Harvard Catalyst Profiles

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Ivan Zanoni, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK115217 (SNAPPER, SCOTT B) Aug 1, 2017 - Jul 31, 2021
    Type III interferon Control of Mucosal Immunity
    Role: Co-Principal Investigator
  2. R01AI121066 (ZANONI, IVAN) Mar 1, 2016 - Feb 28, 2021
    Innate control of the inflammatory process during fungal infections
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Mar 03; 8(1):30. PMID: 36869134; PMCID: PMC9982769.
  2. Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Feb 14; 8(1):18. PMID: 36788219; PMCID: PMC9927065.
  3. Poli V, Zanoni I. Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease. Trends Microbiol. 2023 Mar; 31(3):280-293. PMID: 36344311; PMCID: PMC9974585.
    Citations:    Fields:    Translation:HumansCells
  4. Colombo M, Marongiu L, Mingozzi F, Marzi R, Cigni C, Facchini FA, Rotem R, Valache M, Stucchi G, Rocca G, Gornati L, Rizzuto MA, Salvioni L, Zanoni I, Gori A, Prosperi D, Granucci F. Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells. iScience. 2022 Oct 21; 25(10):105042. PMID: 36124235; PMCID: PMC9482116.
    Citations: 1     
  5. Fajgenbaum DC, Hayday AC, Rogers AJ, Towers GJ, Wack A, Zanoni I. Anti-type I interferon antibodies as a cause of severe COVID-19. Fac Rev. 2022; 11:15. PMID: 35812362; PMCID: PMC9239362.
    Citations: 1     
  6. Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21. PMID: 35148840; PMCID: PMC8857056.
    Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
  7. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305. PMID: 34783582.
    Citations: 23     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  8. Stefanetti G, Borriello F, Richichi B, Zanoni I, Lay L. Immunobiology of Carbohydrates: Implications for Novel Vaccine and Adjuvant Design Against Infectious Diseases. Front Cell Infect Microbiol. 2021; 11:808005. PMID: 35118012; PMCID: PMC8803737.
    Citations: 1     Fields:    Translation:Humans
  9. Poli V, Di Gioia M, Sola-Visner M, Granucci F, Frelinger AL, Michelson AD, Zanoni I. Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia. Immunity. 2022 02 08; 55(2):224-236.e5. PMID: 34995475.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Blosi M, Brigliadori A, Zanoni I, Ortelli S, Albonetti S, Costa AL. Chlorella vulgaris meets TiO2 NPs: Effective sorbent/photocatalytic hybrid materials for water treatment application. J Environ Manage. 2022 Feb 15; 304:114187. PMID: 34875490.
    Citations: 2     Fields:    Translation:AnimalsPHPublic Health
  11. Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, Zanoni I. Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation. iScience. 2021 Nov 19; 24(11):103256. PMID: 34761180; PMCID: PMC8567386.
    Citations: 7     
  12. Sposito B, Broggi A, Pandolfi L, Crotta S, Clementi N, Ferrarese R, Sisti S, Criscuolo E, Spreafico R, Long JM, Ambrosi A, Liu E, Frangipane V, Saracino L, Bozzini S, Marongiu L, Facchini FA, Bottazzi A, Fossali T, Colombo R, Clementi M, Tagliabue E, Chou J, Pontiroli AE, Meloni F, Wack A, Mancini N, Zanoni I. The interferon landscape along the respiratory tract impacts the severity of COVID-19. Cell. 2021 09 16; 184(19):4953-4968.e16. PMID: 34492226; PMCID: PMC8373821.
    Citations: 71     Fields:    Translation:HumansCells
  13. Zanoni I. Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19? Curr Opin Virol. 2021 10; 50:119-127. PMID: 34454352; PMCID: PMC8367741.
    Citations: 15     Fields:    Translation:HumansCells
  14. Di Gioia M, Zanoni I. Aged vasculature drives neutrophils mad. Immunity. 2021 07 13; 54(7):1369-1371. PMID: 34260883.
    Citations:    Fields:    Translation:Cells
  15. Overholt KJ, Krog JR, Zanoni I, Bryson BD. Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution. iScience. 2021 Jul 23; 24(7):102738. PMID: 34179732.
    Citations: 5     
  16. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. PMID: 34031655; PMCID: PMC8142652.
    Citations: 1     
  17. Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity. 2021 06 08; 54(6):1186-1199.e7. PMID: 33915108; PMCID: PMC8080416.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  18. Clementi N, Ghosh S, De Santis M, Castelli M, Criscuolo E, Zanoni I, Clementi M, Mancini N. Viral Respiratory Pathogens and Lung Injury. Clin Microbiol Rev. 2021 06 16; 34(3). PMID: 33789928.
    Citations: 20     Fields:    Translation:HumansCellsPHPublic Health
  19. Sposito B, Broggi A, Pandolfi L, Crotta S, Ferrarese R, Sisti S, Clementi N, Ambrosi A, Liu E, Frangipane V, Saracino L, Marongiu L, Facchini FA, Bottazzi A, Fossali T, Colombo R, Clementi M, Tagliabue E, Pontiroli AE, Meloni F, Wack A, Mancini N, Zanoni I. Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients. bioRxiv. 2021 Mar 30. PMID: 33821280; PMCID: PMC8020981.
  20. Marongiu L, Mingozzi F, Cigni C, Marzi R, Di Gioia M, Garrè M, Parazzoli D, Sironi L, Collini M, Sakaguchi R, Morii T, Crosti M, Moro M, Schurmans S, Catelani T, Rotem R, Colombo M, Shears S, Prosperi D, Zanoni I, Granucci F. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells. Sci Signal. 2021 03 30; 14(676). PMID: 33785611; PMCID: PMC8091591.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Di Gioia M, Zanoni I. Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids. Front Endocrinol (Lausanne). 2021; 12:626842. PMID: 33790857.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Gauthier AE, Chandler CE, Poli V, Gardner FM, Tekiau A, Smith R, Bonham KS, Cordes EE, Shank TM, Zanoni I, Goodlett DR, Biller SJ, Ernst RK, Rotjan RD, Kagan JC. Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Sci Immunol. 2021 03 12; 6(57). PMID: 33712473; PMCID: PMC8367048.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  23. Bigas A, Zanoni I, Hepworth MR, Eisenbarth SC, Masters SL, Kipnis J, Vinuesa CG, Good-Jacobson KL, Tangye SG, Yamazaki S, Hivroz C, Tait Wojno E, Shulman Z, Colonna M. JEM career launchpad. J Exp Med. 2021 02 01; 218(2). PMID: 33464291.
    Citations:    Fields:    Translation:Humans
  24. Ferenczi S, Solymosi N, Horváth I, Szeocs N, Grózer Z, Kuti D, Juhász B, Winkler Z, Pankotai T, Sükösd F, Stágel A, Paholcsek M, Dóra D, Nagy N, Kovács KJ, Zanoni I, Szallasi Z. Efficient treatment of a preclinical inflammatory bowel disease model with engineered bacteria. Mol Ther Methods Clin Dev. 2021 Mar 12; 20:218-226. PMID: 33426148.
    Citations: 2     
  25. Zhivaki D, Borriello F, Chow OA, Doran B, Fleming I, Theisen DJ, Pallis P, Shalek AK, Sokol CL, Zanoni I, Kagan JC. Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity. Cell Rep. 2020 11 17; 33(7):108381. PMID: 33207188.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  26. Martin TR, Wurfel MM, Zanoni I, Ulevitch R. Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness. EBioMedicine. 2020 Jul; 57:102836. PMID: 32574958.
    Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
  27. Broggi A, Ghosh S, Sposito B, Spreafico R, Balzarini F, Lo Cascio A, Clementi N, De Santis M, Mancini N, Granucci F, Zanoni I. Type III interferons disrupt the lung epithelial barrier upon viral recognition. Science. 2020 08 07; 369(6504):706-712. PMID: 32527925.
    Citations: 179     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  28. Prokunina-Olsson L, Alphonse N, Dickenson RE, Durbin JE, Glenn JS, Hartmann R, Kotenko SV, Lazear HM, O'Brien TR, Odendall C, Onabajo OO, Piontkivska H, Santer DM, Reich NC, Wack A, Zanoni I. COVID-19 and emerging viral infections: The case for interferon lambda. J Exp Med. 2020 05 04; 217(5). PMID: 32289152; PMCID: PMC7155807.
    Citations: 107     Fields:    Translation:HumansCellsPHPublic Health
  29. Borriello F, Zanoni I, Granucci F. Cellular and molecular mechanisms of antifungal innate immunity at epithelial barriers: The role of C-type lectin receptors. Eur J Immunol. 2020 03; 50(3):317-325. PMID: 31986556.
    Citations: 8     Fields:    Translation:HumansAnimals
  30. Mancini N, Peri F, Rescigno M, Zanoni I. Microbiome studies in the medical sciences and the need for closer multidisciplinary interplay. Sci Signal. 2020 02 04; 13(617). PMID: 32019901.
    Citations: 1     Fields:    Translation:HumansCells
  31. Broggi A, Granucci F, Zanoni I. Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. J Exp Med. 2020 01 06; 217(1). PMID: 31821443; PMCID: PMC7037241.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  32. Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D, Zanoni I. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020 01; 21(1):42-53. PMID: 31768073; PMCID: PMC6923570.
    Citations: 48     Fields:    Translation:AnimalsCells
  33. Pontiroli AE, Ceriani V, Tagliabue E, Zakaria AS, Veronelli A, Folli F, Zanoni I. Bariatric surgery, compared to medical treatment, reduces morbidity at all ages but does not reduce mortality in patients aged? PMID: 31598798.
    Citations: 5     Fields:    Translation:Humans
  34. Zanoni I, Odendall C. Editorial: Interferon-?s: New Regulators of Inflammatory Processes. Front Immunol. 2019; 10:2117. PMID: 31552047.
    Citations: 3     Fields:    
  35. Rizzuto MA, Salvioni L, Rotem R, Colombo M, Zanoni I, Granucci F, Prosperi D. Are nanotechnological approaches the future of treating inflammatory diseases? Nanomedicine (Lond). 2019 09; 14(17):2379-2390. PMID: 31414616.
    Citations: 3     Fields:    Translation:HumansAnimals
  36. Marongiu L, Gornati L, Artuso I, Zanoni I, Granucci F. Below the surface: The inner lives of TLR4 and TLR9. J Leukoc Biol. 2019 07; 106(1):147-160. PMID: 30900780.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  37. Andreakos E, Zanoni I, Galani IE. Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control. Curr Opin Immunol. 2019 02; 56:67-75. PMID: 30399529.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  38. Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldívar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engström Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Köhler JR. Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. PLoS Pathog. 2018 07; 14(7):e1007076. PMID: 30059535; PMCID: PMC6085062.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  39. Gornati L, Zanoni I, Granucci F. Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines. Front Immunol. 2018; 9:1484. PMID: 29997628; PMCID: PMC6030256.
    Citations: 6     Fields:    
  40. Santus W, Mingozzi F, Vai M, Granucci F, Zanoni I. Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses. J Vis Exp. 2018 06 13; (136). PMID: 29985352.
    Citations: 2     Fields:    Translation:HumansAnimals
  41. Radaelli F, D'Alfonso L, Collini M, Mingozzi F, Marongiu L, Granucci F, Zanoni I, Chirico G, Sironi L. Author Correction: µMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure. Sci Rep. 2018 Apr 17; 8(1):6314. PMID: 29666438.
    Citations: 1     Fields:    
  42. Radaelli F, D'Alfonso L, Collini M, Mingozzi F, Marongiu L, Granucci F, Zanoni I, Chirico G, Sironi L. µMAPPS: a novel phasor approach to second harmonic analysis for in vitro-in vivo investigation of collagen microstructure. Sci Rep. 2017 12 12; 7(1):17468. PMID: 29234132.
    Citations: 5     Fields:    Translation:AnimalsCells
  43. Zanoni I, Granucci F, Broggi A. Interferon (IFN)-? Takes the Helm: Immunomodulatory Roles of Type III IFNs. Front Immunol. 2017; 8:1661. PMID: 29234323.
    Citations: 53     Fields:    
  44. Zanoni I, Tan Y, Di Gioia M, Springstead JR, Kagan JC. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation. Immunity. 2017 10 17; 47(4):697-709.e3. PMID: 29045901.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  45. Santus W, Barresi S, Mingozzi F, Broggi A, Orlandi I, Stamerra G, Vai M, Martorana AM, Polissi A, Köhler JR, Liu N, Zanoni I, Granucci F. Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems. Sci Immunol. 2017 Sep 22; 2(15). PMID: 28939652.
    Citations: 16     Fields:    
  46. Prosperi D, Colombo M, Zanoni I, Granucci F. Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases. Semin Immunol. 2017 12; 34:61-67. PMID: 28855088; PMCID: PMC5705526.
    Citations: 20     Fields:    Translation:HumansCells
  47. Broggi A, Tan Y, Granucci F, Zanoni I. IFN-? suppresses intestinal inflammation by non-translational regulation of neutrophil function. Nat Immunol. 2017 Oct; 18(10):1084-1093. PMID: 28846084; PMCID: PMC5701513.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  48. Rusconi M, Gerardi F, Santus W, Lizio A, Sansone VA, Lunetta C, Zanoni I, Granucci F. Inflammatory role of dendritic cells in Amyotrophic Lateral Sclerosis revealed by an analysis of patients' peripheral blood. Sci Rep. 2017 08 10; 7(1):7853. PMID: 28798369.
    Citations: 18     Fields:    Translation:HumansCells
  49. Mingozzi F, Spreafico R, Gorletta T, Cigni C, Di Gioia M, Caccia M, Sironi L, Collini M, Soncini M, Rusconi M, von Andrian UH, Chirico G, Zanoni I, Granucci F. Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors. EMBO Mol Med. 2016 09; 8(9):1039-51. PMID: 27406819.
    Citations: 18     Fields:    Translation:AnimalsCells
  50. Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016 Jun 03; 352(6290):1232-6. PMID: 27103670; PMCID: PMC5111085.
    Citations: 218     Fields:    Translation:AnimalsCells
  51. Broggi A, Cigni C, Zanoni I, Granucci F. Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions. J Vis Exp. 2016 Apr 20; (110):e52589. PMID: 27166881.
    Citations: 5     Fields:    Translation:AnimalsCells
  52. Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4. Cell Host Microbe. 2015 Dec 09; 18(6):682-93. PMID: 26651944; PMCID: PMC4685476.
    Citations: 23     Fields:    Translation:AnimalsCells
  53. Tan Y, Zanoni I, Cullen TW, Goodman AL, Kagan JC. Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity. 2015 Nov 17; 43(5):909-22. PMID: 26546281.
    Citations: 73     Fields:    Translation:HumansCells
  54. Santini B, Zanoni I, Marzi R, Cigni C, Bedoni M, Gramatica F, Palugan L, Corsi F, Granucci F, Colombo M. Cream formulation impact on topical administration of engineered colloidal nanoparticles. PLoS One. 2015; 10(5):e0126366. PMID: 25962161.
    Citations: 4     Fields:    Translation:HumansAnimals
  55. Brubaker SW, Bonham KS, Zanoni I, Kagan JC. Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol. 2015; 33:257-90. PMID: 25581309; PMCID: PMC5146691.
    Citations: 609     Fields:    Translation:HumansAnimalsCells
  56. Di Gioia M, Zanoni I. Toll-like receptor co-receptors as master regulators of the immune response. Mol Immunol. 2015 Feb; 63(2):143-52. PMID: 24951397.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  57. Guglielmetti S, Zanoni I, Balzaretti S, Miriani M, Taverniti V, De Noni I, Presti I, Stuknyte M, Scarafoni A, Arioli S, Iametti S, Bonomi F, Mora D, Karp M, Granucci F. Murein lytic enzyme TgaA of Bifidobacterium bifidum MIMBb75 modulates dendritic cell maturation through its cysteine- and histidine-dependent amidohydrolase/peptidase (CHAP) amidase domain. Appl Environ Microbiol. 2014 Sep; 80(17):5170-7. PMID: 24814791.
    Citations: 16     Fields:    Translation:AnimalsCells
  58. Petrarca C, Clemente E, Toto V, Iezzi M, Rossi C, Zanotta S, Mistrello G, Zanoni I, Granucci F, Arioli S, Mora D, Guglielmetti S, Paganelli R, Di Gioacchino M. rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant. Hum Vaccin Immunother. 2014; 10(5):1228-37. PMID: 24603094.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  59. Granucci F, Lutz MB, Zanoni I. The nature of activatory and tolerogenic dendritic cell-derived signal 2. Front Immunol. 2014; 5:42. PMID: 24567734.
    Citations: 3     Fields:    
  60. Catucci M, Zanoni I, Draghici E, Bosticardo M, Castiello MC, Venturini M, Cesana D, Montini E, Ponzoni M, Granucci F, Villa A. Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity. Eur J Immunol. 2014 Apr; 44(4):1039-45. PMID: 24338698.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  61. Cighetti R, Ciaramelli C, Sestito SE, Zanoni I, Kubik L, Ardá-Freire A, Calabrese V, Granucci F, Jerala R, Martín-Santamaría S, Jiménez-Barbero J, Peri F. Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic. Chembiochem. 2014 Jan 24; 15(2):250-8. PMID: 24339336.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  62. Gritti N, Caccia M, Sironi L, Collini M, D'Alfonso L, Granucci F, Zanoni I, Chirico G. Modeling leukocyte-leukocyte non-contact interactions in a lymph node. PLoS One. 2013; 8(10):e76756. PMID: 24204669.
    Citations:    Fields:    Translation:HumansCells
  63. Zanoni I, Spreafico R, Bodio C, Di Gioia M, Cigni C, Broggi A, Gorletta T, Caccia M, Chirico G, Sironi L, Collini M, Colombo MP, Garbi N, Granucci F. IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions. Cell Rep. 2013 Sep 26; 4(6):1235-49. PMID: 24055061.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  64. Bissa M, Pacchioni SM, Zanotto C, De Giuli Morghen C, Illiano E, Granucci F, Zanoni I, Broggi A, Radaelli A. Systemically administered DNA and fowlpox recombinants expressing four vaccinia virus genes although immunogenic do not protect mice against the highly pathogenic IHD-J vaccinia strain. Virus Res. 2013 Dec 26; 178(2):374-82. PMID: 24050999; PMCID: PMC9533858.
    Citations: 5     Fields:    Translation:AnimalsCells
  65. Broggi A, Zanoni I, Granucci F. Migratory conventional dendritic cells in the induction of peripheral T cell tolerance. J Leukoc Biol. 2013 Nov; 94(5):903-11. PMID: 23898045.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  66. Zanoni I, Granucci F. Role of CD14 in host protection against infections and in metabolism regulation. Front Cell Infect Microbiol. 2013; 3:32. PMID: 23898465.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  67. Granucci F, Lutz MB, Zanoni I. The nature of activatory and tolerogenic dendritic cell-derived signal 2. Front Immunol. 2013; 4:198. PMID: 23882267.
    Citations: 3     Fields:    
  68. Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F. A novel bioactive peptide: assessing its activity over murine neural stem cells and its potential for neural tissue engineering. N Biotechnol. 2013 Jun 25; 30(5):552-62. PMID: 23541699.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  69. Maggioni D, Fenili F, D'Alfonso L, Donghi D, Panigati M, Zanoni I, Marzi R, Manfredi A, Ferruti P, D'Alfonso G, Ranucci E. Luminescent rhenium and ruthenium complexes of an amphoteric poly(amidoamine) functionalized with 1,10-phenanthroline. Inorg Chem. 2012 Dec 03; 51(23):12776-88. PMID: 23151014.
    Citations: 5     Fields:    Translation:HumansCells
  70. Pontiroli F, Dussurget O, Zanoni I, Urbano M, Beretta O, Granucci F, Ricciardi-Castagnoli P, Cossart P, Foti M. The timing of IFNß production affects early innate responses to Listeria monocytogenes and determines the overall outcome of lethal infection. PLoS One. 2012; 7(8):e43455. PMID: 22912878.
    Citations: 11     Fields:    Translation:AnimalsCells
  71. Zanoni I, Granucci F. Regulation and dysregulation of innate immunity by NFAT signaling downstream of pattern recognition receptors (PRRs). Eur J Immunol. 2012 Aug; 42(8):1924-31. PMID: 22706795.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  72. Vitali C, Mingozzi F, Broggi A, Barresi S, Zolezzi F, Bayry J, Raimondi G, Zanoni I, Granucci F. Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells. Blood. 2012 Aug 09; 120(6):1237-45. PMID: 22760781.
    Citations: 35     Fields:    Translation:AnimalsCells
  73. Zanoni I, Ostuni R, Barresi S, Di Gioia M, Broggi A, Costa B, Marzi R, Granucci F. CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. J Clin Invest. 2012 May; 122(5):1747-57. PMID: 22466648; PMCID: PMC3336986.
    Citations: 22     Fields:    Translation:AnimalsCells
  74. Zanoni I, Bodio C, Broggi A, Ostuni R, Caccia M, Collini M, Venkatesh A, Spreafico R, Capuano G, Granucci F. Similarities and differences of innate immune responses elicited by smooth and rough LPS. Immunol Lett. 2012 Feb 29; 142(1-2):41-7. PMID: 22207037.
    Citations: 18     Fields:    Translation:AnimalsCells
  75. Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 2011 Nov 11; 147(4):868-80. PMID: 22078883.
    Citations: 411     Fields:    Translation:AnimalsCells
  76. Sartorius R, Bettua C, D'Apice L, Caivano A, Trovato M, Russo D, Zanoni I, Granucci F, Mascolo D, Barba P, Del Pozzo G, De Berardinis P. Vaccination with filamentous bacteriophages targeting DEC-205 induces DC maturation and potent anti-tumor T-cell responses in the absence of adjuvants. Eur J Immunol. 2011 Sep; 41(9):2573-84. PMID: 21688262.
    Citations: 32     Fields:    Translation:AnimalsCellsPHPublic Health
  77. Cavalieri D, Rivero D, Beltrame L, Buschow SI, Calura E, Rizzetto L, Gessani S, Gauzzi MC, Reith W, Baur A, Bonaiuti R, Brandizi M, De Filippo C, D'Oro U, Draghici S, Dunand-Sauthier I, Gatti E, Granucci F, Gündel M, Kramer M, Kuka M, Lanyi A, Melief CJ, van Montfoort N, Ostuni R, Pierre P, Popovici R, Rajnavolgyi E, Schierer S, Schuler G, Soumelis V, Splendiani A, Stefanini I, Torcia MG, Zanoni I, Zollinger R, Figdor CG, Austyn JM. DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells. Immunome Res. 2010 Nov 19; 6:10. PMID: 21092113.
    Citations: 16     
  78. Piazza M, Colombo M, Zanoni I, Granucci F, Tortora P, Weiss J, Gioannini T, Prosperi D, Peri F. Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling. Angew Chem Int Ed Engl. 2011 Jan 17; 50(3):622-6. PMID: 21226138.
    Citations: 7     Fields:    Translation:HumansCells
  79. Guglielmetti S, Taverniti V, Minuzzo M, Arioli S, Zanoni I, Stuknyte M, Granucci F, Karp M, Mora D. A dairy bacterium displays in vitro probiotic properties for the pharyngeal mucosa by antagonizing group A streptococci and modulating the immune response. Infect Immun. 2010 Nov; 78(11):4734-43. PMID: 20732995.
    Citations: 19     Fields:    Translation:HumansCells
  80. Villa CE, Caccia M, Sironi L, D'Alfonso L, Collini M, Rivolta I, Miserocchi G, Gorletta T, Zanoni I, Granucci F, Chirico G. Accumulative difference image protocol for particle tracking in fluorescence microscopy tested in mouse lymphonodes. PLoS One. 2010 Aug 17; 5(8):e12216. PMID: 20808918.
    Citations: 3     Fields:    Translation:AnimalsCells
  81. Ostuni R, Zanoni I, Granucci F. Deciphering the complexity of Toll-like receptor signaling. Cell Mol Life Sci. 2010 Dec; 67(24):4109-34. PMID: 20680392.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  82. Zanoni I, Granucci F. The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance. Autoimmunity. 2011 Feb; 44(1):23-32. PMID: 20670116.
    Citations: 12     Fields:    Translation:HumansCells
  83. Ferri E, Donghi D, Panigati M, Prencipe G, D'Alfonso L, Zanoni I, Baldoli C, Maiorana S, D'Alfonso G, Licandro E. Luminescent conjugates between dinuclear rhenium(I) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting. Chem Commun (Camb). 2010 Sep 14; 46(34):6255-7. PMID: 20668778.
    Citations: 6     Fields:    Translation:HumansCells
  84. Zanoni I, Granucci F. Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors. J Mol Med (Berl). 2010 Sep; 88(9):873-80. PMID: 20556351.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  85. Zanoni I, Granucci F. Differences in lipopolysaccharide-induced signaling between conventional dendritic cells and macrophages. Immunobiology. 2010 Sep-Oct; 215(9-10):709-12. PMID: 20579765.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  86. Granucci F, Zanoni I. The dendritic cell life cycle. Cell Cycle. 2009 Dec; 8(23):3816-21. PMID: 19887908.
    Citations: 15     Fields:    Translation:Cells
  87. Zanoni I, Ostuni R, Capuano G, Collini M, Caccia M, Ronchi AE, Rocchetti M, Mingozzi F, Foti M, Chirico G, Costa B, Zaza A, Ricciardi-Castagnoli P, Granucci F. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature. 2009 Jul 09; 460(7252):264-8. PMID: 19525933.
    Citations: 141     Fields:    Translation:AnimalsCells
  88. Granucci F, Zanoni I, Ricciardi-Castagnoli P. Central role of dendritic cells in the regulation and deregulation of immune responses. Cell Mol Life Sci. 2008 Jun; 65(11):1683-97. PMID: 18327662.
    Citations: 24     Fields:    Translation:HumansCells
  89. Granucci F, Zanoni I. Role of Toll like receptor-activated dendritic cells in the development of autoimmunity. Front Biosci. 2008 May 01; 13:4817-26. PMID: 18508547.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  90. Caccia M, Sironi L, Collini M, Chirico G, Zanoni I, Granucci F. Image filtering for two-photon deep imaging of lymphonodes. Eur Biophys J. 2008 Jul; 37(6):979-87. PMID: 18389230.
    Citations: 10     Fields:    Translation:Animals
  91. Zanoni I, Granucci F, Foti M, Ricciardi-Castagnoli P. Self-tolerance, dendritic cell (DC)-mediated activation and tissue distribution of natural killer (NK) cells. Immunol Lett. 2007 May 15; 110(1):6-17. PMID: 17451813.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  92. Peri F, Granucci F, Costa B, Zanoni I, Marinzi C, Nicotra F. Inhibition of lipid a stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides. Angew Chem Int Ed Engl. 2007; 46(18):3308-12. PMID: 17387663.
    Citations: 8     Fields:    Translation:HumansCells
  93. Granucci F, Zanoni I, Ricciardi-Castagnoli P. Natural killer (NK) cell functions can be strongly boosted by activated dendritic cells (DC). Eur J Immunol. 2006 Oct; 36(10):2819-20. PMID: 17013979.
    Citations: 6     Fields:    Translation:AnimalsCells
  94. Vizzardelli C, Pavelka N, Luchini A, Zanoni I, Bendickson L, Pelizzola M, Beretta O, Foti M, Granucci F, Nilsen-Hamilton M, Ricciardi-Castagnoli P. Effects of dexamethazone on LPS-induced activationand migration of mouse dendritic cells revealed by a genome-wide transcriptional analysis. Eur J Immunol. 2006 Jun; 36(6):1504-15. PMID: 16708398.
    Citations: 22     Fields:    Translation:AnimalsCells
  95. Raimondi G, Zanoni I, Citterio S, Ricciardi-Castagnoli P, Granucci F. Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. J Immunol. 2006 Apr 01; 176(7):4012-20. PMID: 16547236.
    Citations: 9     Fields:    Translation:AnimalsCells
  96. Raimondi G, Zanoni I, Citterio S, Ricciardi-Castagnoli P, Granucci F. Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation. J Immunol. 2006 Apr 01; 176(7):4021-8. PMID: 16547237.
    Citations: 12     Fields:    Translation:AnimalsCells
  97. Zanoni I, Foti M, Ricciardi-Castagnoli P, Granucci F. TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells. J Immunol. 2005 Jul 01; 175(1):286-92. PMID: 15972660.
    Citations: 24     Fields:    Translation:AnimalsCells
  98. Granucci F, Zanoni I, Pavelka N, Van Dommelen SL, Andoniou CE, Belardelli F, Degli Esposti MA, Ricciardi-Castagnoli P. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med. 2004 Aug 02; 200(3):287-95. PMID: 15289500; PMCID: PMC2211974.
    Citations: 65     Fields:    Translation:AnimalsCells
  99. Granucci F, Zanoni I, Feau S, Capuano G, Ricciardi-Castagnoli P. The regulatory role of dendritic cells in the immune response. Int Arch Allergy Immunol. 2004 Jul; 134(3):179-85. PMID: 15178886.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  100. Granucci F, Feau S, Zanoni I, Pavelka N, Vizzardelli C, Raimondi G, Ricciardi-Castagnoli P. The immune response is initiated by dendritic cells via interaction with microorganisms and interleukin-2 production. J Infect Dis. 2003 Jun 15; 187 Suppl 2:S346-50. PMID: 12792850.
    Citations: 6     Fields:    Translation:AnimalsCells
  101. Granucci F, Zanoni I, Feau S, Ricciardi-Castagnoli P. Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity. EMBO J. 2003 Jun 02; 22(11):2546-51. PMID: 12773371; PMCID: PMC156758.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.