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Daniel Irimia, Ph.D., M.D.

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Pioneers of Miniaturisation Prize

I am passionate about understanding how neutrophils contribute to health and disease. Neutrophils are the largest white blood cell population in the blood (in humans, 60% of white blood cells are neutrophils). Neutrophils are mentioned daily by physicians and the neutrophil absolute count is one of the most common blood tests prescribed for evaluating patient defenses against microbes. However, new discoveries are changing the paradigm of neutrophil functions. Enabled by novel technologies to study neutrophils ex vivo, new assays are emerging to study the contribution of human neutrophils to the pathology of numerous diseases:

(1) The traffic of neutrophils is traditionally considered to be unidirectional, from the blood to the tissue, guided by chemoattractant gradients (after which neutrophils die and are removed by macrophages). Using inflammation-on-a-chip devices, we showed for the first time that human neutrophils continue migrating persistently after reaching the highest chemoattractant concentration and all (100%) can be directed back to the starting location. Reports in zebrafish and mice confirmed that neutrophils are capable of reversing migration from tissues to circulation. These findings establish the fundamental basis for testing the functionality of neutrophils in blood and designing novel assays to diagnose and monitor inflammations, infections, and sepsis.

(2) Neutrophils often interact with common pathogens that are larger than what one neutrophil could phagocytose (e.g. clusters of bacteria – S.aureus or S.pyogenes, elongated hyphae of filamentous fungi – Candida and Aspergillus). During these interactions, a novel behavior can be observed, where neutrophils cooperate against targets (a process named swarming). We designed the first high-throughput platform for the systematic study of human neutrophil swarming ex vivo (Reategui et al, Nat Bio Eng, 2016). We leveraged this platform to uncover a complex constellation of mediators that coordinate the activity of multiple neutrophils against large targets and mediate their interactions with leukocytes and non-immune cells, effectively placing the neutrophils at the center of immune responses.

(3) Neutrophils can release chromatin to trap microbes (neutrophil extracellular traps - NETs). Originally, NETs were proposed to play antimicrobial functions. This paradigm is shifting, following the discovery of biochemical properties responsible for complications in autoimmune diseases, diabetes, and cancer. Our contribution to this paradigm shift is the design of devices to test the mechanical role for the chromatin fibers encompassing the NETs, during inflammation and sepsis (Boneshaker et al, Int. Bio, 2016). Our findings challenge the traditional view of capillary plexuses providing robust delivery of oxygen to tissues. On the contrary, we determined that capillary plexuses are vulnerable to neutrophils and NETs, which can completely disrupt their normal function, triggering hypoxia and leading to organ failure during infections and sepsis.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Prichard A, Khuu L, Whitmore LC, Irimia D, Allen LH. Helicobacter pylori-infected human neutrophils exhibit impaired chemotaxis and a uropod retraction defect. Front Immunol. 2022; 13:1038349. PMID: 36341418; PMCID: PMC9630475.
    Citations:    Fields:    
  2. Hopke A, Lin T, Scherer AK, Shay AE, Timmer KD, Wilson-Mifsud B, Mansour MK, Serhan CN, Irimia D, Hurley BP. Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi. iScience. 2022 Oct 21; 25(10):105226. PMID: 36267914; PMCID: PMC9576560.
  3. Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia D. Correction to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis. 2022 Jul 07; 22(1):595. PMID: 35799137; PMCID: PMC9260969.
    Citations:    Fields:    
  4. Rosu CA, Martens AM, Sumner J, Farkas EJ, Arya P, Arauz AB, Madhavan VL, Chavez H, Larson SD, Badaki-Makun O, Irimia D, Yonker LM. Heterogeneity in the evaluation of suspected MIS-C: a cross-sectional vignette-based survey. BMC Pediatr. 2022 07 04; 22(1):392. PMID: 35787254; PMCID: PMC9254446.
    Citations:    Fields:    Translation:Humans
  5. Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia D. Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis. 2022 Jun 20; 22(1):563. PMID: 35725405; PMCID: PMC9208352.
    Citations: 1     Fields:    Translation:HumansCells
  6. Sykes DB, Martinelli MM, Negoro P, Xu S, Maxcy K, Timmer K, Viens AL, Alexander NJ, Atallah J, Snarr BD, Baistrocchi SR, Atallah NJ, Hopke A, Scherer A, Rosales I, Irimia D, Sheppard DC, Mansour MK. Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections. J Leukoc Biol. 2022 06; 111(6):1133-1145. PMID: 35355310; PMCID: PMC9133213.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Viens AL, Timmer KD, Alexander NJ, Barghout R, Milosevic J, Hopke A, Atallah NJ, Scherer AK, Sykes DB, Irimia D, Mansour MK. TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils. J Immunol. 2022 04 01; 208(7):1664-1674. PMID: 35277418; PMCID: PMC8976732.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Sakuma M, Wang X, Ellett F, Edd JF, Babatunde KA, Viens A, Mansour MK, Irimia D. Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood. Lab Chip. 2022 03 01; 22(5):936-944. PMID: 35084421; PMCID: PMC8978531.
    Citations:    Fields:    Translation:HumansCells
  9. Chiang N, Sakuma M, Rodriguez AR, Spur BW, Irimia D, Serhan CN. Resolvin T-series reduce neutrophil extracellular traps. Blood. 2022 02 24; 139(8):1222-1233. PMID: 34814186; PMCID: PMC8612755.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  10. Habibabady ZA, Sendil S, Ellett F, Pollok F, Elias GF, French BM, Sun W, Braileanu G, Burdorf L, Irimia D, Pierson RN, Azimzadeh AM. Human erythrocyte fragmentation during ex-vivo pig organ perfusion. Xenotransplantation. 2022 03; 29(2):e12729. PMID: 35112383; PMCID: PMC8995366.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Ellett F, Marand AL, Irimia D. Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood. J Leukoc Biol. 2022 06; 111(6):1175-1184. PMID: 35100458; PMCID: PMC9133106.
    Citations:    Fields:    Translation:HumansCells
  12. Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow A, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LM. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children. bioRxiv. 2021 Dec 20. PMID: 34981052; PMCID: PMC8722589.
    Citations: 1     
  13. Muldur S, Vadysirisack DD, Ragunathan S, Tang Y, Ricardo A, Sayegh CE, Irimia D. Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices. Front Immunol. 2021; 12:777932. PMID: 34899737; PMCID: PMC8653703.
    Citations: 2     Fields:    Translation:HumansCells
  14. Hadjitheodorou A, Bell GRR, Ellett F, Shastry S, Irimia D, Collins SR, Theriot JA. Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity. Nat Commun. 2021 11 16; 12(1):6619. PMID: 34785640.
    Citations:    Fields:    Translation:HumansCells
  15. Hopke A, Mela A, Ellett F, Carter-House D, Peña JF, Stajich JE, Altamirano S, Lovett B, Egan M, Kale S, Kronholm I, Guerette P, Szewczyk E, McCluskey K, Breslauer D, Shah H, Coad BR, Momany M, Irimia D. Crowdsourced analysis of fungal growth and branching on microfluidic platforms. PLoS One. 2021; 16(9):e0257823. PMID: 34587206; PMCID: PMC8480888.
    Citations: 1     Fields:    Translation:Animals
  16. Kim JJ, Jorfi M, Tanzi RE, Kim DY, Doyle PS, Irimia D. Patterning of interconnected human brain spheroids. Lab Chip. 2021 09 14; 21(18):3532-3540. PMID: 34286713; PMCID: PMC9142085.
    Citations: 1     Fields:    Translation:HumansCells
  17. Barros N, Alexander N, Viens A, Timmer K, Atallah N, Knooihuizen SAI, Hopke A, Scherer A, Dagher Z, Irimia D, Mansour MK. Cytokine Augmentation Reverses Transplant Recipient Neutrophil Dysfunction Against the Human Fungal Pathogen Candida albicans. J Infect Dis. 2021 09 01; 224(5):894-902. PMID: 33417688; PMCID: PMC8577195.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  18. Scherer AK, Hopke A, Sykes DB, Irimia D, Mansour MK. Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities? PLoS Pathog. 2021 07; 17(7):e1009691. PMID: 34324592; PMCID: PMC8321001.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmüller W, Lämmermann T. Neutrophils self-limit swarming to contain bacterial growth in vivo. Science. 2021 06 18; 372(6548). PMID: 34140358; PMCID: PMC8926156.
    Citations: 19     Fields:    Translation:AnimalsCells
  20. Muldur S, Ellett F, Marand AL, Marvil C, Branda JA, LeMieux JE, Raff AB, Strle K, Irimia D. Microfluidic Assays for Probing Neutrophil-Borrelia Interactions in Blood During Lyme Disease. Cells Tissues Organs. 2022; 211(3):313-323. PMID: 33735890; PMCID: PMC8448788.
    Citations: 1     Fields:    Translation:HumansCells
  21. Yonker LM, Marand A, Muldur S, Hopke A, Leung HM, De La Flor D, Park G, Pinsky H, Guthrie LB, Tearney GJ, Irimia D, Hurley BP. Neutrophil dysfunction in cystic fibrosis. J Cyst Fibros. 2021 11; 20(6):1062-1071. PMID: 33589340; PMCID: PMC8568301.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  22. Bartsch YC, Wang C, Zohar T, Fischinger S, Atyeo C, Burke JS, Kang J, Edlow AG, Fasano A, Baden LR, Nilles EJ, Woolley AE, Karlson EW, Hopke AR, Irimia D, Fischer ES, Ryan ET, Charles RC, Julg BD, Lauffenburger DA, Yonker LM, Alter G. Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nat Med. 2021 03; 27(3):454-462. PMID: 33589825; PMCID: PMC8315827.
    Citations: 55     Fields:    Translation:HumansCellsPHPublic Health
  23. Jalali F, Ellett F, Balani P, Duncan MJ, Dewhirst FE, Borisy GG, Irimia D. No man's land: Species-specific formation of exclusion zones bordering Actinomyces graevenitzii microcolonies in nanoliter cultures. Microbiologyopen. 2021 01; 10(1):e1137. PMID: 33544453; PMCID: PMC7882712.
    Citations: 3     Fields:    Translation:HumansCells
  24. Babatunde KA, Wang X, Hopke A, Lannes N, Mantel PY, Irimia D. Chemotaxis and swarming in differentiated HL-60 neutrophil-like cells. Sci Rep. 2021 01 12; 11(1):778. PMID: 33436661; PMCID: PMC7804120.
    Citations: 9     Fields:    Translation:HumansCells
  25. Knooihuizen SAI, Alexander NJ, Hopke A, Barros N, Viens A, Scherer A, Atallah NJ, Dagher Z, Irimia D, Chung RT, Mansour MK. Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis. Hepatol Commun. 2021 03; 5(3):502-515. PMID: 33681682; PMCID: PMC7917271.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Irimia D. Neutrophil Swarms Are More Than the Accumulation of Cells. Microbiol Insights. 2020; 13:1178636120978272. PMID: 33354109.
    Citations: 2     
  27. Dieterle PB, Min J, Irimia D, Amir A. Dynamics of diffusive cell signaling relays. Elife. 2020 12 04; 9. PMID: 33275097; PMCID: PMC7781602.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  28. Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De La Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano A. Reply. J Pediatr. 2021 01; 228:317-319. PMID: 32971143; PMCID: PMC7505093.
    Citations:    Fields:    
  29. Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De la Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano A. Reply. J Pediatr. 2021 01; 228:320-323. PMID: 32956696; PMCID: PMC7500434.
    Citations:    Fields:    
  30. Alexander NJ, Bozym DJ, Farmer JR, Parris P, Viens A, Atallah N, Hopke A, Scherer A, Dagher Z, Barros N, Knooihuizen SAI, Saff RR, Pasternack MS, Thompson RW, Irimia D, Mansour MK. Neutrophil functional profiling and cytokine augmentation for patients with multiple recurrent infections: A case study. J Allergy Clin Immunol Pract. 2021 02; 9(2):986-988. PMID: 32853820; PMCID: PMC7870511.
    Citations: 4     Fields:    Translation:HumansCells
  31. Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De la Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano A. Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses. J Pediatr. 2020 12; 227:45-52.e5. PMID: 32827525; PMCID: PMC7438214.
    Citations: 154     Fields:    Translation:HumansPHPublic Health
  32. Hopke A, Scherer A, Kreuzburg S, Abers MS, Zerbe CS, Dinauer MC, Mansour MK, Irimia D. Publisher Correction: Neutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020 05 14; 11(1):2492. PMID: 32409681.
    Citations:    Fields:    
  33. Wang X, Hossain M, Bogoslowski A, Kubes P, Irimia D. Chemotaxing neutrophils enter alternate branches at capillary bifurcations. Nat Commun. 2020 05 13; 11(1):2385. PMID: 32404937.
    Citations: 9     Fields:    Translation:HumansCells
  34. Negoro PE, Xu S, Dagher Z, Hopke A, Reedy JL, Feldman MB, Khan NS, Viens AL, Alexander NJ, Atallah NJ, Scherer AK, Dutko RA, Jeffery J, Kernien JF, Fites JS, Nett JE, Klein BS, Vyas JM, Irimia D, Sykes DB, Mansour MK. Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species. mBio. 2020 05 12; 11(3). PMID: 32398316; PMCID: PMC7218286.
    Citations: 15     Fields:    Translation:AnimalsCells
  35. Hopke A, Scherer A, Kreuzburg S, Abers MS, Zerbe CS, Dinauer MC, Mansour MK, Irimia D. Neutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020 04 27; 11(1):2031. PMID: 32341348.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  36. Frydman GH, Tessier SN, Wong KHK, Vanderburg CR, Fox JG, Toner M, Tompkins RG, Irimia D. Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis. Sci Rep. 2020 03 12; 10(1):4621. PMID: 32165642; PMCID: PMC7067782.
    Citations: 8     Fields:    Translation:HumansCells
  37. Park JK, Hank T, Scherber CM, Lillemoe KD, Fernández-Del Castillo C, Warshaw AL, Toner M, Irimia D, Thayer SP, Liss AS. Primary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials. Pancreas. 2020 01; 49(1):128-134. PMID: 31856088.
    Citations:    Fields:    Translation:HumansCells
  38. Hopke A, Irimia D. Ex Vivo Human Neutrophil Swarming Against Live Microbial Targets. Methods Mol Biol. 2020; 2087:107-116. PMID: 31728986.
    Citations: 2     Fields:    Translation:HumansCells
  39. Irimia D. Assaying leukocyte hallmarks during sepsis. Nat Biomed Eng. 2019 12; 3(12):947-948. PMID: 31811267.
    Citations:    Fields:    Translation:HumansCells
  40. Wang X, Scarfò I, Schmidts A, Toner M, Maus MV, Irimia D. Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays. Adv Sci (Weinh). 2019 Dec; 6(23):1901829. PMID: 31832320; PMCID: PMC6891905.
    Citations: 8     Fields:    
  41. Park J, Baik SH, Mook-Jung I, Irimia D, Cho H. Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil. Front Immunol. 2019; 10:2231. PMID: 31611872.
    Citations: 7     Fields:    Translation:HumansCells
  42. Kim JJ, Ellett F, Thomas CN, Jalali F, Anderson RR, Irimia D, Raff AB. A microscale, full-thickness, human skin on a chip assay simulating neutrophil responses to skin infection and antibiotic treatments. Lab Chip. 2019 09 10; 19(18):3094-3103. PMID: 31423506; PMCID: PMC6776466.
    Citations: 10     Fields:    Translation:HumansCells
  43. Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE, Theriot JA. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 2019 04 22; 49(2):189-205.e6. PMID: 31014479; PMCID: PMC6708378.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  44. Jones CN, Ellett F, Robertson AL, Forrest KM, Judice K, Balkovec JM, Springer M, Markmann JF, Vyas JM, Warren HS, Irimia D. Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Front Immunol. 2019; 10:644. PMID: 31024528.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  45. Ellett F, Jalali F, Marand AL, Jorgensen J, Mutlu BR, Lee J, Raff AB, Irimia D. Microfluidic arenas for war games between neutrophils and microbes. Lab Chip. 2019 03 27; 19(7):1205-1216. PMID: 30865740.
    Citations: 8     Fields:    Translation:HumansCells
  46. Otawara M, Roushan M, Wang X, Ellett F, Yu YM, Irimia D. Microfluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries. Sci Rep. 2018 11 19; 8(1):16983. PMID: 30451882; PMCID: PMC6242863.
    Citations: 10     Fields:    Translation:AnimalsCells
  47. Raymond SL, Hawkins RB, Stortz JA, Murphy TJ, Ungaro R, Dirain ML, Nacionales DC, Hollen MK, Rincon JC, Larson SD, Brakenridge SC, Moore FA, Irimia D, Efron PA, Moldawer LL. Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults. PLoS One. 2018; 13(10):e0205327. PMID: 30300408.
    Citations: 6     Fields:    Translation:HumansCells
  48. Wang X, Jodoin E, Jorgensen J, Lee J, Markmann JJ, Cataltepe S, Irimia D. Progressive mechanical confinement of chemotactic neutrophils induces arrest, oscillations, and retrotaxis. J Leukoc Biol. 2018 12; 104(6):1253-1261. PMID: 30129679; PMCID: PMC6258301.
    Citations: 5     Fields:    Translation:HumansCells
  49. Muldur S, Marand AL, Ellett F, Irimia D. Measuring spontaneous neutrophil motility signatures from a drop of blood using microfluidics. Methods Cell Biol. 2018; 147:93-107. PMID: 30165965; PMCID: PMC6230268.
    Citations: 3     Fields:    Translation:HumansCells
  50. Roushan M, Jorfi M, Mishra A, Wong KHK, Jorgensen J, Ell E, Markmann JF, Lee J, Irimia D. Trapped Chromatin Fibers Damage Flowing Red Blood Cells. Adv Biosyst. 2018 Oct; 2(10). PMID: 31223642.
    Citations: 1     Fields:    
  51. Ellett F, Jorgensen J, Marand AL, Liu YM, Martinez MM, Sein V, Butler KL, Lee J, Irimia D. Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nature Biomedical Engineering. 2018; 2(2):207–214.
  52. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). PMID: 30076281; PMCID: PMC6320225.
    Citations: 74     Fields:    
  53. DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT. Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212. PMID: 29733334; PMCID: PMC6022692.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  54. Kim JJ, Reátegui E, Hopke A, Jalali F, Roushan M, Doyle PS, Irimia D. Large-scale patterning of living colloids for dynamic studies of neutrophil-microbe interactions. Lab Chip. 2018 05 29; 18(11):1514-1520. PMID: 29770423.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  55. Raymond SL, Hawkins RB, Murphy TJ, Rincon JC, Stortz JA, López MC, Ungaro R, Ellett F, Baker HV, Wynn JL, Moldawer LL, Irimia D, Larson SD. Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production. J Mol Med (Berl). 2018 07; 96(7):673-684. PMID: 29808244; PMCID: PMC6091213.
    Citations: 8     Fields:    Translation:HumansCells
  56. Irimia D, Wang X. Inflammation-on-a-Chip: Probing the Immune System Ex Vivo. Trends Biotechnol. 2018 09; 36(9):923-937. PMID: 29728272.
    Citations: 28     Fields:    Translation:HumansCells
  57. Inoue Y, Liu YM, Otawara M, Chico Calero I, Stephanie Nam A, Yu YM, Chang P, Butler KL, Nazarian RM, Goverman J, Vakoc BJ, Irimia D. Resolvin D2 Limits Secondary Tissue Necrosis After Burn Wounds in Rats. J Burn Care Res. 2018 04 20; 39(3):423-432. PMID: 28877131.
    Citations: 5     Fields:    Translation:Animals
  58. Ellett F, Jorgensen J, Marand AL, Liu YM, Martinez MM, Sein V, Butler KL, Lee J, Irimia D. Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nat Biomed Eng. 2018 Apr; 2(4):207-214. PMID: 30283724.
    Citations: 32     Fields:    
  59. Jorfi M, D'Avanzo C, Tanzi RE, Kim DY, Irimia D. Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Sci Rep. 2018 02 05; 8(1):2450. PMID: 29402979.
    Citations: 39     Fields:    Translation:HumansCells
  60. Boneschansker L, Jorgensen J, Ellett F, Briscoe DM, Irimia D. Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes. Sci Rep. 2018 01 30; 8(1):1887. PMID: 29382882.
    Citations: 8     Fields:    Translation:HumansCells
  61. Wang X, Irimia D. Neutrophil Chemotaxis in One Droplet of Blood Using Microfluidic Assays. Methods Mol Biol. 2018; 1749:351-360. PMID: 29526009; PMCID: PMC5949872.
    Citations: 4     Fields:    Translation:HumansCells
  62. Ellett F, Irimia D. Microstructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae. J Vis Exp. 2017 12 08; (130). PMID: 29286475.
    Citations: 2     Fields:    Translation:Animals
  63. Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H, Irimia D. Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. Nature Biomedical Engineering. 2017; 1(7):0094. View Publication.
  64. Weng L, Ellett F, Edd J, Wong KHK, Uygun K, Irimia D, Stott SL, Toner M. A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. Lab Chip. 2017 11 21; 17(23):4077-4088. PMID: 29068447.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  65. Raymond SL, Mathias BJ, Murphy TJ, Rincon JC, López MC, Ungaro R, Ellett F, Jorgensen J, Wynn JL, Baker HV, Moldawer LL, Irimia D, Larson SD. Neutrophil chemotaxis and transcriptomics in term and preterm neonates. Transl Res. 2017 12; 190:4-15. PMID: 28873345; PMCID: PMC5705589.
    Citations: 16     Fields:    Translation:HumansCells
  66. Jorfi M, D'Avanzo C, Kim DY, Irimia D. Three-Dimensional Models of the Human Brain Development and Diseases. Adv Healthc Mater. 2018 01; 7(1). PMID: 28845922; PMCID: PMC5762251.
    Citations: 26     Fields:    Translation:Humans
  67. Sandlin RD, Wong KHK, Boneschansker L, Carey TR, Miller KL, Rose G, Haber DA, Maheswaran S, Irimia D, Stott SL, Toner M. Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions. Sci Rep. 2017 07 18; 7(1):5658. PMID: 28720788.
    Citations: 4     Fields:    Translation:HumansCells
  68. Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H, Irimia D. Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. Nat Biomed Eng. 2017; 1. PMID: 29057147.
    Citations: 37     Fields:    
  69. Jalali F, Ellett F, Irimia D. Rapid antibiotic sensitivity testing in microwell arrays. Technology (Singap World Sci). 2017 06; 5(2):107-114. PMID: 28781994; PMCID: PMC5542807.
    Citations: 1     
  70. Dang I, Linkner J, Yan J, Irimia D, Faix J, Gautreau A. The Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis. Biol Cell. 2017 Apr; 109(4):162-166. PMID: 28186323; PMCID: PMC5506374.
    Citations: 5     Fields:    Translation:HumansAnimals
  71. Ellett F, Irimia D. Microstructured Surface Arrays for Injection of Zebrafish Larvae. Zebrafish. 2017 04; 14(2):140-145. PMID: 28151697.
    Citations: 4     Fields:    Translation:Animals
  72. Ellett F, Jorgensen J, Frydman GH, Jones CN, Irimia D. Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus. PLoS Pathog. 2017 01; 13(1):e1006154. PMID: 28076396; PMCID: PMC5261818.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  73. Chandrasekaran A, Ellett F, Jorgensen J, Irimia D. Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant. Microsyst Nanoeng. 2017; 3. PMID: 28713624; PMCID: PMC5507070.
    Citations: 8     
  74. Frydman GH, Le A, Ellett F, Jorgensen J, Fox JG, Tompkins RG, Irimia D. Technical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay. J Leukoc Biol. 2017 03; 101(3):797-806. PMID: 27630219; PMCID: PMC5295852.
    Citations: 8     Fields:    Translation:HumansCells
  75. Kim JJ, Bong KW, Reátegui E, Irimia D, Doyle PS. Porous microwells for geometry-selective, large-scale microparticle arrays. Nat Mater. 2017 01; 16(1):139-146. PMID: 27595351.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  76. Boneschansker L, Nakayama H, Eisenga M, Wedel J, Klagsbrun M, Irimia D, Briscoe DM. Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo. J Immunol. 2016 08 15; 197(4):1389-98. PMID: 27430720; PMCID: PMC4976028.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  77. Skoge M, Wong E, Hamza B, Bae A, Martel J, Kataria R, Keizer-Gunnink I, Kortholt A, Van Haastert PJ, Charras G, Janetopoulos C, Irimia D. A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. PLoS One. 2016; 11(6):e0154491. PMID: 27332963; PMCID: PMC4917115.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  78. Irimia D, Ellett F. Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics. J Leukoc Biol. 2016 08; 100(2):291-304. PMID: 27194799; PMCID: PMC4945356.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  79. Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia D. Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. Crit Care Med. 2016 May; 44(5):e241-52. PMID: 26509319; PMCID: PMC4833510.
    Citations: 11     Fields:    Translation:Animals
  80. Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN, Perretti M. Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight. 2016 Apr 21; 1(5):e85922. PMID: 27158677; PMCID: PMC4855303.
    Citations: 78     Fields:    
  81. Wong KH, Sandlin RD, Carey TR, Miller KL, Shank AT, Oklu R, Maheswaran S, Haber DA, Irimia D, Stott SL, Toner M. The Role of Physical Stabilization in Whole Blood Preservation. Sci Rep. 2016 Feb 15; 6:21023. PMID: 26876805.
    Citations: 17     Fields:    Translation:HumansCells
  82. Jones CN, Hoang AN, Martel JM, Dimisko L, Mikkola A, Inoue Y, Kuriyama N, Yamada M, Hamza B, Kaneki M, Warren HS, Brown DE, Irimia D. Microfluidic assay for precise measurements of mouse, rat, and human neutrophil chemotaxis in whole-blood droplets. J Leukoc Biol. 2016 07; 100(1):241-7. PMID: 26819316; PMCID: PMC6608085.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  83. Boneschansker L, Inoue Y, Oklu R, Irimia D. Capillary plexuses are vulnerable to neutrophil extracellular traps. Integr Biol (Camb). 2016 Feb; 8(2):149-55. PMID: 26797289.
    Citations: 17     Fields:    Translation:HumansCells
  84. Prentice-Mott HV, Meroz Y, Carlson A, Levine MA, Davidson MW, Irimia D, Charras GT, Mahadevan L, Shah JV. Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1267-72. PMID: 26764383; PMCID: PMC4747767.
    Citations: 28     Fields:    Translation:HumansCells
  85. Orr SK, Butler KL, Hayden D, Tompkins RG, Serhan CN, Irimia D. Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients. Crit Care Med. 2015 Dec; 43(12):2642-50. PMID: 26488221; PMCID: PMC4651815.
    Citations: 24     Fields:    Translation:HumansCells
  86. Bong KW, Kim JJ, Cho H, Lim E, Doyle PS, Irimia D. Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions. Langmuir. 2015 Dec 08; 31(48):13165-71. PMID: 26545155.
    Citations: 8     Fields:    
  87. Jain NG, Wong EA, Aranyosi AJ, Boneschansker L, Markmann JF, Briscoe DM, Irimia D. Microfluidic mazes to characterize T-cell exploration patterns following activation in vitro. Integr Biol (Camb). 2015 Nov; 7(11):1423-31. PMID: 26325525.
    Citations: 9     Fields:    Translation:HumansCells
  88. Cho H, Seo JH, Wong KH, Terasaki Y, Park J, Bong K, Arai K, Lo EH, Irimia D. Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep. 2015 Oct 27; 5:15222. PMID: 26503597.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  89. Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490. PMID: 26458742.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  90. Jones CN, Dimisko L, Forrest K, Judice K, Poznansky MC, Markmann JF, Vyas JM, Irimia D. Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus. J Infect Dis. 2016 Feb 01; 213(3):465-75. PMID: 26272935; PMCID: PMC4704668.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  91. Hamza B, Irimia D. Whole blood human neutrophil trafficking in a microfluidic model of infection and inflammation. Lab Chip. 2015 Jun 21; 15(12):2625-33. PMID: 25987163.
    Citations: 31     Fields:    Translation:HumansCells
  92. Bruneau S, Wedel J, Fakhouri F, Nakayama H, Boneschansker L, Irimia D, Daly KP, Briscoe DM. Translational implications of endothelial cell dysfunction in association with chronic allograft rejection. Pediatr Nephrol. 2016 Jan; 31(1):41-51. PMID: 25903640; PMCID: PMC4619184.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  93. Hsu CH, Chen C, Irimia D, Toner M. Fast sorting of CD4+ T cells from whole blood using glass microbubbles. Technology (Singap World Sci). 2015 Mar; 3(1):38-44. PMID: 26161433; PMCID: PMC4493921.
    Citations: 5     
  94. Heo YS, Nagrath S, Moore AL, Zeinali M, Irimia D, Stott SL, Toth TL, Toner M. "Universal" vitrification of cells by ultra-fast cooling. Technology (Singap World Sci). 2015 Mar; 3(1):64-71. PMID: 25914896; PMCID: PMC4404302.
    Citations: 8     
  95. Aranyosi AJ, Wong EA, Irimia D. A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis. Lab Chip. 2015 Jan 21; 15(2):549-556. PMID: 25412288.
    Citations: 8     Fields:    Translation:HumansCells
  96. Jones CN, Moore M, Dimisko L, Alexander A, Ibrahim A, Hassell BA, Warren HS, Tompkins RG, Fagan SP, Irimia D. Spontaneous neutrophil migration patterns during sepsis after major burns. PLoS One. 2014; 9(12):e114509. PMID: 25489947.
    Citations: 36     Fields:    Translation:Humans
  97. Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid ß in the brain in a transgenic model of Alzheimer disease. J Biol Chem. 2015 Jan 23; 290(4):1966-78. PMID: 25468905; PMCID: PMC4303653.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  98. Nery FC, da Hora CC, Yaqub U, Zhang X, McCarthy DM, Bhide PG, Irimia D, Breakefield XO. New methods for investigation of neuronal migration in embryonic brain explants. J Neurosci Methods. 2015 Jan 15; 239:80-4. PMID: 25291524.
    Citations: 10     Fields:    Translation:AnimalsCells
  99. Boneschansker L, Yan J, Wong E, Briscoe DM, Irimia D. Microfluidic platform for the quantitative analysis of leukocyte migration signatures. Nat Commun. 2014 Sep 03; 5:4787. PMID: 25183261.
    Citations: 49     Fields:    Translation:HumansCells
  100. Yan J, Irimia D. Stochastic variations of migration speed between cells in clonal populations. Technology (Singap World Sci). 2014 Sep; 2(3):185-188. PMID: 25436220; PMCID: PMC4245034.
    Citations: 5     
  101. Wong IY, Javaid S, Wong EA, Perk S, Haber DA, Toner M, Irimia D. Collective and individual migration following the epithelial-mesenchymal transition. Nat Mater. 2014 Nov; 13(11):1063-71. PMID: 25129619; PMCID: PMC4209198.
    Citations: 61     Fields:    Translation:HumansCells
  102. Jones CN, Hoang AN, Dimisko L, Hamza B, Martel J, Irimia D. Microfluidic platform for measuring neutrophil chemotaxis from unprocessed whole blood. J Vis Exp. 2014 Jun 03; (88). PMID: 24962731.
    Citations: 12     Fields:    Translation:HumansCells
  103. Nery FC, Atai NA, da Hora CC, Kim EY, Hettich J, Mempel TR, Breakefield XO, Irimia D. Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia. J Neurosci Methods. 2014 Jul 30; 232:181-188. PMID: 24880044.
    Citations: 6     Fields:    Translation:HumansCells
  104. Cho H, Hamza B, Wong EA, Irimia D. On-demand, competing gradient arrays for neutrophil chemotaxis. Lab Chip. 2014 Mar 07; 14(5):972-978. PMID: 24430002.
    Citations: 12     Fields:    Translation:HumansCells
  105. Sung Y, Lue N, Hamza B, Martel J, Irimia D, Dasari RR, Choi W, Yaqoob Z, So P. Three-Dimensional Holographic Refractive-Index Measurement of Continuously Flowing Cells in a Microfluidic Channel. Phys Rev Appl. 2014 Feb 27; 1. PMID: 25419536; PMCID: PMC4236915.
    Citations: 28     
  106. Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SA. A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med. 2014 Feb 26; 6(225):225ra29. PMID: 24574340; PMCID: PMC4247228.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  107. Hamza B, Wong E, Patel S, Cho H, Martel J, Irimia D. Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels. Integr Biol (Camb). 2014 Feb; 6(2):175-83. PMID: 24419464.
    Citations: 33     Fields:    Translation:HumansCells
  108. Baik SH, Cha MY, Hyun YM, Cho H, Hamza B, Kim DK, Han SH, Choi H, Kim KH, Moon M, Lee J, Kim M, Irimia D, Mook-Jung I. Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model. Neurobiol Aging. 2014 Jun; 35(6):1286-92. PMID: 24485508.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  109. Irimia D. Cell migration in confined environments. Methods Cell Biol. 2014; 121:141-53. PMID: 24560508.
    Citations: 9     Fields:    Translation:HumansCells
  110. Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JV. Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21006-11. PMID: 24324148.
    Citations: 47     Fields:    Translation:HumansCells
  111. Hoang AN, Jones CN, Dimisko L, Hamza B, Martel J, Kojic N, Irimia D. Measuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood. Technology (Singap World Sci). 2013 Oct 02; 1(1):49. PMID: 24809064.
    Citations: 26     
  112. Mantel PY, Hoang AN, Goldowitz I, Potashnikova D, Hamza B, Vorobjev I, Ghiran I, Toner M, Irimia D, Ivanov AR, Barteneva N, Marti M. Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe. 2013 May 15; 13(5):521-534. PMID: 23684304.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  113. Desai SP, Bhatia SN, Toner M, Irimia D. Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophys J. 2013 May 07; 104(9):2077-88. PMID: 23663851.
    Citations: 106     Fields:    Translation:HumansCells
  114. Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan SP, Irimia D. Resolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J. 2013 Jun; 27(6):2270-81. PMID: 23430978.
    Citations: 45     Fields:    Translation:AnimalsCells
  115. Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-ß on microglial accumulation. Sci Rep. 2013; 3:1823. PMID: 23665843.
    Citations: 41     Fields:    Translation:HumansCells
  116. Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN, Irimia D. Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20560-5. PMID: 23185003.
    Citations: 44     Fields:    Translation:HumansCells
  117. Bohr S, Patel SJ, Sarin D, Irimia D, Yarmush ML, Berthiaume F. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen. 2013 Jan-Feb; 21(1):35-43. PMID: 23110665.
    Citations: 56     Fields:    Translation:AnimalsCells
  118. El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AE. Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17460-5. PMID: 23033492.
    Citations: 106     Fields:    Translation:HumansCells
  119. Xu C, Poh YK, Roes I, O'Cearbhaill ED, Matthiesen ME, Mu L, Yang SY, Miranda-Nieves D, Irimia D, Karp JM. A portable chemotaxis platform for short and long term analysis. PLoS One. 2012; 7(9):e44995. PMID: 23028729.
    Citations: 4     Fields:    Translation:HumansCells
  120. Koria P, Bhushan A, Irimia D, Yarmush ML. MICROFLUIDIC DEVICE FOR EXAMINING DIRECTIONAL SENSING IN DENDRITIC CELL CHEMOTAXIS. Nano Life. 2012 Jun 01; 2(2). PMID: 24073020.
    Citations: 2     
  121. Ritch JJ, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey GR, Sinha S, Scherber CM, Zeitlin S, Sadri-Vakili G, Irimia D, Difiglia M, Kegel KB. Multiple phenotypes in Huntington disease mouse neural stem cells. Mol Cell Neurosci. 2012 May; 50(1):70-81. PMID: 22508027.
    Citations: 28     Fields:    Translation:AnimalsCells
  122. Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CN. Resolvin E2 formation and impact in inflammation resolution. J Immunol. 2012 May 01; 188(9):4527-34. PMID: 22450811; PMCID: PMC3331964.
    Citations: 77     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  123. Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D. Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb). 2012 Mar; 4(3):259-69. PMID: 22314635.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  124. Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, Fortune SM. Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science. 2012 Jan 06; 335(6064):100-4. PMID: 22174129.
    Citations: 183     Fields:    Translation:Cells
  125. Watkins N, Irimia D, Toner M, Bashir R. On a chip. IEEE Pulse. 2011 Nov; 2(6):19-27. PMID: 22147065.
    Citations: 3     Fields:    Translation:HumansCells
  126. Heo YS, Lee HJ, Hassell BA, Irimia D, Toth TL, Elmoazzen H, Toner M. Controlled loading of cryoprotectants (CPAs) to oocyte with linear and complex CPA profiles on a microfluidic platform. Lab Chip. 2011 Oct 21; 11(20):3530-7. PMID: 21887438.
    Citations: 24     Fields:    Translation:AnimalsCells
  127. Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011 Sep 09; 286(36):31532-41. PMID: 21757729.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  128. Hoerning A, Koss K, Datta D, Boneschansker L, Jones CN, Wong IY, Irimia D, Calzadilla K, Benitez F, Hoyer PF, Harmon WE, Briscoe DM. Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. Eur J Immunol. 2011 Aug; 41(8):2291-302. PMID: 21538345.
    Citations: 29     Fields:    Translation:HumansCells
  129. Rosenbach AE, Koria P, Goverman J, Kotz KT, Gupta A, Yu M, Fagan SP, Irimia D, Tompkins RG. Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients. Clin Transl Sci. 2011 Feb; 4(1):63-8. PMID: 21348958.
    Citations: 4     Fields:    Translation:HumansCells
  130. Konry T, Smolina I, Yarmush JM, Irimia D, Yarmush ML. Ultrasensitive detection of low-abundance surface-marker protein using isothermal rolling circle amplification in a microfluidic nanoliter platform. Small. 2011 Feb 07; 7(3):395-400. PMID: 21294269.
    Citations: 21     Fields:    Translation:HumansAnimals
  131. Smolen GA, Zhang J, Zubrowski MJ, Edelman EJ, Luo B, Yu M, Ng LW, Scherber CM, Schott BJ, Ramaswamy S, Irimia D, Root DE, Haber DA. A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev. 2010 Dec 01; 24(23):2654-65. PMID: 21062900.
    Citations: 46     Fields:    Translation:HumansCells
  132. Kane BJ, Younan G, Helm D, Dastouri P, Prentice-Mott H, Irimia D, Chan RK, Toner M, Orgill DP. Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing. J Biomed Mater Res A. 2010 Nov; 95(2):333-40. PMID: 20607869.
    Citations: 2     Fields:    Translation:Animals
  133. Prentice-Mott H, Toner M, Irimia D. Microfluidic proportional flow controller. J Micromech Microeng. 2010 Oct 15; 20(11):1-8. PMID: 21874096.
    Citations: 1     
  134. Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, Rothenberg SM, Shah AM, Smas ME, Korir GK, Floyd FP, Gilman AJ, Lord JB, Winokur D, Springer S, Irimia D, Nagrath S, Sequist LV, Lee RJ, Isselbacher KJ, Maheswaran S, Haber DA, Toner M. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18392-7. PMID: 20930119.
    Citations: 595     Fields:    Translation:HumansCells
  135. Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M. Clinical microfluidics for neutrophil genomics and proteomics. Nat Med. 2010 Sep; 16(9):1042-7. PMID: 20802500.
    Citations: 81     Fields:    Translation:HumansCells
  136. Irimia D. Microfluidic technologies for temporal perturbations of chemotaxis. Annu Rev Biomed Eng. 2010 Aug 15; 12:259-84. PMID: 20450351.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  137. Ambravaneswaran V, Wong IY, Aranyosi AJ, Toner M, Irimia D. Directional decisions during neutrophil chemotaxis inside bifurcating channels. Integr Biol (Camb). 2010 Nov; 2(11-12):639-47. PMID: 20676444.
    Citations: 37     Fields:    Translation:HumansCells
  138. Butler KL, Ambravaneswaran V, Agrawal N, Bilodeau M, Toner M, Tompkins RG, Fagan S, Irimia D. Burn injury reduces neutrophil directional migration speed in microfluidic devices. PLoS One. 2010 Jul 30; 5(7):e11921. PMID: 20689600.
    Citations: 62     Fields:    Translation:HumansCells
  139. Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3698-703. PMID: 20133671.
    Citations: 101     Fields:    Translation:Humans
  140. Chen C, Skog J, Hsu CH, Lessard RT, Balaj L, Wurdinger T, Carter BS, Breakefield XO, Toner M, Irimia D. Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip. 2010 Feb 21; 10(4):505-11. PMID: 20126692.
    Citations: 178     Fields:    Translation:HumansCells
  141. Irimia D. Cutting edge: electronic counting of white blood cells. Lab Chip. 2009 Oct 21; 9(20):2875-6. PMID: 19789737.
    Citations:    Fields:    Translation:Humans
  142. Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J Neurochem. 2009 Oct; 111(2):417-27. PMID: 19686388.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  143. Irimia D, Toner M. Spontaneous migration of cancer cells under conditions of mechanical confinement. Integr Biol (Camb). 2009 Sep; 1(8-9):506-12. PMID: 20023765.
    Citations: 101     Fields:    Translation:HumansCells
  144. Russom A, Irimia D, Toner M. Chemical gradient-mediated melting curve analysis for genotyping of SNPs. Electrophoresis. 2009 Jul; 30(14):2536-43. PMID: 19593749.
    Citations:    Fields:    Translation:Cells
  145. Irimia D, Balázsi G, Agrawal N, Toner M. Adaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophys J. 2009 May 20; 96(10):3897-916. PMID: 19450463.
    Citations: 17     Fields:    Translation:HumansCells
  146. Edd JF, Humphry KJ, Irimia D, Weitz DA, Toner M. Nucleation and solidification in static arrays of monodisperse drops. Lab Chip. 2009 Jul 07; 9(13):1859-65. PMID: 19532960.
    Citations: 11     Fields:    Translation:Cells
  147. Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN. Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol. 2008 Dec 15; 181(12):8677-87. PMID: 19050288; PMCID: PMC2664686.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  148. Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M. Genome-wide transcriptome analysis of 150 cell samples. Integr Biol (Camb). 2009 Jan; 1(1):99-107. PMID: 20023796.
    Citations: 5     Fields:    
  149. Agrawal N, Toner M, Irimia D. Neutrophil migration assay from a drop of blood. Lab Chip. 2008 Dec; 8(12):2054-61. PMID: 19023468.
    Citations: 27     Fields:    Translation:HumansCells
  150. Hsu CH, Di Carlo D, Chen C, Irimia D, Toner M. Microvortex for focusing, guiding and sorting of particles. Lab Chip. 2008 Dec; 8(12):2128-34. PMID: 19023476.
    Citations: 29     Fields:    
  151. Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO. TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J Cell Sci. 2008 Oct 15; 121(Pt 20):3476-86. PMID: 18827015; PMCID: PMC3539201.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  152. Prabhakarpandian B, Pant K, Scott RC, Pattillo CB, Patillo CB, Irimia D, Kiani MF, Sundaram S. Synthetic microvascular networks for quantitative analysis of particle adhesion. Biomed Microdevices. 2008 Aug; 10(4):585-95. PMID: 18327641.
    Citations: 33     Fields:    Translation:Humans
  153. Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med. 2008 Jul 24; 359(4):366-77. PMID: 18596266; PMCID: PMC3551471.
    Citations: 672     Fields:    Translation:HumansCells
  154. Edd JF, Di Carlo D, Humphry KJ, Köster S, Irimia D, Weitz DA, Toner M. Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab Chip. 2008 Aug; 8(8):1262-4. PMID: 18651066.
    Citations: 107     Fields:    Translation:HumansCells
  155. Park K, Jang J, Irimia D, Sturgis J, Lee J, Robinson JP, Toner M, Bashir R. 'Living cantilever arrays' for characterization of mass of single live cells in fluids. Lab Chip. 2008 Jul; 8(7):1034-41. PMID: 18584076.
    Citations: 28     Fields:    Translation:HumansCells
  156. Kelly RT, Tang K, Irimia D, Toner M, Smith RD. Elastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime. Anal Chem. 2008 May 15; 80(10):3824-31. PMID: 18419138.
    Citations: 17     Fields:    
  157. Parekkadan B, Berdichevsky Y, Irimia D, Leeder A, Yarmush G, Toner M, Levine JB, Yarmush ML. Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neurosci Lett. 2008 Jun 20; 438(2):190-5. PMID: 18467031.
    Citations: 25     Fields:    Translation:AnimalsCells
  158. Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M. Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin Chem. 2008 May; 54(5):891-900. PMID: 18375483.
    Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
  159. Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M. Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem. 2008 Mar 15; 80(6):2204-11. PMID: 18275222.
    Citations: 90     Fields:    Translation:Cells
  160. Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner M. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature. 2007 Dec 20; 450(7173):1235-9. PMID: 18097410.
    Citations: 1150     Fields:    Translation:HumansCells
  161. Di Carlo D, Irimia D, Tompkins RG, Toner M. Continuous inertial focusing, ordering, and separation of particles in microchannels. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18892-7. PMID: 18025477.
    Citations: 300     Fields:    Translation:HumansCells
  162. Vu HN, Li Y, Casali M, Irimia D, Megeed Z, Yarmush ML. A microfluidic bioreactor for increased active retrovirus output. Lab Chip. 2008 Jan; 8(1):75-80. PMID: 18094764.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  163. Irimia D, Charras G, Agrawal N, Mitchison T, Toner M. Polar stimulation and constrained cell migration in microfluidic channels. Lab Chip. 2007 Dec; 7(12):1783-90. PMID: 18030401.
    Citations: 65     Fields:    Translation:HumansCells
  164. Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez WR. A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. J Acquir Immune Defic Syndr. 2007 Jul 01; 45(3):257-61. PMID: 17414933.
    Citations: 38     Fields:    Translation:HumansCells
  165. Cheng X, Liu YS, Irimia D, Demirci U, Yang L, Zamir L, Rodríguez WR, Toner M, Bashir R. Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. Lab Chip. 2007 Jun; 7(6):746-55. PMID: 17538717.
    Citations: 43     Fields:    Translation:HumansCells
  166. Daniel Irimia. Pneumatic Valves in Encyclopedia of Micro- and Nanofluidics edited by Li, Dongqing. 2006.
  167. Daniel Irimia. Techniques of Manipulating Cells in Encyclopedia of Micro- and Nanofluidics edited by Li, Dongqing. 2006.
  168. Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner M. A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects. Lab Chip. 2007 Feb; 7(2):170-8. PMID: 17268618.
    Citations: 108     Fields:    Translation:HumansCells
  169. King KR, Wang S, Irimia D, Jayaraman A, Toner M, Yarmush ML. A high-throughput microfluidic real-time gene expression living cell array. Lab Chip. 2007 Jan; 7(1):77-85. PMID: 17180208.
    Citations: 66     Fields:    Translation:Cells
  170. Irimia D, Geba DA, Toner M. Universal microfluidic gradient generator. Anal Chem. 2006 May 15; 78(10):3472-7. PMID: 16689552.
    Citations: 66     Fields:    
  171. Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palù G, Irimia D, Toner M, Weissleder R, Poznansky MC. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006 Mar 01; 176(5):2902-14. PMID: 16493048.
    Citations: 51     Fields:    Translation:AnimalsCells
  172. Irimia D, Toner M. Cell handling using microstructured membranes. Lab Chip. 2006 Mar; 6(3):345-52. PMID: 16511616.
    Citations: 24     Fields:    Translation:HumansCells
  173. Daniel Irimia. Capillary Force Valves in Encyclopedia of Micro- and Nanofluidics edited by Li, Dongqing. 2006.
  174. Aksan A, Irimia D, He X, Toner M. Desiccation kinetics of biopreservation solutions in microchannels. J Appl Phys. 2006; 99(6):2181280. PMID: 24155501.
    Citations: 10     
  175. Irimia D, Liu SY, Tharp WG, Samadani A, Toner M, Poznansky MC. Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip. 2006 Feb; 6(2):191-8. PMID: 16450027.
    Citations: 67     Fields:    Translation:HumansCells
  176. Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG, Poznansky MC. Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol. 2006 Mar; 79(3):539-54. PMID: 16365152.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  177. Toner M, Irimia D. Blood-on-a-chip. Annu Rev Biomed Eng. 2005; 7:77-103. PMID: 16004567.
    Citations: 146     Fields:    Translation:HumansAnimals
  178. Irimia D, Tompkins RG, Toner M. Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device. Anal Chem. 2004 Oct 15; 76(20):6137-43. PMID: 15481964.
    Citations: 25     Fields:    Translation:HumansCells
  179. Irimia D, Karlsson JO. Kinetics of intracellular ice formation in one-dimensional arrays of interacting biological cells. Biophys J. 2005 Jan; 88(1):647-60. PMID: 15475590; PMCID: PMC1305042.
    Citations: 6     Fields:    Translation:HumansCells
  180. Stott SL, Irimia D, Karlsson JO. Parametric analysis of intercellular ice propagation during cryosurgery, simulated using monte carlo techniques. Technol Cancer Res Treat. 2004 Apr; 3(2):113-23. PMID: 15059017.
    Citations: 2     Fields:    Translation:HumansCells
  181. Irimia, D., Karlsson, J.O.M. Development of a Cell Patterning Technique Using Poly(Ethylene Glycol) Disilane. Journal of Biomedical Microdevices. 2003; 5(3):185-194.
  182. Irimia D, Karlsson JO. Kinetics and mechanism of intercellular ice propagation in a micropatterned tissue construct. Biophys J. 2002 Apr; 82(4):1858-68. PMID: 11916845; PMCID: PMC1301983.
    Citations: 16     Fields:    Translation: