Rev Endocrinol. 2009 Aug; 5(8):444-52. PMID: 19546863.
    Citations: 20     Fields:    Translation:Humans
  43. Medarova Z, Vallabhajosyula P, Tena A, Evgenov N, Pantazopoulos P, Tchipashvili V, Weir G, Sachs D, Moore A. In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates. Transplantation. 2009 Jun 15; 87(11):1659-66. PMID: 19502957.
    Citations: 19     Fields:    Translation:Animals
  44. Medarova Z, Rashkovetsky L, Pantazopoulos P, Moore A. Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging. Cancer Res. 2009 Feb 01; 69(3):1182-9. PMID: 19141648.
    Citations: 29     Fields:    Translation:HumansAnimalsPHPublic Health
  45. Moore A, Medarova Z. Imaging of siRNA delivery and silencing. Methods Mol Biol. 2009; 487:93-110. PMID: 19301644.
    Citations: 2     Fields:    Translation:HumansAnimals
  46. Medarova Z, Kumar M, Ng SW, Moore A. Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumors. Methods Mol Biol. 2009; 555:1-13. PMID: 19495684.
    Citations: 3     Fields:    Translation:Animals
  47. Medarova Z, Kumar M, Ng SW, Yang J, Barteneva N, Evgenov NV, Petkova V, Moore A. Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets. Transplantation. 2008 Nov 15; 86(9):1170-7. PMID: 19005396.
    Citations: 11     Fields:    Translation:Animals
  48. Medarova Z, Moore A. Non-invasive detection of transplanted pancreatic islets. Diabetes Obes Metab. 2008 Nov; 10 Suppl 4:88-97. PMID: 18834436.
    Citations: 6     Fields:    Translation:Humans
  49. Medarova Z, Tsai S, Evgenov N, Santamaria P, Moore A. In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression. Magn Reson Med. 2008 Apr; 59(4):712-20. PMID: 18302224.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  50. Erdogan S, Medarova ZO, Roby A, Moore A, Torchilin VP. Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes. J Magn Reson Imaging. 2008 Mar; 27(3):574-80. PMID: 18219628.
    Citations: 10     Fields:    Translation:Animals
  51. Medarova Z, Tsai S, Evgenov N, Santamaria P, Moore A. In vivo Imaging of a Diabetogenic CD8+ T cell Response During Type 1 Diabetes Progression. Magn Res Med. 2008; 59(4):712-720.
  52. Erdogan S*, Medarova Z*, Roby A, Moore A, Torchilin V. Enhanced tumor magnetic resonance imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes. J Magn Res Imaging. 2008; 27(3):574-580.
  53. Medarova Z, Castillo G, Dai G, Bolotin E, Bogdanov A, Moore A. Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes. Diabetes. 2007 Nov; 56(11):2677-82. PMID: 17682091.
    Citations: 23     Fields:    Translation:Animals
  54. Medarova Z, Pham W, Farrar C, Petkova V, Moore A. In vivo imaging of siRNA delivery and silencing in tumors. Nat Med. 2007 Mar; 13(3):372-7. PMID: 17322898.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  55. Ran C, Pantazopoulos P, Medarova Z, Moore A. Synthesis and testing of beta-cell specific Streptozotocin-derived near infrared imaging probes. Angew Chem. 2007; 46(47):8998-9001.
  56. Ran C, Pantazopoulos P, Medarova Z, Moore A. Synthesis and testing of beta-cell-specific streptozotocin-derived near-infrared imaging probes. Angew Chem Int Ed Engl. 2007; 46(47):8998-9001. PMID: 17957665.
    Citations: 3     Fields:    Translation:HumansCells
  57. Medarova Z, Moore A. Cellular and Molecular Imaging of the Diabetic Pancreas. Molecular and Cellular MR Imaging, Michael M.J.J. Modo and Jeff W.M. Bulte. 2007.
  58. Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A. In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes. 2006 Sep; 55(9):2419-28. PMID: 16936189.
    Citations: 50     Fields:    Translation:HumansAnimals
  59. Medarova Z, Pham W, Kim Y, Dai G, Moore A. In vivo imaging of tumor response to therapy using a dual-modality imaging strategy. Int J Cancer. 2006 Jun 01; 118(11):2796-802. PMID: 16385568.
    Citations: 37     Fields:    Translation:HumansAnimals
  60. Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A. In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006; 1(1):429-35. PMID: 17406265.
    Citations: 25     Fields:    Translation:HumansAnimals
  61. Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan; 12(1):144-8. PMID: 16380717.
    Citations: 79     Fields:    Translation:HumansAnimals
  62. Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage. 2005 Oct 15; 28(1):287-92. PMID: 16040255.
    Citations: 14     Fields:    Translation:Animals
  63. Medarova Z, Bonner-Weir S, Lipes M, Moore A. Imaging beta-cell death with a near-infrared probe. Diabetes. 2005 Jun; 54(6):1780-8. PMID: 15919800.
    Citations: 13     Fields:    Translation:Animals
  64. Pham W, Medarova Z, Moore A. Synthesis and application of a water-soluble near-infrared dye for cancer detection using optical imaging. Bioconjug Chem. 2005 May-Jun; 16(3):735-40. PMID: 15898745.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  65. Moore A, Medarova Z, Potthast A, Dai G. In vivo targeting of underglycosylated MUC-1 tumor antigen using a multimodal imaging probe. Cancer Res. 2004 Mar 01; 64(5):1821-7. PMID: 14996745.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  66. Moore A, Medarova Z. Approaches for imaging the diabetic pancreas: first results. Curr Med Chem-Immun, Endoc & Metab Agents. 2004; 4:315-332.
  67. Medarova Z, Moore A. Imaging of pancreatic cancer: a promise for early diagnosis through targeted strategies. Cancer Ther. 2004; 2:329-344.
  68. Medarova Z, Briles WE, Taylor RL. Resistance, susceptibility, and immunity to cecal coccidiosis: effects of B complex and alloantigen system L. Poult Sci. 2003 Jul; 82(7):1113-7. PMID: 12872967.
    Citations:    Fields:    Translation:Animals
  69. Medarova Z, Briles WE, Taylor RL, Jr. Immunological functions of avian alloantigens. Recent Res. Dev. Infect. Immun. 2003; 1:145-166.
  70. Medarova Z, Briles WE, Taylor RL, Jr . Alloantigen system L affects antibody responses. Int. J. Poult. Sci. 2003; 2(1):23-27.
  71. Medarova Z, Briles WE, Taylor RL. Alloantigen system L affects the outcome of rous sarcomas. Exp Biol Med (Maywood). 2002 Mar; 227(3):158-63. PMID: 11856813.
    Citations:    Fields:    Translation:Animals
  72. Medarova Z, Briles WE, Taylor RL, Jr. Alloantigen system L affects the outcome of Rous sarcomas. Exp. Biol. Med. 2002; 227(3):158-163.
  73. Medarova Z. The effects of erythrocyte alloantigen L on the avian immune response. 2002.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.